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10:34
The investigators hypothesized that despite cessation recommendations for peri-operative antithrombotic management in the elective setting, the use of these drugs is likely associated with increased odds for bleeding complications.
Mon Oct 07, 2019 03:00
Yusuf S, Joseph P, Rangarajan S, et al. Modifiable risk factors, cardiovascular disease, and mortality in 155 722 individuals from 21 high-income, middle-income, and low-income countries (PURE): a prospective cohort study. Lancet 2019; published online Sept 3. https://dx.doi.org/10.1016/S0140-6736(19)32007-0—In this Article, the data for the difference in PM2·5 between high-income countries and middle-income countries (2·5-fold when it should have been 2·3-fold) and between high-income countries...
01:30
Dentigerous cysts in young adults may compromise the natural evolution of the dentition and can be treated surgically or non-surgically. We report the minimally-invasive treatment of dentigerous cysts in two young patients using a modified Hawley plate to avoid traumatic injury to anatomical structures, with up to four years’ follow up.
Mon Oct 07, 2019 03:00
Are you so happy that you can’t understand depression? Not us! While Gabe and Jackie can’t relate to that level of positivity, there are lots of people in the world who simply can’t fathom what depression feels like. Despite their best efforts, naturally happy people can have a hard time understanding depression and in Episode 2, we discuss how to explain depression to happy people, including both of our spouses who are, to be honest, annoyingly peppy. We give tips on how to approach the topic and...
Mon Oct 07, 2019 13:30
The purpose of this retrospective cohort study was to identify the independent risk factors for long-term skeletal relapse following mandibular advancement with bilateral sagittal split osteotomy. Univariate and multivariate linear regression analyses were performed including nine common risk factors for relapse as independent variables and horizontal/vertical long-term (≥2 years) skeletal relapse as dependent variables. Ninety-six patients were analyzed; 66 were female (68.8%) and the average age...
Mon Oct 07, 2019 03:00
Sarcopenia is characterized by progressive and generalized loss of skeletal muscle mass and strength. The aim of the study was to investigate the impact of skeletal muscle mass on surgical site infection (SSI) in flap reconstruction for defects after oral cancer resection. The subjects were a non-randomized, retrospective cohort of 106 patients who underwent this procedure after preoperative abdominal-lumbar computed tomography (CT). Cross-sectional areas (cm2) of skeletal muscles in the L3 region...
Mon Oct 07, 2019 03:00
Navigation surgery plays an important role in modern craniomaxillofacial surgery, but it is difficult to apply navigation surgery to the mandible, due to its mobility. At present, headbands or headpins are widely used for fixation of the reference frame, and three strategies are generally used for the application of navigation surgery to the mandible. This article reports the application of a novel open position splint integrated with a reference frame and registration markers for mandibular navigation...
Mon Oct 07, 2019 03:00
CONCLUSIONS: NRAS mutations and PD-L1 expression were most prevalent in our cohort of primary vaginal melanomas and can be potentially considered as therapeutic targets. IMPLICATIONS FOR PRACTICE: This study used the Sanger sequencing, immunohistochemistry, and fluorescence in situ hybridization methods to detect common genetic mutations and PD-L1 expression and copy number in 36 primary vaginal melanomas. NRAS mutations and PD-L1 expression were the most prevalent, but KIT and TERT mutations...
Wed Oct 02, 2019 00:00
CONCLUSION: For adults with Ewing and Ewing-like sarcoma, administration of interval-compressed chemotherapy is feasible, without significant dose reductions required. Our results are comparable to prior studies involving a primarily pediatric population. IMPLICATIONS FOR PRACTICE: For Ewing sarcoma, interval-compressed vincristine, doxorubicin, and cyclophosphamide alternating with ifosfamide and etoposide administered every 2 weeks rather than every 3 weeks has been shown to improve event-free...
Wed Oct 02, 2019 00:00
CONCLUSION: Delayed introduction of anti-EGFR had no deleterious effect on OS, PFS, and ORR, compared with doublet chemotherapy with anti-VEGF. IMPLICATIONS FOR PRACTICE: For RAS/RAF wild-type metastatic colorectal cancer, patients may receive 5-fluorouracil-based chemotherapy plus either bevacizumab or an anti-epidermal growth factor receptor (EGFR). In daily practice, the time to obtain the RAS status might be long enough to consider two options: to start the chemotherapy with bevacizumab,...
Wed Oct 02, 2019 00:00
CONCLUSION: Our findings suggest that active surveillance is potentially a safe approach for NF-panNETs <1 cm. Larger tumors likely need active intervention. Intermediate-grade tumors did not result in worse survival outcome compared with low-grade tumors. Future studies might consider prospective randomized clinical trials to validate our findings. IMPLICATIONS FOR PRACTICE: The present study seeks to address the discrepancy in treatment recommendations in the management of nonfunctional...
Wed Oct 02, 2019 00:00
Authors: Klempner SJ, Fabrizio D, Bane S, Reinhart M, Peoples T, Ali SM, Sokol ES, Frampton G, Schrock AB, Anhorn R, Reddy P Abstract Treatment with immune checkpoint inhibitors (ICPIs) extends survival in a proportion of patients across multiple cancers. Tumor mutational burden (TMB)-the number of somatic mutations per DNA megabase (Mb)-has emerged as a proxy for neoantigen burden that is an independent biomarker associated with ICPI outcomes. Based on findings from recent studies, TMB...
Wed Oct 02, 2019 00:00
There are a variety of stable aspects of our selves that help us to define who we are. Two of the most prominent are personality traits and values.
Mon Oct 07, 2019 21:45
What makes a child shy or outgoing? Is shyness something that we’re born with, or is it something we develop over time? Here's what research can tell us.
Mon Oct 07, 2019 15:06
Each gap reflects a serious setback in retirement preparation and needs to be closed.
Mon Oct 07, 2019 14:52
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Criticality is truly a set point, and not a mere inevitability. New research confirms this long-standing prediction in the brains of freely behaving animals.
Mon Oct 07, 2019 18:33
Experiments showed that the brain's parahippocampal place area is involved in recognizing a particular kind of place, while the brain's retrosplenial complex is involved in mentally mapping the locations of particular places.
Mon Oct 07, 2019 18:52
Researchers have created an artificial network to simulate the brain, demonstrating that tinkering with inhibitory circuits leads to extended memory.
Mon Oct 07, 2019 17:04
by Alexandre B. Leitão, Xueni Bian, Jonathan P. Day, Simone Pitton, Eşref Demir, Francis M. Jiggins It is common to find abundant genetic variation in host resistance and parasite infectivity within populations, with the outcome of infection frequently depending on genotype-specific interactions. Underlying these effects are complex immune defenses that are under the control of both host and parasite genes. We have found extensive variation in Drosophila melanogaster’s immune response against...
Mon Oct 07, 2019 21:42
by Eric T. Sumrall, Yang Shen, Anja P. Keller, Jeanine Rismondo, Maria Pavlou, Marcel R. Eugster, Samy Boulos, Olivier Disson, Pierre Thouvenot, Samuel Kilcher, Bernd Wollscheid, Didier Cabanes, Marc Lecuit, Angelika Gründling, Martin J. Loessner The intracellular pathogen Listeria monocytogenes is distinguished by its ability to invade and replicate within mammalian cells. Remarkably, of the 15 serovars within the genus, strains belonging to serovar 4b cause the majority of listeriosis clinical...
Mon Oct 07, 2019 21:42
by Remigiusz A. Serwa, Eiki Sekine, Jonathan Brown, Su Hui Catherine Teo, Edward W. Tate, Peter O’Hare We report the analysis of a complex enveloped human virus, herpes simplex virus (HSV), assembled after in vivo incorporation of bio-orthogonal methionine analogues homopropargylglycine (HPG) or azidohomoalanine (AHA). We optimised protocols for the production of virions incorporating AHA (termed HSVAHA), identifying conditions which resulted in normal yields of HSV and normal particle/pfu ratios....
Mon Oct 07, 2019 21:42
A Capital One survey reported business owners doing well but are preparing for a recession--just in case.
Mon Oct 07, 2019 21:02
Abstract Purpose As the treatment regimens such as metformin could confound the correlation between type 2 diabetes (T2D) and gut microbiome, we should revisit the relationship between gut microbiota and T2D patients who are not currently treated with metformin. Methods The study recruited 65 T2D patients: 49 with and 16 without diabetic complications, and...
Mon Oct 07, 2019 03:00
Abstract Background Implementation of polyurethane-covered (PU) implants into practice requires a reassessment of the experience and a learning curve period. Occasional publications describe a few difficulties in this regard. However, there are no publications covering the spectrum of errors. The absence of definite information and contradictory findings makes the learning curve longer leading to many unsatisfactory results. ...
Mon Oct 07, 2019 03:00
Mon Oct 07, 2019 03:00
A new study offers a closer look at a lesser-known form of psychological abuse: educational sabotage. This type of abuse involves behaviors aimed at hindering or stopping another person’s educational efforts. “This form of violence is used by one of the partners as a means for furthering their own power and control over the other partner,” said Dr. Rachel Voth Schrag, a domestic violence expert and assistant professor in the School of Social Work at The University of Texas at Arlington. “Pursuing...
Mon Oct 07, 2019 13:00
New platform is aiming to keep workforces up to date with the latest developments in additive manufacturing, artificial intelligence, robotics and more.
Mon Oct 07, 2019 19:24
Surgical tool manufacturer Shukla Medical is saving $120,000 per year after harnessing a Markforged metal X 3D printing system to prototype surgical instruments.
Mon Oct 07, 2019 18:24
Stratasys announces launch of new medical-focused 3D printer and materials aimed at improving surgical planning and training.
Mon Oct 07, 2019 16:24
ACS Infectious DiseasesDOI: 10.1021/acsinfecdis.9b00199
Mon Oct 07, 2019 07:00
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