Nature Communications, Published online: 11 October 2019; doi:10.1038/s41467-019-12520-yRetrotransposition events have been linked to some human disorders. Here, Gardner et al. systematically search for mobile genetic elements (ME) in trio whole exome-sequencing datasets and ascertain 9 de novo MEs and further estimate genome-wide germline ME burden and constraint.
Fri Oct 11, 2019 03:00
Nature Communications, Published online: 11 October 2019; doi:10.1038/s41467-019-12688-3Full spectral and temporal control of light has a multitude of applications but is often limited in frequency resolution. The authors implement a scheme using a frequency shifting optical loop for optical field spectral shaping with a high degree of control and megahertz resolution
Fri Oct 11, 2019 03:00
Nature Communications, Published online: 11 October 2019; doi:10.1038/s41467-019-12638-zSynthetic gene oscillators can be used to control timed function and periodic expression of genes. Here the authors demonstrate in vivo implementation in the mammalian gut that can keep time over several days.
Fri Oct 11, 2019 03:00
Nature Communications, Published online: 11 October 2019; doi:10.1038/s41467-019-12419-8The Chlamydia pneumoniae adhesin LIPP plays a role in host cell entry and infection. Here, the authors find that LIPP binds to the host plasma membrane and mediates phosphatidylserine translocation, enhancing pathogen internalization without induction of apoptosis.
Fri Oct 11, 2019 03:00
Nature Communications, Published online: 11 October 2019; doi:10.1038/s41467-019-12605-8The orientation of a molecule on a surface affects many processes, so the ability to control single-molecule rotation could be powerful. Here, the authors use the electric field from a scanning tunneling microscope tip to precisely induce unidirectional rotation of a polar molecule, allowing visualization of the molecule’s internal dipole moment.
Fri Oct 11, 2019 03:00
Nature Communications, Published online: 11 October 2019; doi:10.1038/s41467-019-12669-6Taxonomy classification of amplicon sequences is an important step in investigating microbial communities in microbiome analysis. Here, the authors show incorporating environment-specific taxonomic abundance information can lead to improved species-level classification accuracy across common sample types.
Fri Oct 11, 2019 03:00
Nature Communications, Published online: 11 October 2019; doi:10.1038/s41467-019-12624-5Dynamic mesenchyme derived signals are known to direct proper organ formation and cell specification in vivo. Here the authors show in mice that mesenchyme derived Hedgehog and Wnt instruct the formation of the pancreas and beta cells, and that Wnt inhibition promotes beta cell formation from human pluripotent cells.
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