Frequent appearance of club cell (Clara cell)‐like cells as a histological marker for ALK‐positive lung adenocarcinoma

Anaplastic lymphoma kinase‐rearranged (ALK +) lung cancers show characteristic histological features, such as solid signet ring cell patterns and mucinous cribriform patterns; however, these features are not always observed in ALK + lung cancers. We noticed that club cell (Clara cell)‐like cells (CLCs) were frequently present in the papillary portion of ALK + lung adenocarcinomas. In this study, we investigated the importance of CLCs in papillary patterns of ALK + lung cancers. We compared the...

Pathology International

Thu Oct 17, 2019 20:53

Macrophage‐mediated complications after stem cell transplantation

Complications after hematopoietic stem cell transplantation (HSCT) especially graft versus host disease (GVHD) are serious events and the keys to success of HSCT. Pathological diagnosis of complications is critical but sometimes not definite in GVHD diagnosis. In this review, we focus on the role of macrophages in HSCT complications. In the early period after HSCT, residual recipient macrophages have important roles for engraftment and rejection. Hemophagocytosis is the main feature of activated...

Pathology International

Wed Oct 16, 2019 19:24

A case of renal cell carcinoma unclassified with medullary phenotype without detectable gene deletion

Renal cell carcinoma unclassified with medullary phenotype (RCCU‐MP) is a rare variant of renal medullary carcinoma (RMC) characterized by loss of SMARCB1 (INI1 / SNF5 / BAF47) protein expression in patients without sickle cell trait. Here, we report a case of RCCU‐MP in a Japanese patient who had experienced colon cancer 13 years ago, gastric cancer 11 years ago and lung cancer 9 years ago and had received hemodialysis for 15 years. This is the first report of RCCU‐MP in Japan. The patient was not...

Pathology International

Tue Oct 15, 2019 19:34

Multiple functions of S100A10, an important cancer promoter

The S100 group of calcium binding proteins is composed of 21 members that exhibit tissue/cell specific expressions. These S100 proteins bind a diverse range of targets and regulate multiple cellular processes, including proliferation, migration and differentiation. S100A10, also known as p11, binds mainly to annexin A2 and mediates the conversion of plasminogen to an active protease, plasmin. Higher S100A10 expression has been reported to link to worse outcome and/or chemoresistance in a number of...

Pathology International

Mon Oct 14, 2019 19:18