This case report describes the electrocardiographic characteristics of a trifascicular block.
Tue Oct 01, 2019 03:00
This case study analysis assesses the nature and extent of pharmaceutical industry payments to nonphysician clinicians in Australia and investigates the possible reasons for sponsorship.
Tue Oct 01, 2019 03:00
This Teachable Moment describes challenges faced by clinicians in getting patients to engage in colorectal cancer screening and strategies that clinicians can use to maximize patient adherence to colorectal cancer screening.
Tue Oct 01, 2019 03:00
The 2010 Physician Payments Sunshine Act requires public reporting of industry payments to physicians and teaching hospitals in the United States. Since its passage, the association between receipt of payments and increased prescribing of higher-cost medications has been repeatedly demonstrated. The full impact of these payments remains unclear, however, because the Sunshine Act did not apply to prescribers who were not physicians. In 2022, that will change. A provision, “Fighting the Opioid Epidemic...
Tue Oct 01, 2019 03:00
In this issue of JAMA, Shrank and colleagues report a thorough review of studies published over the past decade to provide updated estimates on the proportion of US health care spending that is wasteful, defined in 6 broad categories: failure of care delivery, failure of care coordination, overtreatment or low-value care, pricing failure, fraud and abuse, and administrative complexity. The authors estimate total annual waste to be $760 billion to $935 billion—smaller as a share of total spending...
Mon Oct 07, 2019 03:00
In this issue of JAMA, Shrank and colleagues examine the critically important issue of waste in the US health care system. Their Special Communication represents an analytic update of 2 prominent previous analyses on waste in US health care, one by the Institute of Medicine in 2010 and the other by Berwick and Hackbarth in 2012.
Mon Oct 07, 2019 03:00
In 1950, at lunch with 3 colleagues, the great physicist Enrico Fermi is alleged to have blurted out a question that became known as “the Fermi paradox.” He asked, “Where is everybody?” referring to calculations suggesting that extraterrestrial life forms are abundant in the universe, certainly abundant enough that many of them should have by then visited our solar system and Earth. But, apparently, none had.
Mon Oct 07, 2019 03:00
Key PointsHigh GILT mRNA expression is associated with improved overall survival in melanoma.IFN-, TNF-α and IL-1β induce GILT expression in melanocytes.An active and intact MHC class II pathway correlates with improved melanoma survival.
Mon Oct 07, 2019 17:53
Key PointsXenopus tadpoles and adults have adapted distinct immune responses to mycobacteria.Disease tolerance involves a noninflammatory iT cell response in tadpoles.Disease resistance involves granuloma, inflammation, and CD8 T cell response in adults.
Mon Oct 07, 2019 17:47
Key PointsIL-33 induces phenotypic transition of monocytes into fibrocytes in vitro.Phenotypic monocyte-to-fibrocyte transition is increased in renal fibrosis.STAT3 inhibition partly abolishes the increased monocyte phenotypic transition.
Mon Oct 07, 2019 17:41
As most of you know, I take security very seriously and I try hard to get the rest of you to do so as well. Sometimes my efforts are to protect patient data and keep practitioners out of trouble with enforcement entities. However other times my efforts are to keep YOUR personal data out of the hands of nefarious types who will use it against you for God knows what.*This is one of those posts.* I have been exploring the subject of this post for a few weeks now through multiple sources and I have...
Mon Oct 07, 2019 14:00
Capsule summary: In humans, the absence of STAT5b mimics the abrogated NK cell terminal maturation observed in Stat5b-/- mice. NK cells from STAT5b patients had a decreased cytolytic function and impaired convergence of lytic granules to the microtubule-organizing center. (Source: Journal of Allergy and Clinical Immunology)
Mon Oct 07, 2019 00:00
(Source: Journal of Allergy and Clinical Immunology)
Mon Oct 07, 2019 00:00
Capsule summary: A new microdeletion syndrome at chromosome 2p11.2 describes a likely new cause of thymic hypoplasia due to haploinsufficiency of FOXI3. (Source: Journal of Allergy and Clinical Immunology)
Mon Oct 07, 2019 00:00
(Source: Journal of Allergy and Clinical Immunology)
Mon Oct 07, 2019 00:00
JCM, Vol. 8, Pages 1641: More Impaired Dynamic Ventilatory Muscle Oxygenation in Congestive Heart Failure than in Chronic Obstructive Pulmonary Disease Journal of Clinical Medicine doi: 10.3390/jcm8101641 Authors: Ming-Lung Chuang I-Feng Lin Meng-Jer Hsieh Patients with chronic obstructive pulmonary disease (COPD) and congestive heart failure (CHF) often have dyspnea. Despite differences in primary organ derangement and similarities in secondary skeletal muscle changes, both patient...
Mon Oct 07, 2019 03:00
JCM, Vol. 8, Pages 1639: The Role of Physical Fitness in Cognitive-Related Biomarkers in Persons at Genetic Risk of Familial Alzheimer’s Disease Journal of Clinical Medicine doi: 10.3390/jcm8101639 Authors: Tsai Sun Kuo Pai Introduction: Nondemented people with a family history of Alzheimer’s disease (ADFH) and the ApoE-4 allele have been demonstrated to show a trend for a higher probability of cognitive decline and aberrant levels of cognitive-related biomarkers....
Mon Oct 07, 2019 03:00
JCM, Vol. 8, Pages 1637: Effects of rAAV-Mediated sox9 Overexpression on the Biological Activities of Human Osteoarthritic Articular Chondrocytes in Their Intrinsic Three-Dimensional Environment Journal of Clinical Medicine doi: 10.3390/jcm8101637 Authors: Oliver Daniels Janina Frisch Jagadeesh K. Venkatesan Ana Rey-Rico Gertrud Schmitt Magali Cucchiarini Gene therapy for osteoarthritis offers powerful, long-lasting tools that are well adapted to treat such a slow, progressive...
Mon Oct 07, 2019 03:00
JCM, Vol. 8, Pages 1638: A Systematic Review and Meta-Analysis of the Impact of Mindfulness Based Interventions on Heart Rate Variability and Inflammatory Markers Journal of Clinical Medicine doi: 10.3390/jcm8101638 Authors: Rådmark Sidorchuk Osika Niemi Mindfulness Based Interventions (MBIs) have recently been increasingly used in clinical settings, and research regarding their effects on health has grown rapidly. However, with regard to the physiological effects of mindfulness...
Mon Oct 07, 2019 03:00
JCM, Vol. 8, Pages 1640: Management Strategies for Antidepressant-Related Sexual Dysfunction: A Clinical Approach Journal of Clinical Medicine doi: 10.3390/jcm8101640 Authors: Angel L. Montejo Nieves Prieto Rubén de Alarcón Nerea Casado-Espada Javier de la Iglesia Laura Montejo Major depressive disorder is a serious mental disorder in which treatment with antidepressant medication is often associated with sexual dysfunction (SD). Given its intimate nature, treatment emergent...
Mon Oct 07, 2019 03:00
Several strategies have been investigated for achieving successful pulpal anesthesia during endodontic treatment of mandibular molars with symptomatic irreversible pulpitis. However, comprehensive evaluation and identification of the most efficacious and safe intervention are lacking. We aimed to determine this using network meta-analysis.
Mon Oct 07, 2019 03:00
Journal of Exposure Science & Environmental Epidemiology, Published online: 07 October 2019; doi:10.1038/s41370-019-0174-xPruning chemicals from the green building landscape
Mon Oct 07, 2019 03:00
Journal of Exposure Science & Environmental Epidemiology, Published online: 07 October 2019; doi:10.1038/s41370-019-0176-8Epidemiological analysis of association between lagged meteorological variables and pneumonia in wet-dry tropical North Australia, 2006–2016
Mon Oct 07, 2019 03:00
Journal of Exposure Science & Environmental Epidemiology, Published online: 07 October 2019; doi:10.1038/s41370-019-0171-0Implications of indoor microbial ecology and evolution on antibiotic resistance
Mon Oct 07, 2019 03:00
Authors: Choi SY, Pi JH, Park SK, Kang CJ Abstract Crlz-1 was expressed along with Wnt3a in the rapidly proliferating centroblasts within the dark zone of germinal center (GC) during humoral immune responses. Significantly, Crlz-1 relayed a Wnt/β-catenin signal to the expression of Bcl-6, the master regulator of centroblasts, by mobilizing the cytoplasmic CBFβ into the nucleus to allow Runx/CBFβ heterodimerization and its subsequent binding to the Bcl-6 promoter. The knockdown of Crlz-1...
Fri Oct 04, 2019 00:00
Authors: Chenery AL, Alhallaf R, Agha Z, Ajendra J, Parkinson JE, Cooper MM, Chan BHK, Eichenberger RM, Dent LA, Robertson AAB, Kupz A, Brough D, Loukas A, Sutherland TE, Allen JE, Giacomin PR Abstract Alternatively activated macrophages are essential effector cells during type 2 immunity and tissue repair following helminth infections. We previously showed that Ym1, an alternative activation marker, can drive innate IL-1R-dependent neutrophil recruitment during infection with the lung-migrating...
Fri Oct 04, 2019 00:00
In this study, we found that depletion of KCs in vivo led to enhanced lipolysis in adipose tissue by increasing the expression of FGF21, a metabolic regulator, in hepatocytes. IL-1β secreted from KCs contributed to the suppression of FGF21 expression in hepatocytes. FGF21 overexpression led to a lean phenotype and enhanced lipolysis in mice. KC depletion resulted in a lack of IL-1β signaling in the liver, leading to elevated expression of FGF21 in hepatocytes. FGF21 promoted lipolysis in adipose...
Fri Oct 04, 2019 00:00
In this study, we show that conventional but not plasmacytoid dendritic cells (DCs) are required for anti-CD3-induced oral tolerance. Moreover, oral anti-CD3 promotes XCL1 secretion by small intestine lamina propria γδ T cells that, in turn, induces tolerogenic XCR1+ DC migration to the mesenteric lymph node, where Treg cells are induced and oral tolerance is established. Consistent with this, TCRδ-/- mice did not develop oral tolerance upon oral administration of anti-CD3. However, XCL1 was not...
Wed Oct 02, 2019 00:00
In this study, we wanted to investigate the impact of human umbilical cord-derived MSCs (hUC-MSCs) on tumor growth in humanized mice generated by the human adoptive transfer of PBMCs or the cotransplantation of hematopoietic stem cells and human thymic tissue (human BLT [Hu-BLT]). Our results showed that the growth and immune rejection of engineered human fibroblastic tumors was not altered by the injection of hUC-MSCs in immune-deficient or humanized mice, respectively. This was observed whether...
Wed Oct 02, 2019 00:00
In this report, we reveal that IL-36γ specifically induces transient neutrophil infiltration but does not impact monocyte and macrophage recruitment. Using IL-36γ-/- mice in a lethal HSV-2 challenge model, we show that neutrophil counts are significantly reduced at 1 and 2 d postinfection and that KC-mediated mature neutrophil recruitment is impaired in IL-36γ-/- mice. Additionally, IL-36γ-/- mice develop genital disease more rapidly, have significantly reduced survival time, and exhibit an increased...
Wed Oct 02, 2019 00:00
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