In this study, we provide evidence that knockout of the relB gene in dendritic cells (DCs) of C57BL/6 mice results in a spontaneous and systemic accumulation of Foxp3+ T regulatory T cells (Tregs) partially at the expense of microbiota-reactive Tregs. Deletion of nfkb2 does not fully recapitulate this phenotype, indicating that alternative NF-κB activation via the RelB/p52 complex is not solely responsible for Treg accumulation. Deletion of RelB in DCs further results in an impaired oral tolerance...
Wed Oct 02, 2019 00:00
In this study, we studied the specific involvement of PPAR-δ in myeloid cells during EAE using mice that had Cre-mediated excision of floxed Ppard driven by the lysozyme M (LysM) promoter (LysM Cre :Ppard fl/fl). We observed that LysM Cre :Ppard fl/fl mice were more susceptible to EAE and developed a more severe course of this disease compared with Ppard fl/fl controls. The more severe EAE in LysM Cre :Ppard fl/fl mice was associated with an increased accumulation of pathogenic CD4+ T cells in the...
Wed Oct 02, 2019 00:00
In this study, we demonstrate that the costimulatory TNF superfamily receptor OX40 was highly expressed in MAIT cells of patients with T2D. Compared with OX40-negative MAIT cells, OX40-positive MAIT cells showed a high activation and a memory phenotype. Surprisingly, OX40 expression was negatively correlated with the frequency of MAIT cells in the peripheral blood of T2D patients. Increased cleaved caspase-3 levels were observed in OX40+-expressing MAIT cells in T2D patients. In vitro, activated...
Wed Oct 02, 2019 00:00
In this study, we evaluated the use of topical CpG oligodeoxynucleotide (ODN) as adjuvant to generate skin TRM in mice. Topical or s.c. CpG ODN adjuvant administration at the time of a s.c. Ag injection led to an accumulation of CD103- CD8 T cells in the epidermis. However, only mice with CpG ODN administered topically had significant numbers of CD103+ Ag-specific CD8 T cells persisting in the local epidermal skin, enhanced circulating memory cells in the blood, and showed protection from intradermal...
Wed Oct 02, 2019 00:00
In “Inferior Alveolar Nerve Block Using the Anterior Technique to Anesthetize Buccal Nerve and Improve Anesthesia Success Rates for Third Molar Extraction: A Randomized Controlled Trial and Magnetic Resonance Imaging Evaluation” by Tsukimoto et al, published in issue 77/10 of JOMS, the incorrect figure 3 was included. The corrected version of the figure appears here.
Mon Oct 07, 2019 03:00
Summary Melatonin is a circadian regulatory hormone with neuroprotective properties. We have previously demonstrated the association of the genetic variant rs12506228 near the melatonin receptor 1A gene (MTNR1A) with intolerance to shift‐work. Furthermore, this variant has been connected to Alzheimer's disease. Because of the previously suggested role of melatonin signalling in foetal neurocognitive and sleep development, we studied here the association of rs12506228 with early development. The...
Mon Oct 07, 2019 14:32
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Journal of the American Chemical SocietyDOI: 10.1021/jacs.9b09220
Mon Oct 07, 2019 07:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.9b08320
Mon Oct 07, 2019 07:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.9b05923
Mon Oct 07, 2019 07:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.9b07919
Mon Oct 07, 2019 07:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.9b07659
Mon Oct 07, 2019 07:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.9b06267
Mon Oct 07, 2019 07:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.9b09209
Mon Oct 07, 2019 07:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.9b08046
Mon Oct 07, 2019 07:00
The diagnosis of laryngopharyngeal reflux is controversial. There is currently no gold standard, so it relies mainly on suspicious clinical symptoms and videolaryngoscopic findings. Unfortunately these signs and symptoms are common to other causes of chronic laryngitis. Scoring systems have been proposed to reduce subjectivity in clinical diagnosis. The most widely used and accepted is the Reflux Symptom Index, which has already been translated into over 10 other languages. (Source: Journal of Voice)
Wed Oct 02, 2019 00:00
This study described voice use and lifestyle information from student speech-language pathologists (SLP) and assessed the impact of history gathering method on the acquired data. (Source: Journal of Voice)
Wed Oct 02, 2019 00:00
The present study aimed to investigate whether there are differences between Arabic-speaking and Finnish-speaking listeners in the impressions of a speaker's personality as evoked by various intentional voice qualities.
Sun Oct 06, 2019 03:00
An otherwise healthy adolescent presents with fatigue and blurry vision and is found to have a significant underlying process.
10:05
Through the implementation of sustained, formal QI, our level IV NICU substantially improved vaccination status by the time of discharge or transfer.
10:05
Three years of surveillance for AFM, a serious paralytic illness, continues to support a pediatric predominance of cases and a likely viral cause.
Mon Oct 07, 2019 10:05
You don’t need to hide professional gaps and quirks, this Career Fable advises
Mon Oct 07, 2019 17:00
Mon Oct 07, 2019 15:28
Abstract Background The optimal targets for deep brain stimulation (DBS) in patients with refractory chronic pain are not clearly defined. We applied sensory functional MRI (fMRI)- and diffusion tensor imaging (DTI)-based DBS in chronic pain patients into 3 different targets to ascertain the most beneficial individual stimulation site. Methods Three patients...
Mon Oct 07, 2019 03:00
Abstract Background Implementation of polyurethane-covered (PU) implants into practice requires a reassessment of the experience and a learning curve period. Occasional publications describe a few difficulties in this regard. However, there are no publications covering the spectrum of errors. The absence of definite information and contradictory findings makes the learning curve longer leading to many unsatisfactory results. ...
Mon Oct 07, 2019 03:00
Mon Oct 07, 2019 03:00
Zusammenfassung Die in vielen Fällen aufgrund mangelnder medizinischer Beratung geringe Aussagekraft und Gültigkeit von Patientenverfügungen (PV) hat dazu geführt, dass in kritischen Behandlungssituationen der Selbstbestimmung des nicht einwilligungsfähigen Patienten oft in unbefriedigender Weise Beachtung geschenkt wird. Um die Schwierigkeiten, die mit der Interpretation von PV entstehen, zu überwinden, wurde seit den 1990er-Jahren mit Advance Care Planning (ACP) eine neue Herangehensweise...
Mon Oct 07, 2019 03:00
Abstract Background Prognostic assessment is crucial for optimal treatment. The aim of our study was to investigate the potential impact of estrogen receptor-α (ER-α) and progesterone receptor (PR) on the prognosis of colorectal cancer (CRC) patients who received curative resection. Methods Retrospective evaluation of two independent cohorts...
Mon Oct 07, 2019 03:00
Abstract Background Leukemia is a cancer of blood and bone marrow cells, causing about 300,000 deaths worldwide. Photodynamic therapy (PDT) is a promising alternative for the treatment of malignant tumors. KillerRed is a genetically encoded red fluorescent protein photosensitizer (PS). In this study, we aimed to investigate the effects of KillerRed-mediated PDT on chronic myelogenous leukemia K562 cells, acute monocytic leukemia...
Mon Oct 07, 2019 03:00
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