The Journal of Antibiotics, Published online: 28 October 2019; doi:10.1038/s41429-019-0233-5Winners of the 2018 JA Ōmura Awards for excellence
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Analyst, 2019, Accepted ManuscriptDOI: 10.1039/C9AN01897B, PaperXuejiao Wang, Shuyan Niu, Manman Wei, Shuai Liu, Rui Liu, Chao Shi, Cuiping MaDNA tetrahedron has been developed a broad spectrum of applications in biosensor construction thanks to its excellent mechanical rigidity and structure stability. However, how to construct a highly sensitive biosensor...The content of this RSS Feed (c) The Royal Society of Chemistry
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Analyst, 2019, Accepted ManuscriptDOI: 10.1039/C9AN01953G, PaperWanyu Zhang, Lihua Jia, Xiangfeng Guo, Rui Yang, Yu Zhang, Zhenlong ZhaoCarbon dots (CDs) are a developing stable, conductive, and environmentally friendly fluorescent nanomaterial with potential applications in biomedicine and sensing. In this study, CDs with up- and down-conversion photoluminescence characteristics...The content of this RSS Feed (c) The Royal Society of Chemistry
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Abstract Rationale Sleep difficulties are one of the problems associated with adolescent binge drinking. However, the mechanisms underlying adolescent alcohol-associated sleep disturbances and potential targets for therapy remain under investigated. Orexin receptor antagonists may have therapeutic value in the treatment of insomnia, yet the use of this class of drugs in the treatment of sleep disturbances following adolescent alcohol exposure...
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Abstract Polyhydroxyalkanoates (PHAs) are considerable biopolymers that have gained an increasing biotechnological interest in different applications, although their industrial production presents several limitations. Filamentous bacterial cells could represent a possible strategy to increase PHA yield, since more abundant PHA inclusions can be stored in elongated than in rod-shaped cells. At first, we determined the optimal batch culture conditions to induce filamentation in Pseudomonas...
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Abstract Quorum-quenching (QQ) enzymes can block the quorum-sensing (QS) system and prevent the expression of QS-controlled pathogenic factors in bacteria. However, the low expression levels of QQ proteins in the original host bacteria have affected their widespread application. In this study, we heterologously expressed momL, encoding a QQ enzyme with high activity, in Lysobacter enzymogenes. A “yellow-to-white” selection marker and the high-constitutive-expression promoter PgroEL...
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After analysing 102 human heart specimens we conclude that the typical ventricular septal defect (VSD) in congenitally corrected transposition of the great arteries (ccTGA) is an outlet VSD and is frequently misdiagnosed as an inlet VSD. The orientation of the septal band is similar in ccTGA and normal heart, and different in ccTGA and TGA. Even if a transposition is present, ccTGA should not be considered a sub‐group of TGA and the term ‘double discordance’ may be more appropriate. Abstract Congenitally...
Sun Oct 27, 2019 19:15
Oncolytic virus therapy is emerging as important means in cancer treatment. In a previous study, we constructed a dual cancer-specific antitumor recombinant adenovirus, designating it Ad-apoptin-hTERTp-E1a (Ad-VT). This study aimed to investigate the anticancer potential of recombinant adenovirus Ad-apoptin-hTERTp-E1a (Ad-VT) in liver cancer. Crystal Violet staining and CCK-8 assays were used to analyse the inhibitory effect of recombinant adenovirus on human hepatoma cell line QGY-7703 and SMMC-7721....
Fri Oct 25, 2019 03:00
A significant subset of patients seen in practices present with more severe hearing loss and more complex medical histories. In this seminar, the nature of severe hearing loss will be discussed along with a discussion of how to best match available technology choices (power devices, BiCROS, etc) to patient needs.
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This protocol describes a step-by-step workflow for immunofluorescent costaining of IBA1 and TMEM119, in addition to analysis of microglial density, distribution, and morphology, as well as peripheral myeloid cell infiltration in mouse brain tissue.
Sun Oct 27, 2019 21:43
Here, a protocol is presented to produce and rear CRISPR/Cas9 genome knockout electric fish. Outlined in detail are the required molecular biology, breeding, and husbandry requirements for both a gymnotiform and a mormyrid, and injection techniques to produce Cas9-induced indel F0 larvae.
Sun Oct 27, 2019 20:44
Here, we describe a single cell micro-aspiration method for the separation of infected amoebae. In order to separate viral subpopulations in Vermamoeba vermiformis infected by Faustoviruses and unknown giant viruses, we developed the protocol detailed below and demonstrated its ability to separate two low-abundance novel giant viruses.
Sun Oct 27, 2019 19:44
Journal Name: Biological ChemistryIssue: Ahead of print
Sun Oct 27, 2019 19:24
To quantify the effects of the Bragg peak degradation due to lung tissue on treatment plans of lung cancer patients with spot scanning proton therapy and to give a conservative approximation of these effects.
Fri Oct 25, 2019 03:00
Publication date: Available online 26 October 2019Source: Annals of Allergy, Asthma & ImmunologyAuthor(s): Adrian Y.S. Lee, Anthony J.F. Smith, Matthew Krummenacher, Tiffany L. Hughes
Sun Oct 27, 2019 17:21
את המילה שָׁעוֹן חידש הרב יחיאל מיכל פינס, מראשוני ועד הלשון. הוא השתמש בה בפומבי לראשונה בעיתון הצבי בשנת תרמ"ה (1885). קודם לכן נהג הצירוף 'מורה שעות', ולצידו שימשו לעיתים הצירופים 'מד זמן', 'כלי שעה' ו'כלי מורה שעות'. עוד נהגו המילים שָׁעָה ואוֹרְלוֹגִין: השימוש במילה שָׁעָה הן ליחידת הזמן הן לכלי המדידה שלה נעשה על דרך הערבית (سَاعَة), ואילו המילה אוֹרְלוֹגין נזכרת בספרות המדרשית ומקורה במילה היוונית horologion ('מודד זמן'; מילולית: 'אמירת זמן'). משנתקבלה המילה שעון התייחדה המילה אורלוגין לשעון...
Sun Oct 27, 2019 14:40
Publication date: Available online 27 October 2019Source: Journal of the American College of SurgeonsAuthor(s): Devon Livingston-Rosanoff, David P. Foley, Glen Leverson, Lee G. WilkeBackgroundKidney transplant recipients with a history of a pre-transplant malignancy (pre-TM) have an increased risk of post-transplant malignancies (post-TM) and suspected inferior long-term outcomes. No large database studies have examined modern day trends and outcomes in this patient population compared with those...
Sun Oct 27, 2019 14:38
Abstract Anxiety disorders are the most frequent mental disorders and are more prevalent in the female population. Up to date, an involvement of guanylate cyclase A and B in anxiety‐like behavior has been suggested. In this study, we showed an expression of guanylate cyclase C (GC‐C) in the amygdala which is regulated by feeding. Therefore, we further investigated sex differences of GC‐C effects on anxiety levels with special attention to female estrous cycle and feeding. The effects of estrous...
Sat Oct 26, 2019 18:59
Publication date: Available online 26 October 2019Source: Allergology InternationalAuthor(s): Izumi Kishimoto, Chuyen Thi Hong Nguyen, Naotomo Kambe, Nhung Thi My Ly, Yoko Ueki, Ikuko Ueda-Hayakawa, Hiroyuki Okamoto
Sun Oct 27, 2019 13:55
Publication date: Available online 26 October 2019Source: Clinical TherapeuticsAuthor(s): Jessica Mason, Alyssa Kiel, Alexis White, Collin M. Clark, Bethany A. Wattengel, John A. Sellick, Kari A. MergenhagenAbstractPurposeThe most commonly reported medication allergies in the United States involve beta-lactam antibiotics, creating an important consideration for prescribers when choosing optimal treatment of infections. Currently, few data exist on outpatient prescribing patterns in response to patients...
Sun Oct 27, 2019 13:10
To assess the effect of comprehensive sexuality education on the comprehensive knowledge and attitude to condom use among first-year students at Arba Minch University.
Sat Oct 26, 2019 03:00
The present study aims to investigate the etiology, clinical profile and resistance pattern of the isolated pathogens in Nepalese adults with acute gastroenteritis. This cross-sectional study was conducted at ...
Sat Oct 26, 2019 03:00
As adolescence is a stage in which human beings face once throughout a lifetime and it is the experimental period for this reason risky sexual behavior is common among young people, and it has several sexual a...
Sat Oct 26, 2019 03:00
Publication date: Available online 26 October 2019Source: European Journal of Vascular and Endovascular SurgeryAuthor(s): Patrick Coughlin
Sun Oct 27, 2019 13:06
Publication date: Available online 26 October 2019Source: Human PathologyAuthor(s): Cherise Meyerson, Bita V. NainiSummaryDrug-induced liver injury (DILI) is a challenging and constantly changing field. The pathologist plays a key role in interpreting liver biopsies by classifying the pattern of injury, grading the severity of injury, and evaluating for other possible causes. Reports of iatrogenic liver injury are reviewed here with a focus on total parenteral nutrition (TPN) [i.e., intestinal failure-associated...
Sun Oct 27, 2019 12:56
Loss‐of‐function mutations in CEP112 were identified from two infertile patients with acephalic spermatozoa. The nonsense mutation c.496C>T produces a truncated CEP112 protein and the bi‐allelic mutations c.2074C>T and c.2104C>T may affect the coiled‐coil domain of CEP112. The expression of CEP112 protein level was reduced significantly in the patients’ spermatozoa. Abstract Acephalic spermatozoa, characterized by the headless sperm in the ejaculate, is a rare type of teratozoospermia....
Sat Oct 26, 2019 17:56
Viruses, Vol. 11, Pages 990: Comparative Virological and Pathogenic Characteristics of Avian Influenza...Viruses, Vol. 11, Pages 990: Comparative Virological and Pathogenic Characteristics of Avian Influenza H5N8 Viruses Detected in Wild Birds and Domestic Poultry in Egypt during the Winter of 2016/2017Viruses, Vol. 11, Pages 990: Comparative Virological and Pathogenic Characteristics of Avian Influenza H5N8 Viruses Detected in Wild Birds and Domestic Poultry in Egypt during the Winter of 2016/2017...
Sun Oct 27, 2019 12:11
Abstract Objectives This study aimed to examine the level of stigma and identify the correlates of stigma among lung cancer patients in China. Methods In total, 283 lung cancer patients were recruited from a tertiary cancer center in China by the convenience sampling method and completed a demographic, disease‐related information and situational characteristics questionnaire and self‐reported measures assessing stigma, state self‐esteem and coping self‐efficacy. Results The mean stigma...
Sat Oct 26, 2019 18:02
Abstract Sleep and circadian rhythms are closely related to physical and psychosocial well‐being. However, sleep and circadian rhythm disruptions are often overlooked in children with cancer, as they are frequently considered temporary side effects of therapy that resolve when treatment ends. Yet, evidence from adult oncology suggests a bidirectional relationship wherein cancer and its treatment disrupt sleep and circadian rhythms, which are associated with negative health outcomes such as poor...
Sat Oct 26, 2019 18:02
Abstract Objective Morbidity from head and neck cancers (HNCs) and their treatment is significant, given their proximity to anatomical sites impacting facial appearance and function. Assessing the needs of HNC patients throughout their cancer journey is critical to informing quality care and improving quality of life. We aimed to identify available unmet needs measures in the HNC setting and appraise their content and psychometric properties. Methods We conducted a systematic search of...
Sat Oct 26, 2019 13:23
Abstract Objective This study aimed to evaluate FCR among lymphoma patients who completed treatment and its impact on survival and quality of life (QOL). Methods In this prospective cohort study, 467 lymphoma patients were included who completed treatment with curative intent between Feb 2012 and March 2017. FCR was measured using a question from the Korean version of the QOL in Cancer Survivors Questionnaire. QOL and general health and functioning were measured using the EORTC QLQ‐C30....
Sat Oct 26, 2019 13:19
Abstract Objective Depression and anxiety lead to reduced treatment adherence, poorer quality of life, and increased care costs amongst cancer patients. Mindfulness‐Based Cognitive Therapy (MBCT) is an effective treatment, but dropout reduces potential benefits. Smart‐message reminders can prevent dropout and improve effectiveness. However, smart‐messaging is untested for MBCT in cancer. This study evaluates smart‐messaging to reduce dropout and improve effectiveness in MBCT for cancer patients...
Sat Oct 26, 2019 13:09
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