Δευτέρα 28 Οκτωβρίου 2019


The Journal of Antibiotics, Published online: 28 October 2019; doi:10.1038/s41429-019-0233-5Winners of the 2018 JA Ōmura Awards for excellence
The Journal of Antibiotics - Issue - nature.com science feeds
02:00
Winners of the 2018 JA Ōmura Awards for excellence
The Journal of Antibiotics - Issue - nature.com science feeds
01:05
Ultrasensitive Electrochemical DNA Biosensor Based on Tetrahedron structure and Proximity-dependent Surface Hybridization
Analyst, 2019, Accepted ManuscriptDOI: 10.1039/C9AN01897B, PaperXuejiao Wang, Shuyan Niu, Manman Wei, Shuai Liu, Rui Liu, Chao Shi, Cuiping MaDNA tetrahedron has been developed a broad spectrum of applications in biosensor construction thanks to its excellent mechanical rigidity and structure stability. However, how to construct a highly sensitive biosensor...The content of this RSS Feed (c) The Royal Society of Chemistry
Royal Society of Chemistry (Great Britain) Society for Analytical Chemistry Society of Public Analysts (Great Britain)
02:00
Green Synthesis of Up- and Down-Conversion Photoluminescent Carbon Dots from Coffee Beans for Fe3+ Detection and Cell Imaging
Analyst, 2019, Accepted ManuscriptDOI: 10.1039/C9AN01953G, PaperWanyu Zhang, Lihua Jia, Xiangfeng Guo, Rui Yang, Yu Zhang, Zhenlong ZhaoCarbon dots (CDs) are a developing stable, conductive, and environmentally friendly fluorescent nanomaterial with potential applications in biomedicine and sensing. In this study, CDs with up- and down-conversion photoluminescence characteristics...The content of this RSS Feed (c) The Royal Society of Chemistry
Royal Society of Chemistry (Great Britain) Society for Analytical Chemistry Society of Public Analysts (Great Britain)
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PSPH-D-18-00526: Effect of a dual orexin receptor antagonist (DORA-12) on sleep and event-related oscillations in rats exposed to ethanol vapor during adolescence
Abstract Rationale Sleep difficulties are one of the problems associated with adolescent binge drinking. However, the mechanisms underlying adolescent alcohol-associated sleep disturbances and potential targets for therapy remain under investigated. Orexin receptor antagonists may have therapeutic value in the treatment of insomnia, yet the use of this class of drugs in the treatment of sleep disturbances following adolescent alcohol exposure...
Latest Results for Psychopharmacology
02:00
Glutamine-induced filamentous cells of Pseudomonas mediterranea CFBP-5447T as producers of PHAs
Abstract Polyhydroxyalkanoates (PHAs) are considerable biopolymers that have gained an increasing biotechnological interest in different applications, although their industrial production presents several limitations. Filamentous bacterial cells could represent a possible strategy to increase PHA yield, since more abundant PHA inclusions can be stored in elongated than in rod-shaped cells. At first, we determined the optimal batch culture conditions to induce filamentation in Pseudomonas...
Latest Results for Applied Microbiology and Biotechnology
02:00
A novel heterologous expression strategy for the quorum-quenching enzyme MomL in Lysobacter enzymogenes to the inhibit pathogenicity of Pectobacterium
Abstract Quorum-quenching (QQ) enzymes can block the quorum-sensing (QS) system and prevent the expression of QS-controlled pathogenic factors in bacteria. However, the low expression levels of QQ proteins in the original host bacteria have affected their widespread application. In this study, we heterologously expressed momL, encoding a QQ enzyme with high activity, in Lysobacter enzymogenes. A “yellow-to-white” selection marker and the high-constitutive-expression promoter PgroEL...
Latest Results for Applied Microbiology and Biotechnology
02:00
Congenitally corrected transposition of the great arteries: is it really a transposition? An anatomical study of the right ventricular septal surface
After analysing 102 human heart specimens we conclude that the typical ventricular septal defect (VSD) in congenitally corrected transposition of the great arteries (ccTGA) is an outlet VSD and is frequently misdiagnosed as an inlet VSD. The orientation of the septal band is similar in ccTGA and normal heart, and different in ccTGA and TGA. Even if a transposition is present, ccTGA should not be considered a sub‐group of TGA and the term ‘double discordance’ may be more appropriate. Abstract Congenitally...
Journal of Anatomy
Sun Oct 27, 2019 19:15
A dual cancer-specific recombinant adenovirus suppresses the growth of liver cancer cells in vivo and in vitro
Oncolytic virus therapy is emerging as important means in cancer treatment. In a previous study, we constructed a dual cancer-specific antitumor recombinant adenovirus, designating it Ad-apoptin-hTERTp-E1a (Ad-VT). This study aimed to investigate the anticancer potential of recombinant adenovirus Ad-apoptin-hTERTp-E1a (Ad-VT) in liver cancer. Crystal Violet staining and CCK-8 assays were used to analyse the inhibitory effect of recombinant adenovirus on human hepatoma cell line QGY-7703 and SMMC-7721....
Anti-Cancer Drugs - Published Ahead-of-Print
Fri Oct 25, 2019 03:00
Managing Severe Hearing Loss
A significant subset of patients seen in practices present with more severe hearing loss and more complex medical histories. In this seminar, the nature of severe hearing loss will be discussed along with a discussion of how to best match available technology choices (power devices, BiCROS, etc) to patient needs.
Audiology
06:00
Immunofluorescence Staining Using IBA1 and TMEM119 for Microglial Density, Morphology and Peripheral Myeloid Cell Infiltration Analysis in Mouse Brain
This protocol describes a step-by-step workflow for immunofluorescent costaining of IBA1 and TMEM119, in addition to analysis of microglial density, distribution, and morphology, as well as peripheral myeloid cell infiltration in mouse brain tissue.
JoVE: Journal of Visualized Experiments
Sun Oct 27, 2019 21:43
Silencing the Spark: CRISPR/Cas9 Genome Editing in Weakly Electric Fish
Here, a protocol is presented to produce and rear CRISPR/Cas9 genome knockout electric fish. Outlined in detail are the required molecular biology, breeding, and husbandry requirements for both a gymnotiform and a mormyrid, and injection techniques to produce Cas9-induced indel F0 larvae.
JoVE: Journal of Visualized Experiments
Sun Oct 27, 2019 20:44
Single Cell Micro-aspiration as an Alternative Strategy to Fluorescence-activated Cell Sorting for Giant Virus Mixture Separation
Here, we describe a single cell micro-aspiration method for the separation of infected amoebae. In order to separate viral subpopulations in Vermamoeba vermiformis infected by Faustoviruses and unknown giant viruses, we developed the protocol detailed below and demonstrated its ability to separate two low-abundance novel giant viruses.
JoVE: Journal of Visualized Experiments
Sun Oct 27, 2019 19:44
Identification of new probe substrates for human CYP20A1
Journal Name: Biological ChemistryIssue: Ahead of print
Biological Chemistry.
Sun Oct 27, 2019 19:24
Effects of the Bragg peak degradation due to lung tissue in proton therapy of lung cancer patients
To quantify the effects of the Bragg peak degradation due to lung tissue on treatment plans of lung cancer patients with spot scanning proton therapy and to give a conservative approximation of these effects.
Radiation Oncology - Latest Articles
Fri Oct 25, 2019 03:00
An unusual case of loperamide anaphylaxis
Publication date: Available online 26 October 2019Source: Annals of Allergy, Asthma & ImmunologyAuthor(s): Adrian Y.S. Lee, Anthony J.F. Smith, Matthew Krummenacher, Tiffany L. Hughes
ScienceDirect Publication: Annals of Allergy, Asthma & Immunology
Sun Oct 27, 2019 17:21
מעיין
The post מעיין appeared first on האקדמיה ללשון העברית.
האקדמיה ללשון העברית
Sun Oct 27, 2019 15:19
שעון מתקתק בעברית
את המילה שָׁעוֹן חידש הרב יחיאל מיכל פינס, מראשוני ועד הלשון. הוא השתמש בה בפומבי לראשונה בעיתון הצבי בשנת תרמ"ה (1885). קודם לכן נהג הצירוף 'מורה שעות', ולצידו שימשו לעיתים הצירופים 'מד זמן', 'כלי שעה' ו'כלי מורה שעות'. עוד נהגו המילים שָׁעָה ואוֹרְלוֹגִין: השימוש במילה שָׁעָה הן ליחידת הזמן הן לכלי המדידה שלה נעשה על דרך הערבית (سَاعَة), ואילו המילה אוֹרְלוֹגין נזכרת בספרות המדרשית ומקורה במילה היוונית horologion ('מודד זמן'; מילולית: 'אמירת זמן'). משנתקבלה המילה שעון התייחדה המילה אורלוגין לשעון...
האקדמיה ללשון העברית
Sun Oct 27, 2019 14:40
Impact of Pre-Transplant Malignancy on Outcomes After Kidney Transplantation: United Network for Organ Sharing Database Analysis
Publication date: Available online 27 October 2019Source: Journal of the American College of SurgeonsAuthor(s): Devon Livingston-Rosanoff, David P. Foley, Glen Leverson, Lee G. WilkeBackgroundKidney transplant recipients with a history of a pre-transplant malignancy (pre-TM) have an increased risk of post-transplant malignancies (post-TM) and suspected inferior long-term outcomes. No large database studies have examined modern day trends and outcomes in this patient population compared with those...
Journal of the American College of Surgeons
Sun Oct 27, 2019 14:38
Anxiety‐like behavior in female mice changes by feeding, possible effect of guanylate cyclase C
Abstract Anxiety disorders are the most frequent mental disorders and are more prevalent in the female population. Up to date, an involvement of guanylate cyclase A and B in anxiety‐like behavior has been suggested. In this study, we showed an expression of guanylate cyclase C (GC‐C) in the amygdala which is regulated by feeding. Therefore, we further investigated sex differences of GC‐C effects on anxiety levels with special attention to female estrous cycle and feeding. The effects of estrous...
European Journal of Neuroscience
Sat Oct 26, 2019 18:59
Circulating intermediate monocytes produce TARC in sarcoidosis
Publication date: Available online 26 October 2019Source: Allergology InternationalAuthor(s): Izumi Kishimoto, Chuyen Thi Hong Nguyen, Naotomo Kambe, Nhung Thi My Ly, Yoko Ueki, Ikuko Ueda-Hayakawa, Hiroyuki Okamoto
Allergology International
Sun Oct 27, 2019 13:55
Impact of Beta-Lactam Allergy on Treatment of Outpatient Infections
Publication date: Available online 26 October 2019Source: Clinical TherapeuticsAuthor(s): Jessica Mason, Alyssa Kiel, Alexis White, Collin M. Clark, Bethany A. Wattengel, John A. Sellick, Kari A. MergenhagenAbstractPurposeThe most commonly reported medication allergies in the United States involve beta-lactam antibiotics, creating an important consideration for prescribers when choosing optimal treatment of infections. Currently, few data exist on outpatient prescribing patterns in response to patients...
Clinical Therapeutics
Sun Oct 27, 2019 13:10
Effects of comprehensive sexuality education on the comprehensive knowledge and attitude to condom use among first-year students in Arba Minch University: a quasi-experimental study
To assess the effect of comprehensive sexuality education on the comprehensive knowledge and attitude to condom use among first-year students at Arba Minch University.
BMC Research Notes
Sat Oct 26, 2019 03:00
Burden of Shigella spp and Vibrio spp, and their antibiotic sensitivity pattern in the patients with acute gastroenteritis in tertiary care hospital in Nepal
The present study aims to investigate the etiology, clinical profile and resistance pattern of the isolated pathogens in Nepalese adults with acute gastroenteritis. This cross-sectional study was conducted at ...
BMC Research Notes
Sat Oct 26, 2019 03:00
Risky sexual behavior practice and associated factors among secondary and preparatory school students of Aksum town, northern Ethiopia, 2018
As adolescence is a stage in which human beings face once throughout a lifetime and it is the experimental period for this reason risky sexual behavior is common among young people, and it has several sexual a...
BMC Research Notes
Sat Oct 26, 2019 03:00
Commentary on “Comparison Between Interwoven Nitinol and Drug Eluting Stents for Endovascular Treatment of Femoropopliteal Artery Disease”
Publication date: Available online 26 October 2019Source: European Journal of Vascular and Endovascular SurgeryAuthor(s): Patrick Coughlin
ScienceDirect Publication: European Journal of Vascular and Endovascular Surgery
Sun Oct 27, 2019 13:06
Something old, something new: liver injury associated with Total parenteral nutrition therapy and immune checkpoint inhibitors
Publication date: Available online 26 October 2019Source: Human PathologyAuthor(s): Cherise Meyerson, Bita V. NainiSummaryDrug-induced liver injury (DILI) is a challenging and constantly changing field. The pathologist plays a key role in interpreting liver biopsies by classifying the pattern of injury, grading the severity of injury, and evaluating for other possible causes. Reports of iatrogenic liver injury are reviewed here with a focus on total parenteral nutrition (TPN) [i.e., intestinal failure-associated...
Human Pathology
Sun Oct 27, 2019 12:56
Loss‐of‐function mutations in centrosomal protein 112 (CEP112) is associated with human acephalic spermatozoa phenotype
Loss‐of‐function mutations in CEP112 were identified from two infertile patients with acephalic spermatozoa. The nonsense mutation c.496C>T produces a truncated CEP112 protein and the bi‐allelic mutations c.2074C>T and c.2104C>T may affect the coiled‐coil domain of CEP112. The expression of CEP112 protein level was reduced significantly in the patients’ spermatozoa. Abstract Acephalic spermatozoa, characterized by the headless sperm in the ejaculate, is a rare type of teratozoospermia....
Clinical Genetics
Sat Oct 26, 2019 17:56
Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00302841026182,00306932607174,alsfakia@gmail.com, Telephone consultation 11855 int 1193,
Viruses, Vol. 11, Pages 990: Comparative Virological and Pathogenic Characteristics of Avian Influenza...Viruses, Vol. 11, Pages 990: Comparative Virological and Pathogenic Characteristics of Avian Influenza H5N8 Viruses Detected in Wild Birds and Domestic Poultry in Egypt during the Winter of 2016/2017Viruses, Vol. 11, Pages 990: Comparative Virological and Pathogenic Characteristics of Avian Influenza H5N8 Viruses Detected in Wild Birds and Domestic Poultry in Egypt during the Winter of 2016/2017...
www Αλέξανδρος Γ. Σφακιανάκης
Sun Oct 27, 2019 12:11
Stigma and its correlates in people living with lung cancer: A cross‐sectional study from China
Abstract Objectives This study aimed to examine the level of stigma and identify the correlates of stigma among lung cancer patients in China. Methods In total, 283 lung cancer patients were recruited from a tertiary cancer center in China by the convenience sampling method and completed a demographic, disease‐related information and situational characteristics questionnaire and self‐reported measures assessing stigma, state self‐esteem and coping self‐efficacy. Results The mean stigma...
Psycho-Oncology
Sat Oct 26, 2019 18:02
A call to action for expanded sleep research in pediatric oncology: A position paper on behalf of the International Psycho‐Oncology Society Pediatrics Special Interest Group
Abstract Sleep and circadian rhythms are closely related to physical and psychosocial well‐being. However, sleep and circadian rhythm disruptions are often overlooked in children with cancer, as they are frequently considered temporary side effects of therapy that resolve when treatment ends. Yet, evidence from adult oncology suggests a bidirectional relationship wherein cancer and its treatment disrupt sleep and circadian rhythms, which are associated with negative health outcomes such as poor...
Psycho-Oncology
Sat Oct 26, 2019 18:02
Content comparison of unmet needs self‐report measures used in patients with head and neck cancer: a systematic review
Abstract Objective Morbidity from head and neck cancers (HNCs) and their treatment is significant, given their proximity to anatomical sites impacting facial appearance and function. Assessing the needs of HNC patients throughout their cancer journey is critical to informing quality care and improving quality of life. We aimed to identify available unmet needs measures in the HNC setting and appraise their content and psychometric properties. Methods We conducted a systematic search of...
Psycho-Oncology
Sat Oct 26, 2019 13:23
Impact of fear of cancer recurrence on survival among lymphoma patients
Abstract Objective This study aimed to evaluate FCR among lymphoma patients who completed treatment and its impact on survival and quality of life (QOL). Methods In this prospective cohort study, 467 lymphoma patients were included who completed treatment with curative intent between Feb 2012 and March 2017. FCR was measured using a question from the Korean version of the QOL in Cancer Survivors Questionnaire. QOL and general health and functioning were measured using the EORTC QLQ‐C30....
Psycho-Oncology
Sat Oct 26, 2019 13:19
Using Smart‐Messaging to Enhance Mindfulness‐Based Cognitive Therapy for Cancer Patients: A Mixed Methods Proof of Concept Evaluation
Abstract Objective Depression and anxiety lead to reduced treatment adherence, poorer quality of life, and increased care costs amongst cancer patients. Mindfulness‐Based Cognitive Therapy (MBCT) is an effective treatment, but dropout reduces potential benefits. Smart‐message reminders can prevent dropout and improve effectiveness. However, smart‐messaging is untested for MBCT in cancer. This study evaluates smart‐messaging to reduce dropout and improve effectiveness in MBCT for cancer patients...
Psycho-Oncology
Sat Oct 26, 2019 13:09

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