Abstract Repeated traumatic brain injury, leads to cumulative neuronal injury and neurological impairments. There are currently no effective treatments to prevent these consequences. Growing interest is building in the use of transcranial photobiomodulation (PBM) therapy to treat TBI. Here, we examined PBM in a repeated closed head injury (rCHI) rat model. Rats were administered a total of three closed head injuries, with each injury separated by 5 days. PBM treatment was initiated 2 h after the...
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Cancers, Vol. 11, Pages 1671: Necessities in the Processing of DNA Double Strand Breaks and Their Effects on Genomic Instability and Cancer Cancers doi: 10.3390/cancers11111671 Authors: George Iliakis Emil Mladenov Veronika Mladenova Double strand breaks (DSBs) are induced in the DNA following exposure of cells to ionizing radiation (IR) and are highly consequential for genome integrity, requiring highly specialized modes of processing. Erroneous processing of DSBs is a cause of...
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Cancers, Vol. 11, Pages 1672: Selectin Binding Sites Are Involved in Cell Adhesive Properties of Head and Neck Squamous Cell Carcinoma Cancers doi: 10.3390/cancers11111672 Authors: Ursula Valentiner Jillian Knips Ralph Pries Till Clauditz Adrian Münscher Guido Sauter Barbara Wollenberg Udo Schumacher The formation of distant metastases often determines the fate of patients with head and neck squamous cell carcinoma (HNSCC). The expression of cell adhesion molecules...
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Cancers, Vol. 11, Pages 1669: Breast Cancer during Pregnancy—Current Paradigms, Paths to Explore Cancers doi: 10.3390/cancers11111669 Authors: Ayelet Alfasi Irit Ben-Aharon Breast cancer is the most common form of malignancy in pregnant women. The prevalence of pregnancy-associated breast cancer (PABC) is up to 0.04% of pregnancies and is expected to rise in developed countries. PABC represents a unique clinical scenario which requires a delicate balance of risks and benefits for...
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Cancers, Vol. 11, Pages 1670: Thyroid Bethesda Category AUS/FLUS in Our Microscopes: Three-Year-Experience and Cyto-Histological Correlation Cancers doi: 10.3390/cancers11111670 Authors: Roope Huhtamella Ivana Kholová The Bethesda System for Reporting Thyroid Cytopathology (TBSRTC) introduced a new category: Atypia of Undetermined Significance/Follicular Lesion of Undetermined Significance (AUS/FLUS) comprising of heterogenous lesions with a lesser degree of atypia. Its routine use...
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Cancers, Vol. 11, Pages 1668: Transcription Factor and miRNA Interplays Can Manifest the Survival of ccRCC Patients Cancers doi: 10.3390/cancers11111668 Authors: Shijie Qin Xuejia Shi Canbiao Wang Ping Jin Fei Ma Clear cell renal cell carcinoma (ccRCC) still remains a higher mortality rate in worldwide. Obtaining promising biomakers is very crucial for improving the diagnosis and prognosis of ccRCC patients. Herein, we firstly identified eight potentially prognostic miRNAs...
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Cancers, Vol. 11, Pages 1667: A Cancer-Favoring, Engineered Vaccinia Virus for Cholangiocarcinoma Cancers doi: 10.3390/cancers11111667 Authors: So Young Yoo Narayanasamy Badrinath Hye Lim Lee Jeong Heo Dae-Hwan Kang While oncolytic vaccinia virus-based therapy has shown promising results for uncured patients with cancer, its effects on cholangiocarcinoma (CCA) remain unclear. Here, we evaluated the anti-cancer activity of the cancer-favoring oncolytic vaccinia virus (CVV),...
Sun Oct 27, 2019 03:00
Cancers, Vol. 11, Pages 1666: Effective Delivery of Anti-Cancer Drug Molecules with Shape Transforming Liquid Metal Particles Cancers doi: 10.3390/cancers11111666 Authors: Dasom Kim Jangsun Hwang Yonghyun Choi Yejin Kwon Jaehee Jang Semi Yoon Jonghoon Choi Liquid metals are being studied intensively because of their potential as a drug delivery system. Eutectic gallium–indium (EGaIn) alloy liquid metals have a low melting point, low toxicity, and excellent...
Sun Oct 27, 2019 03:00
Cancers, Vol. 11, Pages 1665: Unique Molecular Features in High-Risk Histology Endometrial Cancers Cancers doi: 10.3390/cancers11111665 Authors: Pooja Pandita Xiyin Wang Devin E. Jones Kaitlyn Collins Shannon M. Hawkins Endometrial cancer is the most common gynecologic malignancy in the United States and the sixth most common cancer in women worldwide. Fortunately, most women who develop endometrial cancer have low-grade early-stage endometrioid carcinomas, and simple hysterectomy...
Sun Oct 27, 2019 03:00
Abstract Purpose To integrate the available data published on patients with epidermolysis bullosa (EB) rehabilitated with dental implants, as well as to review the recommendations for EB patients receiving implants. Methods An electronic search was undertaken in February 2019 in five databases. ...
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Integrated multilayer stretchable printed circuit boards paving the way for deformable active matrix
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Abstract Cigarette smoke (CS) contains many free radicals and toxic chemicals. Nuclear erythroid-related factor-2 (Nrf2) is a transcriptional regulator of several phase II antioxidant genes, including glutamate-cysteine ligase (GCL). In this study, it was hypothesized that Crocin may mediate antioxidant signaling pathway to protect human lung epithelial cells against CS-mediated toxicity and oxidative stress via inducing glutathione (GSH) biosynthesis and activation of Nrf2 pathway....
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Hummingbirds in flight exhibit the highest metabolic rate of all vertebrates. The bioenergetic requirements associated with hovering flight raise the possibility of positive selection upon proteins encoded by hummingbird mitochondrial DNA. Here, we have identified a non-conservative change within the mitochondria-encoded cytochrome c oxidase subunit I (COI) that is fixed within hummingbirds, yet exceedingly rare among other metazoans. This unusual change can also be identified in several nectarivorous...
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Species delimitation is ever more critical for assessing biodiversity in threatened regions of the world, with cryptic species and rapid radiations offering two of the greatest challenges, especially when they occur in conjunction. Mouse lemurs (Microcebus) are an example of a rapid, cryptic radiation and here we study five phylogenetic lineages that are found within a restricted geographic area in northeastern Madagascar. To delimit and characterize species diversity we utilize a conceptual framework...
Sun Oct 27, 2019 03:00
Acute appendicitis is the most frequent surgical abdominal emergency, but its etiology remains poorly understood. Histological examination of the appendix, following its removal due to acute appendicitis, consistently shows features in common with bronchial asthma, suggesting an allergic reaction as a candidate etiologic factor. Here, we propose the concept of appendicular lavage and use it to study the levels of the Th2 cytokines IL-4, IL-5, and IL-9 in patients with a clinical diagnosis of acute...
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Abstract Background Glucocorticoids (GC) are considered first‐line therapy for most patients with hypereosinophilic syndrome (HES). Although response rates are generally high, many patients require moderate to high doses for control of eosinophilia and symptoms, and up to 15% of patients do not respond at all. Despite this, little is known about the mechanisms of GC resistance in patients with HES. Objective To explore the aetiology of GC resistance in HES. Methods Clinical data and...
Sun Oct 27, 2019 15:39
In the Chinese Han population, prolonged exposure to hypoxic conditions can promote compensatory erythropoiesis which improves hypoxemia. However, Tibetans have developed unique phenotypes, such as downregulation of the hypoxia-inducible factor pathway through EPAS1 gene mutation, thus the mechanism of adaption of the Han population should be further studied. The results indicated that, under plateau hypoxic conditions, the plains population was able to acclimate rapidly to hypoxia through increasing...
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Cenozoic cockroaches are recent and with two indigenous exceptions, based on their fragmentary preservation state, they cannot be discriminated formally from representatives of living genera. Anaplecta vega sp.n. –the second described cockroach from Miocene (23 Ma) Simojovel amber (Mexico: Chiapas: Los Pocitos) is characterized by a slender, under 5 mm long body, prolonged mouthparts bearing long maxillary palps with a distinct flattened triangular terminal palpomere, large eyes and long slender...
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Objective Ultrasound-guided lateral thoracolumbar interfascial plane block (US-TLIP block) is a novel regional technique for anesthesia or analgesia. However, there has been no prospective, randomized and controlled clinical trial investigating the perioperative analgesic effect of US-TLIP block on lumbar spinal fusion surgery. The aim of this study was to investigate the analgesic effect of bilateral single-shot US-TLIP in patients undergoing lumbar spinal fusion surgery. ...
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It is still unclear how humans control mediolateral (ML) stability in walking and even more so for running. Here, foot placement strategy as a main mechanism to control ML stability was compared between walking and running. Moreover, to verify the role of foot placement as a means to control ML stability in both modes of locomotion, this study investigated the effect of external lateral stabilization on foot placement control. Ten young adults participated in this study. Kinematic data of the trunk...
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The inclusion of agro-industry by-products originated from corn ethanol production has increased in animal nutrition in Brazil, reducing formulation costs. In the literature, there is no consensus on how the high inclusion of de-oiled wet distillers grains can affect beef quality and the expression of lipogenic genes in Longissimus muscle. The aim of this study was to evaluate the effects of WDG in the diet of F1 Angus-Nellore cattle on meat quality characteristics, chemical composition and expression...
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Late Pleistocene climate oscillations are believed to have greatly influenced the distribution, population dynamics, and genetic variation of many marine organisms in the western Pacific. However, the impact of the late Pleistocene climate cycles on the demographic history and population genetics of pelagic fish in the northern South China Sea (SCS) remains largely unexplored. In this study, we explored the demographic history, genetic structure, and genetic diversity of Decapterus maruadsi, a typical...
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Abstract Background Hypertrophic cardiomyopathy (HCM) is associated with heart failure, atrial fibrillation and sudden death. Reduced myocardial function has been reported in HCM despite normal left ventricular (LV) ejection fraction. Additionally, LV fibrosis is associated with elevated T1 and might be an outcome predictor. Objective To systematically compare...
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Abstract Most people with cancer have a combination of treatments, such as surgery with chemotherapy and/or radiation therapy. Providing good quality cancer-related information enables patients to be better prepared for treatment and improves their adherence. This study aimed to determine the level of information received and the perceived usefulness of the sources of information to cancer patients. A 4-month study was conducted at a day care oncology unit and oncology ward of...
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Abstract Purpose To investigate the impact of blood-brain barrier (BBB) alterations induced by an experimental tumor and radiotherapy on MRI signal intensity (SI) in deep cerebellar nuclei (DCN) and the presence of gadolinium after repeated administration of a linear gadolinium-based contrast agent in rats. Methods Eighteen Fischer rats were...
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Abstract This study evaluated the effects of the different dietary zinc (Zn) levels on semen quality, on spermatozoa and seminal plasma antioxidant status, and on the seminal and blood plasma mineral status in mature male Cashmere goats during the breeding season. Twenty-eight mature male Liaoning Cashmere goats were divided into four groups based on body weight (56.2 ± 2.45 kg) and semen characteristics; these goats were fed with basal diet supplemented with 0, 20, 40, or 80 mg...
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Abstract Stomach cancer is among the most common forms of cancers, and diet and environmental factors play important roles in its malignancy. This study was conducted to evaluate the trace metal contents in the scalp hair of stomach cancer patients and healthy donors to investigate probable relationship between metal imbalances and cancer. The samples were digested in HNO3-HClO4 mixture and the metals were quantified by flame atomic absorption spectrophotometry. Median level of...
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Abstract Accumulation of lanthanum oxide nanoparticles (La2O3NPs) in the femur bone of rats after 30 days of oral administration was explored. Also, the influence of La2O3NPs on macro and trace elements in the rats’ femur bone was assessed. Inductively coupled plasma mass spectrometry (ICP-MS) and inductively coupled plasma optical spectrometry (ICP OES) were used for total element determination in the bone after decomposition while laser ablation-ICP-MS (LA-ICP-MS) was used to...
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Abstract Background The mechanistic target of rapamycin (MTOR) plays a key role in regulating cell growth and metabolism and is commonly overexpressed in head and neck cancer (HNSCC). This study investigated the association of MTOR with clinical outcome in human papilloma virus (HPV) positive and negative HNSCC patients treated by chemoradiation. Methods A tissue microarray (TMA) consisting of cores from 109 HNSCC patients treated by definitive chemoradiation was constructed and stained...
Sun Oct 27, 2019 19:45
Abstract Background The scapular system free flap has been increasing in popularity to reconstruct short segment mandibular bony defects. It is important to assess donor site morbidities systematically. Methods Prospective cohort study using objective measures of range of motion (ROM) and shoulder strength were measured. Subjective disability was evaluated with validated questionnaires—Neck Disability Impairment Index and Shoulder Pain and Disability Index. Results Twenty‐six patients...
Sun Oct 27, 2019 19:33
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