Musical training sharpens behavioral tuning more saliently than peripheral tuningMusical training appears to enhance performance at both peripheral and central auditory sites. We compared behavioral and peripheral frequency tuning in normal-hearing musicians and nonmusicians, whose native language is Mandarin. The results indicate that, at higher probe frequencies, musical training sharpens behavioral tuning more saliently than peripheral tuning. The improved peripheral tuning for musician appears to result principally from e- Knockdown of circular RNA CEP128 suppresses proliferation and improves cytotoxic efficacy of temozolomide in glioma cells by regulating miR-145-5pBackground Circular RNAs serve as key players in the development of tumorigenesis and chemoresistance. Circular RNA CEP128 has been reported to be involved in the development of chemoresistance. However, the role of circular RNA CEP128 in the resistance of glioma cells to temozolomide has not yet been characterized. Methods The expression of circular RNA CEP128, miR-145-5p, and ATP-binding cassette super-family G member 2 was evaluated us
Diagnostic Cytopathology
- Primary signet ring cell carcinoma of the pancreas: Cytopathology review of a rare entityAbstract Primary signet ring cell carcinoma of the pancreas (PSRCCP) is an extremely rare diagnosis that has not been extensively studied in literature. Primary and metastatic neoplasms to the pancreas may exhibit cytomorphological similarities to signet ring cells, posing diagnostic challenges. In this article, we review PSRCCP and provide a study of several primary pancreatic neoplasms that may mimic the appearance of PSRCCP upon cytopathology
Acta Histochemica
- Effect of gonadotropin releasing hormone on the expression of luteinizing hormone and estrogen in the nerve ganglia and ovary of a tropical abalone, <em>Haliotis asinina</em> LinnaeusPublication date: Available online 9 October 2019Source: Acta HistochemicaAuthor(s): Parinyaporn Nuurai, Chaitip Wanichanon, Ratanasate WanichanonAbstractGonadotropin releasing hormone (GnRH) is a peptide brain hormone that is involved in the regulation of reproduction in vertebrates via stimulation of the secretion of the pituitary hormones, luteinizing hormone (LH) and follicle-stimulating hormone (FSH), which in their turn stimulate sexual dev
- Enhanced melanoma cell-killing by combined phototherapy/radiotherapy using a mesoporous platinum nanostructurePublication date: Available online 10 October 2019Source: Photodiagnosis and Photodynamic TherapyAuthor(s): F. Salehi, F. Daneshvar, M. Karimi, R. Dehdari Vais, M.A. Mosleh-Shirazi, N. SattarahmadyAbstractBackgroundMetal nanomaterials have a significant potential as photosensitizer and radiosensitizer. The purpose of this study was to evaluate the cytotoxicity of a platinum mesoporous nanostructure (Pt MN) toward a melanoma cancer cell line upon
- Phaeohyphomycosis due to <em>Exophiala spinifera</em> greatly improved by ALA-PDT: A case reportPublication date: Available online 10 October 2019Source: Photodiagnosis and Photodynamic TherapyAuthor(s): Hongfang Liu, Jiao Zhang, Yangxia Chen, Ruzeng Xue, Weiying Zeng, Liyan Xi, Yongfeng ChenAbstractAn 80-year-old women complained of painful erythema, papules, nodules on her right wrist for 9 months. Granuloma and inflammatory infiltrates with septate fungal hyphae were observed in pathological sections. Growth of demaciatious fugus on SDA
JAMA Otolaryngology–Head & Neck Surgery Online First
- Challenges of Operating on the Oldest OldThis issue of JAMA Otolaryngology presents “Complications, Mortality, and Functional Decline in Patients 80 Years and Older Undergoing Major Head and Neck Ablation and Reconstruction” by Fancy et al. This work represents a major contribution to the head and neck reconstructive literature in a group that many have long held the speculative opinion do worse with surgery: the oldest of the old. This is a growing population, thus presenting a pressin
- Potential Barriers to Timely Access to Pediatric Hearing AidsThis cohort study of children who were evaluated and fitted for hearing aids at a large urban tertiary care center explores the associations of sociodemographic and clinical factors with access to pediatric hearing aids.
- Outcomes in Patients 80 Years or Older Undergoing Major Head and Neck Ablation and ReconstructionThis cohort study examines factors associated with 30-day postoperative complications, 90-day mortality, and 90-day functional decline and creates a preoperative risk stratification system for elderly patients undergoing head and neck ablation and reconstruction.
- Vocal Fold Mass in a Middle-aged WomanA 45-year-old woman with a history of a left vocal fold polyp presented with hoarseness. What is your diagnosis?
- Prolonging Life, but at What Price?This Viewpoint describes quality of life and other factors that should be considered when elderly patients make cancer treatment decisions.
- Clinical practice guidelines for diagnosis and treatment of chronic tinnitus in JapanPublication date: Available online 9 October 2019Source: Auris Nasus LarynxAuthor(s): Kaoru Ogawa, Hiroaki Sato, Mariko Takahashi, Tetsuro Wada, Yasushi Naito, Tetsuaki Kawase, Shingo Murakami, Akira Hara, Sho KanzakiAbstractClinical practice guidelines in Japan for tinnitus were published in May 2019. Effective treatment of tinnitus contributes to quality of life and may improve depression, anxiety, and cognitive function. The highest priority o
liebertpub1
oto-rhino-laryngologie
- A composite Gelatin/hyaluronic acid hydrogel as an ECM mimic for developing mesenchymal stem cell derived epithelial tissue patches.Related ArticlesA composite Gelatin/hyaluronic acid hydrogel as an ECM mimic for developing mesenchymal stem cell derived epithelial tissue patches. J Tissue Eng Regen Med. 2019 Oct 09;: Authors: Kumar P, Ciftci S, Barthes J, Knopf-Marques H, Muller CB, Debry C, Vrana NE, Ghaemmaghami AM Abstract Here we report fabrication of Gelatin based biocomposite films and their application in developing epithe
The New England Journal of Medicine: Neurology\Neurosurgery
- Case 31-2019: A 45-Year-Old Woman with Headache and SomnolencePresentation of Case. Dr. Elinor L. Baron: A 45-year-old woman with multiple sclerosis, seronegative inflammatory polyarthritis, and migraine was admitted to this hospital during the winter because of lethargy and decreased verbal output. The patient had been in her usual state of health until 13…
- Using 3D MRI Anatomic Maps to Determine Prognosis for Glioblastomas.Related ArticlesUsing 3D MRI Anatomic Maps to Determine Prognosis for Glioblastomas. Radiology. 2019 Oct 08;:192088 Authors: Huang RY PMID: 31596185 [PubMed - as supplied by publisher]
- Detecting Prostate Cancer with Deep Learning for MRI: A Small Step Forward.Related ArticlesDetecting Prostate Cancer with Deep Learning for MRI: A Small Step Forward. Radiology. 2019 Oct 08;:192012 Authors: Padhani AR, Turkbey B PMID: 31596184 [PubMed - as supplied by publisher]
- Improving Postsurgical Outcome in Patients with HCC by Using a Hepatobiliary Contrast Agent.Related ArticlesImproving Postsurgical Outcome in Patients with HCC by Using a Hepatobiliary Contrast Agent. Radiology. 2019 Oct 08;:191990 Authors: Motosugi U PMID: 31596183 [PubMed - as supplied by publisher]
- A Radiologist's Excursion in Four-dimensional Flow and the Bicuspid Aortic Valve:Vorticity, Helicity, Wall Shear Stress, and All That.Related ArticlesA Radiologist's Excursion in Four-dimensional Flow and the Bicuspid Aortic Valve:Vorticity, Helicity, Wall Shear Stress, and All That. Radiology. 2019 Oct 08;:192076 Authors: Mitsouras D, Hope MD PMID: 31596182 [PubMed - as supplied by publisher]
- Voriconazole-Induced PeriostitisA 65-year-old woman who had undergone lung transplantation 8 years earlier was evaluated by the rheumatology service for progressive swelling in both hands and diffuse body pain. Since transplantation, the patient had received antifungal prophylaxis with daily voriconazole. On examination, there…
- Phakomatosis PigmentokeratoticaA 37-year-old man was referred to the dermatology clinic for evaluation of skin lesions that had been present since birth. On physical examination, two types of lesions were observed: brownish hyperkeratotic papules following Blaschko’s lines (arrowhead) and pigmented papules distributed in a…
- Healthcare resource utilization and costs of adverse events among patients with metastatic urothelial cancer in USA.Related ArticlesHealthcare resource utilization and costs of adverse events among patients with metastatic urothelial cancer in USA. Future Oncol. 2019 Oct 09;: Authors: Grivas P, DerSarkissian M, Shenolikar R, Laliberté F, Doleh Y, Duh MS Abstract Aim: To estimate incremental costs and healthcare resource utilization (HRU) associated with select severe adverse events (AEs) and AEs of any severity in
- CT-guided transthoracic needle biopsy: advantages in histopathological and molecular tests.Related ArticlesCT-guided transthoracic needle biopsy: advantages in histopathological and molecular tests. Future Oncol. 2019 Oct 09;: Authors: Porrello C, Gullo R, Gagliardo CM, Vaglica A, Palazzolo M, Giangregorio F, Iadicola D, Catanzaro A, Scerrino G, Faso FL, Carini F, Tomasello G Abstract Aim: The present study aimed to demonstrate that computed tomography-guided transthoracic needle biopsy (T
- The accuracy of panoramic radiographs as a screening of bone mineral density in women: a meta-analysis.Related ArticlesThe accuracy of panoramic radiographs as a screening of bone mineral density in women: a meta-analysis. Dentomaxillofac Radiol. 2019 Oct 09;:20190149 Authors: Kinalski MA, Boscato N, Damian MF Abstract OBJECTIVES: A systematic review (SR) and meta-analysis (MA) of diagnostic test accuracy studies was conducted to assess if the radiomorphometric indexes (RIs) observed in panoramic radi
- Can the lower rate of CT- or MRI-related adverse drug reactions to contrast media due to stricter limitations on patients undergoing contrast-enhanced CT or MRI?Related ArticlesCan the lower rate of CT- or MRI-related adverse drug reactions to contrast media due to stricter limitations on patients undergoing contrast-enhanced CT or MRI? Dentomaxillofac Radiol. 2019 Oct 09;:20190214 Authors: Maeda T, Oda M, Kito S, Tanaka T, Wakasugi-Sato N, Matsumoto-Takeda S, Joujima T, Miyamura Y, Kiyota K, Tsutsumi K, Morimoto Y Abstract OBJECTIVES: The aim of this study
- Hindlimb motor responses evoked by microstimulation of the lumbar dorsal root ganglia during quiet standing.Related ArticlesHindlimb motor responses evoked by microstimulation of the lumbar dorsal root ganglia during quiet standing. J Neural Eng. 2019 Oct 09;: Authors: Urbin MA, Liu M, Bottorff EC, Gaunt RA, Fisher LE, Weber DJ Abstract Somatosensory afferent pathways have been a target for neural prostheses that seek to restore sensory feedback from amputated limbs and to recruit muscles paralyzed by neur
- An exploration of neural dynamics of motor imagery for people with amyotrophic lateral sclerosis.Related ArticlesAn exploration of neural dynamics of motor imagery for people with amyotrophic lateral sclerosis. J Neural Eng. 2019 Oct 09;: Authors: Hosni SI, Deligani RJ, Zisk AH, McLinden J, Borgheai SB, Shahriari Y Abstract OBJECTIVE: Studies of the neuropathological effects of amyotrophic lateral sclerosis (ALS) on the underlying motor system have investigated abnormalities in the magnitude and
- A versatile robotic platform for the design of natural, three-dimensional reaching and grasping tasks in monkeys.Related ArticlesA versatile robotic platform for the design of natural, three-dimensional reaching and grasping tasks in monkeys. J Neural Eng. 2019 Oct 09;: Authors: Barra B, Badi M, Perich MG, Conti S, Mirrazavi Salehian SS, Moreillon F, Bogaard A, Wurth S, Kaeser M, Passeraub P, Milekovic T, Billard A, Micera S, Capogrosso M Abstract OBJECTIVE: Translational studies on motor control and neurologic
- New life for old wires: Electrochemical sensor method for neural implants.Related ArticlesNew life for old wires: Electrochemical sensor method for neural implants. J Neural Eng. 2019 Oct 09;: Authors: Weltin A, Ganatra D, König K, Joseph K, Hofmann UG, Urban G, Kieninger J Abstract OBJECTIVE: Electrochemical microsensors based on noble metals can give essential information on their microenvironment with high spatio-temporal resolution. However, most advanced chemo- and bi
- Controlled Trial of Two Incremental Milk-Feeding Rates in Preterm InfantsInfants who are very preterm ( Existing trial data are insufficient to determine whether advancing enteral feeding volumes slowly (typically by Methods. Trial Design and Procedures. The trial was a multicenter, parallel-group, randomized, controlled trial that followed a published protocol also…
- Patient-Customized Oligonucleotide Therapy for a Rare Genetic DiseaseRare diseases in aggregate affect approximately 30 million persons in the United States alone. Although next-generation sequencing is revolutionizing their diagnosis, the sheer number of distinct conditions (more than 7000 [https://globalgenes.org/rare-list]) and the limited number of patients…
Annals of Clinical Microbiology and Antimicrobials - Latest Articles
- Determining the clinical significance of co-colonization of vancomycin-resistant enterococci and methicillin-resistant Staphylococcus aureus in the intestinal tracts of patients in intensive care units: a case–control studyThe emergence of vancomycin-resistant Staphylococcus aureus (VRSA) has become a global concern for public health. The proximity of vancomycin-resistant enterococcus (VRE) and methicillin-resistant S. aureus (MRSA...
ClinicalTrials
- Study to Assess Safety and Efficacy of the Second Mitochondrial-derived Activator of Caspases (SMAC) Mimetic Debio 1143Condition: Solid TumorInterventions: Drug: Debio 1143; Drug: NivolumabSponsor: Debiopharm International SARecruiting
- Single Ascending Dose Study of ALA-1000Condition: Opioid-use DisorderInterventions: Drug: ALA-1000; Drug: buprenorphine sublingual filmSponsor: Alar Pharmaceuticals Inc.Recruiting
Disease Markers
- Association of Galectin-3 and Soluble ST2, and Their Changes, with Echocardiographic Parameters and Development of Heart Failure after ST-Segment Elevation Myocardial InfarctionPurpose. To investigate the association of galectin-3 (Gal-3) and soluble ST2 (sST2) and their follow-up changes with the development of heart failure (HF) and echocardiographic parameters of HF (ejection fraction, atrial and ventricular size, left ventricular hypertrophy, e, and E/e) in patients with ST-segment elevation myocardial infarction (STEMI) treated with primary percutaneous coronary intervention (pPCI). Methods. A prospective, observat
- Genetic Polymorphisms of IFNG and IFNGR1 with Latent Tuberculosis InfectionPrevious studies indicated that single-nucleotide polymorphisms (SNPs) of interferon gamma (IFNG) and IFNG receptor 1 (IFNGR1) may be involved in the pathogenesis of pulmonary tuberculosis (PTB) in different populations. In order to further explore the results in a Chinese Han population, this study was designed to investigate potential associations between the polymorphisms in IFNG and IFNGR1 and susceptibility to latent tuberculosis infection (
- An overview of endoscopy in neurologic surgery.Related ArticlesAn overview of endoscopy in neurologic surgery. Cleve Clin J Med. 2019 Oct;86(10):16ME-24ME Authors: Rigante L, Borghei-Razavi H, Recinos PF, Roser F Abstract Endoscopy allows neurosurgeons to reach regions in the brain and spine through minimally invasive approaches. Such areas were previously accessible only by extensive and invasive approaches that limited the ability to see the ar
- Would a right shift of the oxy-hemoglobin dissociation curve improve exercise capacity in patients with heart failure?Publication date: Available online 10 October 2019Source: Medical HypothesesAuthor(s): Kisuk Min, Dongwook Yeo, Jeung-Ki Yoo, Bruce D. Johnson, Chul-Ho KimAbstractExercise intolerance is a hallmark of symptoms in patients with heart failure. In addition to reduced cardiac output, a series of impairments in pulmonary and vascular systems leads to decreases in oxygen delivery and availability in locomotor muscles. This contributes to exercise intol
- Preventive potential of low intensity pulsed ultrasound for chronic traumatic encephalopathy after repetitive head collisions in contact sportsPublication date: Available online 10 October 2019Source: Medical HypothesesAuthor(s): Shih-Jen TsaiAbstractChronic traumatic encephalopathy (CTE), a disease process well-recognized in boxers, American football players and military personnel, is a progressive neurodegenerative disease caused by repetitive blows to the head. Subjects with CTE can have a wide range of emotional, cognitive and physical symptoms. The cognitive group patients had a si
- The Depressogenic Potential of Added Dietary SugarsPublication date: Available online 10 October 2019Source: Medical HypothesesAuthor(s): Daniel J. Reis, Stephen S. Ilardi, Michael S. Namekata, Erik K. Wing, Carina H. FowlerAbstractAdded sugars are ubiquitous in contemporary Western diets. Although excessive sugar consumption is now robustly associated with an array of adverse health consequences, comparatively little research has thus far addressed its impact on the risk of mental illness. But a
- Recurrent non-coding U1-snRNA mutations drive cryptic splicing in Shh medulloblastoma.Related ArticlesRecurrent non-coding U1-snRNA mutations drive cryptic splicing in Shh medulloblastoma. Nature. 2019 Oct 09;: Authors: Suzuki H, Kumar SA, Shuai S, Diaz-Navarro A, Gutierrez-Fernandez A, De Antonellis P, Cavalli FMG, Juraschka K, Farooq H, Shibahara I, Vladoiu MC, Zhang J, Abeysundara N, Przelicki D, Skowron P, Gauer N, Luu B, Daniels C, Wu X, Forget A, Momin A, Wang J, Dong W, Kim SK, Grajkowska WA, Jo
- Sugar-sweetened beverages and colorectal cancer risk in the California Teachers Study.Related ArticlesSugar-sweetened beverages and colorectal cancer risk in the California Teachers Study. PLoS One. 2019;14(10):e0223638 Authors: Pacheco LS, Anderson CAM, Lacey JV, Giovannucci EL, Lemus H, Araneta MRG, Sears DD, Talavera GA, Martinez ME Abstract BACKGROUND: The association between sugar-sweetened beverage (SSB) consumption and colorectal cancer (CRC) risk remains unclear and published
- Simultaneous occurrence of Kaposi sarcoma and tuberculosis; Kaposi sarcoma and lymphoma in the same lymph node: a report on two HIV-positive patients from Zimbabwe.Related ArticlesSimultaneous occurrence of Kaposi sarcoma and tuberculosis; Kaposi sarcoma and lymphoma in the same lymph node: a report on two HIV-positive patients from Zimbabwe. Rev Soc Bras Med Trop. 2019;52:e20180188 Authors: Paksoy N Abstract Reports of simultaneous infections and neoplasms in patients with acquired immune deficiency syndrome (AIDS) are occasionally seen in the literature. Howe
- Elucidating the roles of ASPM isoforms reveals a novel prognostic marker for pancreatic cancer.Related ArticlesElucidating the roles of ASPM isoforms reveals a novel prognostic marker for pancreatic cancer. J Pathol. 2019 Oct 09;: Authors: Timaner M, Shaked Y Abstract Pancreatic ductal adenocarcinoma (PDAC) is one of the deadliest cancers worldwide. Late diagnosis, desmoplastic tissue and intrinsic resistance to therapy are among the main reasons for its aggressive phenotype. In addition, it i
- Attendance at National Cancer Institute and Children's Oncology Group Facilities for Children, Adolescents, and Young Adults with Cancer in Pennsylvania: A Population-Based StudyJournal of Adolescent and Young Adult Oncology, Ahead of Print.
- Ethanol Extract of Sesamum indicum Linn. Inhibits FcεRI-Mediated Allergic Reaction via Regulation of Lyn/Syk and Fyn Signaling Pathways in Rat Basophilic Leukemic RBL-2H3 Mast CellsThis study is aimed at determining whether Sesamum indicum Linn. beneficially influences FcεRI-mediated allergic reactions in RBL-2H3 mast cells; it is also aimed at further investigating Lyn/Fyn and Syk signaling pathways. To examine the antiallergic effect of Sesamum indicum Linn. extract (SIE), we treated antigen/immunoglobulin E- (IgE-) sensitized mast cells with extracts of various concentrations. We examined the degranulation release and co
Cancer Immunology, Immunotherapy
- Potential clinical application of tumor-infiltrating lymphocyte therapy for ovarian epithelial cancer prior or post-resistance to chemotherapyAbstract Background Immunotherapy has become a powerful treatment option for several solid tumor types. The presence of tumor-infiltrating lymphocytes (TIL) is correlated with better prognosis in ovarian cancer, pointing at the possibility to benefit from harnessing their anti-tumor activity. This preclinical study explores the feasibility of adoptive cell therapy (ACT) with TIL using
- LncRNA LINC00974 Upregulates CDK6 to Promote Cell Cycle Progression in Gastric Carcinoma.Related ArticlesLncRNA LINC00974 Upregulates CDK6 to Promote Cell Cycle Progression in Gastric Carcinoma. Cancer Biother Radiopharm. 2019 Oct 09;: Authors: Gao H, Yin Y, Qian A, Guo R, Qi J Abstract Background: It is known that LINC00974 is an oncogenic long noncoding RNA in liver cancer. Results: The authors observed in this study that LINC00974 was upregulated in gastric cancer (GC) and positively
- HSP90 regulates osteosarcoma cell apoptosis by targeting the p53/TCF-1-mediated transcriptional network.Related ArticlesHSP90 regulates osteosarcoma cell apoptosis by targeting the p53/TCF-1-mediated transcriptional network. J Cell Physiol. 2019 Oct 09;: Authors: Yang J, Li YH, He MT, Qiao JF, Sang Y, Cheang LH, Gomes FC, Hu Y, Li ZY, Liu N, Zhang HT, Zha ZG Abstract Osteosarcoma (OS) is the most common bone tumor that occurs predominantly in children and teenagers. Although many genes, such as p53 and
- Intraperitoneal Chemotherapy: A Strategy for the Treatment of Refractory Ascites in Recurrent Endometrial Cancer Patients - Three Case Reports and Review of the Literature.Related ArticlesIntraperitoneal Chemotherapy: A Strategy for the Treatment of Refractory Ascites in Recurrent Endometrial Cancer Patients - Three Case Reports and Review of the Literature. Oncology. 2019 Oct 09;:1-4 Authors: Perniola G, Santangelo G, Palaia I, Musella A, Tomao F, Di Donato V, Muzii L, Benedetti Panici P Abstract BACKGROUND: Endometrial cancer currently represents the most frequent gy
- Palliative radiotherapy: what do nurses know?Related ArticlesPalliative radiotherapy: what do nurses know? Br J Nurs. 2019 Oct 10;28(18):1202-1206 Authors: Hayden K, Connolly M Abstract BACKGROUND: palliative radiotherapy can improve quality of life for patients who are symptomatic of advanced cancers. However, this treatment modality is underused and is often mistimed, which negates its potential benefit. AIM: the aim of this study wa
- Development and Validation of a Score to Predict Acute Care Use After Initiation of Systemic Therapy for Cancer.Related ArticlesDevelopment and Validation of a Score to Predict Acute Care Use After Initiation of Systemic Therapy for Cancer. JAMA Netw Open. 2019 Oct 02;2(10):e1912823 Authors: Grant RC, Moineddin R, Yao Z, Powis M, Kukreti V, Krzyzanowska MK Abstract Importance: Emergency department visits and hospitalizations after starting systemic therapy for cancer are frequent, undesirable, and costly. A sc
- Sensitivity and Specificity of the Modified Epworth Sleepiness Scale in Children With Craniopharyngioma.Related ArticlesSensitivity and Specificity of the Modified Epworth Sleepiness Scale in Children With Craniopharyngioma. J Clin Sleep Med. 2019 Oct 15;15(10):1487-1493 Authors: Crabtree VM, Klages KL, Sykes A, Wise MS, Lu Z, Indelicato D, Merchant TE, Avent Y, Mandrell BN Abstract STUDY OBJECTIVES: Children with craniopharyngioma are at risk for excessive daytime sleepiness (EDS). Multiple Sleep Late
- Prevalence and Predictors of Distress, Anxiety, Depression, and Quality of Life in Bereaved Family Caregivers of Patients With Advanced Cancer.Related ArticlesPrevalence and Predictors of Distress, Anxiety, Depression, and Quality of Life in Bereaved Family Caregivers of Patients With Advanced Cancer. Am J Hosp Palliat Care. 2019 Oct 09;:1049909119872755 Authors: Oechsle K, Ullrich A, Marx G, Benze G, Wowretzko F, Zhang Y, Dickel LM, Heine J, Wendt KN, Nauck F, Bokemeyer C, Bergelt C Abstract OBJECTIVE: To investigate prevalence and predict
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Πέμπτη 10 Οκτωβρίου 2019
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