Δευτέρα 28 Οκτωβρίου 2019


The role of oxytocin in regulation of appetitive behavior, body weight and glucose homeostasis
Abstract Obesity and its associated complications have reached epidemic proportions in the US and worldwide, highlighting the need for new and more effective treatments. While the neuropeptide oxytocin (OXT) is well recognized for its peripheral effects on reproductive behavior, release of OXT from somatodendrites and axonal terminals within the central nervous system (CNS) is also implicated in the control of control of energy balance. In this review we summarize historical data highlighting the...
Journal of Neuroendocrinology
now
Cervical cancer and vaginal microbiota changes
Abstract Microbial changes in vaginal ecosystem may accelerate the process of cervical carcinogenesis. The developed cervical cancer can lead to changes in the vaginal microbiota. The aim of our study is to determine the vaginal microbiota changes at women with FIGO I stage cervical cancer. We conducted an open, single-site survey in the Department of Gynecology of the Military Medical Academy in Sofia, Bulgaria, from 2014 to 2019 year. The study included a total of 32 women aged...
Latest Results for Archives/ /of/ /Microbiology
3h
Vitamin D3 supplementation and neurofilament light chain in multiple sclerosis
Abstract Objectives Low circulating vitamin D levels are associated with an increased risk of active MRI lesions and relapses in several cohorts with relapsing remitting multiple sclerosis (RRMS). Randomized controlled supplementation trials are, however, negative on their primary endpoints, while secondary MRI‐endpoints suggest anti‐inflammatory effects. Circulating levels of neurofilament light chain (NfL) are a biomarker of disease activity in RRMS. We explored whether 48 weeks high‐dose vitamin...
Acta Neurologica Scandinavica
3h
In the ZOne: How Impedance Facilitates Progress in Functional Dyspepsia Research
Latest Results for Digestive Diseases and Sciences
3h
Timely Use of Biologics in Early Crohn’s Disease: The Return of “Hit Hard and Early”?
Latest Results for Digestive Diseases and Sciences
3h
Predictive Value of Procalcitonin in Acute Severe Ulcerative Colitis: Not Quite PerfeCT?
Latest Results for Digestive Diseases and Sciences
3h
Predictive Value of Anastomotic Blood Supply for Anastomotic Stricture After Esophagectomy in Esophageal Cancer
Abstract Background Insufficient blood supply in the gastric tube is considered as a risk factor for postoperative anastomotic strictures in patients receiving esophagectomy, but the direct evidence is lacking. Aims We aimed to investigate the correlation between perioperative blood supply in the anastomotic area of the gastric tube and the...
Latest Results for Digestive Diseases and Sciences
3h
Impact of brain tumors and radiotherapy on the presence of gadolinium in the brain after repeated administration of gadolinium-based contrast agents: an experimental study in rats
Abstract Purpose To investigate the impact of blood-brain barrier (BBB) alterations induced by an experimental tumor and radiotherapy on MRI signal intensity (SI) in deep cerebellar nuclei (DCN) and the presence of gadolinium after repeated administration of a linear gadolinium-based contrast agent in rats. Methods Eighteen Fischer rats were...
Neuroradiology
3h
European Society of Neuroradiology (ESNR)
Neuroradiology
3h
Prognostic significance of MTOR expression in HPV positive and negative head and neck cancers treated by chemoradiation
Abstract Background The mechanistic target of rapamycin (MTOR) plays a key role in regulating cell growth and metabolism and is commonly overexpressed in head and neck cancer (HNSCC). This study investigated the association of MTOR with clinical outcome in human papilloma virus (HPV) positive and negative HNSCC patients treated by chemoradiation. Methods A tissue microarray (TMA) consisting of cores from 109 HNSCC patients treated by definitive chemoradiation was constructed and stained...
Head & Neck
3h
Assessment of shoulder function following scapular free flap
Abstract Background The scapular system free flap has been increasing in popularity to reconstruct short segment mandibular bony defects. It is important to assess donor site morbidities systematically. Methods Prospective cohort study using objective measures of range of motion (ROM) and shoulder strength were measured. Subjective disability was evaluated with validated questionnaires—Neck Disability Impairment Index and Shoulder Pain and Disability Index. Results Twenty‐six patients...
Head & Neck
3h
Correction to: Cu/N-codoped TiO 2 prepared by the sol-gel method for phenanthrene removal under visible light irradiation
The article “Cu/N-codoped TiO2 prepared by the sol-gel method for phenanthrene removal under visible light irradiation,” written by Zhenhua Zhao, Abduelrahman Adam Omer, Zhirui Qin, Salaheldein Osman, Liling Xia, and Rajendra Prasad Singh
Environmental+Science+and+Pollution+Research
3h
Multi-scaled response of groundwater nitrate contamination to integrated anthropogenic activities in a rapidly urbanizing agricultural catchment
Abstract Anthropogenic activities have a significant contribution to groundwater nitrate contamination at multiple spatial scales in urbanizing agricultural catchments, while how to derive the optimal researching scale and explore the relative importance among anthropogenic activities for groundwater nitrate contamination still remains challenging. In this study, 165 perched groundwater and 120 shallow groundwater samples were collected in two urbanizing agricultural catchments,...
Environmental+Science+and+Pollution+Research
9h
Epoxidation is the preferred pathway of first-stage metabolism of abiraterone acetate in brown bullhead ( Ameiurus nebulosus )
Abstract Twenty juvenile individuals of brown bullhead (Ameiurus nebulosus), average weight 77 g, were fed by abiraterone acetate prodrug dissolved in olive oil via gastric probe. Dose applied was 3 mg/10 g fish weight. After feeding, they were let out into aquarium and kept there for 3 days. Aquarium water containing excreted metabolites was extracted, and sample was purified and finally analyzed by means of HPLC/MS. Expected both primary (products of hydroxylation) and secondary...
Environmental+Science+and+Pollution+Research
1d
Biocide emissions from building materials during wet weather: identification of substances, mechanism of release and transfer to the aquatic environment
Abstract Biocides are added to or applied on building materials to prevent microorganisms from growing on their surface or to treat them. They are leached into building runoff and contribute to diffuse contamination of receiving waters. This review aimed at summarizing the current state of knowledge concerning the impact of biocides from buildings on the aquatic environment. The objectives were (i) to assess the key parameters influencing the leaching of biocides and to quantify...
Environmental+Science+and+Pollution+Research
1d
Beyond the biomarker role: prostate-specific antigen (PSA) in the prostate cancer microenvironment
Abstract The prostate-specific antigen (PSA) blood test is the accepted biomarker of tumor recurrence. PSA levels in serum correlate with disease progression, though its diagnostic accuracy is questionable. As a result, significant progress has been made in developing modified PSA tests such as PSA velocity, PSA density, 4Kscore, PSA glycoprofiling, Prostate Health Index, and the STHLM3 test. PSA, a serine protease, is secreted from the epithelial cells of the prostate. PSA has...
Latest Results for Cancer/ /and/ /Metastasis/ /Reviews
4h
Ultrasensitive Electrochemical DNA Biosensor Based on Tetrahedron structure and Proximity-dependent Surface Hybridization
Analyst, 2019, Accepted ManuscriptDOI: 10.1039/C9AN01897B, PaperXuejiao Wang, Shuyan Niu, Manman Wei, Shuai Liu, Rui Liu, Chao Shi, Cuiping MaDNA tetrahedron has been developed a broad spectrum of applications in biosensor construction thanks to its excellent mechanical rigidity and structure stability. However, how to construct a highly sensitive biosensor...The content of this RSS Feed (c) The Royal Society of Chemistry
Royal Society of Chemistry (Great Britain) Society for Analytical Chemistry Society of Public Analysts (Great Britain)
4h
Green Synthesis of Up- and Down-Conversion Photoluminescent Carbon Dots from Coffee Beans for Fe3+ Detection and Cell Imaging
Analyst, 2019, Accepted ManuscriptDOI: 10.1039/C9AN01953G, PaperWanyu Zhang, Lihua Jia, Xiangfeng Guo, Rui Yang, Yu Zhang, Zhenlong ZhaoCarbon dots (CDs) are a developing stable, conductive, and environmentally friendly fluorescent nanomaterial with potential applications in biomedicine and sensing. In this study, CDs with up- and down-conversion photoluminescence characteristics...The content of this RSS Feed (c) The Royal Society of Chemistry
Royal Society of Chemistry (Great Britain) Society for Analytical Chemistry Society of Public Analysts (Great Britain)
6h
Interpreting HIV diagnostic histories into infection time estimates: analytical framework and online tool
It is frequently of epidemiological and/or clinical interest to estimate the date of HIV infection or time-since-infection of individuals. Yet, for over 15 years, the only widely-referenced infection dating al...
BMC Infectious Diseases - Latest Articles
4h
Case report: whole genome sequencing based investigation of maternal-neonatal listeriosis in Sichuan, China
Neonatal listeriosis is a rare but severe disease manifesting as septicemia and central nervous system (CNS) infections with a high fatality rate of around 20 to 30%. Whole genome sequencing (WGS) is a promisi...
BMC Infectious Diseases - Latest Articles
4h
Congenitally corrected transposition of the great arteries: is it really a transposition? An anatomical study of the right ventricular septal surface
After analysing 102 human heart specimens we conclude that the typical ventricular septal defect (VSD) in congenitally corrected transposition of the great arteries (ccTGA) is an outlet VSD and is frequently misdiagnosed as an inlet VSD. The orientation of the septal band is similar in ccTGA and normal heart, and different in ccTGA and TGA. Even if a transposition is present, ccTGA should not be considered a sub‐group of TGA and the term ‘double discordance’ may be more appropriate. Abstract Congenitally...
Journal of Anatomy
5h
Glutamine-induced filamentous cells of Pseudomonas mediterranea CFBP-5447T as producers of PHAs
Abstract Polyhydroxyalkanoates (PHAs) are considerable biopolymers that have gained an increasing biotechnological interest in different applications, although their industrial production presents several limitations. Filamentous bacterial cells could represent a possible strategy to increase PHA yield, since more abundant PHA inclusions can be stored in elongated than in rod-shaped cells. At first, we determined the optimal batch culture conditions to induce filamentation in Pseudomonas...
Latest Results for Applied Microbiology and Biotechnology
5h
A novel heterologous expression strategy for the quorum-quenching enzyme MomL in Lysobacter enzymogenes to the inhibit pathogenicity of Pectobacterium
Abstract Quorum-quenching (QQ) enzymes can block the quorum-sensing (QS) system and prevent the expression of QS-controlled pathogenic factors in bacteria. However, the low expression levels of QQ proteins in the original host bacteria have affected their widespread application. In this study, we heterologously expressed momL, encoding a QQ enzyme with high activity, in Lysobacter enzymogenes. A “yellow-to-white” selection marker and the high-constitutive-expression promoter PgroEL...
Latest Results for Applied Microbiology and Biotechnology
6h
Bovine besnoitiosis in an endemically infected dairy cattle herd in Italy: serological and clinical observations, risk factors, and effects on reproductive and productive performances
Abstract Bovine besnoitiosis (Besnoitia besnoiti) is an emerging parasitic disease of cattle in Europe. This study reports a case of bovine besnoitiosis in a dairy farm housing 217 cattle in Italy. A serological screening was performed on the whole herd using the recommended approach of ELISA and confirmatory Western Blot. Seropositive animals were clinically examined to reveal symptoms and lesions of besnoitiosis. Risk factors and the effects of the parasite infection on reproductive...
Latest Results for Parasitology Research
5h
Tumor vasculature remolding by thalidomide increases delivery and efficacy of cisplatin
Abstract Background A promising strategy to overcome the chemoresistance is the tumor blood vessel normalization, which restores the physiological perfusion and oxygenation of tumor vasculature. Thalidomide (Thal) has been shown to increase the anti-tumor effect of chemotherapy agents in solid tumors. However, it is not yet known whether the synergistic effect of Thal combined with other cytotoxic drugs is attributable to tumor vascular...
http://link.springer.com/search.rss?facet-content-type=Article&facet-journal-id=13046&channel-name=Journal+of+Experimental+%26+Clinical+Cancer+Research
5h
Reverse Warburg Effect-Related Mitochondrial Activity and 18 F-FDG Uptake in Invasive Ductal Carcinoma
Abstract Purpose We evaluated the relationship between fluorine-18 fluoro-2-deoxy-glucose (18F-FDG) uptake and mitochondrial activity in cancer cells and investigated the prognostic implications of this relationship in patients with invasive ductal carcinoma of the breast (IDCB). Methods One hundred forty-six patients with primary IDCB who underwent preoperative...
http://link.springer.com/search.rss?facet-content-type=Article&facet-journal-id=13139&channel-name=Nuclear+Medicine+and+Molecular+Imaging
5h
A dual cancer-specific recombinant adenovirus suppresses the growth of liver cancer cells in vivo and in vitro
Oncolytic virus therapy is emerging as important means in cancer treatment. In a previous study, we constructed a dual cancer-specific antitumor recombinant adenovirus, designating it Ad-apoptin-hTERTp-E1a (Ad-VT). This study aimed to investigate the anticancer potential of recombinant adenovirus Ad-apoptin-hTERTp-E1a (Ad-VT) in liver cancer. Crystal Violet staining and CCK-8 assays were used to analyse the inhibitory effect of recombinant adenovirus on human hepatoma cell line QGY-7703 and SMMC-7721....
Anti-Cancer Drugs - Published Ahead-of-Print
5h
Successful treatment with secukinumab of three psoriatic patients undergoing dialysis
The Journal of Dermatology
6h
Cellulitis with Pseudomonas putida bacteremia in a patient with systemic lupus erythematosus: A case report
The Journal of Dermatology
6h
Phase 1 study of crisaborole in Japanese healthy volunteers and patients with atopic dermatitis
Abstract Crisaborole ointment, 2%, is a non‐steroidal phosphodiesterase 4 inhibitor for the treatment of mild to moderate atopic dermatitis (AD). This parallel‐cohort, phase 1 study was conducted to investigate skin irritation potential and safety of crisaborole in healthy Japanese adults (cohort 1) and the safety and pharmacokinetic profile of crisaborole and metabolites AN7602 and AN8323 in Japanese adults with mild to moderate AD (cohort 2). In cohort 1, 20 healthy volunteers received single...
The Journal of Dermatology
6h
Improved cell-purification techniques and safety monitoring needed for olfactory ensheathing cell transplantation [Letters]
Canadian Medical Association Journal current issue
6h
Coverage and equity of maternal and newborn health care in rural Nigeria, Ethiopia and India [Research]
BACKGROUND:Despite progress toward meeting the Sustainable Development Goals, a large burden of maternal and neonatal mortality persists for the most vulnerable people in rural areas. We assessed coverage, coverage change and inequity for 8 maternal and newborn health care indicators in parts of rural Nigeria, Ethiopia and India. METHODS:We examined coverage changes and inequity in 2012 and 2015 in 3 high-burden populations where multiple actors were attempting to improve outcomes. We conducted...
Canadian Medical Association Journal current issue
6h
Magnetic resonance imaging diagnosis of prostate cancer: promise and caution [Commentary]
Canadian Medical Association Journal current issue
6h
Testing group differences for confounder selection in nonrandomized studies: flawed practice [Analysis]
Canadian Medical Association Journal current issue
6h
Are fees for cataract surgery still too high? [News]
Canadian Medical Association Journal current issue
6h
The cardiovascular benefits of low-dosage acetylsalicylic acid [Practice]
Canadian Medical Association Journal current issue
6h
Is it time to develop AGREE III? [Letters]
Canadian Medical Association Journal current issue
6h
Erythema multiforme major associated with Mycoplasma pneumoniae infection [Practice]
Canadian Medical Association Journal current issue
6h
How "digital therapeutics" differ from traditional health and wellness apps [News]
Canadian Medical Association Journal current issue
6h

Disclosure [Humanities]
Canadian Medical Association Journal current issue
6h
Medical students give lower marks to training in some specialties [News]
Canadian Medical Association Journal current issue
6h

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