Abstract Obesity and its associated complications have reached epidemic proportions in the US and worldwide, highlighting the need for new and more effective treatments. While the neuropeptide oxytocin (OXT) is well recognized for its peripheral effects on reproductive behavior, release of OXT from somatodendrites and axonal terminals within the central nervous system (CNS) is also implicated in the control of control of energy balance. In this review we summarize historical data highlighting the...
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Abstract Microbial changes in vaginal ecosystem may accelerate the process of cervical carcinogenesis. The developed cervical cancer can lead to changes in the vaginal microbiota. The aim of our study is to determine the vaginal microbiota changes at women with FIGO I stage cervical cancer. We conducted an open, single-site survey in the Department of Gynecology of the Military Medical Academy in Sofia, Bulgaria, from 2014 to 2019 year. The study included a total of 32 women aged...
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Abstract Objectives Low circulating vitamin D levels are associated with an increased risk of active MRI lesions and relapses in several cohorts with relapsing remitting multiple sclerosis (RRMS). Randomized controlled supplementation trials are, however, negative on their primary endpoints, while secondary MRI‐endpoints suggest anti‐inflammatory effects. Circulating levels of neurofilament light chain (NfL) are a biomarker of disease activity in RRMS. We explored whether 48 weeks high‐dose vitamin...
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Abstract Background Insufficient blood supply in the gastric tube is considered as a risk factor for postoperative anastomotic strictures in patients receiving esophagectomy, but the direct evidence is lacking. Aims We aimed to investigate the correlation between perioperative blood supply in the anastomotic area of the gastric tube and the...
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Abstract Purpose To investigate the impact of blood-brain barrier (BBB) alterations induced by an experimental tumor and radiotherapy on MRI signal intensity (SI) in deep cerebellar nuclei (DCN) and the presence of gadolinium after repeated administration of a linear gadolinium-based contrast agent in rats. Methods Eighteen Fischer rats were...
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Abstract Background The mechanistic target of rapamycin (MTOR) plays a key role in regulating cell growth and metabolism and is commonly overexpressed in head and neck cancer (HNSCC). This study investigated the association of MTOR with clinical outcome in human papilloma virus (HPV) positive and negative HNSCC patients treated by chemoradiation. Methods A tissue microarray (TMA) consisting of cores from 109 HNSCC patients treated by definitive chemoradiation was constructed and stained...
Abstract Background The scapular system free flap has been increasing in popularity to reconstruct short segment mandibular bony defects. It is important to assess donor site morbidities systematically. Methods Prospective cohort study using objective measures of range of motion (ROM) and shoulder strength were measured. Subjective disability was evaluated with validated questionnaires—Neck Disability Impairment Index and Shoulder Pain and Disability Index. Results Twenty‐six patients...
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The article “Cu/N-codoped TiO2 prepared by the sol-gel method for phenanthrene removal under visible light irradiation,” written by Zhenhua Zhao, Abduelrahman Adam Omer, Zhirui Qin, Salaheldein Osman, Liling Xia, and Rajendra Prasad Singh
Abstract Anthropogenic activities have a significant contribution to groundwater nitrate contamination at multiple spatial scales in urbanizing agricultural catchments, while how to derive the optimal researching scale and explore the relative importance among anthropogenic activities for groundwater nitrate contamination still remains challenging. In this study, 165 perched groundwater and 120 shallow groundwater samples were collected in two urbanizing agricultural catchments,...
Abstract Twenty juvenile individuals of brown bullhead (Ameiurus nebulosus), average weight 77 g, were fed by abiraterone acetate prodrug dissolved in olive oil via gastric probe. Dose applied was 3 mg/10 g fish weight. After feeding, they were let out into aquarium and kept there for 3 days. Aquarium water containing excreted metabolites was extracted, and sample was purified and finally analyzed by means of HPLC/MS. Expected both primary (products of hydroxylation) and secondary...
Abstract Biocides are added to or applied on building materials to prevent microorganisms from growing on their surface or to treat them. They are leached into building runoff and contribute to diffuse contamination of receiving waters. This review aimed at summarizing the current state of knowledge concerning the impact of biocides from buildings on the aquatic environment. The objectives were (i) to assess the key parameters influencing the leaching of biocides and to quantify...
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Abstract The prostate-specific antigen (PSA) blood test is the accepted biomarker of tumor recurrence. PSA levels in serum correlate with disease progression, though its diagnostic accuracy is questionable. As a result, significant progress has been made in developing modified PSA tests such as PSA velocity, PSA density, 4Kscore, PSA glycoprofiling, Prostate Health Index, and the STHLM3 test. PSA, a serine protease, is secreted from the epithelial cells of the prostate. PSA has...
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Analyst, 2019, Accepted ManuscriptDOI: 10.1039/C9AN01897B, PaperXuejiao Wang, Shuyan Niu, Manman Wei, Shuai Liu, Rui Liu, Chao Shi, Cuiping MaDNA tetrahedron has been developed a broad spectrum of applications in biosensor construction thanks to its excellent mechanical rigidity and structure stability. However, how to construct a highly sensitive biosensor...The content of this RSS Feed (c) The Royal Society of Chemistry
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Analyst, 2019, Accepted ManuscriptDOI: 10.1039/C9AN01953G, PaperWanyu Zhang, Lihua Jia, Xiangfeng Guo, Rui Yang, Yu Zhang, Zhenlong ZhaoCarbon dots (CDs) are a developing stable, conductive, and environmentally friendly fluorescent nanomaterial with potential applications in biomedicine and sensing. In this study, CDs with up- and down-conversion photoluminescence characteristics...The content of this RSS Feed (c) The Royal Society of Chemistry
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It is frequently of epidemiological and/or clinical interest to estimate the date of HIV infection or time-since-infection of individuals. Yet, for over 15 years, the only widely-referenced infection dating al...
Neonatal listeriosis is a rare but severe disease manifesting as septicemia and central nervous system (CNS) infections with a high fatality rate of around 20 to 30%. Whole genome sequencing (WGS) is a promisi...
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After analysing 102 human heart specimens we conclude that the typical ventricular septal defect (VSD) in congenitally corrected transposition of the great arteries (ccTGA) is an outlet VSD and is frequently misdiagnosed as an inlet VSD. The orientation of the septal band is similar in ccTGA and normal heart, and different in ccTGA and TGA. Even if a transposition is present, ccTGA should not be considered a sub‐group of TGA and the term ‘double discordance’ may be more appropriate. Abstract Congenitally...
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Abstract Polyhydroxyalkanoates (PHAs) are considerable biopolymers that have gained an increasing biotechnological interest in different applications, although their industrial production presents several limitations. Filamentous bacterial cells could represent a possible strategy to increase PHA yield, since more abundant PHA inclusions can be stored in elongated than in rod-shaped cells. At first, we determined the optimal batch culture conditions to induce filamentation in Pseudomonas...
Abstract Quorum-quenching (QQ) enzymes can block the quorum-sensing (QS) system and prevent the expression of QS-controlled pathogenic factors in bacteria. However, the low expression levels of QQ proteins in the original host bacteria have affected their widespread application. In this study, we heterologously expressed momL, encoding a QQ enzyme with high activity, in Lysobacter enzymogenes. A “yellow-to-white” selection marker and the high-constitutive-expression promoter PgroEL...
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Abstract Bovine besnoitiosis (Besnoitia besnoiti) is an emerging parasitic disease of cattle in Europe. This study reports a case of bovine besnoitiosis in a dairy farm housing 217 cattle in Italy. A serological screening was performed on the whole herd using the recommended approach of ELISA and confirmatory Western Blot. Seropositive animals were clinically examined to reveal symptoms and lesions of besnoitiosis. Risk factors and the effects of the parasite infection on reproductive...
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Abstract Background A promising strategy to overcome the chemoresistance is the tumor blood vessel normalization, which restores the physiological perfusion and oxygenation of tumor vasculature. Thalidomide (Thal) has been shown to increase the anti-tumor effect of chemotherapy agents in solid tumors. However, it is not yet known whether the synergistic effect of Thal combined with other cytotoxic drugs is attributable to tumor vascular...
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Abstract Purpose We evaluated the relationship between fluorine-18 fluoro-2-deoxy-glucose (18F-FDG) uptake and mitochondrial activity in cancer cells and investigated the prognostic implications of this relationship in patients with invasive ductal carcinoma of the breast (IDCB). Methods One hundred forty-six patients with primary IDCB who underwent preoperative...
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Oncolytic virus therapy is emerging as important means in cancer treatment. In a previous study, we constructed a dual cancer-specific antitumor recombinant adenovirus, designating it Ad-apoptin-hTERTp-E1a (Ad-VT). This study aimed to investigate the anticancer potential of recombinant adenovirus Ad-apoptin-hTERTp-E1a (Ad-VT) in liver cancer. Crystal Violet staining and CCK-8 assays were used to analyse the inhibitory effect of recombinant adenovirus on human hepatoma cell line QGY-7703 and SMMC-7721....
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Abstract Crisaborole ointment, 2%, is a non‐steroidal phosphodiesterase 4 inhibitor for the treatment of mild to moderate atopic dermatitis (AD). This parallel‐cohort, phase 1 study was conducted to investigate skin irritation potential and safety of crisaborole in healthy Japanese adults (cohort 1) and the safety and pharmacokinetic profile of crisaborole and metabolites AN7602 and AN8323 in Japanese adults with mild to moderate AD (cohort 2). In cohort 1, 20 healthy volunteers received single...
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BACKGROUND:Despite progress toward meeting the Sustainable Development Goals, a large burden of maternal and neonatal mortality persists for the most vulnerable people in rural areas. We assessed coverage, coverage change and inequity for 8 maternal and newborn health care indicators in parts of rural Nigeria, Ethiopia and India. METHODS:We examined coverage changes and inequity in 2012 and 2015 in 3 high-burden populations where multiple actors were attempting to improve outcomes. We conducted...
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