Δευτέρα 28 Οκτωβρίου 2019


Propionate, together with triple antibiotics, inhibits the growth of Enterococci
Abstract Enterococci are Gram-positive facultative anaerobic bacteria that colonize the oral cavity and gastrointestinal tract. Enterococcal infections, mainly caused by Enterococcus faecalis and Enterococcus faecium, include apical periodontitis, endocarditis, and bloodstream infections. Recently, vancomycinresistant Enterococci are considered major pathogens that are common but difficult to treat, especially in nosocomial settings. Moreover, E. faecalis is closely associated...
Latest Results for Journal of Microbiology
2h
Tumors diagnosed as cerebellar glioblastoma comprise distinct molecular entities
Abstract In this multi-institutional study we compiled a retrospective cohort of 86 posterior fossa tumors having received the diagnosis of cerebellar glioblastoma (cGBM). All tumors were reviewed histologically and subjected to array-based methylation analysis followed by algorithm-based classification into distinct methylation classes (MCs). The single MC containing the largest proportion of 25 tumors diagnosed as cGBM was MC anaplastic astrocytoma with piloid features representing...
Latest Results for Acta Neuropathologica Communications
2h
Phosphorylated TDP-43 aggregates in skeletal and cardiac muscle are a marker of myogenic degeneration in amyotrophic lateral sclerosis and various conditions
Abstract Background Amyotrophic lateral sclerosis (ALS) is characterized pathologically by the occurrence of phosphorylated TDP-43 (pTDP-43)-immunoreactive neuronal and glial inclusions in the central nervous system. Recent studies have shown that pTDP-43 aggregates also occur in the skeletal muscles in a certain proportion of ALS patients. Aim ...
Latest Results for Acta Neuropathologica Communications
2h
[ 18 F]-AV-1451 binding profile in chronic traumatic encephalopathy: a postmortem case series
Abstract Introduction Chronic traumatic encephalopathy (CTE) is a tauopathy associated to repetitive head trauma. There are no validated in vivo biomarkers of CTE and a definite diagnosis can only be made at autopsy. Recent studies have shown that positron emission tomography (PET) tracer AV-1451 (Flortaucipir) exhibits high binding affinity for paired helical filament (PHF)-tau aggregates in Alzheimer (AD) brains but relatively...
Latest Results for Acta Neuropathologica Communications
2h
Transforming growth factor beta receptor II (TGFBR2) promoter region polymorphism
http://link.springer.com/search.rss?facet-content-type=Article&facet-journal-id=10549&channel-name=Breast+Cancer+Research+and+Treatment
2h
Obstetrical outcomes in women with history of breast cancer: a systematic review and meta-analysis
Abstract Purpose Potential risk of adverse obstetrical outcomes has been shown among breast cancer survivors. Therefore, the aim of this systematic review and meta-analysis was to evaluate the relationship between history of breast cancer (BC) and obstetrical outcomes. Methods PubMed, EMBASE, and Medline were searched from the inception of each...
http://link.springer.com/search.rss?facet-content-type=Article&facet-journal-id=10549&channel-name=Breast+Cancer+Research+and+Treatment
2h
A population-based recurrence risk management study of patients with pT1 node-negative HER2+ breast cancer: a National Clinical Database study
Abstract Purpose Recurrence risk management of patients with small (≤ 2 cm), node-negative, human epidermal growth factor receptor 2 (HER2)-positive breast cancer remains challenging. We studied the effects of adjuvant chemotherapy and/or trastuzumab and survival outcomes among these patients, using data from the population-based Japanese National Clinical Database (NCD). ...
http://link.springer.com/search.rss?facet-content-type=Article&facet-journal-id=10549&channel-name=Breast+Cancer+Research+and+Treatment
2h
Prognostic value of receptor status conversion following neoadjuvant chemotherapy in breast cancer patients: a systematic review and meta-analysis
Abstract Biomarkers of breast cancer such as hormone receptors (HR) and human epidermal growth factor 2 (HER2) can be altered after neoadjuvant chemotherapy (NAC). However, whether the conversion of these receptors affects the prognosis of patients remains to be determined. We sought to evaluate the prognostic value of HR and HER2 receptors before and after NAC and to analyze their clinical implications. Relevant studies were used to calculate the pooled hazard ratios, 95% confidence...
http://link.springer.com/search.rss?facet-content-type=Article&facet-journal-id=10549&channel-name=Breast+Cancer+Research+and+Treatment
2h
Effectiveness of radiotherapy after breast-conserving surgery in older patients with T1-2N0 breast cancer
Abstract Purpose In the Netherlands, radiotherapy after breast-conserving surgery (BCS) is omitted in up to 30% of patients aged ≥ 75 years. Although omission of radiotherapy is considered an option for older women treated with endocrine treatment, the majority of these patients do not receive systemic treatment following Dutch treatment guidelines. Therefore, the aim of this study was to evaluate the effect of omission of radiotherapy...
http://link.springer.com/search.rss?facet-content-type=Article&facet-journal-id=10549&channel-name=Breast+Cancer+Research+and+Treatment
2h
CDC20 expression in oestrogen receptor positive breast cancer predicts poor prognosis and lack of response to endocrine therapy
Abstract Purpose Endocrine therapy is the standard treatment for oestrogen receptor positive (ER+) breast cancer. Despite its efficacy, around half of patients will develop resistance to this treatment and eventually relapse. Identification of effective and reliable biomarkers to predict the efficacy of endocrine therapy is of crucial importance in the management of ER+ breast cancer. Emerging evidence has revealed that the cell...
http://link.springer.com/search.rss?facet-content-type=Article&facet-journal-id=10549&channel-name=Breast+Cancer+Research+and+Treatment
2h
BCRT: a brief valedictory
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2h
Chemotherapy-induced peripheral neuropathy (CIPN) in breast cancer survivors: a comparison of patient-reported outcomes and quantitative sensory testing
Abstract Purpose CIPN is a common, debilitating, and dose-limiting side effect of chemotherapy. Here, we describe characteristics of patients with CIPN using both patient-reported outcomes (PRO) and quantitative sensory testing (QST). Methods Breast cancer survivors with persistent moderate to severe CIPN defined by a rating of 4 or greater...
http://link.springer.com/search.rss?facet-content-type=Article&facet-journal-id=10549&channel-name=Breast+Cancer+Research+and+Treatment
2h
Germline pathogenic variants in BRCA1, BRCA2, PALB2 and RAD51C in breast cancer women from Argentina
Abstract Purpose Each year, 17,000 new breast cancer cases are diagnosed in Argentina, and 5400 women die of breast cancer. The contribution of cancer-related mutations to the incidence of breast cancer in Argentina has not yet been explored. Methods We sequenced the entire coding regions of BRCA1, BRCA2, PALB2 and RAD51C in 112 unselected Argentinian...
http://link.springer.com/search.rss?facet-content-type=Article&facet-journal-id=10549&channel-name=Breast+Cancer+Research+and+Treatment
2h
The microbiome and breast cancer: a review
Abstract The human microbiome plays an integral role in physiology, with most microbes considered benign or beneficial. However, some microbes are known to be detrimental to human health, including organisms linked to cancers and other diseases characterized by aberrant inflammation. Dysbiosis, a state of microbial imbalance with harmful bacteria species outcompeting benign bacteria, can lead to maladies including cancer. The microbial composition varies across body sites, with...
http://link.springer.com/search.rss?facet-content-type=Article&facet-journal-id=10549&channel-name=Breast+Cancer+Research+and+Treatment
2h
Altered regional myocardial velocities by tissue phase mapping and feature tracking in pediatric patients with hypertrophic cardiomyopathy
Abstract Background Hypertrophic cardiomyopathy (HCM) is associated with heart failure, atrial fibrillation and sudden death. Reduced myocardial function has been reported in HCM despite normal left ventricular (LV) ejection fraction. Additionally, LV fibrosis is associated with elevated T1 and might be an outcome predictor. Objective To systematically compare...
Pediatric Radiology
2h
Biofilm Formation and Virulence Determinants of Klebsiella oxytoca Clinical Isolates from Patients with Colorectal Cancer
Abstract Objective Biofilm formation has made the therapy of bacterial infections more difficult. The objective our study was assessment of pan-drug-resistant (PDR) Klebsiella oxytoca pathogenicity and virulence factors causing AAHC in patients with colorectal cancer (CRC). Materials and Methods Among a total of 300 healthy and 300 patients with antibiotic-associated...
Latest Results for Journal of Gastrointestinal Cancer
2h
Incidence of arcuate line hernia in patients with abdominal complaints: radiological and clinical features
Abstract Introduction Acute abdominal complaints are a frequent cause for consultation in the emergency department, with a large differential diagnosis. One cause is arcuate line herniation, but this entity is little known and rarely considered during initial analysis. The incidence of arcuate line herniation in this population is unknown. Methods A retrospective...
Latest Results for Hernia
2h
Information Received and Usefulness of the Sources of Information to Cancer Patients at a Tertiary Care Centre in Malaysia
Abstract Most people with cancer have a combination of treatments, such as surgery with chemotherapy and/or radiation therapy. Providing good quality cancer-related information enables patients to be better prepared for treatment and improves their adherence. This study aimed to determine the level of information received and the perceived usefulness of the sources of information to cancer patients. A 4-month study was conducted at a day care oncology unit and oncology ward of...
Journal of Cancer Education
2h
FDA vs EMA: review times and clinical evidence on novel drugs at the time of approval
Abstract The FDA and EMA now have expedited review procedures for new drugs. We compared the review times of medicines licensed by the two agencies and explored differences in the evidence submitted. In 2015‐2017 the FDA licensed 113 drugs, 66 of which reached Europe. The median review time was longer at the EMA than FDA and was shorter for drugs undergoing FDA expedited programmes compared to the same drugs approved by the EMA through the standard procedure. We identified differences regarding...
British Journal of Clinical Pharmacology
2h
Raltegravir pharmacokinetics before and during treatment with ombitasvir, paritaprevir/ritonavir plus dasabuvir in adults with HIV‐1 and hepatitis C virus co‐infection: AIDS Clinical Trials Group Sub‐Study A5334s
ABSTRACT Aims AIDS Clinical Trials Group study A5334s evaluated the pharmacokinetics of raltegravir before and during combined administration of ombitasvir, paritaprevir/ritonavir, plus dasabuvir (OBV/PTV/r + DSV) and weight‐based ribavirin in HIV and hepatitis C virus (HCV) co‐infected adults. The pharmacokinetics of OBV/PTV/r + DSV during raltegravir co‐administration were also characterized. Methods Adults living with HIV/HCV co‐infection receiving steady‐state raltegravir (400 mg twice...
British Journal of Clinical Pharmacology
2h
Adverse events following Cannabis for medical use in Tuscany: an analysis of the Italian Phytovigilance database
Abstract Aim Despite a significant increase in using Cannabis for medical purposes, current evidence on its safety in real‐world clinical practice is still poorly characterized. By a case‐by‐case analysis of spontaneous reports of suspected adverse events (AEs) collected in Tuscany within the Italian Phytovigilance database, the aim of the present study was to describe AEs occurred in patients exposed to medical Cannabis. Methods We evaluated all reports of Cannabis‐related suspected AEs...
British Journal of Clinical Pharmacology
2h
Usefulness of gradient tree boosting for predicting histological subtype and EGFR mutation status of non-small cell lung cancer on 18 F FDG-PET/CT
Abstract Objective To develop and evaluate a radiomics approach for classifying histological subtypes and epidermal growth factor receptor (EGFR) mutation status in lung cancer on PET/CT images. Methods PET/CT images of lung cancer patients were obtained from public databases and used to establish two datasets, respectively to classify histological subtypes...
Latest Results for Annals of Nuclear Medicine
2h
Glypican-1 as a Therapy Target in Esophageal Squamous Cell Carcinoma
Latest Results for Digestive Diseases and Sciences
2h
Hepatitis B Virus X Protein Induces SATB1 Expression Through Activation of ERK and p38MAPK Pathways to Suppress Anoikis
Abstract Background We previously reported that there were potentially certain correlations between the high expression of SATB1 and the HBV infection in human hepatocellular carcinoma tissues, and SATB1 promoted tumor growth and metastasis in liver cancer. Hepatitis B virus (HBV) infection is internationally recognized as a contributing factor to metastasis in liver cancer. The anoikis prevention of detached malignant cancer cells...
Latest Results for Digestive Diseases and Sciences
2h
Foregone Inclusion: Neonatal CMV Hepatitis and Cholestasis
Latest Results for Digestive Diseases and Sciences
2h
Some Like It Cold: Postpolypectomy Delayed Hemorrhage in Anticoagulated Patients
Latest Results for Digestive Diseases and Sciences
2h
An Original Description of Granulomatous Liver Cirrhosis in Blau Syndrome
Latest Results for Digestive Diseases and Sciences
2h
Involvement of Potassium Channels, Nitric Oxide Synthase, and Guanylate Cyclase in the Spasmolytic Effect of Simaba ferruginea A.St.-Hil on Rat Isolated Ileum
Abstract Background and Aim Simaba ferruginea A.St.-Hil. Popularly known as “calunga,” is a typical Brazilian cerrado plant whose rhizomes are popular for treating diarrhea. Aims The aim of this study was to evaluate the spasmolytic activity and the antidiarrheal effect of the ethanolic extract obtained from S. ferruginea (Sf-EtOH). ...
Latest Results for Digestive Diseases and Sciences
2h
It’s What’s Up Front That Counts—Part One: Endoscopic Diagnosis and Therapy of Esophageal Crohn’s Disease
Latest Results for Digestive Diseases and Sciences
2h
False in Name Only—Gastroduodenal Artery Pseudoaneurysm in a Recurrently Bleeding Patient: Case Report and Literature Review
Abstract Although the diagnosis of visceral pseudoaneurysm is unusual, it requires emergent attention due to the risk of rupture. We describe a 70-year-old man with a gastroduodenal artery pseudoaneurysm that manifested as recurrent hemorrhage. We highlight the possible etiologies, clinical presentations, diagnostic tools, and treatment options for this condition. In this instance, the patient was successfully treated by selective angioembolization. A visceral pseudoaneurysm...
Latest Results for Digestive Diseases and Sciences
2h
ANCA-Associated Vasculitis in Inflammatory Bowel Disease
Latest Results for Digestive Diseases and Sciences
2h
Concise Commentary: Pocketing the Difference—Genetics and the Changing Paradigms of Diverticulitis Management
Latest Results for Digestive Diseases and Sciences
2h
Outcomes of mitral valve replacement with bileaflet mechanical prosthetic valve in children
Abstract Objectives We examined the outcomes following mitral valve replacement with bileaflet mechanical prosthetic valve in children and identified the predictors for mortality and reoperation. Methods Medical records from 49 children who underwent mitral valve replacement between 1982 and 2015 were reviewed retrospectively. Median age and body weight at...
Latest Results for General Thoracic and Cardiovascular Surgery
2h
Solitary peribronchiolar metaplasia and bronchiolar adenoma: do they represent an equal entity?
Latest Results for General Thoracic and Cardiovascular Surgery
3h
The learning curve of minimally invasive aortic valve replacement for aortic valve stenosis
Abstract Objective Few clinical studies have been conducted to evaluate the learning curve of minimally invasive aortic valve replacement. The purpose of this study was to retrospectively analyze the learning curve of initial and isolated minimally invasive aortic valve replacement for aortic valve stenosis which performed at our institution. Methods This...
Latest Results for General Thoracic and Cardiovascular Surgery
3h
Change in Estimated GFR and Albuminuria as End Points in Clinical Trials: A Perspective of People Living With Kidney Disease
As people living with kidney disease, we are excited about the innovations that are being developed in kidney replacement therapies, but we and our families wonder why we do not have innovations in early stages of kidney disease that prevent us from progressing to kidney failure. It seems that at times the health care community emphasizes treating kidney failure rather than early detection, intervention, and coordination of care.
American Journal of Kidney Diseases
2h
Change in Estimated GFR and Albuminuria as End Points in Clinical Trials: A Viewpoint From the FDA
It is a promising time for drug development for chronic kidney diseases. Recent randomized controlled trials in patients with diabetic kidney disease have reported success in slowing disease progression, and drug development for rare and uncommon kidney diseases is increasing. The larger nephrology community has also come together under various initiatives to address barriers to drug development and ensure incorporation of the patient voice. However, challenges remain, particularly for drug development...
American Journal of Kidney Diseases
2h
Change in Albuminuria and Estimated GFR as End Points for Clinical Trials in Early Stages of CKD: A Perspective From European Regulators
The 2018 workshop sponsored by the National Kidney Foundation (NKF) in collaboration with the US Food and Drug Administration (FDA) and the European Medicines Agency (EMA) explored the predictive performance of change in albuminuria and estimated glomerular filtration rate (eGFR) slope to evaluate whether both biomarkers qualify as surrogate end points in drug development studies in early stages of chronic kidney disease (CKD). The data presented constitute the largest meta-analyses of data derived...
American Journal of Kidney Diseases
2h

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