Abstract Enterococci are Gram-positive facultative anaerobic bacteria that colonize the oral cavity and gastrointestinal tract. Enterococcal infections, mainly caused by Enterococcus faecalis and Enterococcus faecium, include apical periodontitis, endocarditis, and bloodstream infections. Recently, vancomycinresistant Enterococci are considered major pathogens that are common but difficult to treat, especially in nosocomial settings. Moreover, E. faecalis is closely associated...
Mark above section as read
Abstract In this multi-institutional study we compiled a retrospective cohort of 86 posterior fossa tumors having received the diagnosis of cerebellar glioblastoma (cGBM). All tumors were reviewed histologically and subjected to array-based methylation analysis followed by algorithm-based classification into distinct methylation classes (MCs). The single MC containing the largest proportion of 25 tumors diagnosed as cGBM was MC anaplastic astrocytoma with piloid features representing...
Abstract Background Amyotrophic lateral sclerosis (ALS) is characterized pathologically by the occurrence of phosphorylated TDP-43 (pTDP-43)-immunoreactive neuronal and glial inclusions in the central nervous system. Recent studies have shown that pTDP-43 aggregates also occur in the skeletal muscles in a certain proportion of ALS patients. Aim ...
Abstract Introduction Chronic traumatic encephalopathy (CTE) is a tauopathy associated to repetitive head trauma. There are no validated in vivo biomarkers of CTE and a definite diagnosis can only be made at autopsy. Recent studies have shown that positron emission tomography (PET) tracer AV-1451 (Flortaucipir) exhibits high binding affinity for paired helical filament (PHF)-tau aggregates in Alzheimer (AD) brains but relatively...
Mark above section as read
2h
Abstract Purpose Potential risk of adverse obstetrical outcomes has been shown among breast cancer survivors. Therefore, the aim of this systematic review and meta-analysis was to evaluate the relationship between history of breast cancer (BC) and obstetrical outcomes. Methods PubMed, EMBASE, and Medline were searched from the inception of each...
2h
Abstract Purpose Recurrence risk management of patients with small (≤ 2 cm), node-negative, human epidermal growth factor receptor 2 (HER2)-positive breast cancer remains challenging. We studied the effects of adjuvant chemotherapy and/or trastuzumab and survival outcomes among these patients, using data from the population-based Japanese National Clinical Database (NCD). ...
2h
Abstract Biomarkers of breast cancer such as hormone receptors (HR) and human epidermal growth factor 2 (HER2) can be altered after neoadjuvant chemotherapy (NAC). However, whether the conversion of these receptors affects the prognosis of patients remains to be determined. We sought to evaluate the prognostic value of HR and HER2 receptors before and after NAC and to analyze their clinical implications. Relevant studies were used to calculate the pooled hazard ratios, 95% confidence...
2h
Abstract Purpose In the Netherlands, radiotherapy after breast-conserving surgery (BCS) is omitted in up to 30% of patients aged ≥ 75 years. Although omission of radiotherapy is considered an option for older women treated with endocrine treatment, the majority of these patients do not receive systemic treatment following Dutch treatment guidelines. Therefore, the aim of this study was to evaluate the effect of omission of radiotherapy...
2h
Abstract Purpose Endocrine therapy is the standard treatment for oestrogen receptor positive (ER+) breast cancer. Despite its efficacy, around half of patients will develop resistance to this treatment and eventually relapse. Identification of effective and reliable biomarkers to predict the efficacy of endocrine therapy is of crucial importance in the management of ER+ breast cancer. Emerging evidence has revealed that the cell...
2h
2h
Abstract Purpose CIPN is a common, debilitating, and dose-limiting side effect of chemotherapy. Here, we describe characteristics of patients with CIPN using both patient-reported outcomes (PRO) and quantitative sensory testing (QST). Methods Breast cancer survivors with persistent moderate to severe CIPN defined by a rating of 4 or greater...
2h
Germline pathogenic variants in BRCA1, BRCA2, PALB2 and RAD51C in breast cancer women from Argentina
Abstract Purpose Each year, 17,000 new breast cancer cases are diagnosed in Argentina, and 5400 women die of breast cancer. The contribution of cancer-related mutations to the incidence of breast cancer in Argentina has not yet been explored. Methods We sequenced the entire coding regions of BRCA1, BRCA2, PALB2 and RAD51C in 112 unselected Argentinian...
2h
Abstract The human microbiome plays an integral role in physiology, with most microbes considered benign or beneficial. However, some microbes are known to be detrimental to human health, including organisms linked to cancers and other diseases characterized by aberrant inflammation. Dysbiosis, a state of microbial imbalance with harmful bacteria species outcompeting benign bacteria, can lead to maladies including cancer. The microbial composition varies across body sites, with...
2h
Mark above section as read
Abstract Background Hypertrophic cardiomyopathy (HCM) is associated with heart failure, atrial fibrillation and sudden death. Reduced myocardial function has been reported in HCM despite normal left ventricular (LV) ejection fraction. Additionally, LV fibrosis is associated with elevated T1 and might be an outcome predictor. Objective To systematically compare...
Mark above section as read
Abstract Objective Biofilm formation has made the therapy of bacterial infections more difficult. The objective our study was assessment of pan-drug-resistant (PDR) Klebsiella oxytoca pathogenicity and virulence factors causing AAHC in patients with colorectal cancer (CRC). Materials and Methods Among a total of 300 healthy and 300 patients with antibiotic-associated...
Mark above section as read
Abstract Introduction Acute abdominal complaints are a frequent cause for consultation in the emergency department, with a large differential diagnosis. One cause is arcuate line herniation, but this entity is little known and rarely considered during initial analysis. The incidence of arcuate line herniation in this population is unknown. Methods A retrospective...
Mark above section as read
Abstract Most people with cancer have a combination of treatments, such as surgery with chemotherapy and/or radiation therapy. Providing good quality cancer-related information enables patients to be better prepared for treatment and improves their adherence. This study aimed to determine the level of information received and the perceived usefulness of the sources of information to cancer patients. A 4-month study was conducted at a day care oncology unit and oncology ward of...
Mark above section as read
Abstract The FDA and EMA now have expedited review procedures for new drugs. We compared the review times of medicines licensed by the two agencies and explored differences in the evidence submitted. In 2015‐2017 the FDA licensed 113 drugs, 66 of which reached Europe. The median review time was longer at the EMA than FDA and was shorter for drugs undergoing FDA expedited programmes compared to the same drugs approved by the EMA through the standard procedure. We identified differences regarding...
ABSTRACT Aims AIDS Clinical Trials Group study A5334s evaluated the pharmacokinetics of raltegravir before and during combined administration of ombitasvir, paritaprevir/ritonavir, plus dasabuvir (OBV/PTV/r + DSV) and weight‐based ribavirin in HIV and hepatitis C virus (HCV) co‐infected adults. The pharmacokinetics of OBV/PTV/r + DSV during raltegravir co‐administration were also characterized. Methods Adults living with HIV/HCV co‐infection receiving steady‐state raltegravir (400 mg twice...
Abstract Aim Despite a significant increase in using Cannabis for medical purposes, current evidence on its safety in real‐world clinical practice is still poorly characterized. By a case‐by‐case analysis of spontaneous reports of suspected adverse events (AEs) collected in Tuscany within the Italian Phytovigilance database, the aim of the present study was to describe AEs occurred in patients exposed to medical Cannabis. Methods We evaluated all reports of Cannabis‐related suspected AEs...
Mark above section as read
Abstract Objective To develop and evaluate a radiomics approach for classifying histological subtypes and epidermal growth factor receptor (EGFR) mutation status in lung cancer on PET/CT images. Methods PET/CT images of lung cancer patients were obtained from public databases and used to establish two datasets, respectively to classify histological subtypes...
Mark above section as read
Abstract Background We previously reported that there were potentially certain correlations between the high expression of SATB1 and the HBV infection in human hepatocellular carcinoma tissues, and SATB1 promoted tumor growth and metastasis in liver cancer. Hepatitis B virus (HBV) infection is internationally recognized as a contributing factor to metastasis in liver cancer. The anoikis prevention of detached malignant cancer cells...
Abstract Background and Aim Simaba ferruginea A.St.-Hil. Popularly known as “calunga,” is a typical Brazilian cerrado plant whose rhizomes are popular for treating diarrhea. Aims The aim of this study was to evaluate the spasmolytic activity and the antidiarrheal effect of the ethanolic extract obtained from S. ferruginea (Sf-EtOH). ...
Abstract Although the diagnosis of visceral pseudoaneurysm is unusual, it requires emergent attention due to the risk of rupture. We describe a 70-year-old man with a gastroduodenal artery pseudoaneurysm that manifested as recurrent hemorrhage. We highlight the possible etiologies, clinical presentations, diagnostic tools, and treatment options for this condition. In this instance, the patient was successfully treated by selective angioembolization. A visceral pseudoaneurysm...
Mark above section as read
Abstract Objectives We examined the outcomes following mitral valve replacement with bileaflet mechanical prosthetic valve in children and identified the predictors for mortality and reoperation. Methods Medical records from 49 children who underwent mitral valve replacement between 1982 and 2015 were reviewed retrospectively. Median age and body weight at...
Abstract Objective Few clinical studies have been conducted to evaluate the learning curve of minimally invasive aortic valve replacement. The purpose of this study was to retrospectively analyze the learning curve of initial and isolated minimally invasive aortic valve replacement for aortic valve stenosis which performed at our institution. Methods This...
Mark above section as read
As people living with kidney disease, we are excited about the innovations that are being developed in kidney replacement therapies, but we and our families wonder why we do not have innovations in early stages of kidney disease that prevent us from progressing to kidney failure. It seems that at times the health care community emphasizes treating kidney failure rather than early detection, intervention, and coordination of care.
It is a promising time for drug development for chronic kidney diseases. Recent randomized controlled trials in patients with diabetic kidney disease have reported success in slowing disease progression, and drug development for rare and uncommon kidney diseases is increasing. The larger nephrology community has also come together under various initiatives to address barriers to drug development and ensure incorporation of the patient voice. However, challenges remain, particularly for drug development...
The 2018 workshop sponsored by the National Kidney Foundation (NKF) in collaboration with the US Food and Drug Administration (FDA) and the European Medicines Agency (EMA) explored the predictive performance of change in albuminuria and estimated glomerular filtration rate (eGFR) slope to evaluate whether both biomarkers qualify as surrogate end points in drug development studies in early stages of chronic kidney disease (CKD). The data presented constitute the largest meta-analyses of data derived...
Mark above section as read
Δεν υπάρχουν σχόλια:
Δημοσίευση σχολίου