Publication date: December 2019Source: International Immunopharmacology, Volume 77Author(s): Chun Xin, Joungmin Kim, Hui Quan, Mei Yin, Seongtae Jeong, Jeong-Il Choi, Eun-A Jang, Chang-Hun Lee, Dae-Hun Kim, Hong-Beom BaeAbstractGinsenoside Rg3 is a steroidal saponin abundant in Korean red ginseng that has high anti-inflammatory activity. Rg3 exerts an immunomodulatory effect in acute inflammatory conditions such as bacterial infections. In this study, we determined the effect of Rg3 on bacterial...
Mon Oct 21, 2019 14:23
Publication date: December 2019Source: International Immunopharmacology, Volume 77Author(s): Qingqing Xu, Suqin Yin, Yao Yao, Xiaofeng Li, Biao Song, Yang Yang, Yaru Liu, Ruonan Chen, Juanjuan Li, Taotao Ma, Xiaoming Meng, Cheng Huang, Jun LiAbstractVia promoting synovitis, pannus growth and cartilage/bone destruction, fibroblast-like synovial cells (FLSs) play a significant role in the pathogenesis of rheumatoid arthritis (RA). In our study, rats were induced with complete freund’s adjuvant (CFA)...
Mon Oct 21, 2019 14:23
Publication date: Available online 20 October 2019Source: International ImmunopharmacologyAuthor(s): Sandeep Kumar, Alok Kumar Verma, Akanksha Sharma, Ruchi Roy, Dinesh Kumar, Giridhar BH, Anurag Tripathi, Bhushan P. Chaudhari, Mukul Das, S.K. Jain, Premendra D. Dwivedi
Mon Oct 21, 2019 14:23
Abstract Sexual barriers associated with mate choice are often found to be associated with some level of ecological isolation between species. The independence and relative strength of sexual isolation are thus difficult to assess. Here we take advantage of a pair of marine isopod species (Jaera albifrons and J. praehirsuta) that show sexual isolation and coexist in populations where they share the same microhabitat or not (i.e. without or with ecological isolation). We estimated the strength of...
Mon Oct 21, 2019 14:23
Abstract Beta-adrenergic blockers (β-blockers) are clearly indicated for the long-term treatment of patients with systolic heart failure and post-acute myocardial infarction. Early small-scale studies reported their potential benefits for perioperative use; subsequent randomized controlled trials, however, failed to reproduce earlier findings. Furthermore, their role in reducing major postoperative cardiac events following noncardiac and cardiac surgery remains controversial. This...
Mon Oct 21, 2019 03:00
Abstract Objectives A change in how children were treated and valued occurred in premodern Japan, as popularized ideas of an inheritance‐based family system led to more careful and affectionate child‐rearing practices by lower social‐status groups. A number of books were written, advising that breastfeeding should last approximately 3 years. The objective of this study is to reconstruct and compare breastfeeding and weaning practices before and after the transition, to illuminate the impact of...
Mon Oct 21, 2019 12:34
Our study demonstrates that an acute administration of fructans increases the number of postprandial TLESRs slighlty compared to placebo. Post‐hoc analysis demonstrated only a significant difference in the number of TLESRs during the fourth hour postprandial between the fructan condition and placebo (Pcorr = .03). Abstract Introduction Dietary measures are often advised to patients with gastro‐esophageal reflux disease (GERD). Fermentable Oligo‐, Di‐, Mono‐saccharides and Polyols (FODMAPs)...
Mon Oct 21, 2019 12:34
Related ArticlesNLRP Inflammasomes and Induced Skin Inflammation, Barrier Recovery and Extended Skin Hydration. Int J Cosmet Sci. 2019 Oct 19;: Authors: Gruber JV, Stojkoska V Abstract OBJECTIVE: In vitro assays were designed to examine the release of active Caspase-1 (ACasp-1) from NLRP inflammasome-activated Normal Human Epidermal Keratinocytes (NHEK) employing a bioluminescent assay specific for measuring inflammasome-induced ACasp-1 expression. ...
Mon Oct 21, 2019 15:42
Related ArticlesDigital explanations and nursing students' perception of learning science. Nurse Educ Pract. 2019 Oct 05;41:102636 Authors: Meedya S, Moroney T, Nielsen W, Najafi Bokat I Abstract A thorough understanding of human physiology and anatomy are pivotal in the preparation of competent nursing students for clinical practice. However, anatomy and physiology are among the most conceptually perplexing subjects that nursing students will encounter...
Mon Oct 21, 2019 15:42
Related ArticlesREFUGE Challenge: A unified framework for evaluating automated methods for glaucoma assessment from fundus photographs. Med Image Anal. 2019 Oct 08;59:101570 Authors: Orlando JI, Fu H, Barbossa Breda J, van Keer K, Bathula DR, Diaz-Pinto A, Fang R, Heng PA, Kim J, Lee J, Lee J, Li X, Liu P, Lu S, Murugesan B, Naranjo V, Phaye SSR, Shankaranarayana SM, Sikka A, Son J, van den Hengel A, Wang S, Wu J, Wu Z, Xu G, Xu Y, Yin P, Li F, Zhang X, Xu Y, Bogunović...
Mon Oct 21, 2019 15:42
Related ArticlesDivergent immune responses in behaviorally-inhibited vs. non-inhibited male rats. Physiol Behav. 2019 Oct 17;:112693 Authors: Michael KC, Bonneau RH, Bourne RA, Godbolt L, Caruso MJ, Hohmann C, Cavigelli SA Abstract Stable behavioral traits (temperament, personality) often predict health outcomes. Temperament-specific differences in immune function could explain temperament-specific health outcomes, however, we have limited information...
Mon Oct 21, 2019 15:42
Related ArticlesEvaluation of transcriptional levels of the natriuretic peptides, endothelin-1, adrenomedullin, their receptors and long non-coding RNAs in rat cardiac tissue as cardiovascular biomarkers of aging. Peptides. 2019 Oct 17;:170173 Authors: Cabiati M, Sapio A, Salvadori C, Burchielli S, Carlucci L, Mattii L, Del Ry S Abstract Chronological age is considered one of the major risk factors for cardiovascular disease and mortality. The study...
Mon Oct 21, 2019 15:42
Related ArticlesRe-evaluating genetic variants identified in candidate gene studies of breast cancer risk using data from nearly 280,000 women of Asian and European ancestry. EBioMedicine. 2019 Oct 16;: Authors: Yang Y, Shu X, Shu XO, Bolla MK, Kweon SS, Cai Q, Michailidou K, Wang Q, Dennis J, Park B, Matsuo K, Kwong A, Park SK, Wu AH, Teo SH, Iwasaki M, Choi JY, Li J, Hartman M, Shen CY, Muir K, Lophatananon A, Li B, Wen W, Gao YT, Xiang YB, Aronson KJ, Spinell JJ, Gago-Dominguez...
Mon Oct 21, 2019 15:42
Related ArticlesAngiotensin-(1-12)/chymase axis modulates cardiomyocyte L-type calcium currents in rats expressing human angiotensinogen. Int J Cardiol. 2019 Oct 08;: Authors: Reyes S, Cheng CP, Roberts DJ, Yamashita T, Ahmad S, VonCannon JL, Wright KN, Dell'Italia LJ, Varagic J, Ferrario CM Abstract BACKGROUND: Activation of the intracrine renin angiotensin systems (RAS) is increasingly recognized as contributing to human pathologies, yet non-canonical...
Mon Oct 21, 2019 15:42
Related ArticlesAltered DNA ligase activity in human disease. Mutagenesis. 2019 Oct 20;: Authors: Tomkinson AE, Naila T, Khattri Bhandari S Abstract The joining of interruptions in the phosphodiester backbone of DNA is critical to maintain genome stability. These breaks, which are generated as part of normal DNA transactions, such as DNA replication, V(D)J recombination and meiotic recombination as well as directly by DNA damage or due to DNA damage...
Mon Oct 21, 2019 14:11
Abstract We thank Drs Stellaard and Lütjohann for their interest in our study and for their question regarding the nature of apoB48‐containing lipoprotein particles found in the VLDL1 and VLDL2 density ranges (1). The correspondents are correct in pointing out that chylomicron remnants and apoB100‐containing VLDL of liver origin co‐exist in the VLDL1 (Sf60‐400) and VLDL2 (Sf20‐60) fractions, especially after a fat‐rich meal.
Mon Oct 21, 2019 13:23
Abstract Triglyceride rich lipoproteins (TRLs) in plasma are generally associated with a risk for atherosclerosis and cardiovascular disease. TRLs form in the enterocyte as chylomicrons built around apolipoprotein B48 (ApoB48) and in the liver as very low‐density lipoprotein (VLDL) built around apolipoprotein B100 (ApoB100). The kinetics of ApoB48 and ApoB100 are generally measured in humans after intravenous administration of deuterated leucine with the application of multi‐compartmental modelling.
Mon Oct 21, 2019 13:23
Abstract Background Periodontal disease is associated with cardiovascular disease (CVD) but it is unknown if periodontal disease severity is associated with asymptomatic carotid plaque. The aim of the current population‐based, observational study was to investigate if signs of periodontal disease are associated with the occurrence of carotid plaque and total plaque area (TPA). Methods The Malmö Offspring Study (MOS) is a population‐based study. MOS participants underwent a thorough...
Mon Oct 21, 2019 12:16
Abstract Background Innate and adaptive immune responses are pivotal in atherosclerosis, but their association with early‐stage atherosclerosis in humans is incompletely understood. In this regard, untreated children with familial hypercholesterolemia may serve as a human model to investigate the effect of elevated low‐density lipoprotein (LDL)‐cholesterol. Objectives We aimed to study the immunological and inflammatory pathways involved in early atherosclerosis by examining mRNA...
Mon Oct 21, 2019 11:59
Abstract We appreciate the interest expressed by Bartoloni et al. in our study on cardiovascular disease (CVD) risk in patients with primary Sjögren´s syndrome (pSS) [1]. As these investigators comment, in concordance with our results, their previous study showed an increased prevalence of cerebrovascular events (not further defined) and myocardial infarction [2]. However, differences in the designs of the studies should be considered when contrasting their respective findings. Bartoloni et al....
Sun Oct 20, 2019 19:49
Related ArticlesImpaired Movement Scaling and Reduced Synchrony with Vestibule Closure Characterize Swallowing in Severe Dysphagia. Dysphagia. 2019 Oct 19;: Authors: Wong SM, Kamarunas E, Ludlow CL Abstract The contribution of hyoid and laryngeal movement deficits to penetration or aspiration in dysphagia is unclear, partly due to large variations in normal hyolaryngeal kinematics for swallowing. In healthy volunteers, laryngeal and hyoid kinematics...
Mon Oct 21, 2019 14:23
Related ArticlesPrediction of aspiration in dysphagia using logistic regression: oral intake and self-evaluation. Eur Arch Otorhinolaryngol. 2019 Oct 19;: Authors: Heijnen BJ, Böhringer S, Speyer R Abstract OBJECTIVES: Oropharyngeal dysphagia (OD) has a major influence on health in general and health-related quality of life (HR-QoL) in particular. The gold standard assessments for OD, especially for aspiration in OD, are fiberoptic endoscopic evaluation...
Mon Oct 21, 2019 14:23
Related ArticlesEsculetin Inhibits Proliferation, Invasion, and Migration of Laryngeal Cancer In Vitro and In Vivo by Inhibiting Janus Kinas (JAK)-Signal Transducer and Activator of Transcription-3 (STAT3) Activation. Med Sci Monit. 2019 Oct 20;25:7853-7863 Authors: Zhang G, Xu Y, Zhou HF Abstract BACKGROUND Laryngeal cancer is one of the most common malignant tumors of the head and neck. Natural compounds in traditional Chinese medicine provide many...
Mon Oct 21, 2019 14:23
Related ArticlesNodular fasciitis of the parotid gland engulfing the facial nerve: a conservative approach. BMJ Case Rep. 2019 Oct 18;12(10): Authors: Bennett S, Hutson K, Ajayi O, Hilger A Abstract Nodular fasciitis (NF) is a rapidly growing benign lesion rarely reported in the parotid gland. It shares cytological features with other benign and malignant parotid neoplasms and may be difficult to diagnose based on fine needle aspiration cytology alone....
Mon Oct 21, 2019 14:23
Related ArticlesChanges over time in the electrically evoked compound action potential (ECAP) interphase gap (IPG) effect following cochlear implantation in Guinea pigs. Hear Res. 2019 Oct 04;383:107809 Authors: Schvartz-Leyzac KC, Colesa DJ, Buswinka CJ, Swiderski DL, Raphael Y, Pfingst BE Abstract The electrically-evoked compound action potential (ECAP) is correlated with spiral ganglion neuron (SGN) density in cochlear implanted animals. In a previous...
Mon Oct 21, 2019 14:23
Related ArticlesSymptom burden among head and neck cancer patients in the first year after diagnosis: Association with primary treatment modality. Oral Oncol. 2019 Oct 17;99:104434 Authors: Allen-Ayodabo CO, Eskander A, Davis LE, Zhao H, Mahar AL, Karam I, Singh S, Gupta V, Bubis LD, Moody L, Barbera L, Coburn NG Abstract PURPOSE: Head and neck cancer (HNC) and its treatment affects quality of life, with significant symptom burden. The main objectives...
Mon Oct 21, 2019 14:23
Related ArticlesVitamin E protects against cisplatin-induced genotoxicity in human lymphocytes. Toxicol In Vitro. 2019 Oct 17;:104672 Authors: Al-Eitan LN, Alzoubi KH, Al-Smadi LI, Khabour OF Abstract Cisplatin is an anticancer drug that is widely used in treatments of human malignancies such as ovaries,' testes,' and solid tumors of the head and neck. However, the use of cisplatin in the treatments can be associated with DNA damage and high risk to...
Mon Oct 21, 2019 14:23
Related Articles3-Benzyl-5-((2-nitrophenoxy) methyl)-dihydrofuran-2(3H)-one suppresses FcεRI-mediated mast cell degranulation via the inhibition of mTORC2-Akt signaling. Biochem Biophys Res Commun. 2019 Oct 16;: Authors: Rakhmanova V, Park S, Lee S, Kim YH, Shin J Abstract Mast cells express high-affinity IgE receptor (FcεRI) on their surface, cross-linking of which leads to the immediate release of proinflammatory mediators such as histamine but also...
Mon Oct 21, 2019 14:23
Publication date: Available online 20 October 2019Source: International Journal of PsychophysiologyAuthor(s): Eliana Vassena, Filip Van Opstal, Ingeborg Goethals, Tom VergutsAbstractThe ability to exert control has been widely investigated as a hallmark of adaptive behaviour. Dopamine is recognized as the key neuromodulator mediating various control-related processes. The neural mechanisms underlying the subjective perception of being in control, or Locus of Control (LOC) are however less clear....
Mon Oct 21, 2019 13:07
Publication date: Available online 20 October 2019Source: International Journal of PsychophysiologyAuthor(s): Olga Boukrina, Ekaterina Dobryakova, Veronica Schneider, John DeLuca, Nancy ChiaravallotiAbstractThe modified Story Memory Technique (mSMT) is a memory rehabilitation program that combines training in visualization and context formation to improve learning and memory. Previous studies have shown improvement in learning and memory in individuals with multiple sclerosis (MS) after undergoing...
Mon Oct 21, 2019 13:07
Publication date: Available online 20 October 2019Source: International Journal of PsychophysiologyAuthor(s): Yi Qin, Wei Lü, Brian M. Hughes, Lukasz D. KaczmarekAbstractOne of the potential mechanisms of positive affect (PA) in promoting physical health is by speeding up stress cardiovascular recovery. However, little is known whether high and low approach-motivated PA (AMPA) equally speed stress cardiovascular recovery and whether these effects are affected by personality traits that are associated...
Mon Oct 21, 2019 13:07
Publication date: Available online 20 October 2019Source: British Journal of Oral and Maxillofacial SurgeryAuthor(s): R. Sacco, S. Shah, R. Leeson, V. Moraschini, C.F. de Almeida Barros Mourão, O. Akintola, A. LalliAbstractTumour necrosis factor-α (TNF-α) inhibitors are increasingly being used as immunomodulators to manage inflammatory conditions such as rheumatoid arthritis and Crohn’s disease. Reported serious side effects include an increased incidence of lymphoma and greater susceptibility to...
Mon Oct 21, 2019 12:46
Purinergic receptors, especially P2RX, are associated to the severity of symptoms in patients suffering from depressive and bipolar disorders, and genetic deletion or pharmacological blockade of P2RX7 induces antidepressant-like effect in preclinical models. However, there is scarce evidence about the alterations in P2RX7 or P2RX4 levels and in behavioral consequences induced by previous exposure to stress, a major risk factor for depression in humans. In the present study, we evaluated the effect...
Mon Oct 21, 2019 03:00
Before visiting or leaving their remote island colonies, seabirds often engage in a behaviour termed ‘rafting’, where birds sit, often in groups, on the water close to the colony. Despite rafting being a widespread behaviour across many seabird taxa, the functional significance of rafting remains unknown. Here we combine global positioning system (GPS) tracks, observational and wind condition data to investigate correlates of rafting behaviour in Manx shearwaters (Puffinus puffinus) at a large colony...
Mon Oct 21, 2019 03:00
A study was conducted to investigate the potential of Aspergillus terreus obtained from Avicennia marina mangrove roots in inhibiting Pythium aphanidermatum and damping-off disease of cucumber. Aspergillus terreus exhibited in vitro inhibition of Pythium aphanidermatum growth. Electron microscope examination revealed that the antagonistic fungal isolate resulted in shrinking and groves in Pythium hypha. When Aspergillus terreus culture filtrate was added to Pythium aphanidermatum, it resulted in...
Mon Oct 21, 2019 03:00
The conformational space of the ribose-phosphate backbone is very complex as it is defined in terms of six torsional angles. To help delimit the RNA backbone conformational preferences, 46 rotamers have been defined in terms of these torsional angles. In the present work, we use the ribose experimental and theoretical 13C′ chemical shifts data and machine learning methods to classify RNA backbone conformations into rotamers and families of rotamers. We show to what extent the experimental 13C′ chemical...
Mon Oct 21, 2019 03:00
According to the intelligence-creativity threshold hypothesis, there should be a positive association between intelligence and creative potential up to a certain point, the threshold, after which a further increase in intelligence should have no association with creativity. In the present simulation study, the measured intelligence and creativity of virtual subjects were affected by their true abilities as well as a disturbance factor that varied in magnitude between subjects. The results indicate...
Mon Oct 21, 2019 03:00
Background Mycoplasma hyopneumoniae (Mhp) is the main pathogen causing respiratory disease in the swine industry. Mhp infection rates differ across pig breeds, with Chinese native pig breeds that exhibit high fecundity (e.g., Jiangquhai, Meishan, Erhualian) more sensitive than Duroc, Landrace, and other imported pig breeds. However, the genetic basis of the immune response to Mhp infection in different pig breeds is largely unknown. Aims...
Mon Oct 21, 2019 03:00
Aortic valve regurgitation (AR) can result in heart failure from chronic overloading of the left ventricle (LV). Little is known of the role of estrogens in the LV responses to this condition. The aim of the study was to compare LV remodeling in female rats with severe AR in absence of estrogens by ovariectomy (Ovx). In a first study, we investigated over 6 months the development of hypertrophy in four groups of female Wistar rats: AR or sham-operated (sham) and Ovx or not. Ovx reduced normal heart...
Mon Oct 21, 2019 03:00
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