Publication date: Available online 20 October 2019Source: Behavioural Brain ResearchAuthor(s): Sylvia F. Fawzi, Esther T. Menze, Mariane G. TadrosAbstractAlzheimer’s disease (AD) is a neurodegenerative disease characterized by cognitive and memory problems. Scopolamine (SCOP) is a natural anticholinergic drug that was proven to cause memory impairment in rats. Chelating agents are potential neuroprotective and memory enhancing agents as they can trap iron that enters in pathological deposition of...
Mon Oct 21, 2019 17:17
Publication date: Available online 20 October 2019Source: Behavioural Brain ResearchAuthor(s): Wuyi Wang, Simon Zhornitsky, Herta H. Chao, Ifat Levy, Jutta Joormann, Chiang-shan R. LiAbstractSelf-initiated action is critical to social interaction and individuals with social anxiety find it particularly difficult to initiate social interactions. We showed earlier that social exclusion encumbered self-initiated actions in the Cyberball task in young adults. Here, we examined whether behavioral performance...
Mon Oct 21, 2019 17:17
Background/Aims. Diabetic kidney disease (DKD) is a leading cause of end-stage renal disease. Calcium dobesilate (CaD) is widely used to treat diabetic retinopathy. Recent studies have demonstrated that CaD exerts protective effects against diabetic nephropathy. The aim of this study was to elucidate the molecular and cellular mechanisms underlying the protective effects of CaD. Methods. Human umbilical vein endothelial cells (HUVECs) were cultured with different D-glucose concentrations to determine...
Mon Oct 21, 2019 15:05
Background. The relevance of neutrophil extracellular traps (NETs) in acute ST-elevation myocardial infarction (STEMI) is unclear. We explored the temporal profile of circulating NET markers and their associations to myocardial injury and function and to adverse clinical events in STEMI patients. Methods and Results. In 259 patients, blood samples were drawn before and after PCI, on day 1, and after 4 months. Double-stranded deoxyribonucleic acid (dsDNA) and myeloperoxidase-DNA (MPO-DNA) were measured...
Mon Oct 21, 2019 15:05
Aim. Aware that Down Syndrome patients present among their clinical characteristics impaired immunity, the aim of this study is to identify the statistically significant differences in inflammation-related gene expression by comparing Down Syndrome patients with Periodontal Disease (DS+PD+) with Down Syndrome patients without Periodontal Disease (DS+PD-), and their relationship with periodontitis as a chronic oral inflammatory clinical feature. Materials and Methods. Case study and controls on eleven...
Mon Oct 21, 2019 15:05
Intraperitoneal adhesion is a common complication after abdominal surgery, which seriously affects the quality of life of patients. HuoXueTongFu Formula (HXTF) plays an important role in the prevention and treatment of intraperitoneal adhesions. However, the molecular-related mechanisms are still not fully known. In this study, the model of Intrapetitoneal adhesion was established by cecum abrasion and treated with HXTF for one week. RAW264.7 cells were given LPS, IFN-γ, IL-4, HXTF-medicated serum,...
Mon Oct 21, 2019 15:05
The pathophysiology of the acute lung injury (ALI) is characterized by the damage of alveolar epithelial cells, which can be repaired by exogenous bone marrow-derived mesenchymal stem cells (BMSCs). However, the migration and differentiation abilities of BMSCs are not sufficient for the purpose, and a new approach that could strengthen the repair effects of BMSCs in ALI still needs to be clarified. We have previously proved that in vitro large tumor suppressor kinase 2- (Lats2-) underexpressing BMSCs...
Mon Oct 21, 2019 14:05
Publication date: December 2019Source: Biomedicine & Pharmacotherapy, Volume 120Author(s): Longfei Lin, Fang yuan, Yuling Liu, Ming Zhong, Tanggui Xie, Jian Ni, Hui LiAbstractTo better understand the hepatotoxicity of anthraquinone glycosides, the hepatotoxicity of six anthraquinone glycosides was evaluated. The results show that chrysophanol-8-O-glucoside(C8G) has strong hepatotoxicity and can lead to increased LDH leakage and ROS, decreased GSH and MMP in L-02 hepatocytes. The results of C8G...
Mon Oct 21, 2019 16:59
Publication date: December 2019Source: Biomedicine & Pharmacotherapy, Volume 120Author(s): Tiantian Cai, Chengzhe Zhang, Xiaohui Zeng, Ziming Zhao, Yan Yan, Xuhua Yu, Lei Wu, Lin Lin, Huafeng PanAbstractGastric cancer is recognized as one of the most common cancer. In-depth research of gastric precancerous lesions (GPL) plays an important role in preventing the occurrence of gastric cancer. Meanwhile, traditional treatment provides a novel sight in the prevention of occurrence and development...
Mon Oct 21, 2019 16:59
Background. Interventional therapy has been widely used in the medical field as its advantages of minimally invasive, safe and quick recovery. Bloodstream infection (BSI) is the most common healthcare-associated infections (HAIs) after interventional therapy, but there are few reports about it. This study intends to analyze the clinical characteristics and relevant factors of BSI after six years of interventional therapy in a large tertiary teaching hospital, in order to provide guidances for the...
Mon Oct 21, 2019 16:30
New Findings •What is the central question of this study? We hypothesized that central inflammatory processes that involve activation of microglia and astrocytes contribute to the development of Gαi2 protein‐dependent, salt‐sensitive hypertension. •What is the main finding and its importance? The main finding is that PVN‐specific inflammatory processes, driven by microglial activation, appear to be linked to the development of Gαi2 protein‐dependent, salt‐sensitive hypertension in Sprague–Dawley...
Sun Oct 20, 2019 22:00
Publication date: Available online 21 October 2019Source: NeuroImageAuthor(s): Blake L. Elliott, Chris Blais, Samuel M. McClure, Gene A. BrewerAbstractThe prioritized encoding and retrieval of valuable information is an essential aspect of human memory. We used electroencephalography (EEG) to determine which of two hypothesized processes underlies the influence of reward value on episodic memory. One hypothesis is that value engages prefrontal executive control processes, so that valuable stimuli...
Mon Oct 21, 2019 16:54
Publication date: Available online 21 October 2019Source: Medical HypothesesAuthor(s): Dong-Gyun Han, Dong-Jun KimAbstractHuman otoliths, primarily formed from salts of calcium and carbonate, are different from bones of the skeleton, which are composed of calcium phosphate. The echinoderms, which share the earliest common ancestor with us, began to protect the body by making an endoskeleton out of calcium and carbon dioxide dissolved in the sea. In subsequent vertebrates, aerobic respiration supported...
Mon Oct 21, 2019 16:37
Publication date: Available online 21 October 2019Source: Medical HypothesesAuthor(s): He lin-hai, Zhang Zhi-Yong, Zhang Xiao, Xiao E, Liu Meng, Zhang YiAbstractBone augmentation is increasingly important in implantology. Bone substitute materials exert essential roles during bone augmentation process. However, accelerating bone substitute materials remodeling and acquiring high bone architecture quality was still the challenges of bone augmentation.Accumulated studies had suggested osteoclasts is...
Mon Oct 21, 2019 16:37
Abstract Background Kikuchi-Fujimoto disease, known as histiocytic necrotizing lymphadenitis, is a benign, self-limiting and systemic disorder involving lymph nodes with unknown aetiology. First reported in Japan, there has been an increase in its incidence globally. Because of its non-specific clinical features, the disease can be easily mistaken for other forms of lymphadenitis with a high rate of misdiagnosis and mistreatment,...
Mon Oct 21, 2019 03:00
Publication date: Available online 20 October 2019Source: Clinical Neurology and NeurosurgeryAuthor(s): Maziar Azar, Amin Jahanbakhshi, Maryam Jalessi, Iran Chanideh, Foad Kazemi, Elahe AminiAbstractObjectiveMeningiomas comprise 6-15 % of cerebellopontine angle (CPA) tumors. Surgical treatment is a real challenge because this area is occupied by several critical neurovascular elements. Currently, surgery is the first choice of treatment, however several factors may be present that necessitate choosing...
Mon Oct 21, 2019 15:32
Publication date: Available online 21 October 2019Source: Pathology - Research and PracticeAuthor(s): Khusbu Khetan, Vandana Baloda, Ranjit K. Sahoo, Sreenivas Vishnubhathla, Rajni Yadav, Anoop Saraya, Atul Sharma, Siddhartha Datta Gupta, Prasenjit DasAbstractBackgroundThe pancreatobiliary carcinomas are characterized by presence of desmoplastic stroma. Overexpression of secreted protein acid and rich in cysteine (SPARC), a matrix producing agent has been documented in pancreatic ductal adenocarcinomas,...
Mon Oct 21, 2019 15:29
16 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: "BMJ Open"[jour] These pubmed results were generated on 2019/10/21PubMed comprises more than millions of citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
Mon Oct 21, 2019 15:22
16 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: "BMJ Open"[jour] These pubmed results were generated on 2019/10/21PubMed comprises more than millions of citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
Mon Oct 21, 2019 13:24
452 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: medical science These pubmed results were generated on 2019/10/21PubMed comprises more than millions of citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
Mon Oct 21, 2019 15:22
452 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: medical science These pubmed results were generated on 2019/10/21PubMed comprises more than millions of citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
Mon Oct 21, 2019 13:25
Abstract Objective To evaluate the association between high uric acid (UA), reduced estimated glomerular filtration rate (eGFR), and non-alcoholic fatty liver disease (NAFLD) in outpatient children and adolescents with overweight (OW) or obesity (OB). Methods Anthropometric, biochemical, hepatic ultrasound and eGFR data were available from 2565 young people...
Mon Oct 21, 2019 03:00
Related ArticlesGenetic variation in HSD17B13 reduces the risk of developing cirrhosis and hepatocellular carcinoma in alcohol misusers. Hepatology. 2019 Oct 19;: Authors: Stickel F, Lutz P, Buch S, Nischalke HD, Silva I, Rausch V, Fischer J, Weiss KH, Gotthardt D, Rosendahl J, Marot A, Elamly M, Krawczyk M, Casper M, Lammert F, Buckley TW, McQuillin A, Spengler U, Eyer F, Vogel A, Marhenke S, von Felden J, Wege H, Sharma R, Atkinson S, Franke A, Nehring S, Moser V, Schafmayer...
Mon Oct 21, 2019 14:51
Related ArticlesPhenolic Constituents with Antioxidative, Tyrosinase Inhibitory and Anti-aging Activities from Dendrobium loddigesii Rolfe. Nat Prod Bioprospect. 2019 Oct 19;: Authors: Ma RJ, Yang L, Bai X, Li JY, Yuan MY, Wang YQ, Xie Y, Hu JM, Zhou J Abstract Aqueous ethanol extracts of powdered stems of Dendrobium loddigesii afforded three new phenolics including threo-7-O-ethyl-9-O-(4-hydroxyphenyl)propionyl-guaiacylglycerol (1), (R)-4,5,4'-trihydroxy-3,3',α-trimethoxybibenzyl...
Mon Oct 21, 2019 14:51
Related ArticlesDefining Sexual Risk in the Era of Biomedical HIV Prevention: Implications for HIV Research and Practice. Arch Sex Behav. 2019 Oct 19;: Authors: Horvath KJ, Lammert S, Martinka A, Erickson D Abstract Advancing HIV behavioral science and its integration with recent biomedical prevention strategies-treatment as prevention and pre-exposure prophylaxis (PrEP)-is complicated because traditional definitions of sexual risk (condomless anal sex...
Mon Oct 21, 2019 14:51
Related ArticlesAir quality of an urban school in São Paulo city. Environ Monit Assess. 2019 Oct 19;191(11):659 Authors: Pereira DCA, Custódio D, de Andrade MF, Alves C, de Castro Vasconcellos P Abstract A major campaign was carried out in indoor and outdoor environments in a school located in the university campus of the city of São Paulo. Elements, PAH, oxy-PAH, water-soluble ions and black carbon were determined and compared with preliminary campaigns....
Mon Oct 21, 2019 14:51
Related ArticlesPrevalence and correlates of smoking and nicotine dependence: results of a nationwide cross-sectional survey among Singapore residents. BMJ Open. 2019 Oct 18;9(10):e032198 Authors: Shahwan S, Abdin E, Shafie S, Chang S, Sambasivam R, Zhang Y, Vaingankar JA, Teo YY, Heng D, Chong SA, Subramaniam M Abstract BACKGROUND: Since the Singapore Mental Health Study in 2010 which reported a 16.0% prevalence rate for current smokers and 4.5% for...
Mon Oct 21, 2019 14:51
Related ArticlesElectrophysiological responses to appetitive and aversive outcomes: A comparison of college drinkers and non-drinkers. Neurosci Lett. 2019 Oct 17;:134549 Authors: Soder HE, Suchting R, Potts GF Abstract The current study compared electrophysiological responses (the feedback-related negativity [FRN]) to appetitive and aversive outcomes between a group of college drinkers and non-drinkers. 50 undergraduate students completed a passive,...
Mon Oct 21, 2019 14:51
Related ArticlesPartition efficiency of cytochrome c with alcohol/salt aqueous biphasic flotation system. J Biosci Bioeng. 2019 Oct 17;: Authors: Ng HS, Ng TC, Kee PE, Tan JS, Yim HS, Lan JC Abstract Aqueous biphasic flotation (ABF) integrates aqueous biphasic system (ABS) and solvent sublation for recovery of target biomolecules. The feasibility of the alcohol/salt ABF for exclusive partition of cytochrome c to one specific phase of the system was investigated....
Mon Oct 21, 2019 14:51
Related ArticlesSex difference in IL-6 modulation of cognition among Chinese individuals with major depressive disorder. J Clin Neurosci. 2019 Oct 16;: Authors: Qu N, Zhang SF, Xia B, Xie JZ, Wang XM, Liu J, Xiong J, Ren N, Wang Y, Tian Q, Li Y Abstract Cognitive dysfunction and pro-inflammatory effect has been associated with major depressive disorder (MDD), but sex differences have seldom been studied. The study was to determine the sex difference...
Mon Oct 21, 2019 14:51
Related ArticlesShort communication: Physicochemical features and microbial community of milk kefir using a potential probiotic Saccharomyces cerevisiae KU200284. J Dairy Sci. 2019 Oct 16;: Authors: Hong JY, Lee NK, Yi SH, Hong SP, Paik HD Abstract The aim of this study was to analyze the β-glucan contents, physicochemical features, and microbial communities in milk kefir prepared using Saccharomyces cerevisiae KU200284 isolated from cucumber jangajji,...
Mon Oct 21, 2019 14:51
Publication date: Available online 20 October 2019Source: Archives of Oral BiologyAuthor(s): Rayana Duarte Khoury, Renata Falchete do Prado, Felipe de Souza Matos, Bruna Ribas de Meireles, Flávia Goulart da Rosa Cardoso, Luciane Dias de Oliveira, Cláudio Antonio Talge Carvalho, Marcia Carneiro ValeraAbstractObjectiveTo investigate the influence of chronic stress and adrenergic blockade in a rat model of apical periodontitis.MethodsThirty-two Wistar rats were submitted to an animal model of periapical...
Mon Oct 21, 2019 14:42
Related ArticlesExamining Radiation Treatment Appointment Times at a Canadian Cancer Centre: A Timing Study. J Med Imaging Radiat Sci. 2019 Oct 16;: Authors: Stewart E, Sun I, Kim C, Giddings A, Silverio F, Taruc O, Nica L Abstract INTRODUCTION: Technological advancements in radiation therapy have led to more complex treatment techniques such as volumetric modulated arc therapy, and in turn, more daily image verification. As treatment complexity increases,...
Mon Oct 21, 2019 14:41
Abstract Purpose We evaluated myelin changes throughout the central nervous system in Multiple Sclerosis (MS) patients by using hybrid [18F]florbetapir PET-MR imaging. Methods We included 18 relapsing-remitting MS patients and 12 healthy controls. Each subject performed a hybrid [18F]florbetapir PET-MR and both a clinical and cognitive assessment. [18F]florbetapir...
Mon Oct 21, 2019 03:00
Abstract Positron emission tomography/computed tomography (PET/CT) is a nuclear medicine functional imaging technique with proven clinical value in oncology. PET/CT indications are continually evolving with fresh advances made through research. French practice on the use of PET in oncology was framed in recommendations based on Standards–Options–Recommendations methodology and coordinated by the French federation of Comprehensive Cancer Centres (FNLCC). The recommendations were...
Mon Oct 21, 2019 03:00
Related ArticlesDocosahexaenoic acid,22:6n-3: its roles in the structure and function of the brain. Int J Dev Neurosci. 2019 Oct 17;: Authors: Mallick R, Basak S, Duttaroy AK Abstract Docosahexaenoic acid,22:6n-3 (DHA) and its metabolites are vital for the structure and functional brain development of the fetus and infants, and also for maintenance of healthy brain function of adults. DHA is thought to be an essential nutrient required throughout the...
Mon Oct 21, 2019 14:38
Related ArticlesElicitation of the Swallowing Reflex by Esophageal Stimulation in Healthy Subjects: An Evaluation Using High-Resolution Manometry. Dysphagia. 2019 Oct 19;: Authors: Taniguchi H, Aoyagi Y, Matsuo K, Imaeda S, Hirumuta M, Saitoh E Abstract The purposes of this human study using high-resolution manometry were to verify whether the swallowing reflex can be evoked by intra-esophageal fluid injection and whether the reflex latency and manometric...
Mon Oct 21, 2019 14:31
We describe an exceptionally rare case of a male patient with newly diagnosed advanced human immunodeficiency virus (HIV) infection, who presented with a plasmablastic lymphoma involving the right maxillary alveolar ridge with associated cervical lymphadenopathy. On a staging positron emission tomography computed tomography (PET-CT) scan, he was incidentally found to have an endotracheal tumour involving the anterolateral aspect of the mid-trachea. The tumour appeared to be well-vascularised at bronchoscopy...
Mon Oct 21, 2019 13:28
Publication date: December 2019Source: International Immunopharmacology, Volume 77Author(s): Chun Xin, Joungmin Kim, Hui Quan, Mei Yin, Seongtae Jeong, Jeong-Il Choi, Eun-A Jang, Chang-Hun Lee, Dae-Hun Kim, Hong-Beom BaeAbstractGinsenoside Rg3 is a steroidal saponin abundant in Korean red ginseng that has high anti-inflammatory activity. Rg3 exerts an immunomodulatory effect in acute inflammatory conditions such as bacterial infections. In this study, we determined the effect of Rg3 on bacterial...
Mon Oct 21, 2019 14:23
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