Nature Communications, Published online: 21 October 2019; doi:10.1038/s41467-019-12667-8Myosin, a motor protein essential for intracellular transport to muscle contraction, requires a chaperone UNC-45 for folding and assembly. Here authors use in vitro reconstitution and structural biology to characterize the interplay between UNC-45 and muscle myosin MHC-B.
Mon Oct 21, 2019 03:00
Nature Communications, Published online: 21 October 2019; doi:10.1038/s41467-019-12603-wProtected areas are important refugia for wildlife, so if climate conditions within them change, wildlife could lose critical suitable habitat. Here the authors calculate the projected gain and loss of climate conditions within terrestrial protected areas worldwide.
Mon Oct 21, 2019 03:00
Nature Communications, Published online: 21 October 2019; doi:10.1038/s41467-019-12704-6Roquin-1 is a posttranscriptional regulator that controls the expression of many immune-related genes such as ICOS and TNFA. Here, the authors report a homozygous R688* loss of function mutation in Roquin-1 in a patient with syndromic uncontrolled hyperinflammation associated with immune cell activation and hypercytokinemia.
Mon Oct 21, 2019 03:00
Nature Communications, Published online: 21 October 2019; doi:10.1038/s41467-019-12778-2Traditional photonic crystals consist of periodic media with a pre-defined optical response. Here, the authors combine nanostructured back-gate insulators with a continuous layer of graphene to demonstrate an electrically tunable two-dimensional photonic crystal suitable for controlling the propagation of surface plasmon polaritons.
Mon Oct 21, 2019 03:00
Nature Communications, Published online: 21 October 2019; doi:10.1038/s41467-019-12702-8The authors report the synthesis of an enantiomeric block co-beta-peptide that kills methicillin-resistant Staphylococcus aureus, including biofilm and persister bacterial cells, and disperses biofilms. The copolymer displays antibacterial activity in human ex vivo and mouse in vivo infection models without toxicity.
Mon Oct 21, 2019 03:00
Nature Communications, Published online: 21 October 2019; doi:10.1038/s41467-019-12698-1Machine learning is increasingly used in nanophotonics for designing novel classes of complex devices but the general parameter behavior is often neglected. Here, the authors report a new methodology to discover and visualize optimal design spaces with respect to multiple performance objectives.
Mon Oct 21, 2019 03:00
Nature Communications, Published online: 21 October 2019; doi:10.1038/s41467-019-12637-0Here, the authors demonstrate a multi-momentum transformation metasurface. The orbital angular momentum meta-transformer reconstructs different vortex beams into on-axis distinct patterns, and the linear momentum meta-transformer converts red, green and blue beams to vivid color images.
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Abstract Purpose Several studies have reported different findings on the prognosis of differentiated thyroid carcinoma combined with Graves’ disease. To assess the effect of Graves’ disease on differentiated thyroid carcinoma, a meta-analysis was undertaken. Methods PubMed, OVID and the Cochrane Library were systematically searched for trials published prior...
Mon Oct 21, 2019 03:00
Abstract Purpose Radiation exposure has been reported to cause thyroid nodules. The study area was Karunagapally, which has several areas with high natural radiation levels derived from thorium and its decay products. Since thyroid abnormalities are more common in women, the focus was only on women. Methods The examinations included interview, ultrasonography...
Mon Oct 21, 2019 03:00
Snails were fed with three medicinal plants belonging to the Lamiaceae family (rosemary, sage, and peppermint) in order to test their effects on those animals with high nutritive values. The media of raising were flour containing different percentages of the cited plants ranging from 1% to 9%. The feed had benefits on the raised snails depending on the plant and its percentage. Minerals in those aromatic plants, especially zinc and magnesium, had their effect on protein synthesis in snails fed with...
Mon Oct 21, 2019 16:05
An evolutionary idea: Organic molecules in zeolite synthesis switch the predominant mode of silicalite‐1 growth between classical and nonclassical pathways by mediating the degree to which silica nanoparticle precursors undergo microstructural evolution. Abstract Differentiating mechanisms of zeolite crystallization is challenging owing to the vast number of species in growth solutions. The presence of amorphous colloidal particles is ubiquitous in many zeolite syntheses, and has led to extensive...
Mon Oct 21, 2019 18:38
FeN 4 moieties embedded in partially graphitized carbon are the most efficient platinum group metal‐free active sites for oxygen reduction reaction in acidic proton exchange membrane fuel cells. However, their formation mechanisms have been remaining elusive for decades. Because the Fe‐N bond formation process always convolutes with uncontrolled carbonization and nitrogen doping during high‐temperature treatments. Here, we elucidate the Fe‐N 4 site formation mechanisms through hosting Fe ions...
Mon Oct 21, 2019 17:44
A mononuclear Fe(II) complex, that shows a high‐spin (S = 2) paramagnetic behavior at all temperatures (with standard temperature scan‐rates, of about 1 Kmin −1 ), has indeed a low‐spin (S = 0) ground state below 100 K. This low‐spin state is not easily accessible due to the extremely slow dynamics of the spin‐crossover process. Indeed, a full relaxation of the metastable high‐spin state to the low‐spin ground state takes more than five hours below 80 K. Bidirectional photoswitching of the Fe(II)...
Mon Oct 21, 2019 17:43
Developing noble‐metal‐free electrocatalysts is of utmost importance to industrially viable ammonia synthesis through nitrogen reduction reaction (NRR). However, the present transition metal electrocatalysts still suffer from low activity and Faradaic efficiency due to poor interfacial reaction kinetics. Herein, an interface‐engineered heterojunction, composed of CoS nanosheets anchored on a TiO2 nanofibrous membrane, is developed. As an active matrix, the TiO2 nanofibrous membrane can uniformly...
Mon Oct 21, 2019 16:42
Herein we described an expeditious Rh(II)‐catalysed enantioselective cyclopropenation reaction of internal alkynes with a masked difluorodiazoethane reagent (PhSO2CF2CHN2,Ps‐DFA). This asymmetric transformation offers efficient access to a broad range of enantioenriched difluoromethylated cyclopropenes (40 examples, up to 99% yield, 97% ee). The synthetic utility of obtained strained carbocycles is demonstrated by subsequent stereo‐defined processes including cross‐couplings, hydrogenation, Diels‐Alder...
Mon Oct 21, 2019 16:15
Planarization‐enhanced stability: Dibenzo[g,p]chrysene (DBC), a “closed” version of tetraphenylethene (4PE), was integrated into a 2D heteroporous imine covalent organic framework (COF). The resulting DBC‐COF exhibited much better crystallinity and stability than its counterpart 4PE‐COF, and is a promising host material for ionic conduction. Abstract Two‐dimensional (2D) covalent organic frameworks (COFs) feature open and ordered one‐dimensional column nanochannels which offer immense possibilities...
Mon Oct 21, 2019 13:29
Cell‐matrix adhesions not only mediate the binding interactions between cell and extracellular matrix but also play essential roles in a variety of biological processes. Herein we report a label‐free method to map cell‐matrix adhesions of single living cells on the electrode surface by electrochemiluminescence (ECL). The indium tin oxide electrode modified with silica nanochannel membrane was used as the substrate electrode, at which the enhanced ECL generation from freely diffusing luminophores...
Sun Oct 20, 2019 17:20
The chemistry of coordination polymers (CPs) has progressed significantly in the last century. There are two categories of CPs; one is inorganic CPs (i‐CPs) and the other is organic ligand‐bridged CPs (o‐CPs). o‐CPs rapidly expanded to form a library of crystal structures. The discovery of permanent porosity in o‐CPs is among the most notable breakthroughs, whose appearance was so groundbreaking that they specially named metal–organic frameworks (MOFs) or porous coordination polymers (PCPs). They...
Sun Oct 20, 2019 17:14
Silver is the key: A polyoxometalate cluster based on the superlacunary heteropolyanion [P8W48O184]40− (abbreviated as {P8W48}) reacts with silver ions to self‐assemble three new all‐inorganic metal–oxide porous materials that expand the family of zeolitic polyoxometalate frameworks. The silver ions both enable reactions on the clusters as well as link them together. Abstract The construction of pure‐inorganic framework materials with well‐defined design rules and building blocks is challenging....
Thu Oct 17, 2019 22:00
Nature Chemistry, Published online: 21 October 2019; doi:10.1038/s41557-019-0346-2Asymmetric Sonogashira C(sp3)–C(sp) couplings provide complementary approaches to established C(sp3)–C(sp2/sp3) couplings for chiral C–C bond formation; however, relatively few reactions have been developed. Now, a versatile, enantioconvergent Sonogashira coupling via a radical intermediate has been developed. The approach uses a copper catalyst featuring a multidentate electron-rich cinchona alkaloid-derived ligand.
Mon Oct 21, 2019 03:00
Nature Chemistry, Published online: 21 October 2019; doi:10.1038/s41557-019-0347-1The oxidation of water remains the kinetic bottleneck of solar-to-fuel synthesis. Now, spectroelectrochemical evidence together with density functional theory calculations show that charge accumulation determines the reaction mechanism on metal–oxide photoanodes. These insights reveal features that are common to the mechanisms of water oxidation carried out by other inorganic and biological systems.
Mon Oct 21, 2019 03:00
Nature Chemistry, Published online: 21 October 2019; doi:10.1038/s41557-019-0345-3Generating stable single-atom catalysts is far from straightforward and can involve complicated preparation procedures. Now, mononuclear gold oxo-clusters formed in alkaline solutions through a facile one-pot synthesis are shown to catalyse the heterogeneous methanol self-coupling reaction to methyl formate and hydrogen. The intrinsic activity is the same for both supported and unsupported gold catalysts.
Mon Oct 21, 2019 03:00
Nature Chemistry, Published online: 21 October 2019; doi:10.1038/s41557-019-0348-0The isoelectronic series of alanes [R3Al] and silylium cations [R3Si]+ has now been extended with the synthesis and characterization of two phosphorandiylium dications ([R3P]2+), which are trigonal planar Lewis superacids. The electrophilicity at the phosphorus atom is governed by the π-electron-donating ability of the attached N-heterocyclic imine substituents.
Mon Oct 21, 2019 03:00
The Journal of Antibiotics, Published online: 21 October 2019; doi:10.1038/s41429-019-0250-4New azaphilones from Penicillium variabile, a fungal endophyte from roots of Aconitum vilmorinianum
Mon Oct 21, 2019 03:00
AbstractForgotten stents may lead to serious complications. We present a case report of a forgotten common bile duct (CBD) fully covered metal stent presenting with recurrent cholangitis. A 79-years-old female patient presented with a history of recurrent cholangitis. Past surgical history was notable for open cholecystectomy for symptomatic cholelithiasis in 2016. Subsequently, she was found to have retained CBD stones in the same year. She had endoscopic retrograde cholangiopancreatography (ERCP),...
Mon Oct 21, 2019 03:00
Publication date: 1 February 2020Source: Talanta, Volume 208Author(s): Jun Yao, Cheng Huang, Chaohui Liu, Mei YangAbstractUpconversion luminescence is an optical process that emits high-energy photons by absorbing two or more low-energy photons, which is caused by anti-Stokes luminescence, has attracted significant attention in recent years. Upconversion nanomaterials are superior to quantum dots and organic dyes because of their unique properties, including non-photobleaching, non-blinking, low-toxicity,...
Mon Oct 21, 2019 17:47
Key points •Hair cell mechanoelectrical transducer channels are opened by deflections of the hair bundle about a resting position set by incompletely understood adaptation mechanisms. •We used three characteristics to define adaptation in hair cell mutants of transmembrane channel‐like proteins, TMC1 and TMC2, which are thought to be channel constituents. •Our results demonstrate that the three characteristics are not equivalent, and raise doubts about simple models in which intracellular Ca2+...
Mon Oct 21, 2019 14:09
Key points •Bile acids, ethanol and fatty acids deteriorate pancreatic ductal fluid and bicarbonate secretion via mitochondrial damage, ATP depletion and calcium overload. •It is known that pancreatitis inducing factors open the membrane transition pore (mPTP) channel via cyclophilin D activation in acinar cells causing calcium overload and cell death and genetic or pharmacological inhibition of mPTP improves the outcome of acute pancreatitis in animal models. •In our study we show that genetic...
Sun Oct 20, 2019 21:08
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