Δευτέρα 7 Οκτωβρίου 2019


Prognostic Nutritional Index and Neutrophil-to-Lymphocyte Ratio Are Respectively Associated with Prognosis of Gastric Cancer with Liver Metatasis Undergoing and without Hepatectomy
Background. To clarify the efficacy of hepatectomy for gastric cancer liver metastasis (GCLM) and to investigate the association between prognostic nutrition index (PNI) or neutrophil-to-lymphocyte ratio (NLR) and prognosis of GCLM undergoing or without hepatectomy. Methods. We retrospectively studied 374 patients with GCLM. The ROC curve was used to determine the optimal cut-off of PNI and NLR. Patients were divided into groups based on whether hepatectomy was performed, and survival analysis was...
BioMed Research International
Mon Oct 07, 2019 15:05
Predictors for Unfavorable Early Outcomes in Elective Total Hip Arthroplasty: Does Extreme Body Mass Index Matter?
Background. Studies of previous cohorts have demonstrated a controversial association between extreme body mass index (BMI) and complication rates following total hip arthroplasty (THA). The purpose of this study was to compare 30-day perioperative complications in underweight (BMI
BioMed Research International
Mon Oct 07, 2019 12:05
Evaluation of Drug Susceptibility of Microorganisms in Odontogenic Inflammations and Dental Surgery Procedures Performed on an Outpatient Basis
Bacterial infections are the most common cause of purulent soft tissue inflammations in the head and neck area. These bacteria are also responsible for the majority of inflammatory complications after third molar removal. The key to success of antibacterial treatment in both cases is the use of an appropriate antibacterial agent. The aim of the study was to evaluate the susceptibility profile of bacteria isolated from material collected from patients with intraoral odontogenic abscesses. The test...
BioMed Research International
Mon Oct 07, 2019 12:05
Era of Genomic Medicine: A Narrative Review on CRISPR Technology as a Potential Therapeutic Tool for Human Diseases
Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) provides acquired immunity in microorganisms against exogenous DNA that may hinder the survival of the organism. Pioneering work by Doudna and Charpentier in 2012 resulted in the creation of the CRISPR/Cas9 genome editing tool on the basis of this concept. The aim of this was to create a rapid, efficient, and versatile genome-editing tool to facilitate genetic manipulation. The mechanism relies on two components: the RNA guide which...
BioMed Research International
Mon Oct 07, 2019 11:05
External Control Viral-Like Particle Construction for Detection of Emergent Arboviruses by Real-Time Reverse-Transcription PCR
Arboviruses have been emerging and reemerging worldwide, predominantly in tropical and subtropical areas. As many arbovirus infections, including dengue (DENV), Zika (ZIKV), and chikungunya (CHIKV), have similar signs and symptoms, clinical diagnosis of arbovirus infections is challenging. Therefore, reliable laboratory tests are necessary to improve the clinical management of patients with suspected arbovirus infections. Real-time reverse-transcription PCR (RT-qPCR) is among the more effective methods...
BioMed Research International
Mon Oct 07, 2019 11:05
Soft Robotic Glove for Hand Grasp Rehab
All sorts of conditions, including muscular dystrophy, ALS, and partial spinal cord injury, result in patients losing their ability to confidently grasp objects with their hands. Regaining this important capability is usually a priority, as it is one of the biggest impediments to living a normal life. Now, researchers at Harvard’s Wyss Institute have developed and are clinically testing a soft robotic glove that helps to restore hand function. The device was developed with constant...
Medgadget
Mon Oct 07, 2019 19:50
Nobel Prize in Physiology or Medicine 2019 Announced for Cell Oxygen Regulation
Two Americans and an English knight have won this year’s Nobel Prize in Physiology or Medicine for their discovery of how cells detect how much oxygen is available to them and the mechanism that regulates how they adapt to changes in oxygen levels. The Nobel Laureates: William G. Kaelin Jr., Sir Peter J. Ratcliffe and Gregg L. Semenza While the scientific community recognized the importance of oxygen for animal cells a very long time ago, what actually happens at the cellular level...
Medgadget
Mon Oct 07, 2019 17:42
Red Light Activated Cancer Drug Improves Treatment in Mice
Researchers from the City University of Hong Kong have developed a new, controllable cancer drug called phorbiplatin that only becomes active and potent after red light stimulation. Their work demonstrates that in the dark the cancer drug does not have substantial toxicity, but the drug is able to substantially reduce tumor size when activated by red light. One day, this technology may be used to improve cancer treatment and reduce its side effects. Currently, many cancer drugs are administered...
Medgadget
Mon Oct 07, 2019 16:40
Bees may drive the reproduction of four sympatric cacti in a vanishing coastal mediterranean-type ecosystem
Background Sympatric congeneric plants might share pollinators, or each species might avoid competition by evolving specialized traits that generate partitions in pollinator assemblages. In both cases, pollen limitation (a decrease in the quality and quantity of compatible reproductive pollen) can occur, driving the plant mating system to autogamy as a mechanism of reproductive assurance. We assessed the relationships between pollinator assemblages and mating systems in a group of sympatric congeneric...
PeerJ
Mon Oct 07, 2019 03:00
Complete mitochondrial genome sequence of Labriocimbex sinicus, a new genus and new species of Cimbicidae (Hymenoptera) from China
Labriocimbex sinicus Yan & Wei gen. et sp. nov. of Cimbicidae is described. The new genus is similar to Praia Andre and Trichiosoma Leach. A key to extant Holarctic genera of Cimbicinae is provided. To identify the phylogenetic placement of Cimbicidae, the mitochondrial genome of L. sinicus was annotated and characterized using high-throughput sequencing data. The complete mitochondrial genome of L. sinicus was obtained with a length of 15,405 bp (GenBank: MH136623; SRA: SRR8270383) and a typical...
PeerJ
Mon Oct 07, 2019 03:00
Integrative transcriptome data mining for identification of core lncRNAs in breast cancer
Background Cumulative evidence suggests that long non-coding RNAs (lncRNAs) play an important role in tumorigenesis. This study aims to identify lncRNAs that can serve as new biomarkers for breast cancer diagnosis or screening. Methods First, the linear fitting method was used to identify differentially expressed genes from the breast cancer RNA expression profiles in The Cancer Genome Atlas (TCGA). Next, the diagnostic...
PeerJ
Mon Oct 07, 2019 03:00
In vivo acute toxicity evaluation and in vitro molecular mechanism study of antiproliferative activity of a novel indole Schiff base β-diiminato manganeseIII complex in hormone-dependent and triple negative breast cancer cells
Breast cancer is the most frequently diagnosed cancer among women worldwide. Recently, increasing attention has been paid to the anticancer effects of transition metal complexes of indole Schiff bases. β-diiminato ManganeseIII complex has shown promising cell cycle arrest and apoptosis induction against MCF-7 and MDA-MB-231 breast cancer cells. In this study, time- and dose- dependent inhibitory activity were evaluated using MTT assay after 48 h and 72 h exposure time. In addition, median effect...
PeerJ
Mon Oct 07, 2019 03:00
Social Motor Priming: when offline interference facilitates motor execution
Many daily activities involve synchronizing with other people’s actions. Previous literature has revealed that a slowdown of performance occurs whenever the action to be carried out is different to the one observed (i.e., visuomotor interference). However, action execution can be facilitated by observing a different action if it calls for an interactive gesture (i.e., social motor priming). The aim of this study is to investigate the costs and benefits of spontaneously processing a social response...
PeerJ
Mon Oct 07, 2019 03:00
Analyzing the interpretative ability of landscape pattern to explain thermal environmental effects in the Beijing-Tianjin-Hebei urban agglomeration
The development of the urban agglomeration has caused drastic changes in landscape pattern and increased anthropogenic heat emission and lead to the urban heat island (UHI) effect more serious. Therefore, understanding the interpretation ability of landscape pattern on the thermal environment has gradually become an important focus. In the study, the spatial heterogeneity of the surface temperature was analyzed using the hot-spot analysis method which was improved by changing the calculation of space...
PeerJ
Mon Oct 07, 2019 03:00
Validation of COI metabarcoding primers for terrestrial arthropods
Metabarcoding can rapidly determine the species composition of bulk samples and thus aids biodiversity and ecosystem assessment. However, it is essential to use primer sets that minimize amplification bias among taxa to maximize species recovery. Despite this fact, the performance of primer sets employed for metabarcoding terrestrial arthropods has not been sufficiently evaluated. This study tests the performance of 36 primer sets on a mock community containing 374 insect species. Amplification success...
PeerJ
Mon Oct 07, 2019 03:00
CELSR3 mRNA expression is increased in hepatocellular carcinoma and indicates poor prognosis
Objective Hepatocellular carcinoma (HCC) is a disease that is associated with high mortality; currently, there is no curative and reliable treatment. Cadherin EGF LAG seven-pass G-type receptor 3 (CELSR3) is the key signaling molecule in the wingless and INT-1/planar cell polarity (WNT/PCP) pathway. This study aimed to elucidate the prognostic significance of CELSR3 in HCC patients. Methods The Cancer Genome Atlas (TCGA)...
PeerJ
Mon Oct 07, 2019 03:00
Plastome sequences help to improve the systematic position of trinerved Lindera species in the family Lauraceae
Lindera is a genus (c. 100 spp.) of trees belonging to the “core Laureae” group in the family Lauraceae. It is often confused with Litsea, and the systematics of the genus is unclear. Here, total 10 complete plastomes from nine trinerved Lindera species and another species Lindera obtusiloba (sect. Palminerviae Meissn.) were sequenced. Nine highly variable regions, trnH-GUG/psbA, psbM/trnD-GUC, petA/psbL, ndhF, trnL-UAG/ndhD, and ycf1, were identified among the 10 Lindera species. In addition, a...
PeerJ
Mon Oct 07, 2019 03:00

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