Abstract Background The STOPP/START criteria are an explicit tool to detect potentially inappropriate medications (PIMs). Patient clinical information may not be available in all settings. Objective To identify patient clinical information needed to apply the STOPP/START criteria. Setting: Four nursing homes in Portugal. Methods First, a theoretical analysis was performed to identify the patient information required to apply the STOPP/START criteria (v2), according to the following...
Abstract Background Proton pump inhibitors are among the most widely prescribed drugs in the world, but more than half of the indications for prescription are unjustified. The misuse of this therapeutic class has heavy consequences such as additional health costs, adverse drug reactions following long-term use and gastric acid rebound when the proton pump inhibitor is discontinued. Objective The overprescription of proton pump inhibitors is therefore becoming a public health problem,...
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Background Colorectal cancer screening uptake is low, particularly among individuals enrolled in Medicaid. To the authors' knowledge, little is known regarding the effectiveness of direct‐to‐member outreach by Medicaid health insurance plans to raise colorectal cancer screening use, nor how best to deliver such outreach. Methods BeneFIT is a hybrid implementation‐effectiveness study of 2 program models that health plans developed for a mailed fecal immunochemical test (FIT) intervention. The...
Background Sixty percent of patients with stage IV melanoma may develop brain metastases, which result in significantly increased morbidity and a poor overall prognosis. Phase 3 studies of melanoma usually exclude patients with untreated brain metastases; therefore, clinical data for intracranial responses to treatments are limited. Methods A multicenter, retrospective case series investigation of consecutive BRAF‐mutant patients with melanoma brain metastases (MBMs) treated with a combination...
Background News of cancer progression is critical to setting accurate prognostic understanding, which guides patients' treatment decision making. This study examines whether religious belief in miracles modifies the effect of receiving news of cancer progression on change in prognostic understanding. Methods In a multisite, prospective cohort study, 158 patients with advanced cancer, whom oncologists expected to die within 6 months, were assessed before and after the visit at which scan results...
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IJMS, Vol. 20, Pages 5379: Liver X Receptors and Male (In)fertility International Journal of Molecular Sciences doi: 10.3390/ijms20215379 Authors: Sheba Jarvis Catherine Williamson Charlotte L Bevan Liver X receptors (LXRs) are ligand-dependent transcription factors acting as ‘cholesterol sensors’ to regulate lipid homeostasis in cells. The two isoforms, LXRα (NR1H3) and LXRβ (NR1H2), are differentially expressed, with the former expressed...
IJMS, Vol. 20, Pages 5381: Variable Smear Layer and Adhesive Application: The Pursuit of Clinical Relevance in Bond Strength Testing International Journal of Molecular Sciences doi: 10.3390/ijms20215381 Authors: Abu Faem Mohammad Almas Chowdhury Rafiqul Islam Arefin Alam Mariko Matsumoto Monica Yamauti Ricardo Marins Carvalho Hidehiko Sano The removal or modification of smear layers that cover the dentin is critical to allow the penetration of adhesive molecules and...
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ACS NanoDOI: 10.1021/acsnano.9b02362
ACS NanoDOI: 10.1021/acsnano.9b03050
ACS NanoDOI: 10.1021/acsnano.9b05908
ACS NanoDOI: 10.1021/acsnano.9b04366
ACS NanoDOI: 10.1021/acsnano.9b03351
ACS NanoDOI: 10.1021/acsnano.9b05979
ACS NanoDOI: 10.1021/acsnano.9b07144
ACS NanoDOI: 10.1021/acsnano.9b04148
ACS NanoDOI: 10.1021/acsnano.9b06774
ACS NanoDOI: 10.1021/acsnano.9b04536
ACS NanoDOI: 10.1021/acsnano.9b06164
ACS NanoDOI: 10.1021/acsnano.9b04375
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Episodic memory allows us to mentally travel through time. How does the brain convert a simple reminder cue into a full-blown memory of past events and experiences? In this review, we integrate recent developments in the cognitive neuroscience of human memory retrieval, pinpointing the neural chronometry underlying successful recall. Electrophysiological recordings suggest that sensory cues proceed into the medial temporal lobe within the first 500 ms. At this point, a hippocampal process sets in,...
The distinction between episodic and semantic memory was first proposed in 1972 by Endel Tulving and is still of central importance in cognitive neuroscience. However, data obtained over the past 30 years or so support the idea that the frontiers between perception and knowledge and between episodic and semantic memory are not as clear cut as previously thought, prompting a rethink of the episodic–semantic distinction. Here, we review recent research on episodic and semantic memory, highlighting...
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Analytical ChemistryDOI: 10.1021/acs.analchem.9b02699
Analytical ChemistryDOI: 10.1021/acs.analchem.9b02756
Analytical ChemistryDOI: 10.1021/acs.analchem.9b03916
Analytical ChemistryDOI: 10.1021/acs.analchem.9b03372
Analytical ChemistryDOI: 10.1021/acs.analchem.9b02734
Analytical ChemistryDOI: 10.1021/acs.analchem.9b03518
Analytical ChemistryDOI: 10.1021/acs.analchem.9b03612
Analytical ChemistryDOI: 10.1021/acs.analchem.9b03798
Analytical ChemistryDOI: 10.1021/acs.analchem.9b02924
Analytical ChemistryDOI: 10.1021/acs.analchem.9b03908
Analytical ChemistryDOI: 10.1021/acs.analchem.9b03332
Analytical ChemistryDOI: 10.1021/acs.analchem.9b03008
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I was a consultant in neurological rehabilitation for acquired brain injury when, at the age of 62 years, I had a stroke. Running for a train, I experienced pain in the right side of my head and mild weakness and sensory loss in my left limbs. I thought I'd had a stroke, but I was remarkably calm. It was late and my instinct was to get home, where I went to the study. In the morning, I found myself on the floor, half-blind, half-paralysed, and terrified.
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Following publication of the original article [1], we have been notified that the final specification of randomisation implemented in the study is slightly different to that stated in the protocol and needs to...
Wound repair is one of the most complex biological processes of human life. Allogeneic cell-based engineered skin substitutes provide off-the-shelf temporary wound coverage and act as biologically active dress...
Poor recruitment to, and retention in, clinical trials is a source of research waste that could be reduced by more informed choices about participation. Barriers to effective recruitment and retention can be w...
Following publication of the original article [1], we have been notified that one of an error in the Conclusions section of the Abstract.
Palliative antalgic treatments represent an issue for clinical management and a challenge for scientific research. Radiotherapy (RT) plays a central role. Techniques such as stereotactic body radiotherapy (SBR...
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