Abstract Purpose No study has evaluated the prognostic impact of the age-adjusted Charlson comorbidity index (AACI) in those with renal cell carcinoma (RCC). This study aimed to evaluate the utility of the AACI for predicting long-term survival in patients with surgically treated non-metastatic clear cell RCC (ccRCC). Methods Data from 698 patients with non-metastatic...
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Abstract Purpose Glioma is one of the lethal cancers which needs effective therapeutic target. TRIM44 has been found playing a carcinogenic role in human tumors such as breast cancer and ovarian cancer. However, the pathophysiological significance of TRIM44 in glioma is still unclear. Methods Quantitative-PCR and western blot were used to assess the expression...
Fri Oct 11, 2019 03:00
Abstract Purpose To evaluate feasibility and efficacy of Stereotactic Body Radiation Therapy (SBRT) for unresectable liver metastasis in oligometastatic patients. Methods Oligometastatic patients with up to three liver metastases of a maximum diameter of 6 cm were treated with SBRT. Total dose was 75 Gy in three consecutive fractions. Study endpoints were...
Fri Oct 11, 2019 03:00
Publication date: November 2019Source: European Journal of Cancer, Volume 122Author(s): Amal Kamal Abdel-Aziz, Mona Kamal Saadeldin, Paolo D'Amico, Stefania Orecchioni, Francesco Bertolini, Giuseppe Curigliano, Saverio MinucciAbstractThe Food and Drug Administration has lately approved atezolizumab, anti-programmed death ligand 1 (PD-L1), to be used together with nanoparticle albumin-bound (nab) paclitaxel in treating patients with triple negative breast cancer (BC) expressing PD-L1. Nonetheless,...
Fri Oct 11, 2019 18:00
Publication date: November 2019Source: European Journal of Cancer, Volume 122Author(s): Michael Davidson, Lauren I. Aronson, Julie Howard-Reeves, Hanna Bryant, Rosalind J. Cutts, Sanna Hulkki-Wilson, Kyriakos Kouvelakis, Eftheleria Kalaitzaki, David Watkins, Naureen Starling, Sheela Rao, Marta Llorca Cardenosa, Ruwaida Begum, Isma Rana, Retchel Lazaro-Alcausi, Monica Terlizzo, Andrew Wotherspoon, Gina Brown, John Swansbury, Christopher J. LordAbstractIntroductionThe MYC proto-oncogene is among the...
Fri Oct 11, 2019 18:00
Cancers, Vol. 11, Pages 1540: Tumor Expression of Cyclin-Dependent Kinase 5 (Cdk5) Is a Prognostic Biomarker and Predicts Outcome of Oxaliplatin-Treated Metastatic Colorectal Cancer Patients Cancers doi: 10.3390/cancers11101540 Authors: Ruiz de Porras Bystrup Cabrero-de las Heras Musulén Palomero Alonso Nieto Arango Moreno Queralt Manzano Layos Bugés Martinez-Balibrea In recent years, an increasing number of studies have shown that...
Fri Oct 11, 2019 03:00
Cancers, Vol. 11, Pages 1539: PARP1 Co-Regulates EP300–BRG1-Dependent Transcription of Genes Involved in Breast Cancer Cell Proliferation and DNA Repair Cancers doi: 10.3390/cancers11101539 Authors: Sobczak Pitt Spickett Robaszkiewicz BRG1, an active subunit of the SWI/SNF chromatin-remodeling complex, enables the EP300-dependent transcription of proliferation and DNA repair genes from their E2F/CpG-driven promoters in breast cancer cells. In the current study, we show that...
Fri Oct 11, 2019 03:00
Cancers, Vol. 11, Pages 1538: Expression of Irisin/FNDC5 in Cancer Cells and Stromal Fibroblasts of Non-small Cell Lung Cancer Cancers doi: 10.3390/cancers11101538 Authors: Nowinska Jablonska Pawelczyk Piotrowska Partynska Gomulkiewicz Ciesielska Katnik Grzegrzolka Glatzel-Plucinska Ratajczak-Wielgomas Podhorska-Okolow Dziegiel Background: Recent in vitro studies have indicated that irisin inhibits proliferation, migration and epithelial-mesenchymal...
Fri Oct 11, 2019 03:00
Publication date: December 2019Source: Cancer Epidemiology, Volume 63Author(s): Daniella Gilboa, Gideon Koren, Yael Barer, Rachel Katz, Ram Rotem, Eitan Lunenfeld, Varda ShalevAbstractBackgroundThere is controversy whether exposure to assisted reproductive technology (ART) is associated with increased risk of pediatric cancer.We aimed at calculating the overall risk of pediatric cancers after ART in a large cohort of exposed women; and to conduct a systematic review and meta- analysis of cohort studies...
Fri Oct 11, 2019 17:04
Cancers, Vol. 11, Pages 1537: PATZ1 Is Overexpressed in Pediatric Glial Tumors and Correlates with Worse Event-Free Survival in High-grade Gliomas Cancers doi: 10.3390/cancers11101537 Authors: Annalisa Passariello Maria Elena Errico Vittoria Donofrio Manuela Maestrini Alia Zerbato Laura Cerchia Maria Capasso Mario Capasso Monica Fedele Glial tumors are the leading cause of cancer-related death and morbidity in children. Their diagnosis, mainly based on clinical...
Fri Oct 11, 2019 03:00
Abstract Radiation therapy (RT) is a crucial part of cancer care, but previous work suggests that many non-radiation oncologist physicians are uncomfortable referring for RT. To evaluate training and understanding of RT, the authors sent invitations to complete an online questionnaire to all physicians at a community hospital in Bronx, NY, which asked about oncology training and self-rated and objective knowledge of RT. Out of 247 invited participants, 87 responded (35%). Among...
Fri Oct 11, 2019 03:00
Cancers, Vol. 11, Pages 1535: Detailed Characterization of Immune Cell Infiltrate and Expression of Immune Checkpoint Molecules PD-L1/CTLA-4 and MMR Proteins in Testicular Germ Cell Tumors Disclose Novel Disease Biomarkers Cancers doi: 10.3390/cancers11101535 Authors: João Lobo Ângelo Rodrigues Rita Guimarães Mariana Cantante Paula Lopes Joaquina Maurício Jorge Oliveira Carmen Jerónimo Rui Henrique Background: The immune infiltrate plays an important part in testicular...
Fri Oct 11, 2019 03:00
Cancers, Vol. 11, Pages 1536: Understanding the Interplay between COX-2 and hTERT in Colorectal Cancer Using a Multi-Omics Analysis Cancers doi: 10.3390/cancers11101536 Authors: Georgios D. Ayiomamitis George Notas Thivi Vasilakaki Aikaterini Tsavari Styliani Vederaki Theodosis Theodosopoulos Elias Kouroumalis Apostolos Zaravinos Background: Cyclooxygenase 2 (COX-2) is involved in the initial steps of colorectal cancer (CRC) formation, playing a key role in the catalysis...
Fri Oct 11, 2019 03:00
Abstract Immune checkpoint inhibitors (ICIs) have demonstrated remarkable efficacy in a variety of solid tumors; nonetheless, they have not been well investigated and are still recognized as a relative contraindication for patients with a liver transplantation (LT) history, since ICIs treatment might potentially lead to graft rejection. The program death-1 (PD-1) and the cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) pathways are implicated in the tolerance of transplanted...
Fri Oct 11, 2019 03:00
Abstract Objective This paper presents the results of a study developed to inform the design of a multigenerational digital lifestyle intervention for overweight/obese women cancer survivors and their families. We followed the first six phases of the Integrate, Design, Assess, and Share (IDEAS) framework. Methods Grandmothers with breast, endometrial, or ovarian cancers (n=46; 66.1±0.9 years old; 34% Hispanic, 33% non‐Hispanic black, 33% non‐Hispanic white) self‐reported their lifestyle...
Thu Oct 10, 2019 11:54
Abstract Objective Internet‐delivered interventions may alleviate distress in cancer survivors with limited access to psychological face‐to‐face treatment. In collaboration with a group of cancer survivors, we developed and tested the efficacy of a therapist‐assisted internet‐delivered mindfulness‐based cognitive therapy (iMBCT) program for anxiety and depression in cancer survivors. Methods A total of 1282 cancer survivors were screened for anxiety and depression during their routine oncology...
Thu Oct 10, 2019 11:44
Abstract Objectives Breast cancer (BC) can be understood as a we‐disease, which affects the couple as a unit and requires coping as a unit (e.g., common dyadic coping, CDC). However, partners can be incongruent in their perception of CDC, for example due to misunderstandings, lack of mutuality or conflict, which may likely be associated with greater distress. Thus, this paper examines the effect of CDC congruence on individual psychological distress in cancer patients and their partners. ...
Thu Oct 10, 2019 11:38
Abstract Uterine leiomyosarcoma (ULMS) is the major subtype of uterine sarcoma (US), and contributes to uterine cancer deaths. Although preoperative diagnosis of US remains challenging, frequent application of laparoscopic surgery for benign uterine leiomyomas (ULMs) requires precise exclusion of US. MicroRNAs are stably present in the bloodstream, and the application of circulating miRNAs as disease biomarkers has been recognized. In the present study, we aimed to identify diagnostic biomarkers...
Thu Oct 10, 2019 13:13
Abstract Abnormal function of human body enzymes and epigenetic alterations such as DNA methylation have been shown to lead to human carcinogenesis. Lysyl oxidase (LOX) enzyme has attracted attention due to its involvement in tumor progression in various cancers. The purpose of this study was to clarify clinical importance of LOX expression and its epigenetic regulation in pathogenesis of esophageal squamous cell carcinoma (ESCC). Using a database of 284 ESCCs, we examined LOX expression and its...
Thu Oct 10, 2019 13:09
Multimorbidity in women with breast cancer may delay presentation, affect treatment decisions and outcomes. We described the multimorbidity profile of women with breast cancer, its determinants, associations with stage at diagnosis and treatments received. We collected self‐reported data on five chronic conditions (hypertension, diabetes, cerebrovascular diseases, asthma/chronic obstructive pulmonary disease, tuberculosis), determined obesity using body mass index (BMI), and tested HIV status, in...
Thu Oct 10, 2019 19:09
Survivors of childhood cancer are at risk for obesity, a condition potentially modifiable if dietary intake and physical activity are optimized. These health behaviors are likely influenced by neighborhood of residence, a determinant of access to healthy, affordable food and safe and easy exercise opportunities. We examined associations between neighborhood level factors and obesity among survivors in the St. Jude Lifetime cohort and community comparison group members. Persons with residential addresses...
Thu Oct 10, 2019 19:03
Cancers, Vol. 11, Pages 1533: 17β-Estradiol Activates HSF1 via MAPK Signaling in ERα-Positive Breast Cancer Cells Cancers doi: 10.3390/cancers11101533 Authors: Natalia Vydra Patryk Janus Agnieszka Toma-Jonik Tomasz Stokowy Katarzyna Mrowiec Joanna Korfanty Anna Długajczyk Bartosz Wojtaś Bartłomiej Gielniewski Wiesława Widłak Heat Shock Factor 1 (HSF1) is a key regulator of gene expression during acute environmental stress that enables the cell survival, which...
Fri Oct 11, 2019 03:00
Cancers, Vol. 11, Pages 1534: Natural Killer Cell Therapy: A New Treatment Paradigm for Solid Tumors
Cancers, Vol. 11, Pages 1534: Natural Killer Cell Therapy: A New Treatment Paradigm for Solid Tumors Cancers doi: 10.3390/cancers11101534 Authors: Sooyeon Oh Joo-Ho Lee KyuBum Kwack Sang-Woon Choi In treatments of solid tumors, adoptive transfer of ex vivo expanded natural killer (NK) cells has dawned as a new paradigm. Compared with cytotoxic T lymphocytes, NK cells take a unique position targeting tumor cells that evade the host immune surveillance by down-regulating self-antigen...
Fri Oct 11, 2019 03:00
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