Publication date: Available online 10 August 2020Source: American Journal of OtolaryngologyAuthor(s): Giuseppe Brescia, Roberto Padoan, Franco Schiavon, Giacomo Contro, Daniela Parrino, Giulia Tealdo, Mara Felicetti, Anna Chiara Frigo, Lara Alessandrini, Gino Marioni
Tue Aug 11, 2020 16:04
Publication date: Available online 10 August 2020Source: American Journal of OtolaryngologyAuthor(s): Taha Mur, Krishna Madhav Sambhu, Amit Mahajan, Seyedmehdi Payabvash, Jeyanth Fernandez, Heather Ann Edwards
Tue Aug 11, 2020 16:04
Condition: Nasopharyngeal CarcinomaIntervention: Drug: cetuximab (CTX) or nimotuzumab (NTZ)Sponsor: Fudan UniversityRecruiting
Tue Aug 11, 2020 17:42
Condition: Oropharyngeal CarcinomaIntervention: Drug: Anti-EGFR monoclonal antibodySponsor: Fudan UniversityRecruiting
Tue Aug 11, 2020 17:42
Conditions: Optic Nerve Sheath Diameter; Point of Care UltrasoundIntervention: Device: cervical neck collarSponsor: Tanta UniversityRecruiting
Tue Aug 11, 2020 17:42
Conditions: Covid19; Diabetes Mellitus; Hypertension; ObesityInterventions: Dietary Supplement: Nutritional support system (NSS); Other: ControlSponsor: Anahuac UniversityNot yet recruiting
Tue Aug 11, 2020 17:42
ABSTRACT Acne is the most common skin disease in adolescent Westernized populations. Several data support the involvement of the mammalian target of rapamycin complex 1 (mTORC1) signaling in the interplay between androgens, insulin, insulin‐like growth factor (IGF1), and high glycemic index diet in acne. The Peroxisome Proliferator Activated Receptor γ (PPARγ) is involved in both differentiation and anti‐inflammatory response. Low differentiated sebocytes showed decreased expression of PPARγ and...
Tue Aug 11, 2020 13:49
Abstract The negative outcomes of COVID‐19 diseases respiratory distress (ARDS) and the damage to other organs are secondary to a “cytokine storm” and to the attendant oxidative stress. Active hydroxyl‐forms of vitamin D are anti‐inflammatory, induce anti‐oxidative responses, and stimulate innate immunity against infectious agents. These properties are shared by calcitriol and the CYP11A1‐generated non‐calcemic hydroxyderivatives. They inhibit the production of pro‐inflammatory cytokines, downregulate...
Tue Aug 11, 2020 11:50
ABSTRACT Current experimental research on acne pathophysiology has revealed a more complicated template than the classically reported four factor etiology. Cells of the pilosebaceous unit, which represent the template for the developments of acne lesions seem to be parallelly affected by endocrinological/metabolic factors as well as inflammatory/immunological ones, which influence cooperate in sebocyte differentiation/lipogenesis, holocrine secretion and sebum production. Indeed, the unique programme...
Mon Aug 10, 2020 16:43
Zusammenfassung Hintergrund Die Radiotherapie (RT) ist integraler Bestandteil der Behandlung vieler Tumoren in der Nachbarschaft empfindlicher Organe und Strukturen, zu denen insbesondere auch Kopf-Hals- und Schädelbasistumoren zählen. Aufgrund der mit einer Strahlentherapie verbundenen Risiken von Nebenwirkungen wird die Nutzung hochkonformaler RT-Techniken favorisiert. Für viele Indikationen ist daher die Protonentherapie (PT) bereits...
Tue Aug 11, 2020 03:00
Cranial polyneuropathy caused by herpes zoster infection: a retrospective single-center analysis. Eur Arch Otorhinolaryngol. 2020 Aug 10;: Authors: Pupić-Bakrač J, Pupić-Bakrač A, Terkeš V, Baraka I Abstract PURPOSE: Cranial polyneuropathy (CP) is a rare complication of herpes zoster (HZ) infection. This entity often produces situations of a diagnostic dilemma, as can be seen in a wide spectrum of clinical presentations. The aim of this study...
Tue Aug 11, 2020 15:10
Correction to: Sinus and anterior skull base surgery during the COVID-19 pandemic: systematic review, synthesis and YO-IFOS position. Eur Arch Otorhinolaryngol. 2020 Aug 10;: Authors: Radulesco T, Lechien JR, Sowerby LJ, Saussez S, Chiesa-Estomba C, Sargi Z, Lavigne P, Calvo-Henriquez C, Lim CM, Tangjaturonrasme N, Vatanasapt P, Dehgani-Mobaraki P, Fakhry N, Ayad T, Michel J Abstract In the original publication of the article, one of the author's...
Tue Aug 11, 2020 15:10
Sarcopenia predicts a poor treatment outcome in patients with head and neck squamous cell carcinoma receiving concurrent chemoradiotherapy. Eur Arch Otorhinolaryngol. 2020 Aug 08;: Authors: Shodo R, Yamazaki K, Ueki Y, Takahashi T, Horii A Abstract PURPOSE: Sarcopenia, defined as a decrease in the skeletal muscle mass and its function, is associated with a poor clinical outcome in several malignancies. We aimed to examine whether sarcopenia...
Tue Aug 11, 2020 15:10
Comparison of the results of caloric and video head impulse tests in patients with Meniere's disease and vestibular migraine. Eur Arch Otorhinolaryngol. 2020 Aug 09;: Authors: Yilmaz MS, Egilmez OK, Kara A, Guven M, Demir D, Genc Elden S Abstract PURPOSE: To compare the results of video head impulse test (vHIT) and caloric testing (CT) in patients with vestibular migraine (VM) and Ménière's disease (MD) and to investigate the relationship between...
Tue Aug 11, 2020 15:10
Endoscopic endonasal approach for repairing an outwardly herniated blow-out fracture lateral to the infraorbital nerve. Eur Arch Otorhinolaryngol. 2020 Aug 09;: Authors: Takaishi S, Iimura J, Otori N Abstract BACKGROUND: To repair a blow-out fracture, the endonasal approach is indicated when the center of the fracture occurs in the orbital floor medial to the infraorbital nerve, or when the orbital tissue is herniated inwards; additionally,...
Tue Aug 11, 2020 15:10
Abstract Tympanometry is a relatively simple non-invasive test of the status of the middle ear. An important step towards understanding the mechanics of the middle ear during tympanometry is to make vibration measurements on the eardrum under tympanometric pressures. In this study, we measured in vivo vibration responses in 11 gerbils while varying the middle-ear pressure quasi-statically, with the ear canal at ambient pressure. Vibrations were recorded using a single-point laser...
Tue Aug 11, 2020 03:00
Abstract To explore the effects of cochlear hair cell displacement, researchers have previously monitored functional and mechanical responses during low-frequency (LF) acoustic stimulation of the cochlea. The induced changes are believed to result from modulation of the conductance of mechano-electrical transduction (MET) channels on cochlear hair cells, along with receptor potential modulation. It is less clear how, or if, vestibular hair cell displacement affects vestibular...
Tue Aug 11, 2020 03:00
Abstract Mechanical properties of the tympanic membrane (TM) play an important role in sound transmission through the middle ear. While numerous studies have investigated the mechanical properties of the adult human TM, the effects of age on the TM’s properties remain unclear because of the limited published data on the TM of young children. To address this deprivation, we used baboons in this study as an animal model for investigating the effect of age on the mechanical properties...
Tue Aug 11, 2020 03:00
Introduction Hemophagocytic lymphohistiocytosis (HLH) has been only rarely reported in patients with BRAF-mutated advanced melanoma treated with targeted therapies and never with first-line dabrafenib/trametinib combination thus far. Observations Two patients treated with first-line dabrafenib and trametinib combination therapy for metastatic melanoma presented with sudden occurrence of fever, cytopenia, rhabdomyolysis, hepatic cytolysis, hypertriglyceridemia and very high ferritin...
Fri Aug 07, 2020 03:00
Publication date: Available online 10 August 2020Source: European Annals of Otorhinolaryngology, Head and Neck DiseasesAuthor(s): F. Artières-Sterkers, M. Mondain, K. Aubry, P. Bordure, A. Bozorg-Grayeli, O. Deguine, C. Eyermann, V. Franco-Vidal, B. Godey, N. Guevara, A. Karkas, N. Klopp, M. Labrousse, J.-P. Lebreton, Y. Lerosey, E. Lescanne, N. Loundon, R. Marianowski, F. Merklen, K. Mezouaghi
Tue Aug 11, 2020 16:58
Publication date: Available online 11 August 2020Source: International Journal of Pediatric OtorhinolaryngologyAuthor(s): Rahul Krishnamurthy, Radish Kumar Balasubramanium, Nutan Kamath, Kamalakshi G. Bhat
Tue Aug 11, 2020 13:00
Objectives/Hypothesis To determine insurance coverage for gender‐affirming surgery and voice therapy for individuals who seek to align their voice with their gender identity, and to analyze differences based on state‐by‐state transgender equality. Study Design Cross‐sectional study. Methods Policies from the top three commercial insurers per state in 2019 were reviewed. Coverage status was determined by web‐based search, telephone interviews, and email inquiries. A state‐by‐state equality...
Mon Aug 10, 2020 14:54
Objective To explore the feasibility and efficacy of transoral radiofrequency coblation surgery (TRS) in the treatment of adult laryngopharyngeal vascular lesion (LVL). Methods A total of 15 patients with LVL were retrospectively studied, including 11 capillary lesions and five cavernous lesions (there was one case with two separate lesions). All of the lesions were treated with TRS alone (capillary lesion) or with a combination of TRS and sclerotherapy (cavernous lesion). The treatment efficacy...
Mon Aug 10, 2020 14:44
Objective Treatment decision‐making for patients with laryngeal cancer consists of a complex trade‐off between survival and quality of life. For decision makers on coverage and guidelines, costs come in addition to this equation. Our aim was to perform a cost‐effectiveness analysis of surgery (laryngectomy with or without radiotherapy) versus organ preservation (OP: radiotherapy, chemo‐ and/or bioradiation) in advanced laryngeal cancer patients from a healthcare perspective. Methods A cost‐effectiveness...
Mon Aug 10, 2020 14:04
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