Abstract Objective This systematic review examined the current literature, summarized research findings and identified research gaps regarding the efficacy of statins on audiological outcomes. Methods Systematic search of electronic databases and grey literature was performed. Eligibility criteria was the study of a statin drug with report of audiological outcomes such as hearing, tinnitus, or balance in either human or animal studies. Data extraction and quality assessment were performed...
Thu Oct 10, 2019 20:50
Abstract Objectives Shared decision making describes a collaborative process in which healthcare providers and patients/families make treatment decisions using the best available evidence, while taking into account the patient’s values and preferences. The objectives of this study were to assess the level of decisional conflict and shared decision‐making experienced by older children and their parents when considering elective adentonsillectomies. Design A prospective cohort study. ...
Thu Oct 10, 2019 20:49
Abstract Tumour cell invasion is one of the key processes during cancer progression, leading to life‐threatening metastatic lesions in melanoma. As methylation of cancer‐related genes plays a fundamental role during tumorigenesis and may lead to cellular plasticity which promotes invasion, our aim was to identify novel epigenetic markers on selected invasive melanoma cells. Using Illumina BeadChip assays and Affymetrix Human Gene 1.0 microarrays, we explored the DNA methylation landscape of selected...
Fri Oct 11, 2019 22:23
Objective(s) To characterize procedural trends in facial plastic and reconstructive surgery procedures in relation to the United States economy. Methods Retrospective cohort study examining annual procedure rates were determined from the American Society of Plastic Surgeons (ASPS) National Clearinghouse of Plastic Surgery Procedural Statistics from January 1 2007 to December 30, 2017. Procedures were compared to economic activity of the United States as measured by gross domestic product (GDP)...
Fri Oct 11, 2019 16:25
Objectives The aim of this study was to compare the diagnostic accuracy of salivary pepsin with oropharyngeal pH monitoring using the Restech measurement system (Dx‐pH) for the diagnosis of laryngopharyngeal reflux (LPR). Study Design Prospective cohort study. Methods Seventy patients with primary symptoms related to LPR underwent gastroscopy, high‐resolution manometry, pH throughout 24‐hour monitoring (MII‐pH), and barium esophagography between October 2015 and May 2018. In addition,...
Fri Oct 11, 2019 16:23
Objective Most patients with vestibular schwannoma (VS) have significant hearing loss in the affected ear as a result of either their tumor or treatment. There is a paucity of data on which hearing rehabilitation options, if any, are preferred by patients with VS. Our study analyzed the use of hearing rehabilitation devices among VS patients. Methods Patients with unilateral VS treated at our institution from January 2008 to August 2018 were identified. Those with bilateral VS, profound hearing...
Fri Oct 11, 2019 16:22
Objectives Nasal steroids, oral anti‐leukotrienes and supplemental oxygen are effective in the treatment of mild obstructive sleep apnea (OSA) in otherwise healthy children. However, their efficacy is unknown in children with Down syndrome (DS). Here we examine the effect of single medication therapy versus observation versus oxygen on polysomnographic outcomes in these children. Methods We reviewed children (<18 years) diagnosed with DS and mild OSA (obstructive apnea‐hypopnea index [oAHI]...
Fri Oct 11, 2019 16:21
Objectives To compare the circulating microRNA (miRNA) expression profiles between sudden sensory neural hearing loss (SSNHL) patients and age‐matched normal hearing controls. Study Design Prospective cohort multi‐center study. Methods Patients presenting within 28 days of onset of SSNHL were prospectively recruited along with contemporaneous age‐matched controls. Pooled sera of four patient (n = 09, mean age = 53.0 years; 07, 55.0; 10, 52.9; 10, 51.6) and two control (09, 51.2 and 03,...
Fri Oct 11, 2019 16:21
A 6‐month‐old female presented for 2 months of noisy breathing. Flexible laryngoscopy showed limited bilateral vocal fold abduction. Computed tomography revealed a non‐enhancing 3.6 × 2.3 × 3.5 cystic prevertebral mass spanning C2‐T. Using an endoscopic approach, the overlying mucosa was incised, and the cyst was freed and fully excised from the surrounding mucosa with blunt microlaryngeal instruments without complication. Three months postoperatively she had no respiratory issues and was eating...
Fri Oct 11, 2019 16:19
Objective Outcome measures in healthcare that presume a higher level of patient health and overall literacy may inadequately estimate the disease experiences of less‐educated patients and further disadvantage them. Patient‐Reported Outcome Measures (PROMs) are widely used communication tools for clinical practice and are often used to evaluate and guide management for chronic rhinosinusitis (CRS) and skull base diseases. However, their readability and subsequent incomprehensibility for patients...
Fri Oct 11, 2019 16:06
Objectives/Hypothesis We previously developed an instrument called the Aerodynamic Vocal Fold Driver (AVFD) for intraoperative magnified assessment of vocal fold (VF) vibration during microlaryngoscopy under general anesthesia. Excised larynx testing showed that the AVFD could provide useful information about the vibratory characteristics of each VF independently. The present investigation expands those findings by testing new iterations of the AVFD during microlaryngoscopy in the canine model....
Fri Oct 11, 2019 16:06
Objectives Prior studies have indicated that olfactory cleft (OC) opacification correlates with olfaction in patients with chronic rhinosinusitis (CRS). However, the results have been unclear in patients without polyps. The purpose of this study was to further explore the relationship between OC opacification, sinus opacification, and olfactory function in patients with CRS. Methods One hundred and forty‐eight patients with CRS were prospectively enrolled across five institutions. Olfactory...
Fri Oct 11, 2019 16:04
Objectives We aimed to assess the role of spirometry measures and Dyspnea Index (DI) in response to treatment of subglottic stenosis (SGS) and ability to predict need for surgery. We also assessed correlations between spirometry measures, DI, and physical SGS parameters. Methods Thirty‐seven adult female SGS patients were prospectively enrolled. Spirometry data and DI were obtained at serial clinic visits; physical SGS parameters were obtained intraoperatively. PIFR, PEFR, EDI, FEV1/FVC, and...
Fri Oct 11, 2019 16:03
Satisfaction in Academic Otolaryngology: Do Physician Demographics Impact Press Ganey Survey Scores?
Objectives/Hypothesis Patient satisfaction is increasingly emphasized and measured in healthcare delivery. However, patient satisfaction is multifactorial and difficult to comprehensively assess. The objective of this study was to assess for correlation between patient satisfaction measured by Press Ganey surveys (PGS) and physician demographics of gender, years in practice, academic rank, and specialty in academic otolaryngology. Study Design Review of publicly available PGS scores in academic...
Fri Oct 11, 2019 16:03
Objectives Adult tonsillectomy causes significant postoperative pain that can last over 14 days, but narcotic regimens only provide a modest reduction in pain. Auricular acupuncture has been demonstrated to improve pain with minimal complications. This study compared acupuncture versus control for pain, opioid consumption, nausea, and return of diet and activity following tonsillectomy. Methods A prospective, single‐blinded randomized controlled trial was performed on 134 adults undergoing...
Fri Oct 11, 2019 16:01
Objective 22q11.2‐deletion syndrome is a genetic condition that affects 1:3000 births. In addition to cardiac anomalies and immunosuppression, individuals with 22q11.2‐deletion syndrome can have feeding difficulties from birth resulting in failure to thrive and infections. This study aims to characterize the dysphagia seen in infants with 22q11.2‐deletion syndrome. Methods This is a retrospective chart review of infants with 22q11.2‐deletion syndrome who underwent videofluoroscopic swallow...
Fri Oct 11, 2019 15:53
Abstract Introduction Autoimmune inner disease (AIED) is an uncommon cause of sensorineural hearing loss and poses a diagnostic challenge. The present study aims to review the existing knowledge on the clinicopathological aspects, the diagnostic challenges, and therapeutic interventions in AIED. Discussion The incidence of AIED is less than five cases per...
Fri Oct 11, 2019 03:00
Conditions: Oropharynx Cancer; Oropharynx Squamous Cell Carcinoma; Carcinoma, Squamous Cell; Carcinoma; Oropharyngeal Neoplasms; Neoplasms, Squamous Cell; Neoplasms, Glandular and Epithelial; Neoplasms by Histologic Type; Pharyngeal Neoplasms Malignant and Unspecified; Otorhinolaryngologic Neoplasms; Head and Neck Neoplasms; Neoplasms by Site; Otorhinolaryngologic Diseases; Pharyngeal Diseases; Papillomavirus Infections; Virus Diseases; DNA Virus Infections; Tumor Virus Infections;...
Fri Oct 11, 2019 16:46
Abstract Purpose As the pathological cause of benign paroxysmal positional vertigo (BPPV), the dislocation or degeneration of otoconia in the utricle and saccule is suggested. Vestibular evoked myogenic potential (VEMP) could reflect otolithic dysfunction due to these etiologies of BPPV. The aim of this study was to validate the clinical significance of cervical (c) and ocular (o) VEMP in BPPV by a meta-analysis of previous articles. ...
Fri Oct 11, 2019 03:00
Publication date: Available online 11 October 2019Source: International Journal of Pediatric OtorhinolaryngologyAuthor(s): Patrick Kiessling, Anthony A. Stans, Joseph A. Dearani, R. Paul Boesch, Jeremy L. Fogelson, Jane M. Matsumoto, Dawit T. Haile, Karthik BalakrishnanAbstractMorquio syndrome (Mucopolysaccharidosis IVA) is an autosomal recessive lysosomal storage disease with manifestations ranging from mild to severe phenotype. Mechanical spinal cord injury and airway insufficiency are major causes...
Fri Oct 11, 2019 12:40
Publication date: Available online 11 October 2019Source: International Journal of Pediatric OtorhinolaryngologyAuthor(s): Gang Li, Fei Zhao, Yong Tao, Lin Zhang, Xinyi Yao, Yun ZhengAbstractObjectivesThe aim of this longitudinal follow-up study was to explore the trajectories of early auditory and language development in Mandarin speaking children younger than 3 years of age following switch-on of their cochlear implants (CIs).MethodsEarly auditory and language development was measured longitudinally...
Fri Oct 11, 2019 12:40
Abstract Sclerosing polycystic adenosis (SPA) is a rare benign salivary gland lesion that usually arises from the parotid gland. SPA was originally interpreted to be a non-neoplastic alteration analogous to fibrocystic changes of the breast, but now there is uncertainty about whether it may represent a neoplasm. SPA often contains intraductal proliferations with an appearance similar to ductal neoplasia of the breast, and one study reported X-chromosome inactivation using polymorphisms...
Fri Oct 11, 2019 03:00
Abstract Purpose Specially processed cereals (SPC) that increase endogenous antisecretory factor (AF) synthesis have been proposed to improve symptoms of Meniere’s disease (MD) with controversial results. The aim of this study was to evaluate the effects of SPC in patients with definite unilateral MD and compare the results to a treatment protocol with intravenous glycerol and dexamethasone. ...
Fri Oct 11, 2019 03:00
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