Abstract Objective Recent studies have demonstrated the pro‐tumour role of CD36 in multiple cancer types. However, its role has not been well elucidated in oral squamous cell carcinoma (OSCC). Here, we aimed to evaluate the role of CD36 in proliferation and migration of OSCC cells. Methods Human OSCC cell lines HSC‐2, HSC‐3, HSC‐4, and Ca9‐22 were assessed for proliferation by staining with the cell proliferation marker Ki‐67. We also assessed migration activity, and the expression of cell...
Fri Oct 11, 2019 16:27
Abstract Objective To investigate the effect of AMPK on tight junction (TJ) components, ZO‐1 and F‐actin, and the underlying mechanisms of AMPK in inhibiting migration of tongue squamous cell carcinoma (TSCC) cells. Methods Expression and distribution of mRNA and/or protein was detected by qRT‐PCR, western blot or immunofluorescence. The migration ability was tested by scratch and transwell migration assays. Transient knockdown of ZO‐1 was achieved by siRNA transfection. Results AMPK...
Fri Oct 11, 2019 11:48
Abstract Objective This study was conducted to distinguish salivary metabolites in oral squamous cell carcinoma (OSCC) from those in oral lichen planus (OLP) to identify practical biomarkers for the discrimination of OSCC from OLP. Subjects and methods: Whole unstimulated saliva samples were collected from patients with OSCC (n = 34) and OLP (n = 26). Hydrophilic metabolites in the saliva samples were comprehensively analysed by capillary electrophoresis mass spectrometry. To evaluate the...
Thu Oct 10, 2019 19:19
Wed Sep 25, 2019 22:00
Publication date: December 2019Source: Archives of Oral Biology, Volume 108Author(s):
Fri Oct 11, 2019 16:58
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