Objectives: Cancer patients with comorbid diabetes have a 50% increased risk of all-cause mortality compared with cancer patients without diabetes. Less attention to diabetes management (glucose control, medication adherence, and diabetes self-management behaviors) during active cancer treatment is hypothesized as an explanation for worse outcomes among diabetic cancer patients. The objective of this systematic review is to determine and quantify how a cancer diagnosis impacts diabetes management. ...
Thu Oct 03, 2019 03:00
Objectives: In endometrial cancer, the appropriate sequence of adjuvant chemotherapy (aCT) and adjuvant radiation therapy (aRT) is unclear. We aim evaluated whether early chemotherapy is associated with improved overall survival (OS) and cancer-specific survival (CSS). Methods: Endometrial cancer patients that received aCT and aRT were selected from the SEER-Medicare database. Early chemotherapy was defined as receiving aCT before aRT, with or without additional aCT (“sandwich” regimens)....
Thu Oct 03, 2019 03:00
Objectives: To investigate local control and functional outcome following state-of-the-art fractionated stereotactic radiotherapy (FSRT) for paragangliomas of the head and neck. Methods: In total, 40 consecutive patients with paragangliomas of the head and neck received conventionally FSRT from 2003 to 2016 at the Department of Radiation Oncology of the University Hospital Erlangen. Local control, toxicities, and functional outcome were examined during follow-up. In total, 148 magnetic resonance...
Thu Oct 03, 2019 03:00
Objective: Pleurex catheters are a form of palliative therapy for patients, offering relief from symptomatic ascites while also affording greater independence and flexibility; however, aggressive drainage can lead to significant total body sodium losses. We describe the course of patients with “Pleurex desalination,” an under-appreciated cause of hypovolemic hyponatremia, highlighting its unique pathophysiology and providing recommendations on how to manage these complex patients. Patients and...
Thu Oct 03, 2019 03:00
British Journal of Cancer, Published online: 08 October 2019; doi:10.1038/s41416-019-0598-zMetformin use and risk of gastric adenocarcinoma in a Swedish population-based cohort study
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British Journal of Cancer, Published online: 04 October 2019; doi:10.1038/s41416-019-0555-xSelected Abstracts from the 2019 NCRI Cancer Conference of National Cancer Research Institute
Fri Oct 04, 2019 03:00
A specialist in alternative “functional medicine” has been suspended from the UK medical register for nine months after a tribunal found that he “persistently overdiagnosed thyroid problems” and...
Mon Oct 07, 2019 19:46
In June this year, the Lancet published results of a randomised trial by the Evidence for Contraceptive Options and HIV Outcomes (ECHO) consortium.1 The main purpose of this trial, according to the...
Mon Oct 07, 2019 13:00
AbstractObjectiveTo compare the efficacy and safety of first line treatments for patients with advanced epidermal growth factor receptor (EGFR) mutated non-small cell lung cancer...
Mon Oct 07, 2019 13:00
Gerada calls for better suicide prevention for medical staff.1 The Society of Occupational Medicine’s recent report on the mental health of UK doctors notes that occupational and individual factors...
Mon Oct 07, 2019 11:06
A senior member of the independent panel that advises the government on drug related issues has resigned amid what he says is “political vetting” of members.Alex Stevens, professor in criminal...
Mon Oct 07, 2019 18:06
Public Health England (PHE) has launched a new campaign aimed at helping people manage and improve their mental health.1The Every Mind Matters campaign includes a website which provides users with a...
Mon Oct 07, 2019 17:56
About 3.2 million people in the UK vape, and Public Health England has said that “the variety of devices available means that the term e-cigarette is no longer appropriate.”1 The head of tobacco...
Mon Oct 07, 2019 17:36
A doctor accused of running a “pill mill” has been sentenced to 40 years’ imprisonment by a federal court in Virginia.Joel Smithers, 36, was convicted of 859 counts of illegally distributing opioids,...
Mon Oct 07, 2019 17:31
That’s an inflammatory headline!Yes, but that is kind of the point. You may remember that when temperatures were rising this summer the media started warning us that a “deadly” heatwave12 was...
Mon Oct 07, 2019 16:40
The number of patients with type 1 diabetes who are receiving “flash” glucose monitoring devices on the NHS has increased markedly since NHS England told clinical commissioning groups to end the...
Mon Oct 07, 2019 15:46
A man with Duchenne muscular dystrophy who was forcibly removed from his home at 3 am and taken to hospital after a judge made an emergency order has been given permission to appeal against the order...
Mon Oct 07, 2019 12:46
I was moved by Gerada’s reflections about her work with relatives bereaved by suicide of a doctor.1 One doctor dying by suicide every three weeks is shocking and tragic. This led me to consider how...
Mon Oct 07, 2019 12:31
Background Male breast cancer (MBC) is a rare disease for which there is limited understanding of treatment patterns and prognostic factors. Methods Men with TNM stage I to stage III breast cancer diagnosed between 2004 and 2014 in the National Cancer Data Base were included. Trends in treatment modalities were described using the average annual percentage change (AAPC) and estimated using Joinpoint software for the analysis of trends. Kaplan‐Meier curves and the multivariate Cox proportional...
Mon Oct 07, 2019 10:41
Background The use of topically applied hemostatic substances during surgery has become a common practice. In some cases, the material is not absorbed or induces a granulomatous reaction resulting in a pseudotumoral lesion. With imaging studies, it is not possible to differentiate this from a tumor recurrence or abscess. This study describes the authors' cytologic experience with a large series of pseudotumoral lesions induced by oxidized cellulose, one of the most commonly used hemostatic agents....
Mon Oct 07, 2019 20:53
The process of metastasis is characterized by the shedding of tumor cells into the bloodstream, where they are transported to other parts of the body to seed new tumors. These cells, known as circulating tumor cells (CTCs), have the potential to reveal much about an individual cancer case, and theoretically can aid in the prediction of outcomes and design of precision treatments. Recent advances in technology now allow for the robust and reproducible characterization of CTCs from a simple blood draw....
Mon Oct 07, 2019 17:09
Background High‐risk human papillomavirus (HPV)–Papanicolaou (Pap) cotesting is recommended for cervical cancer screening in women aged ≥30 years. The current study analyzed the effectiveness of cotesting on risk management in different age groups. Methods A retrospective review of a 5‐year cytology database identified 9434 women with HPV‐Pap cotesting and follow‐up cervical biopsy. The 3‐year cumulative risk of developing high‐grade cervical lesions (≥high‐grade squamous intraepithelial lesion...
Mon Oct 07, 2019 17:09
Cancer Gene Therapy, Published online: 08 October 2019; doi:10.1038/s41417-019-0140-8CLEC5A expressed on myeloid cells as a M2 biomarker relates to immunosuppression and decreased survival in patients with glioma
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Nivolumab‐related toxicities in advanced hepatocellular carcinoma were generally tolerable regardless of the history of radiotherapy. Previous and/or concurrent application of radiotherapy in the course of nivolumab treatment was related with longer progression‐free survival and overall survival. Abstract Background This study aimed to investigate the clinical significance of previous and/or concurrent application of radiotherapy (RT) in the course of nivolumab treatment for advanced hepatocellular...
Mon Oct 07, 2019 22:02
For the first time, we show potent anti‐tumor effects in uveal melanoma (UM) cells following propranolol administration and positive expression of β1 and β2 adrenoceptors in all human UM specimens, correlating with aggressiveness of the tumor. Collectively our data suggest that a nonselective beta‐blocker may be effective against melanoma, and further studies are warranted to validate this as an adjuvant therapy in melanoma. Abstract Background Melanoma is a life‐threatening group of...
Mon Oct 07, 2019 22:00
The probability of death from papillary thyroid microcarcinoma is very low. The nomogram constructed based on the competing risks model is helpful to predict the cumulative incidence of death from papillary thyroid microcarcinoma. Abstract Background Papillary thyroid microcarcinoma (PTMC) is an indolent carcinoma. The cumulative incidence of death from patients with PTMC and the nomogram built based on the competing risks model have not been described. Methods Patients diagnosed...
Sun Oct 06, 2019 21:59
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