The overall use of antibiotics has increased significantly in recent years. Besides fighting infections, antibiotics also alter the gut microbiota. Commensal bacteria in the gastrointestinal tract are crucial to maintain immune homeostasis, and microbial imbalance or dysbiosis affects disease susceptibility and progression. We hypothesized that antibiotic-induced dysbiosis of the gut microbiota would suppress cytokine profiles in the host, thereby leading to changes in the tumor microenvironment....
Mon Oct 07, 2019 18:08
The addition of apalutamide to androgen deprivation therapy is well tolerated and significantly improves survival while maintaining health-related quality of life in men with prostate cancer. (Source: CancerNetwork)
Mon Oct 07, 2019 06:00
Researchers look at how mutation status can influence responses to targeted therapy in thyroid cancer. (Source: CancerNetwork)
Mon Oct 07, 2019 06:00
Genetic profiles of thyroid cancer shed light on molecular mechanisms. (Source: CancerNetwork)
Mon Oct 07, 2019 06:00
CAR T cells are a more effective therapy if manufactured for patients with multiple myeloma prior to the onset of relapsed or refractory disease. (Source: CancerNetwork)
Mon Oct 07, 2019 06:00
Autologous stem cell transplant has become safer over the years for patients with multiple myeloma and renal insufficiency. (Source: CancerNetwork)
Mon Oct 07, 2019 06:00
The addition of the PARP inhibitor veliparib to carboplatin and paclitaxel offered significant improvement to patients with HER2-negative breast cancer. (Source: CancerNetwork)
Mon Oct 07, 2019 06:00
COX7RP contributes to endometrial and breast cancer growth. (Source: CancerNetwork)
Fri Oct 04, 2019 06:00
Diagnosis of endometrial carcinoma made easier by analysis of mutations in cervix or endometrial tissue. (Source: CancerNetwork)
Wed Oct 02, 2019 06:00
Cancers, Vol. 11, Pages 1499: Implementation of the Chick Chorioallantoic Membrane (CAM) Model in Radiation Biology and Experimental Radiation Oncology Research Cancers doi: 10.3390/cancers11101499 Authors: Dünker Jendrossek Radiotherapy (RT) is part of standard cancer treatment. Innovations in treatment planning and increased precision in dose delivery have significantly improved the therapeutic gain of radiotherapy but are reaching their limits due to biologic constraints. Thus,...
Mon Oct 07, 2019 03:00
Cancers, Vol. 11, Pages 1498: Long-Term Outcomes of Stereotactic Radiosurgery for Vestibular Schwannoma Associated with Neurofibromatosis Type 2 in Comparison to Sporadic Schwannoma Cancers doi: 10.3390/cancers11101498 Authors: Shinya Hasegawa Shin Sugiyama Kawashima Takahashi Iwasaki Kashio Nakatomi Saito The efficacy of radiosurgery for neurofibromatosis type 2 (NF2)-associated vestibular schwannoma (VS) remains debatable. We retrospectively analyzed...
Mon Oct 07, 2019 03:00
Purpose:Advanced breast cancer (ABC) has not been subjected to the same degree of molecular scrutiny as early primary cancer. Breast cancer evolves with time and under the selective pressure of treatment, with the potential to acquire mutations with resistance to treatment and disease progression. To identify potentially targetable mutations in advanced breast cancer, we performed prospective molecular characterisation of a cohort of patients with ABC. Experimental Design:Biopsies from patients with...
Mon Oct 07, 2019 16:38
Future Oncology, Ahead of Print.
Mon Oct 07, 2019 13:56
ABSTRACT Synovial chondromatosis (SC) is a rare benign cartilaginous neoplasm in which recurrent FN1 and ACVR2A gene rearrangements have been recently reported. Triggered by a case of malignant transformation in SC (synovial chondrosarcoma) showing a novel KMT2A‐BCOR gene fusion by targeted RNA sequencing, we sought to evaluate the molecular abnormalities in a cohort of 27 SC cases using a combined methodology of FISH and/or targeted RNA sequencing. Results showed that FN1 and /or ACVR2A gene rearrangements...
Mon Oct 07, 2019 19:49
Abstract Current clinical guidelines recommend mutation analysis for select codons in KRAS and NRAS exons 2, 3 and 4 and BRAF V600E to guide therapy selection and prognostic stratification in advanced colorectal cancer. This study evaluates the impact of extended molecular testing on the detection of RAS‐MAPK pathway mutations. Panel next‐generation sequencing results of colorectal cancer specimens from 5795 individuals from the AACR Project GENIE were included. Mutations in RAS‐MAPK pathway genes...
Mon Oct 07, 2019 19:47
This study estimated genital warts prevalence, genital-warts-related healthcare resource use and costs, and self-reported human-papillomavirus-related psychosocial impact among male and female patients aged 18...
Mon Oct 07, 2019 03:00
CyclinD1 is crucial for cell cycling and can regulate the expression of Dicer, a crucial regulator of microRNA maturation. However, little is known on how CyclinD1 regulates Dicer and miRNA expression, and the...
Mon Oct 07, 2019 03:00
Abstract Purpose Total skin electron beam therapy (TSEBT) has proved to be a safe and effective treatment for cutaneous T‑cell lymphomas. Here, we examined the impact of this treatment on patient quality of life and outcome. Patients and methods Forty-four patients with mycosis fungoides (MF) or Sezary syndrome (SS) received 48 TSEBT courses with a median...
Mon Oct 07, 2019 03:00
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