Voice ,
- Self-Assessment of Vocal Fatigue in Muscle Tension Dysphonia and Vocal Nodules: A Preliminary Analysis of the Discriminatory Potential of the Croatian Adaptation of the Vocal Fatigue Index (VFI-C)Publication date: Available online 9 October 2019Source: Journal of VoiceAuthor(s): Ana Bonetti, Luka Bonetti, Ozana ČipčićABSTRACTIn this paper the authors hypothesize that the intensity of subjective experience of vocal fatigue (VF) potentially reflects primary (hyper) functional vocal disorders (primary muscle tension dysphonia – MTD) differently than structural vocal disorders of functional etiology (MTD type 2a). Given the reported benefit o
- Breathiness and Consensus Auditory-Perceptual Evaluation of Voice (CAPE-V) in Patients Undergoing Medialization Laryngoplasty With or Without Arytenoid AdductionPublication date: Available online 9 October 2019Source: Journal of VoiceAuthor(s): Stephanie Youssef, Semirra Bayan, Dale Ekbom, Christine Lohse, Terence Zimmermann, Rebecca Pittelko, Diana M. OrbeloABSTRACTObjectivesWe hypothesized that, in patients with unilateral vocal fold paralysis (UVFP), the auditory-perception of breathiness measured with Consensus Auditory-Perceptual Evaluation of Voice (CAPE-V) would be higher preoperatively in patient
Evolutionary Biology News -- ScienceDaily
- Koala epidemic provides lesson in how DNA protects itself from virusesIn animals, infections are fought by the immune system. Studies on an unusual virus infecting wild koalas reveal a new form of 'genome immunity.'
- Meet Siamraptor suwati, a new species of giant predatory dinosaur from ThailandFossils discovered in Thailand represent a new genus and species of predatory dinosaur, according to a new study.
- Reef fish caring for their young are taken advantage of by other fishAmong birds, the practice of laying eggs in other birds' nests is surprisingly common. This phenomenon, known as brood parasitism, was unknown in coral reef fish because most marine fish don't provide any parental care at all. Now, however, biologists studying an unusual kind of coral reef fish that does care for its young have found that, sure enough, other fish are taking advantage of this to get free parental care for their offspring.
Clinical Cancer Research Online First Articles
- Probody Therapeutics: An Emerging Class of Therapies Designed to Enhance On-target Effects with Reduced Off-tumor Toxicity for Use in Immuno-OncologyThe deep and durable antitumor effects of antibody-based immunotherapies such as immune checkpoint inhibitors (ICIs) have revolutionized oncology and transformed the therapeutic landscape for many cancers. Several anti-programmed death receptor 1 and anti-programmed death receptor ligand 1 antibodies have been approved for use in advanced solid tumors, including melanoma, non-small cell lung cancer (NSCLC), bladder cancer, and other cancers. ICIs
- A Phase II Trial of Hu14.18K322A in Combination with Induction Chemotherapy in Children with Newly Diagnosed High-Risk NeuroblastomaPurpose:We sought to evaluate whether combining a humanized antidisialoganglioside mAb (hu14.18K322A) with induction chemotherapy improves early responses and outcomes in children with newly diagnosed high-risk neuroblastoma.Patients and Methods:We conducted a prospective nonrandomized, single-arm, two-stage, phase II clinical trial. Six courses of induction chemotherapy were coadministered with hu14.18K322A and followed with granulocyte–macropha
RNA In Advance
- Alterations of signaling pathways in response to chemical perturbations used to measure mRNA decay rates in yeast [Letter to the Editor]Assessing variations in mRNA stability typically involves inhibiting transcription either globally or in a gene-specific manner. Alternatively, mRNA pulse-labelling strategies offer a means to calculate mRNA stability without inhibiting transcription. However, key stress-responsive cell signaling pathways, which affect mRNA stability, may themselves be perturbed by the approaches used to measure mRNA stability, leading to artifactual results. Her
Journal of Medical Case Reports - Latest Articles
- Transcatheter occlusion of giant congenital coronary cameral fistulae: a case seriesA coronary cameral fistula is a rare connection between a coronary artery and a cardiac chamber or vein bypassing the cardiac capillary bed system. Most of these fistulae are congenital and solitary, although ...
- A single intranigral administration of β-sitosterol β-d-glucoside elicits bilateral sensorimotor and non-motor alterations in the ratPublication date: Available online 10 October 2019Source: Behavioural Brain ResearchAuthor(s): Luis O. Soto-Rojas, Linda Garces-Ramirez, Claudia Luna-Herrera, Jazmin M. Flores-Martinez, Guadalupe Soto-Rodriguez, Bismark Gatica-Garcia, Francisco E. Lopez-Salas, José Ayala-Davila, Maria E. Gutierrez-Castillo, America Padilla-Viveros, Cecilia Bañuelos, Fidel de la Cruz-Lopez, Irma A. Martinez-Davila, Daniel Martinez-FongABSTRACTParkinson's disease (
- Pre-training inactivation of basolateral amygdala and mediodorsal thalamus, but not orbitofrontal cortex or prelimbic cortex, impairs devaluation in a multiple-response/multiple-reinforcer cued operant taskPublication date: Available online 9 October 2019Source: Behavioural Brain ResearchAuthor(s): Hayley Fisher, Alisa Pajser, Charles L. PickensAbstractReinforcer devaluation is a task often used to model flexible goal-directed behavior. Here, we inactivated basolateral amygdala (BLA), orbitofrontal cortex (OFC), mediodorsal thalamus (MD.) (Exp. 1) and prelimbic cortex (PL) (Exp. 3) in rats during multiple-response/multiple-reinforcer operant traini
Systematic Reviews - Latest Articles
- Neurocognitive outcome of school-aged children with congenital heart disease who underwent cardiopulmonary bypass surgery: a systematic review protocolOver the past decades, survival rates of children born with congenital heart disease (CHD) have increased dramatically. Progress in prenatal diagnosis, less-invasive catheter techniques and perioperative inten...
- The therapeutic effects of microRNAs in preclinical studies of acute kidney injury: a systematic review protocolAcute kidney injury (AKI) causes significant morbidity and mortality in humans, and there are currently no effective treatments to enhance renal recovery. MicroRNAs (miRNAs) are short chain nucleotides that re...
- Proteomic analysis of sheep uterus reveals its role in prolificacyPublication date: Available online 9 October 2019Source: Journal of ProteomicsAuthor(s): Yongfu La, Jishun Tang, Xiaofei Guo, Liping Zhang, Shangquan Gan, Xiaosheng Zhang, Jinlong Zhang, Wenping Hu, Mingxing ChuAbstractSmall Tail Han sheep have attracted attention for their high fecundity and year-round estrus. However, the molecular mechanisms of this fecundity are unknown. Polymorphism of the FecB gene has been shown to be associated with the o
- Proteomic analysis of extracellular vesicles derived from platelet concentrates treated with Mirasol® identifies biomarkers of platelet storage lesionPublication date: Available online 9 October 2019Source: Journal of ProteomicsAuthor(s): Lidia Hermida-Nogueira, María N. Barrachina, Irene Izquierdo, María García-Vence, Serena Lacerenza, Susana Bravo, Azucena Castrillo, Ángel GarcíaAbstractIn blood banks, platelets are stored until 7 days after a pathogen reduction technology (PRT) treatment, Mirasol® (vitamin B2 plus UVB light) in the present case. The storage time under these conditions may h
Clinical Genetics
- Toni Mochty : Bardet Biedl syndrome “avant la lettre”Abstract Long before Georges Louis Bardet and Artur Biedl described their syndrome, “the fattest boy in the world”, “a wonder of nature” with at least 4 symptoms and signs of the Bardet‐Biedl syndrome was exhibited in different places all over Europe, before his manager got disabled. This article is protected by copyright. All rights reserved.
- Gut microbiota perturbation is associated with acute sleep disturbance among rectal cancer patientsSummary Cancer treatment‐associated gut microbial perturbation/dysbiosis has been implicated in the pathobiology of sleep disturbance; however, evidence is scarce. Eighteen newly diagnosed rectal cancer patients (ages 52–81 years; 10 males) completed a sleep disturbance questionnaire and provided stool samples for 16s RNA gene sequencing during chemo‐radiotherapy. Descriptive statistics, Wilcoxon test and regression analyses were computed. Regre
- Visual novelty, curiosity, and intrinsic reward in machine learning and the brainPublication date: October 2019Source: Current Opinion in Neurobiology, Volume 58Author(s): Andrew Jaegle, Vahid Mehrpour, Nicole RustA strong preference for novelty emerges in infancy and is prevalent across the animal kingdom. When incorporated into reinforcement-based machine learning algorithms, visual novelty can act as an intrinsic reward signal that vastly increases the efficiency of exploration and expedites learning, particularly in situa
O.R.L. Journal for oto-rhino-laryngology and its borderlands
- Clinical and Radiographic Characteristics of Sinonasal Posttransplant Lymphoproliferative Disorder and Invasive Fungal SinusitisBackground: Sinonasal posttransplant lymphoproliferative disorder (PTLD) is a serious but uncommon complication of solid organ and hematopoietic stem cell transplantation that can overlap in many features with invasive fungal sinusitis (IFS). Objective: To identify clinical, laboratory, and radiographic features that may help to differentiate sinonasal IFS and PTLD in the posttransplant population. Methods: We performed a retrospective chart revi
Neuroradiology
- MRI Features of Histologically Diagnosed Supratentorial Primitive Neuroectodermal Tumors and Pineoblastomas in Correlation with Molecular Diagnoses and Outcomes: A Report from the Childrens Oncology Group ACNS0332 Trial [PEDIATRICS]BACKGROUND AND PURPOSE:Supratentorial primitive neuroectodermal tumors and pineoblastomas have traditionally been grouped together for treatment purposes. Molecular profiling of these tumors has revealed a number of distinct entities and has led to the term "CNS-primitive neuroectodermal tumors" being removed from the 2016 World Health Organization classification. The purpose of this study was to describe the MR imaging findings of histologically
- Age-Dependent Signal Intensity Changes in the Structurally Normal Pediatric Brain on Unenhanced T1-Weighted MR Imaging [PEDIATRICS]BACKGROUND AND PURPOSE:Various pathologic and nonpathologic states result in brain parenchymal signal intensity changes on unenhanced T1-weighted MR imaging. However, the absence of quantitative data to characterize typical age-related signal intensity values limits evaluation. We sought to establish a range of age-dependent brain parenchymal signal intensity values on unenhanced T1WI in a sample of individuals (18 years of age or younger) with s
- The Fate of Unruptured Intracranial Vertebrobasilar Dissecting Aneurysm with Brain Stem Compression According to Different Treatment Modalities [INTERVENTIONAL]BACKGROUND AND PURPOSE:Unruptured intracranial vertebrobasilar dissecting aneurysms with brain stem compression are difficult to treat. In the present study, the clinical and radiologic outcomes of unruptured intracranial vertebrobasilar dissecting aneurysms with brain stem compression based on different treatment modalities were evaluated.MATERIALS AND METHODS:This study included 28 patients with unruptured intracranial vertebrobasilar dissectin
- Bayesian Estimation of CBF Measured by DSC-MRI in Patients with Moyamoya Disease: Comparison with 15O-Gas PET and Singular Value Decomposition [ADULT BRAIN]BACKGROUND AND PURPOSE:CBF analysis of DSC perfusion using the singular value decomposition algorithm is not accurate in patients with Moyamoya disease. This study compared the Bayesian estimation of CBF against the criterion standard PET and singular value decomposition methods in patients with Moyamoya disease.MATERIALS AND METHODS:Nineteen patients with Moyamoya disease (10 women; 22–52 years of age) were evaluated with both DSC and 15O-gas PE
- Dose Reduction While Preserving Diagnostic Quality in Head CT: Advancing the Application of Iterative Reconstruction Using a Live Animal Model [PATIENT SAFETY]BACKGROUND AND PURPOSE:Iterative reconstruction has promise in lowering the radiation dose without compromising image quality, but its full potential has not yet been realized. While phantom studies cannot fully approximate the subjective effects on image quality, live animal models afford this assessment. We characterize dose reduction in head CT by applying advanced modeled iterative reconstruction (ADMIRE) in a live ovine model while evaluatin
Oral and Maxillofacial Surgery
- Alveolar repair after the use of piezosurgery in the removal of lower third molars: a prospective clinical, randomised, double-blind, split-mouth studyThe objective of this study was to evaluate the use of piezosurgery for osteotomy and odontosection in the repair of the alveoli four months after exodontia. Fifteen young patients who needed third molars extracted were included. During the extractions, one of the teeth was included in the Piezo group, in which ultrasound motor tips were used in both procedures. The other tooth was removed with a conventional rotary instrument. The values of dens
vestibular evoked
- Investigating short latency subcortical vestibular projections in humans: What have we learned?Related ArticlesInvestigating short latency subcortical vestibular projections in humans: What have we learned? J Neurophysiol. 2019 Oct 09;: Authors: Colebatch JG, Rosengren SM Abstract Vestibular evoked myogenic potentials (VEMPs) are now widely used for the non-invasive assessment of vestibular function and diagnosis in humans. This review focusses on the origin, properties and mechanisms of cervi
- Sequential stream segregation with bilateral cochlear implantsPublication date: Available online 9 October 2019Source: Hearing ResearchAuthor(s): Aswin A. Wijetillake, Richard J.M. van Hoesel, Robert CowanAbstractSequential stream segregation on the basis of binaural ‘ear-of-entry’, modulation rate and electrode place-of-stimulation cues was investigated in bilateral cochlear implant (CI) listeners using a rhythm anisochrony detection task. Sequences of alternating ‘A’ and ‘B’ bursts were presented via dire
- Rapid modulations of the vocal structure in marmoset monkeysPublication date: Available online 9 October 2019Source: Hearing ResearchAuthor(s): Lingyun Zhao, Sabyasachi Roy, Xiaoqin WangAbstractHumans and some animal species show flexibility in vocal production either voluntarily or in response to environmental cues. Studies have shown rapid spectrotemporal changes in speech or vocalizations during altered auditory feedback in humans, songbirds and bats. Non-human primates, however, have long been conside
Cancers
- Cancers, Vol. 11, Pages 1531: 99mTc-A1 as a Novel Imaging Agent Targeting Mesothelin-Expressing Pancreatic Ductal AdenocarcinomaCancers, Vol. 11, Pages 1531: 99mTc-A1 as a Novel Imaging Agent Targeting Mesothelin-Expressing Pancreatic Ductal Adenocarcinoma Cancers doi: 10.3390/cancers11101531 Authors: Montemagno Cassim Trichanh Savary Pouyssegur Pagès Fagret Broisat Ghezzi : Mesothelin is a membrane-associated protein overexpressed in pancreatic ductal adenocarcinoma (PDAC). Some mesothelin-targeted therapies are in clinical d
- Cancers, Vol. 11, Pages 1532: Virotherapy as a Potential Therapeutic Approach for the Treatment of Aggressive Thyroid CancerCancers, Vol. 11, Pages 1532: Virotherapy as a Potential Therapeutic Approach for the Treatment of Aggressive Thyroid Cancer Cancers doi: 10.3390/cancers11101532 Authors: Malfitano Somma Prevete Portella Virotherapy is a novel cancer treatment based on oncolytic viruses (OVs), which selectively infect and lyse cancer cells, without harming normal cells or tissues. Several viruses, either naturally occurring or developed
- Cancers, Vol. 11, Pages 1526: Increased Expression and Activation of FAK in Small-Cell Lung Cancer Compared to Non-Small-Cell Lung CancerCancers, Vol. 11, Pages 1526: Increased Expression and Activation of FAK in Small-Cell Lung Cancer Compared to Non-Small-Cell Lung Cancer Cancers doi: 10.3390/cancers11101526 Authors: Frank Aboubakar Nana Delphine Hoton Jérôme Ambroise Marylène Lecocq Marie Vanderputten Yves Sibille Bart Vanaudenaerde Charles Pilette Caroline Bouzin Sebahat Ocak Introduction: Focal adhesion kinase (FAK) plays a crucial role
- Cancers, Vol. 11, Pages 1529: Three-Dimensional Conformal Radiotherapy-Based or Intensity-Modulated Radiotherapy-Based Concurrent Chemoradiotherapy in Patients with Thoracic Esophageal Squamous Cell CarcinomaCancers, Vol. 11, Pages 1529: Three-Dimensional Conformal Radiotherapy-Based or Intensity-Modulated Radiotherapy-Based Concurrent Chemoradiotherapy in Patients with Thoracic Esophageal Squamous Cell Carcinoma Cancers doi: 10.3390/cancers11101529 Authors: Wei-Cheng Lin Chia-Lun Chang Han-Lin Hsu Kevin Sheng-Po Yuan Alexander T. H. Wu Szu-Yuan Wu Background: To date, intensity-modulated radiation therapy (IMRT) with conc
- Cancers, Vol. 11, Pages 1528: Inhibition of TFF3 Enhances Sensitivity—and Overcomes Acquired Resistance—to Doxorubicin in Estrogen Receptor-Positive Mammary CarcinomaCancers, Vol. 11, Pages 1528: Inhibition of TFF3 Enhances Sensitivity—and Overcomes Acquired Resistance—to Doxorubicin in Estrogen Receptor-Positive Mammary Carcinoma Cancers doi: 10.3390/cancers11101528 Authors: Han Ming Poh Yi Shiou Chiou Qing Yun Chong Ru-Mei Chen Kanchugarakoppal S. Rangappa Lan Ma Tao Zhu Alan Prem Kumar Vijay Pandey Basappa Soo-Chin Lee Peter E. Lobie Dose-dependent toxicity an
- Cancers, Vol. 11, Pages 1527: The PAK1-Stat3 Signaling Pathway Activates IL-6 Gene Transcription and Human Breast Cancer Stem Cell FormationCancers, Vol. 11, Pages 1527: The PAK1-Stat3 Signaling Pathway Activates IL-6 Gene Transcription and Human Breast Cancer Stem Cell Formation Cancers doi: 10.3390/cancers11101527 Authors: Ji-Hyang Kim Hack Sun Choi Su-Lim Kim Dong-Sun Lee Cancer stem cells (CSCs) have unique properties, including self-renewal, differentiation, and chemoresistance. In this study, we found that p21-activated kinase (PAK1) inhibitor (Group I, PA
- Cancers, Vol. 11, Pages 1530: Epigenetic Drugs for Cancer and microRNAs: A Focus on Histone Deacetylase InhibitorsCancers, Vol. 11, Pages 1530: Epigenetic Drugs for Cancer and microRNAs: A Focus on Histone Deacetylase Inhibitors Cancers doi: 10.3390/cancers11101530 Authors: Pierre Autin Christophe Blanquart Delphine Fradin Over recent decades, it has become clear that epigenetic abnormalities are involved in the hallmarks of cancer. Histone modifications, such as acetylation, play a crucial role in cancer development and progression, by re
- Cancers, Vol. 11, Pages 1522: Mesenchymal Cells Support the Oncogenicity and Therapeutic Response of the Hedgehog Pathway in Triple-Negative Breast CancerCancers, Vol. 11, Pages 1522: Mesenchymal Cells Support the Oncogenicity and Therapeutic Response of the Hedgehog Pathway in Triple-Negative Breast Cancer Cancers doi: 10.3390/cancers11101522 Authors: Ana M. Reyes-Ramos Karla P. Ramos-Cruz Nelson J. Rodríguez-Merced Michelle M. Martínez-Montemayor Nelson D. Franqui-Ríos Jan P. Ríos-Grant Andrea Flores Gerónimo Maldonado-Martínez Wandaliz Torres-García Maribella D
- Cancers, Vol. 11, Pages 1525: Revising PTEN in the Era of Immunotherapy: New Perspectives for an Old StoryCancers, Vol. 11, Pages 1525: Revising PTEN in the Era of Immunotherapy: New Perspectives for an Old Story Cancers doi: 10.3390/cancers11101525 Authors: Geny Piro Carmine Carbone Luisa Carbognin Sara Pilotto Chiara Ciccarese Roberto Iacovelli Michele Milella Emilio Bria Giampaolo Tortora Immunotherapy has emerged as the new therapeutic frontier of cancer treatment, showing enormous survival benefits in multipl
- Cancers, Vol. 11, Pages 1523: Targeting Lysophosphatidic Acid in Cancer: The Issues in Moving from Bench to BedsideCancers, Vol. 11, Pages 1523: Targeting Lysophosphatidic Acid in Cancer: The Issues in Moving from Bench to Bedside Cancers doi: 10.3390/cancers11101523 Authors: Yan Xu Since the clear demonstration of lysophosphatidic acid (LPA)’s pathological roles in cancer in the mid-1990s, more than 1000 papers relating LPA to various types of cancer were published. Through these studies, LPA was established as a target for cancer. Althoug
- Cancers, Vol. 11, Pages 1521: Potential and Challenges of Aptamers as Specific Carriers of Therapeutic Oligonucleotides for Precision Medicine in CancerCancers, Vol. 11, Pages 1521: Potential and Challenges of Aptamers as Specific Carriers of Therapeutic Oligonucleotides for Precision Medicine in Cancer Cancers doi: 10.3390/cancers11101521 Authors: Silvia Nuzzo Giuseppina Roscigno Alessandra Affinito Francesco Ingenito Cristina Quintavalle Gerolama Condorelli Due to the progress made in the area of precision and personalized medicine in the field of cancer therapy, st
- Cancers, Vol. 11, Pages 1524: LncRNAs as Chromatin Regulators in Cancer: From Molecular Function to Clinical PotentialCancers, Vol. 11, Pages 1524: LncRNAs as Chromatin Regulators in Cancer: From Molecular Function to Clinical Potential Cancers doi: 10.3390/cancers11101524 Authors: Rodiola Begolli Nikos Sideris Antonis Giakountis During the last decade, high-throughput sequencing efforts in the fields of transcriptomics and epigenomics have shed light on the noncoding part of the transcriptome and its potential role in human disease. Regulator
Journal of Experimental & Clinical Cancer Research - Latest Articles
- Inhibiting PAD2 enhances the anti-tumor effect of docetaxel in tamoxifen-resistant breast cancer cellsTamoxifen resistance presents a huge clinical challenge for breast cancer patients. An understanding of the mechanisms of tamoxifen resistance can guide development of efficient therapies to prevent drug resis...
- State-of-the-art Speaker Recognition with Neural Network Embeddings in NIST SRE18 and Speakers In The Wild EvaluationsPublication date: Available online 9 October 2019Source: Computer Speech & LanguageAuthor(s): Jesús Villalba, Nanxin Chen, David Snyder, Daniel Garcia-Romero, Alan McCree, Gregory Sell, Jonas Borgstrom, Leibny Paola García-Perera, Fred Richardson, Réda Dehak, Pedro A. Torres-Carrasquillo, Najim DehakAbstractWe present a thorough analysis of the systems developed by the JHU-MIT consortium in the context of NIST speaker recognition evaluation 2018.
G3: .Genes, Genomes, Genetics Mission - Online First Articles
- rmtA-Dependent Transcriptome and Its Role in Secondary Metabolism, Environmental Stress, and Virulence in Aspergillus flavusAspergillus flavus colonizes numerous oil seed crops such as maize, peanuts, treenuts and cottonseed worldwide, contaminating them with aflatoxins and other harmful toxins. Previously our lab characterized the gene rmtA, which encodes an arginine methyltransferase in A. flavus, and demonstrated its role governing the expression of regulators in the aflatoxin gene cluster and subsequent synthesis of toxin. Furthermore, our studies revealed that rm
- Target‐mediated drug disposition pharmacokinetic/pharmacodynamic model‐informed dose selection for the first‐in‐human study of AVB‐S6‐500Abstract AVB‐S6‐500 neutralized growth arrest‐specific 6 protein (GAS6) and effectively inhibited AXL signaling in preclinical cancer models. A target‐mediated drug disposition (TMDD) pharmacokinetic/pharmacodynamic (PK/PD) model was used to select first‐in‐human (FIH) doses for AVB‐S6‐500 based on predicted target (GAS6) suppression in the clinic. The effect of TMDD on AVB‐S6‐500 clearance was incorporated into a standard 2‐compartment model, p
Clinical Ophthalmology
Πληροφορίες
Πέμπτη 10 Οκτωβρίου 2019
Εγγραφή σε:
Σχόλια ανάρτησης (Atom)
Δεν υπάρχουν σχόλια:
Δημοσίευση σχολίου