• The Journal of Nuclear Medicine (JNM) , 
• Preoperative localisation of adenomas in primary hyperparathyroidism: the value of 11C-choline PET/CT in patients with negative or discordant ultrasonography and 99mTc-Sesta-MIBI-SPECT/CT

  Purpose: We aimed to assess the value of 11C-choline positron emission tomography (PET) in patients with primary hyperparathyroidism (pHPT) with negative or discordant results in methoxyisobutylisonitrile (MIBI) imaging and neck ultrasound. Methods: Eighty-seven patients with pHPT and negative or discordant neck ultrasound and MIBI single photon emission computed tomography/computed tomography (SPECT/CT) were assessed using 11C-choline PET/CT

  The Journal of Nuclear Medicine (JNM)

  Thu Oct 10, 2019 14:15
• PET Imaging of Pancreatic Dopamine D3/D2 receptor density with 11C (+)-PHNO in Type-1 Diabetes Mellitus

  Type-1 diabetes mellitus (T1DM) has traditionally been characterized by a complete destruction of beta-cell mass (BCM); however, there is growing evidence of possible residual BCM present in T1DM. Given the absence of in vivo tools to measure BCM, routine clinical measures of beta cell function (e.g., C-peptide release) may not reflect BCM. We previously demonstrated the potential utility of positron emission tomography (PET) imaging with the do

  The Journal of Nuclear Medicine (JNM)

  Thu Oct 10, 2019 14:15
• Clarifying the Utility of Myocardial Blood Flow and Myocardial Flow Reserve After Cardiac Transplant

  The Journal of Nuclear Medicine (JNM)

  Thu Oct 10, 2019 14:15
• Patients resistant against PSMA-targeting alpha-radiation therapy often harbor mutations in DNA-repair associated genes

  Prostate-specific membrane antigen (PSMA) targeting alpha-radiation therapy (TAT) is an emerging treatment modality for metastatic castration-resistant prostate cancer. There is a subgroup of patients with poor response despite sufficient expression of PSMA in their tumors. The aim of this work was to characterize PSMA-TAT non-responding lesions by targeted next-generation sequencing (tNGS). Methods: Out of 60 patients treated with 225Ac-PSMA-6

  The Journal of Nuclear Medicine (JNM)

  Thu Oct 10, 2019 14:15
• Additional local therapy of liver metastases in mCRPC patients receiving systemic PSMA targeted therapy

  The aim of this study was to evaluate the efficacy of 177Lu-PSMA-617 (Lu-PSMA) and Selective Internal Radiation Therapy (SIRT) for the treatment of liver metastases of castration resistant prostate cancer (mCRPC). Materials and Methods: Safety and survival of patients with mCRPC and liver metastases assigned to Lu-PSMA alone (n = 31) or in combination with SIRT (n = 5) was retrospectively analyzed. Additionally, a subgroup (n = 10) was analyze

  The Journal of Nuclear Medicine (JNM)

  Thu Oct 10, 2019 14:15
• First evidence for a dose-response relationship in patients treated with 166Ho-radioembolization: a prospective study

  Holmium-166 (166Ho)-microspheres have recently been approved for clinical use for hepatic radioembolization in the EU. The aim of this study was to investigate the absorbed dose-response relationship and its association with overall survival for 166Ho-radioembolization in patients with liver metastases. Methods: Patients who were treated in the HEPAR I and II studies and who underwent an FDG-PET/CT scan at baseline, a post-treatment 166Ho-S

  The Journal of Nuclear Medicine (JNM)

  Thu Oct 10, 2019 14:15
• Pharmacokinetic assessment of 18F-(2S,4R)-4-fluoroglutamine in patients with cancer

  18F-(2S,4R)-4-fluoroglutamine (18F-FGln) is an investigational positron emission tomography (PET) radiotracer for imaging tumor glutamine flux and metabolism. The aim of this study was to investigate its pharmacokinetic properties in patients with cancer. Methods: Fifty lesions from 41 patients (21M/20F, aged 54±14 years) were analyzed. 30-min dynamic PET scans were performed concurrent with a rapid intravenous bolus injection of 232±82 MBq

  The Journal of Nuclear Medicine (JNM)

  Thu Oct 10, 2019 14:15
• Automated synthesis module and sterile cold kit for 68Ga-PSMA-11 do not show differences in PET/CT image quality

  Introduction: 68Ga-labeled urea-based inhibitors of the prostate-specific membrane antigen (PSMA), such as 68Ga-PSMA-11, are promising small molecules for targeting prostate cancer (PCa). Although this radiopharmaceutical was mostly produced by the means of automated synthesis modules, a sterile cold kit was recently introduced. The aim of our study was to evaluate the image quality of 68Ga-PSMA-11 PET/CT (PSMA-PET) in a population of PCa patien

  The Journal of Nuclear Medicine (JNM)

  Thu Oct 10, 2019 14:15
• Development of Improved Tumor-Residualizing, GRPR-Targeted Agents: Preclinical Comparison of an Endolysosomal Trapping Approach in Agonist and Antagonistic Constructs.

  Receptor-targeted radiopharmaceuticals based on low molecular weight carriers offer many clinically advantageous attributes relative to macromolecules, but have generally been hampered by their rapid clearance from tumors thus diminishing tumor to non-target tissue (T/NT) ratios. Herein, we present a strategy using irreversible inhibitors (E-64 derivative) of cysteine cathepsins (CCs) as trapping agents to increase the tumor retention of receptor

  The Journal of Nuclear Medicine (JNM)

  Thu Oct 10, 2019 14:15
• Targeting P-selectin Adhesion Molecule in Molecular Imaging: P-selectin Expression as Valuable Imaging Biomarker of Inflammation in Cardiovascular Disease.

  P-selectin is an adhesion molecule translocated to the surface of endothelial cells and platelets under inflammatory stimuli, and its potential as a biomarker in inflammatory conditions has driven pre-clinical studies in investigating its application for molecular imaging of inflammation. Clinical imaging of P-selectin expression for disease characterization could have an important role in stratifying patients and determining treatment strategies

  The Journal of Nuclear Medicine (JNM)

  Thu Oct 10, 2019 14:15
• Long-Term Clinical and Neuronuclear Imaging Sequelae of Cancer Therapy, Trauma, and Brain Injury

  Neuronuclear imaging has been utilized for several decades in the study of primary neurodegenerative conditions, such as dementia and parkinsonian syndromes, both for research and clinical purposes. There has been a relative paucity of application of neuronuclear imaging to evaluate non-neurodegenerative conditions that can also have long-term effects on cognition and function. This article summarizes clinical and imaging aspects of three such co

  The Journal of Nuclear Medicine (JNM)

  Thu Oct 10, 2019 14:15
• European Journal of Neuroscience
• A novel fMRI paradigm to dissociate the behavioral and neural components of mixed‐strategy decision‐making from non‐strategic decisions in humans

  Abstract During competitive interactions, such as predator‐prey or team sports, the outcome of one's actions is dependent on both their own choices and those of their opponents. Success in these rivalries requires that individuals choose dynamically and unpredictably, often adopting a mixed‐strategy. Understanding the neural basis of strategic decision‐making is complicated by the fact that it recruits various cognitive processes that are often

  European Journal of Neuroscience

  Wed Oct 09, 2019 10:49
• Female adult zebrafish (Danio rerio) show higher levels of anxiety‐like behavior than males, but do not differ in learning and memory capacity

  Abstract Zebrafish (Danio rerio) are widely used as a translational model for human neuropsychiatric conditions. Many studies have not considered sex differences in their analyses. Here, we studied sex differences of adult zebrafish in two behavioral domains: Anxiety and Memory. To assess whether sex influences anxiety‐like responses, we used two different behavioral protocols, the novel tank diving task and the light‐dark test. To assess sex di

  European Journal of Neuroscience

  Wed Oct 09, 2019 02:03
• Royal Society of Chemistry (Great Britain) Society for Analytical Chemistry Society of Public Analysts (Great Britain)
• QCM Sensing of miR-21 by Formation of MicroRNA-DNA Hybrid Duplexes and Intercalation on Surface-Functionalized Pyrene

  Analyst, 2019, Accepted ManuscriptDOI: 10.1039/C9AN01645G, PaperHyeoun Ji Park, SOO SUK LEEMicroRNAs (miRNAs) are small non-coding RNA molecules that serve as important biomarkers for a variety of diseases such as cancer and vascular disease. However, sensitive and accurate detection of miR-21...The content of this RSS Feed (c) The Royal Society of Chemistry

  Royal Society of Chemistry (Great Britain) Society for Analytical Chemistry Society of Public Analysts (Great Britain)

  Thu Oct 10, 2019 16:00
• Rapid Detection of Group B Streptococcus (GBS) from artificial urine samples based on IFAST and ATP Bioluminescence Assay: from development to practical challenges during protocol testing in Kenya

  Analyst, 2019, Accepted ManuscriptDOI: 10.1039/C9AN01808E, PaperBongkot Ngamsom, Ernest Apondi Wandera, Alexander Iles, Racheal Kimani, Francis Muregi, Jesse Gitaka, Nicole PammeWe report the rapid detection (20 min) of Streptococcus agalactiae, Group B Streptococcus (GBS) employing on-chip magnetic isolation of GBS based on immiscible filtration assisted by surface tension (IFAST), followed...The content of this RSS Feed (c) The Royal Society

  Royal Society of Chemistry (Great Britain) Society for Analytical Chemistry Society of Public Analysts (Great Britain)

  Wed Oct 09, 2019 16:00
• Biosensor surface functionalization by a simple photochemical immobilization of antibodies: An Experimental characterization by Mass Spectrometry and Surface Enhanced Raman Spectroscopy

  Analyst, 2019, Accepted ManuscriptDOI: 10.1039/C9AN00443B, PaperBartolomeo Della Ventura, martina banchelli, Riccardo Funari, Anna Illiano, Marella de Angelis, Paola Taroni, Angela Amoresano, Paolo Matteini, Raffaele VelottaSurface functionalization is a key step in biosensing since it is at the base of an effective analyte recognition. Among all the bioreceptors, antibodies (Abs) occupy a key role thanks...The content of this RSS Feed (c) The Ro

  Royal Society of Chemistry (Great Britain) Society for Analytical Chemistry Society of Public Analysts (Great Britain)

  Wed Oct 09, 2019 16:00
• Design and Synthesis of Vanadate-Based Ratiometric Fluorescence Probe for Sequential Recognition of Cu2+ and Biothiol

  Analyst, 2019, Accepted ManuscriptDOI: 10.1039/C9AN01518C, PaperHui-Hui Zeng, Zhou Zhi-Ying , Liu Fang , Deng Jie , Huang Shu-Yun , Li Guo-Ping, Pei-Qing Lai, Yue-Ping Xie, Xiao Wei A novel YVO4:Eu3+@CDs core-shell nanomaterial with two main emission peaks at 405 and 617 nm was synthesized through a simple mixing method, in which the carbon quantum dots (CDs) self-assembled...The content of this RSS Feed (c) The Royal Society of Chemistry

  Royal Society of Chemistry (Great Britain) Society for Analytical Chemistry Society of Public Analysts (Great Britain)

  Wed Oct 09, 2019 16:00
• Imaging live bacteria at the nanoscale: comparison of immobilisation strategies

  Analyst, 2019, Accepted ManuscriptDOI: 10.1039/C9AN01185D, Paper Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Georgina Benn, Alice Pyne, Maxim Ryadnov, Bart HoogenboomAtomic force microscopy (AFM) provides an effective, label-free technique enabling the imaging of live bacteria under physiological conditions with nanometre precision. However, AFM is a surface scanning technique, and the...The co

  Royal Society of Chemistry (Great Britain) Society for Analytical Chemistry Society of Public Analysts (Great Britain)

  Wed Oct 09, 2019 16:00