Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00302841026182,
- Conjunctival Trichodiscoma of the Lower EyelidConjunctival Trichodiscoma of the Lower Eyelid: Trichodiscomas are benign tumors of the skin which develop around a hair follicle. They usually present on the face, neck, or trunk region. The authors report a rare case of a 63-year-old man who presented with a tumor on the left lower eyelid that was histologically proven to be a trichodiscoma of conjunctival origin.Accepted for publication August 4, 2019.The authors have no financial or conflicts
- Renal Medullary Carcinoma With Metastasis to the Temporal Fossa and OrbitRenal Medullary Carcinoma With Metastasis to the Temporal Fossa and Orbit: A 22-year-old Hispanic man with sickle cell trait presented with blurred vision, double vision, and pain with OD movement. MRI demonstrated an extra-axial mass centered around the temporal bone with extension into the middle cranial fossa and lateral aspect of the extra-conal right orbit, and mass effect on the lateral rectus muscle. Biopsy of the lesion was consistent wit
- Benign Meningioma With Rare Osteolytic BehaviorBenign Meningioma With Rare Osteolytic Behavior:
- Clinicopathological Features and Outcomes in Lymphoma of Extraocular MusclesClinicopathological Features and Outcomes in Lymphoma of Extraocular Muscles: Purpose: To describe the clinicopathological features and report the outcomes of treatment in lymphoma involving the extraocular muscles (EOM), the largest reported case-series.Methods: A retrospective case series of patients with lymphoma involving the EOM from a single tertiary referral orbital center, between March 1992 and March 2018. Patients with other histopathol
- Orbital Teratoma: MRI Changes From Fetal Life to ExenterationOrbital Teratoma: MRI Changes From Fetal Life to Exenteration:
- The “Bone Dry” Temporal Artery Biopsy Surgical Field in Giant Cell ArteritisThe “Bone Dry” Temporal Artery Biopsy Surgical Field in Giant Cell Arteritis:
- Ocular Adnexal Adenomatoid Sebaceous Gland Hyperplasia: A Clinical and Immunopathologic Analysis in Relation to the Muir-Torre SyndromeOcular Adnexal Adenomatoid Sebaceous Gland Hyperplasia: A Clinical and Immunopathologic Analysis in Relation to the Muir-Torre Syndrome: The purposeof this study is to codify the microscopic diagnostic criteria for ocular adnexal brow and caruncular sebaceous gland hyperplasias (pseudoadenomatoid) that distinguish it from an adenoma. Clinical records and photographs were critically reviewed and microscopic slides were stained with hematoxylin and
- A Modified Levator Resection to Improve Postoperative Lagophthalmos and Eyelid LagA Modified Levator Resection to Improve Postoperative Lagophthalmos and Eyelid Lag: Purpose: To assess the effect of releasing the central attachment between the Whitnall’s ligament (WL) and the levator palpebrae superioris muscle on the postoperative levator function (LF), eyelid lag, and degree of lagophthalmos.Methods: This retrospective case-control study included patients with moderate and severe simple congenital ptosis who underwent skin a
- Cerebrofacial Arteriovenous Metameric Syndrome Type 2Cerebrofacial Arteriovenous Metameric Syndrome Type 2:
- Nontraumatic Orbital Subperiosteal Hematoma in a Case of Bernard-Soulier Syndrome With Bilateral PansinusitisNontraumatic Orbital Subperiosteal Hematoma in a Case of Bernard-Soulier Syndrome With Bilateral Pansinusitis: Orbital subperiosteal hemorrhages are usually due to trauma. However, nontraumatic subperiosteal hemorrhages have also been rarely reported. Here, the authors present a 13-year-old boy with Bernard-Soulier syndrome who presented with right orbital subperiosteal hemorrhage causing optic neuropathy which was surgically drained with full vi
- Lacrimal Drainage Anomalies in CHARGE Syndrome: Case Report and Review of LiteratureLacrimal Drainage Anomalies in CHARGE Syndrome: Case Report and Review of Literature: Abstract: The common ocular manifestations of CHARGE syndrome include colobomatous defects in the eye, strabismus, nystagmus, and micropthalmia. Lacrimal drainage anomalies have been rarely reported and to the best of the authors' knowledge, only 5 such cases have been reported earlier. The present case describes CHARGE syndrome associated with bilateral complex
- Orbital Pheochromocytoma Metastasis in 2 Patients With Known PheochromocytomaOrbital Pheochromocytoma Metastasis in 2 Patients With Known Pheochromocytoma: Two patients with previously diagnosed pheochromocytoma presented with facial pain and ptosis. Imaging revealed orbital lesions. Both patients were referred for surgical evaluation of the orbital mass. Surgical excision was performed for both. Pathology confirmed metastatic pheochromocytoma. Pheochromocytomas commonly metastasize to bone, liver, and other tissues. Five
- Management of a Large Congenital Hemangioma Obstructing Visual Axis: A Case Report and Review of LiteratureManagement of a Large Congenital Hemangioma Obstructing Visual Axis: A Case Report and Review of Literature: Congenital hemangiomas comprise a subset of vascular tumors with clinicopathologic features that are distinct from the more common infantile hemangioma. The authors present a patient with a large congenital hemangioma involving the forehead and brow which obstructed the visual axis and created significant risk for deprivational amblyopia.
- Nasal and Lacrimal Sac Histopathology in Patients With Granulomatous Polyangiitis Undergoing Lacrimal Drainage SurgeryNasal and Lacrimal Sac Histopathology in Patients With Granulomatous Polyangiitis Undergoing Lacrimal Drainage Surgery: Purpose: To examine histological changes within nasal and lacrimal sac mucosa harvested from patients with granulomatous polyangiitis (GPA) who required lacrimal drainage surgery. As these patients were considered quiescent on clinical and serological grounds, particular attention was paid to the presence of active vasculitis.De
- Orbital Diffuse Large B-Cell Lymphoma Initially Presenting as Neovascular GlaucomaOrbital Diffuse Large B-Cell Lymphoma Initially Presenting as Neovascular Glaucoma: Orbital lymphoma can result in rapid loss of vision if not diagnosed and treated in a timely manner. This patient presented with rapid visual loss and on examination had a rubeosis iridis with a hyphema as well as neovascular glaucoma with vitreous hemorrhage. His medical history included systemic diffuse large B-cell lymphoma and a workup ultimately revealed an o
- Sarcoid Orbital Myopathy: Clinical Presentation and OutcomesSarcoid Orbital Myopathy: Clinical Presentation and Outcomes: Purpose: To describe the clinical manifestations, systemic associations, radiological features, and treatment outcome for patients presenting with sarcoid-like granulomatous disease involving the extraocular muscles.Study design: Retrospective noncomparative case series and literature review.Methods: Patients presenting with presumed sarcoid orbital myopathy between 1990 and 2016 were
- Sarcoid Orbital Myopathy: Clinical Presentation and OutcomesSarcoid Orbital Myopathy: Clinical Presentation and Outcomes: Purpose: To describe the clinical manifestations, systemic associations, radiological features, and treatment outcome for patients presenting with sarcoid-like granulomatous disease involving the extraocular muscles.Study design: Retrospective noncomparative case series and literature review.Methods: Patients presenting with presumed sarcoid orbital myopathy between 1990 and 2016 were
- Chronic, Symptomatic Orbital Inflammation Resulting From Retained Bone WaxChronic, Symptomatic Orbital Inflammation Resulting From Retained Bone Wax: A 58-year-old man presented with a 9-month history of a chronically draining surgical wound and low-grade periorbital inflammation following a right lateral orbitotomy. Imaging of the right orbit revealed a peculiar lesion in the right lateral orbit that was hypointense on both T1- and T2-weighted MRI with peripheral enhancement. Exploratory orbitotomy and biopsy establis
- The Programmed Death Pathway in Ocular Adnexal Sebaceous CarcinomaThe Programmed Death Pathway in Ocular Adnexal Sebaceous Carcinoma: Purpose: Sebaceous carcinoma can be highly malignant and difficult to treat. Surgical excision followed by periocular reconstruction is the primary method of treatment. In aggressive cases, radiation, topical chemotherapy, and systemic chemotherapy have been explored as adjuvant therapy. Immunotherapy, through immune checkpoint inhibitors, has proven to have significant antitumor
- Glaucoma Filtering Bleb Analysis Before and After Aponeurotic Blepharoptosis SurgeryGlaucoma Filtering Bleb Analysis Before and After Aponeurotic Blepharoptosis Surgery: Purpose: To evaluate the effectiveness and safety of aponeurotic blepharoptosis surgery and the morphology of filtering bleb in patients with filtrating bleb.Methods: This retrospective case series included 7 consecutive patients (9 eyes) with filtering bleb after trabeculectomy. They underwent transcutaneous levator aponeurotic advancement from May 2018 to Apri
- Medicine by Alexandros G. Sfakianakis Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios...Medicine by Alexandros G. SfakianakisMedicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00302841026182,00306932607174,alsfakia@gmail.com,AMEDEO Otorhinolaryngologyhttp://www.amedeo.comhttp://m.amedeo.com2019-10-07Your Personal Amedeo Web...AMEDEO Otorhinolaryngologyhttp://www.amedeo.comhttp://m.amedeo.com2019-10-07Your Personal Amedeo Web PageComputer: http://amedeo.com/summary/px.php?table=orl&cid=386453+Smartph
- Giant Bilateral Cysts of the Accessory Lacrimal Glands of Wolfring in a ChildGiant Bilateral Cysts of the Accessory Lacrimal Glands of Wolfring in a Child: Ductal cysts of the accessory lacrimal glands of Wolfring are rare clinical entities. They typically present as mobile and translucent lesions on the superior or inferior tarsal borders. Here, the authors describe a 7-year-old male child presenting with giant bilateral cysts of Wolfring. Management of such cysts is primarily surgical and the preferred route for excisio
- Electrochemotherapy for Palliative Periorbital MalignancyMaintaining Quality of Life: Electrochemotherapy for Palliative Periorbital Malignancy: Electrochemotherapy has been used successfully for treatment of recurrent head and neck skin cancers and skin metastasis. It combines both electroporation and chemotherapy. The authors report 4 patients, who all had metastatic periorbital malignancy. These patients were palliative with widespread metastatic malignancy. All patients had either already had multi
- Incorporation of the Milan system in reporting salivary gland fine needle aspiration cytology—An insight into its value addition to the conventional systemIncorporation of the Milan system in reporting salivary gland fine needle aspiration cytology—An insight into its value addition to the conventional system: AbstractBackgroundMilan System for Reporting Salivary Gland Cytology (MSRSGC) was introduced to standardise the terminology and reporting of salivary gland cytology. The purpose of our study was to compare the conventional system and the proposed Milan System to look for concordance rates in
- Thiel Embalming: Quantifying histological changes in skeletal muscle and tendon and investigating the role of boric acidThiel Embalming: Quantifying histological changes in skeletal muscle and tendon and investigating the role of boric acid: IntroductionCadaver preservation methods impact their utilisation in anatomical research and teaching. Thiel‐embalmed cadavers show flexibility, however, the cause remains poorly understood. This study aimed to i) describe qualitative and quantitative histological differences between Thiel‐embalmed and formalin‐fixed skeletal
- Human Platelet Lysate Sustains the Osteogenic/Adipogenic Differentiation Potential of Adipose-Derived Mesenchymal Stromal Cells and Maintains Their DNA Integrity in vitroHuman Platelet Lysate Sustains the Osteogenic/Adipogenic Differentiation Potential of Adipose-Derived Mesenchymal Stromal Cells and Maintains Their DNA Integrity in vitro: Human platelet lysate (HPL) is a promising alternative to fetal calf serum (FCS) for the expansion of adipose tissue mesenchymal stromal cells (AT-MSCs) for translational medicine applications. However, some biological effects of HPL are still to be elucidated. We aimed to comp
- Age‐specific 3‐year cumulative risk of cervical cancer and high‐grade dysplasia on biopsy in 9434 women who underwent HPV cytology cotestingAge‐specific 3‐year cumulative risk of cervical cancer and high‐grade dysplasia on biopsy in 9434 women who underwent HPV cytology cotesting: BackgroundHigh‐risk human papillomavirus (HPV)–Papanicolaou (Pap) cotesting is recommended for cervical cancer screening in women aged ≥30 years. The current study analyzed the effectiveness of cotesting on risk management in different age groups.MethodsA retrospective review of a 5‐year cytology database i
- FNA cytology of postoperative pseudotumoral lesions induced by oxidized cellulose hemostatic agentsFNA cytology of postoperative pseudotumoral lesions induced by oxidized cellulose hemostatic agents: BackgroundThe use of topically applied hemostatic substances during surgery has become a common practice. In some cases, the material is not absorbed or induces a granulomatous reaction resulting in a pseudotumoral lesion. With imaging studies, it is not possible to differentiate this from a tumor recurrence or abscess. This study describes the au
- Readmissions after endoscopic skull base surgery: associated risk factors and preventionReadmissions after endoscopic skull base surgery: associated risk factors and prevention: BackgroundUnplanned readmissions within 30 days of discharge is a quality measure introduced by the Centers for Medicare Services. This measure has been used to rate hospital quality and also to penalize hospitals for excess readmissions. It has been hypothesized that shorter hospital stays and fewer readmissions are associated with endoscopic skull base pro
- Sinonasal mucosal vasculature in yellow nail syndrome and chronic rhinosinusitis with or without polypsSinonasal mucosal vasculature in yellow nail syndrome and chronic rhinosinusitis with or without polyps: BackgroundLymphatic dysfunction is hypothesized to be an underlying factor in the pathophysiology of yellow nail syndrome (YNS) (yellow nails, lymphedema, pleural effusions, and frequently chronic rhinosinusitis [CRS]). It is unclear why some YNS patients develop CRS. We quantified lymphatic and total vasculature of sinonasal mucosa in YNS pat
- Repeated bronchoconstriction attenuates the cough response to bronchoconstriction in naïve guinea pigsRepeated bronchoconstriction attenuates the cough response to bronchoconstriction in naïve guinea pigs: Publication date: Available online 7 October 2019Source: Allergology InternationalAuthor(s): Kenta Yamamura, Johsuke Hara, Tamami Sakai, Noriyuki Ohkura, Miki Abo, Naohiko Ogawa, Akihito Okazaki, Takashi Sone, Hideharu Kimura, Masaki Fujimura, Shinji Nakao, Kazuo KasaharaAbstractBackgroundCough variant asthma (CVA) is recognized as a precursor
- Anesthesia techniques for fetal therapiesThe first national survey of anesthesia techniques for fetal therapies in Japan: AbstractPurposeThe aim of this study was to survey the frequency of various anesthetic techniques used in the anesthetic management of both the mother and fetus during fetal therapies in Japan.MethodsWe sent a postal survey to the institutions with physicians who held membership of the Japan Society of Fetal Therapy to describe maternal and fetal anesthetic managemen
- Efficacy of the Antibody-Drug Conjugate W0101 in Preclinical Models of IGF-1 Receptor Overexpressing Solid TumorsEfficacy of the Antibody-Drug Conjugate W0101 in Preclinical Models of IGF-1 Receptor Overexpressing Solid Tumors: The insulin-like growth factor type 1 receptor (IGF-1R) is important in tumorigenesis and its overexpression occurs in numerous tumor tissues. To date, therapeutic approaches based on monoclonal antibodies and tyrosine kinase inhibitors targeting IGF-1R have only shown clinical benefit in specific patient populations. We report a uni
- The novel glutamine antagonist prodrug JHU395 has antitumor activity in malignant peripheral nerve sheath tumorThe novel glutamine antagonist prodrug JHU395 has antitumor activity in malignant peripheral nerve sheath tumor: The carbon and nitrogen components of glutamine are used for multiple biosynthetic processes by tumors. Glutamine metabolism and the therapeutic potential of glutamine antagonists (GA), however, are incompletely understood in malignant peripheral nerve sheath tumor (MPNST), an aggressive soft tissue sarcoma observed in patients with ne
- Application of High-Resolution C-Arm CT Combined with Streak Metal Artifact Removal Technology for the Stent-Assisted Embolization of Intracranial Aneurysms [INTERVENTIONAL]Application of High-Resolution C-Arm CT Combined with Streak Metal Artifact Removal Technology for the Stent-Assisted Embolization of Intracranial Aneurysms [INTERVENTIONAL]: BACKGROUND AND PURPOSE:Metal artifacts from coils and stents limit the level of detail in C-arm CT images of stent attachment and coiling attenuation in the aneurysm neck. We evaluated the utility of high-resolution C-arm CT combined with streak metal artifact removal techno
- Progressive Dominant Hearing Loss (Autosomal Dominant Deafness‐41) and P2RX2 Gene Mutations: A Phenotype–Genotype StudyProgressive Dominant Hearing Loss (Autosomal Dominant Deafness‐41) and P2RX2 Gene Mutations: A Phenotype–Genotype Study: Objectives/HypothesisP2RX2 encoding P2X purinoreceptor 2 has been identified as the gene responsible for autosomal dominant deafness‐41 (DFNA41) as well as mediating vulnerability to noise‐induced hearing loss (NIHL). The objective of this study was to investigate the audiological and molecular characteristics of P2RX2‐related
- Metformin effects on FOXP3+ and CD8+ T cell infiltrates of head and neck squamous cell carcinomaMetformin effects on FOXP3+ and CD8+ T cell infiltrates of head and neck squamous cell carcinoma: ObjectivesAlterations of cellular metabolism have been implicated in immune dysfunction in the tumor microenvironment (TME) of head and neck squamous cell carcinoma (HNSCC). Metformin has recently emerged as a candidate of interest for combination with immunotherapy in HNSCC. This study investigated the effect of metformin on immune cell infiltrates
- Unexpected High‐Risk Pathologic Features Following Thyroidectomy in the Chinese Immigrant PopulationUnexpected High‐Risk Pathologic Features Following Thyroidectomy in the Chinese Immigrant Population: ObjectiveTo compare rates of unexpected high‐risk pathologic features between Chinese and non‐Asian patients who underwent thyroidectomy for papillary thyroid cancer.MethodsThis was a retrospective cohort study at a tertiary academic urban medical center. Patients who underwent thyroidectomy for papillary carcinoma from 2015 to 2017 were included
- The minimal clinically important difference of the dyspnea index in laryngotracheal stenosisThe minimal clinically important difference of the dyspnea index in laryngotracheal stenosis: ObjectiveThe Dyspnea Index (DI) is a validated patient‐reported outcome (PRO) instrument that has been used in the management of laryngotracheal stenosis (LTS). The minimal clinically important difference (MCID) is an established concept to help determine the change in a PRO instrument that reflects meaningful change for the patient. It is not known what
- Accuracy of the minimal leak test for endotracheal cuff pressure monitoringAccuracy of the minimal leak test for endotracheal cuff pressure monitoring: ObjectivesTo determine the accuracy of the minimum leak test as a surrogate for target endotracheal cuff pressure of 20–30 cm H2O in intubated patients.MethodsCuff pressures were measured at the University of Miami Hospital using the minimum leak test on every intubated patient once per shift, then cuff pressure was reevaluated using handheld numerical manometers and rec
- Expression of aquaporins in inner ear diseaseExpression of aquaporins in inner ear disease: The inner ear is responsible for hearing and balance and consists of a membranous labyrinth within a bony labyrinth. The balance structure is divided into the otolith organ that recognizes linear acceleration and the semicircular canal that is responsible for rotational movement. The cochlea is the hearing organ. The external and middle ear are covered with skin and mucosa, respectively, and the spac
- An assessment of transparency and reproducibility‐related research practices in otolaryngologyAn assessment of transparency and reproducibility‐related research practices in otolaryngology: Objectives/HypothesisClinical research serves as the foundation for evidence‐based patient care, and reproducibility of results is consequently critical. We sought to assess the transparency and reproducibility of research studies in otolaryngology by evaluating a random sample of publications in otolaryngology journals between 2014 and 2018.Study Desi
- Elective neck dissection during salvage laryngectomy: A systematic review and meta‐analysisElective neck dissection during salvage laryngectomy: A systematic review and meta‐analysis: ObjectivesThe primary objective was to determine the rate of occult cervical nodal metastasis in patients undergoing elective neck dissection (END) during salvage laryngectomy. The secondary objective was to compare survival and postoperative complication rates between patients undergoing END versus observation.MethodsA medical librarian performed a compr
- Transcripto‐based network analysis reveals a model of gene activation in tongue squamous cell carcinomasTranscripto‐based network analysis reveals a model of gene activation in tongue squamous cell carcinomas: AbstractBackgroundTongue squamous cell carcinoma (TSCC) is the most common malignant tumor derived from the oral cavity, yet its specific molecular mechanisms have not been fully clarified. The aim of this study was to evaluate the association between potential genes and clinical features through constructing gene co‐expression networks.Metho
- Malignant development in patients with oral potentially malignant disorders detected through nationwide screening: Outcomes of 5‐year follow‐up at a single hospitalMalignant development in patients with oral potentially malignant disorders detected through nationwide screening: Outcomes of 5‐year follow‐up at a single hospital: AbstractBackgroundAlthough survival rate and quality of life are improved if patients with oral carcinoma can be detected early, however, such lesions are usually asymptomatic; therefore, it is hard to raise awareness. Screening has proved to be cost‐effective for early detection.Met
- Isthmusectomy in selected patients with well‐differentiated thyroid carcinomaIsthmusectomy in selected patients with well‐differentiated thyroid carcinoma: AbstractBackgroundIsthmusectomy in the treatment of well‐differentiated thyroid carcinoma (WDTC) is controversial. In this study, we analyze the outcomes of WDTC managed by isthmusectomy alone.MethodsForty‐three patients treated with isthmusectomy alone were identified from an institutional database of 6259 surgically treated patients with WDTC. Patient and tumor chara
- Postoperative radiation therapy vs observation for pN1 oral cavity squamous cell carcinomaPostoperative radiation therapy vs observation for pN1 oral cavity squamous cell carcinoma: AbstractBackgroundAmerican Society of Clinical Oncology guidelines recommend that the decision to give postoperative radiotherapy (PORT) for pN1 oral cavity squamous cell carcinoma (OCSCC) without other adverse features be based on the adequacy of the neck dissection (<18 or ≥18 nodes).MethodsWe conducted a cohort study of the National Cancer Database exam
- Journal of Biophotonics Multimodal imaging for tumour characterization from micro to macroscopic...Journal of BiophotonicsMultimodal imaging for tumour characterization from micro to macroscopic level using a newly developed dorsal chamber designed for long‐term follow‐upABSTRACT Optical imaging of living animals is a unique method of studying the dynamics of physiological and pathological processes at a subcellular level. One‐shot acquisitions at high resolution can be achieved on exteriorized organs before animal euthanasia. For longitudinal
- Cutaneous nevi and internal cancer risk: results from two large prospective cohorts of US womenCutaneous nevi and internal cancer risk: results from two large prospective cohorts of US women: Elevated cutaneous nevus number has been linked to longer telomeres. Recently, a large systematic Mendelian randomization study identified a significant positive association between telomere length and risk of cancer. Here, we hypothesized that higher nevus count, as a phenotypic marker of longer telomere, may be associated with increased risk of inte
- Inactivating NF1 mutations are enriched in advanced breast cancer and contribute to endocrine therapy resistanceInactivating NF1 mutations are enriched in advanced breast cancer and contribute to endocrine therapy resistance: Purpose:Advanced breast cancer (ABC) has not been subjected to the same degree of molecular scrutiny as early primary cancer. Breast cancer evolves with time and under the selective pressure of treatment, with the potential to acquire mutations with resistance to treatment and disease progression. To identify potentially targetable mu
- Molecular Cancer Therapeutics Online First Articles ADP-ribosylation Levels and Patterns Correlate...Molecular Cancer Therapeutics Online First ArticlesADP-ribosylation Levels and Patterns Correlate with Gene Expression and Clinical Outcomes in Ovarian CancersInhibitors of nuclear poly(ADP-ribose) polymerase (PARP) enzymes (e.g., PARP-1) have improved clinical outcomes in ovarian cancer, especially in patients with BRCA1/2 gene mutations or additional homologous recombination (HR) DNA repair pathway deficiencies. These defects serve as biomarker
- Physiological effects of high-flow oxygen in tracheostomized patientsPhysiological effects of high-flow oxygen in tracheostomized patients: High-flow oxygen therapy via nasal cannula (HFOTNASAL) increases airway pressure, ameliorates oxygenation and reduces work of breathing. High-flow oxygen can be delivered through tracheostomy (HFOTTRACHEAL), but ...
- The Journal of Physiology Maternal obesity accelerates rat offspring metabolic aging in a sex...The Journal of PhysiologyMaternal obesity accelerates rat offspring metabolic aging in a sex dependent mannerAbstract Human epidemiological studies show that maternal obesity (MO) shortens offspring life and health span. Life course cellular mechanisms involved in this developmental programming‐aging interaction are poorly understood. In a well‐established rat MO model, female Wistar rats ate chow (controls ‐ C) or high energy, obesogenic diet to
- The Journal of Immunology current issue T Cell-Specific Adaptor Protein Regulates Mitochondrial...The Journal of Immunology current issueT Cell-Specific Adaptor Protein Regulates Mitochondrial Function and CD4+ T Regulatory Cell Activity In Vivo following Transplantation [TRANSPLANTATION]Key PointsTSAd knockout mice mount accelerated rejection responses following transplantation. TSAd is a potent regulator of cellular activation in CD4+ Tregs. TSAd knockout CD4+ Tregs fail to shuttle Lck from the cytoplasm to mitochondria.The Journal of Immun
- Metformin use and risk of gastric adenocarcinoma in a Swedish population-based cohort studyMetformin use and risk of gastric adenocarcinoma in a Swedish population-based cohort study: British Journal of Cancer, Published online: 08 October 2019; doi:10.1038/s41416-019-0598-zMetformin use and risk of gastric adenocarcinoma in a Swedish population-based cohort study
- European Journal of Neuroscience Bidirectional Gut‐Microbial‐Brain Signaling: A New Player in...European Journal of NeuroscienceBidirectional Gut‐Microbial‐Brain Signaling: A New Player in Stress Physiology? (Commentary on O’Mahoney et al 2019)Abstract The acute stress response is initiated by exposure to a stressor; where a stressor is an adverse event that would be avoided by the organism if given the opportunity. The stress response encompasses a cascade of physiological responses that function in concert to promote fight/flight behavior
- G3: Genes, Genomes, Genetics current issue Tissue-Specific Transcriptomes Reveal Gene Expression...G3: Genes, Genomes, Genetics current issueTissue-Specific Transcriptomes Reveal Gene Expression Trajectories in Two Maturing Skin Epithelial Layers in Zebrafish EmbryosEpithelial cells are the building blocks of many organs, including skin. The vertebrate skin initially consists of two epithelial layers, the outer periderm and inner basal cell layers, which have distinct properties, functions, and fates. The embryonic periderm ultimately disappea
- JoVE: Journal of Visualized Experiments In Vivo Optical Calcium Imaging of Learning-Induced Synaptic...JoVE: Journal of Visualized ExperimentsIn Vivo Optical Calcium Imaging of Learning-Induced Synaptic Plasticity in Drosophila melanogasterHere we present a protocol with which pre- and/or postsynaptic calcium can be visualized in the context of Drosophila learning and memory. In vivo calcium imaging using synaptically localized calcium sensors is combined with a classical olfactory conditioning paradigm such that the synaptic plasticity underlying
- ScienceDirect Publication: Talanta Soft glass multi-channel capillaries as a platform for bioimprinting...ScienceDirect Publication: TalantaSoft glass multi-channel capillaries as a platform for bioimprintingPublication date: Available online 6 October 2019Source: TalantaAuthor(s): Natalia A. Burmistrova, Pavel S. Pidenko, Sergey A. Pidenko, Andrey M. Zacharevich, Yulia S. Skibina, Natalia V. Beloglazova, Irina Yu GoryachevaAbstractMulti-channel capillaries (MC) formed from thousands individual microcapillaries with diameters ranging 10–100 μm are of
- Banning paraquat would prevent nearly 200 deaths from suicide per year in Taiwan Shu- Sen Chang, David...Banning paraquat would prevent nearly 200 deaths from suicide per year in TaiwanShu- Sen Chang, David GunnellTaiwanese Journal of Psychiatry 2019 33(3):119-121Unmet needs for the management of depressionYi-Ju PanTaiwanese Journal of Psychiatry 2019 33(3):122-124Tobacco and smoking cessationNan- Ying Chiu, Cheng- Ju ChangTaiwanese Journal of Psychiatry 2019 33(3):125-134Background: Tobacco products have been used by human for a long history. The p
- TECENTRIQ (atezolizumab) is leading the next era of treatment for locally advanced or metastatic urothelial...TECENTRIQ (atezolizumab) is leading the next era of treatment for locally advanced or metastatic urothelial carcinoma (mUC). Results from the prospective, international, multicentre, SAUL trial support the safety and efficacy of TECENTRIQ in a real-world mUC patient population, including patient groups that present in routine clinical practice but are usually excluded from clinical trials.1SAUL enrolled a broad patient population with locally adv
- International Journal of Molecular Sciences IJMS, Vol. 20, Pages 4971: Sucrose Synthase Enhances...International Journal of Molecular SciencesIJMS, Vol. 20, Pages 4971: Sucrose Synthase Enhances Hull Size and Grain Weight by Regulating Cell Division and Starch Accumulation in Transgenic RiceIJMS, Vol. 20, Pages 4971: Sucrose Synthase Enhances Hull Size and Grain Weight by Regulating Cell Division and Starch Accumulation in Transgenic Rice International Journal of Molecular Sciences doi: 10.3390/ijms20204971 Authors: Chunfen Fan Guangya Wang Yo
- Antioxidants, Vol. 8, Pages 461: C-terminal Redox Domain of Arabidopsis APR1 is a Non-Canonical...Antioxidants, Vol. 8, Pages 461: C-terminal Redox Domain of Arabidopsis APR1 is a Non-Canonical Thioredoxin Domain with Glutaredoxin FunctionAntioxidants, Vol. 8, Pages 461: C-terminal Redox Domain of Arabidopsis APR1 is a Non-Canonical Thioredoxin Domain with Glutaredoxin Function Antioxidants doi: 10.3390/antiox8100461 Authors: Chen Chien Cho Chang Hsu Sulfur is an essential nutrient that can be converted into utilizable metabolic forms to prod
- The Effects of a 10-wk Outpatient Pulmonary Rehabilitation Program on Exercise Performance, Muscle Strength,...The Effects of a 10-wk Outpatient Pulmonary Rehabilitation Program on Exercise Performance, Muscle Strength, Soluble Biomarkers, and Quality of Life in Patients With Pulmonary HypertensionPurpose: Pulmonary arterial hypertension (PAH) is characterized by right ventricular failure, leading to exertional dyspnea, skeletal muscle weakness, and poor quality of life (QOL). Apart from treatment with PAH-specific drugs, guidelines recommend pulmonary re
- Endoscopy-Assisted Intraoral Removal of Elongated Styloid Process: Mini-Invasive Surgical Treatment...Endoscopy-Assisted Intraoral Removal of Elongated Styloid Process: Mini-Invasive Surgical Treatment of Eagle SyndromeThe aim of this work is to illustrate a transoral mini-invasive approach to safely remove elongated styloid process in Eagle syndrome. A 34-year-old Asian male came to our center referring pharyngeal and cervical pain on the right side on swallowing and opening the mouth. Computed tomography showed elongation of the right styloid p
- Impact of extracellular vesicles on innate immunity Purpose of review Extracellular vesicles released...Impact of extracellular vesicles on innate immunityPurpose of review Extracellular vesicles released by prokaryote or eukaryote cells are emerging as mechanisms of cell-to-cell communication, by either physically interacting with the surface of target cells or transferring proteins/peptides, lipids, carbohydrates, and nuclei acids to acceptor cells. Accumulating evidence indicates that extracellular vesicles, among other functions, regulate innat
- Cancer cachexia in thoracic malignancy: a narrative review Purpose of review Thoracic malignancies are...Cancer cachexia in thoracic malignancy: a narrative reviewPurpose of review Thoracic malignancies are amongst the most lethal of all cancers. Cancer cachexia lacks unanimously accepted diagnostic criteria, and therefore is referenced to as a conceptual framework whereby cancer cachexia is ‘an ongoing loss of skeletal muscle mass (termed sarcopenia), with or without loss of fat mass that cannot be reversed by conventional nutritional support and l
- Pediatric hereditary angioedema: what the otolaryngologist should know Purpose of review To review pediatric...Pediatric hereditary angioedema: what the otolaryngologist should knowPurpose of review To review pediatric hereditary angioedema for otolaryngologists, with emphasis on articles within the past 12–18 months. Recent findings Biologic therapies are accepted for adult hereditary angioedema (HAE), but have been studied less for pediatric HAE. Recent literature supports expanded use of biologic agents in pediatrics as acute treatment and prophylaxis.
- Implications of serial coronary computed tomography angiography in the evaluation of coronary plaque...Implications of serial coronary computed tomography angiography in the evaluation of coronary plaque progressionPurpose of review The purpose is to review the use of coronary computed tomography (CT) angiography to assess coronary plaque burden/progression and to discuss about recent clinical trials that have utilized this imaging modality to study the effect of new pharmacotherapies on plaque burden/progression. Recent findings There are numerou
- Not just to survive but to thrive: delirium in the pediatric cardiac ICU Purpose of review Pediatric...Not just to survive but to thrive: delirium in the pediatric cardiac ICUPurpose of review Pediatric delirium has recently been recognized to occur frequently in the pediatric general and cardiac ICU. The purpose of this review is to highlight recent data on the prevalence, prevention, and management of this condition. Recent findings Pediatric delirium occurs in the pediatric cardiac ICU (PCICU) in as many as 67% of patients. Validated screening
- No hyperfibrinolysis following subarachnoid or intracerebral haemorrhage: a prospective cohort study...No hyperfibrinolysis following subarachnoid or intracerebral haemorrhage: a prospective cohort studyChanges in fibrinolysis following subarachnoid haemorrhage (SAH) and intracerebral haemorrhage (ICH) are sparsely investigated. To investigate fibrinolysis in the acute phase in SAH and ICH patients compared with healthy individuals, fibrinolysis after 24 h in ICH patients and the in-vivo effect of tranexamic acid (TXA) on fibrinolysis in SAH patie
- Biochemie der Östrogene Erratum zu: J. Gynäkol. Endokrinol. CH 2019 https://doi.org/10.1007/s41975-019-0083-3...Biochemie der ÖstrogeneErratum zu:J. Gynäkol. Endokrinol. CH 2019https://doi.org/10.1007/s41975-019-0083-3Leider wurde die Abb. 2 in der Printversion nicht richtig wiedergegeben.Wir bitten Sie, die korrigierte Abbildung zu beachten und den Fehler zu …Aus aller WeltDer rätselhafte FallZusammenfassungEine erhöhte Histaminkonzentration im Körper, wie sie bei dem Krankheitsbild der Histaminintoleranz auftritt, kann zu diversen unspezifischen Symptome
- Normal anorectal musculatures and changes in anorectal malformation AbstractPurpose We investigated...Normal anorectal musculatures and changes in anorectal malformationAbstractPurposeWe investigated the anorectal musclulature in normal children and anorectal malformations (ARM) to evaluate its role in bowel control mechanism.MethodsPelves of 50 neonates died of ARM-unrelated diseases and 16 patients with anorectal malformations (8 high, 5 intermediate, and 3 low ARMs) were dissected and analyzed.ResultsNormal anorectal musculature was divided in
- Signalling games, sociolinguistic variation and the construction of style Abstract This paper develops...Signalling games, sociolinguistic variation and the construction of styleAbstractThis paper develops a formal model of the subtle meaning differences that exist between grammatical alternatives in socially conditioned variation (called variants) and how these variants can be used by speakers as resources for constructing personal linguistic styles. More specifically, this paper introduces a new formal system, called social meaning games (SMGs), w
Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00302841026182,00306932607174,alsfakia@gmail.com,
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Τετάρτη 9 Οκτωβρίου 2019
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Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00302841026182,00306932607174,alsfakia@gmail.com,
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00302841026182,
00306932607174,
alsfakia@gmail.com,
Anapafseos 5 Agios Nikolaos 72100 Crete Greece,
Medicine by Alexandros G. Sfakianakis
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