• Molecular Cancer Therapeutics Online First Articles
• ADP-ribosylation Levels and Patterns Correlate with Gene Expression and Clinical Outcomes in Ovarian Cancers

  Inhibitors of nuclear poly(ADP-ribose) polymerase (PARP) enzymes (e.g., PARP-1) have improved clinical outcomes in ovarian cancer, especially in patients with BRCA1/2 gene mutations or additional homologous recombination (HR) DNA repair pathway deficiencies. These defects serve as biomarkers for response to PARP inhibitors (PARPi). We sought to identify an additional biomarker that could predict responses to both conventional chemotherapy and P

  Molecular Cancer Therapeutics Online First Articles

  Tue Oct 08, 2019 06:49
• The novel glutamine antagonist prodrug JHU395 has antitumor activity in malignant peripheral nerve sheath tumor

  The carbon and nitrogen components of glutamine are used for multiple biosynthetic processes by tumors. Glutamine metabolism and the therapeutic potential of glutamine antagonists (GA), however, are incompletely understood in malignant peripheral nerve sheath tumor (MPNST), an aggressive soft tissue sarcoma observed in patients with neurofibromatosis type I. We investigated glutamine dependence of MPNST using JHU395, a novel orally-bioavailable G

  Molecular Cancer Therapeutics Online First Articles

  Tue Oct 08, 2019 06:49
• Efficacy of the Antibody-Drug Conjugate W0101 in Preclinical Models of IGF-1 Receptor Overexpressing Solid Tumors

  The insulin-like growth factor type 1 receptor (IGF-1R) is important in tumorigenesis and its overexpression occurs in numerous tumor tissues. To date, therapeutic approaches based on monoclonal antibodies and tyrosine kinase inhibitors targeting IGF-1R have only shown clinical benefit in specific patient populations. We report a unique IGF-1R-targeted antibody-drug conjugate (ADC), W0101, designed to deliver a highly potent cytotoxic auristatin

  Molecular Cancer Therapeutics Online First Articles

  Tue Oct 08, 2019 06:49
• Exportin 1 inhibition induces nerve growth factor receptor expression to inhibit the NF-kB pathway in preclinical models of pediatric high-grade glioma

  High-grade glioma (HGG) is the leading cause of cancer death among children. Selinexor, an orally bioavailable, reversible inhibitor of the nuclear export protein, exportin 1, is in clinical trials for a range of cancers, including HGG. It inhibits the NF-kB pathway and strongly induces the expression of nerve growth factor receptor (NGFR) in preclinical cancer models. We hypothesized that selinexor inhibits NF-kB via upregulation of NGFR. In HGG

  Molecular Cancer Therapeutics Online First Articles

  Tue Oct 08, 2019 06:49
• Evolutionary Biology News -- ScienceDaily
• Scientists identify molecule that could have helped cells thrive on early Earth

  A new study offers an explanation for how ''protocells'' could have emerged on early Earth, eventually leading to the cells we know today. The work suggests that molecules called cyclophospholipids may have been the ingredient necessary for protocells to form important internal structures called vesicles, which likely kicked off the evolutionary process.

  Evolutionary Biology News -- ScienceDaily

  Tue Oct 08, 2019 13:58
• Genes play a role in dog breed differences in behavior

  Border collies are highly trainable, greyhounds love to chase, and German shepherds make good guard dogs. While the environment plays a role, traits like these are highly heritable, according to a study of 101 dog breeds. The work identifies 131 genetic variants associated with breed differences in behavior.

  Evolutionary Biology News -- ScienceDaily

  Tue Oct 08, 2019 13:58
• Histone modifications are the influencers of zygotic genome awakening

  Scientists have observed changes to the gene-regulating factors during zebrafish development and discovered that modifications to 'histone H3', one of the proteins around which DNA is bound, play an important role in 'zygotic genome activation' or transition of control of zebrafish embryonic development from maternal material to the zygote.

  Evolutionary Biology News -- ScienceDaily

  Mon Oct 07, 2019 10:09
• The cholera bacterium can steal up to 150 genes in one go

  Scientists have discovered that predatory bacteria like the cholera pathogen can steal up to 150 genes in one go from their neighbors. The study sheds light on one of the most fundamental mechanisms of horizontal gene transfer.

  Evolutionary Biology News -- ScienceDaily

  Mon Oct 07, 2019 09:32
• Was early stick insect evolution triggered by birds and mammals?

  Stick and leaf insects are a strikingly bizarre group of insects with a worldwide distribution. They are famous for their impressively large body size and their remarkable ability to camouflage themselves as twigs, leaves or bark in order to hide from potential predators. A team of international researchers has now generated the first phylogenomic tree of these insects.

  Evolutionary Biology News -- ScienceDaily

  Mon Oct 07, 2019 09:32