Antibodies, Vol. 8, Pages 51: Therapeutic Monoclonal Antibodies Targeting Immune Checkpoints for the Treatment of Solid Tumors Antibodies doi: 10.3390/antib8040051 Authors: Gravbrot Gilbert-Gard Mehta Ghotmi Banerjee Mazis Sundararajan Recently, modulation of immune checkpoints has risen to prominence as a means to treat a number of solid malignancies, given the durable response seen in many patients and improved side effect profile compared to conventional chemotherapeutic...
Mon Oct 21, 2019 03:00
Antioxidants, Vol. 8, Pages 501: Thioredoxin Downregulation Enhances Sorafenib Effects in Hepatocarcinoma Cells Antioxidants doi: 10.3390/antiox8100501 Authors: María José López-Grueso Raúl González Jordi Muntané José Antonio Bárcena C. Alicia Padilla Sorafenib is the first-line recommended therapy for patients with advanced hepatocarcinoma (HCC) in de-differentiation stage (presenting epithelial–mesenchymal transition, EMT). We studied the role of the thioredoxin...
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Antioxidants, Vol. 8, Pages 498: Impact of Intravenous Iron on Oxidative Stress and Mitochondrial Function in Experimental Chronic Kidney Disease Antioxidants doi: 10.3390/antiox8100498 Authors: Faisal Nuhu Anne-Marie Seymour Sunil Bhandari Background: Mitochondrial dysfunction is observed in chronic kidney disease (CKD). Iron deficiency anaemia (IDA), a common complication in CKD, is associated with poor clinical outcomes affecting mitochondrial function and exacerbating oxidative...
Mon Oct 21, 2019 03:00
Antioxidants, Vol. 8, Pages 499: Impact of Cold versus Hot Brewing on the Phenolic Profile and Antioxidant Capacity of Rooibos (Aspalathus linearis) Herbal Tea Antioxidants doi: 10.3390/antiox8100499 Authors: Elisabetta Damiani Patricia Carloni Gabriele Rocchetti Biancamaria Senizza Luca Tiano Elizabeth Joubert Dalene de Beer Luigi Lucini Consumption of rooibos (Aspalathus linearis) as herbal tea is growing in popularity worldwide and its health-promoting attributes...
Mon Oct 21, 2019 03:00
Antioxidants, Vol. 8, Pages 500: Influence of Bioactive Compounds Incorporated in a Nanoemulsion as Coating on Avocado Fruits (Persea americana) during Postharvest Storage: Antioxidant Activity, Physicochemical Changes and Structural Evaluation Antioxidants doi: 10.3390/antiox8100500 Authors: Antonio de Jesus Cenobio-Galindo Juan Ocampo-López Abigail Reyes-Munguía María Luisa Carrillo-Inungaray Maria Cawood Gabriela Medina-Pérez Fabián Fernández-Luqueño Rafael Germán Campos-Montiel...
Mon Oct 21, 2019 03:00
Antioxidants, Vol. 8, Pages 497: N-Acetylcysteine Attenuates the Increasing Severity of Distant Organ Liver Dysfunction after Acute Kidney Injury in Rats Exposed to Bisphenol A Antioxidants doi: 10.3390/antiox8100497 Authors: Wachirasek Peerapanyasut Anongporn Kobroob Siripong Palee Nipon Chattipakorn Orawan Wongmekiat Distant organ liver damage after acute kidney injury (AKI) remains a serious clinical setting with high mortality. This undesirable outcome may be due to some...
Mon Oct 21, 2019 03:00
Atmosphere, Vol. 10, Pages 634: The Incidence of Skin Cancer in Relation to Climate Change in South Africa Atmosphere doi: 10.3390/atmos10100634 Authors: Caradee Y. Wright Mary Norval Thandi Kapwata David Jean du Preez Bianca Wernecke Bianca M. Tod Willem I. Visser Climate change is associated with shifts in global weather patterns, especially an increase in ambient temperature, and is deemed a formidable threat to human health. Skin cancer, a non-communicable disease,...
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Atmosphere, Vol. 10, Pages 633: How Much Does Weather Matter? Effects of Rain and Wind on PM Accumulation by Four Species of Australian Native Trees Atmosphere doi: 10.3390/atmos10100633 Authors: Robert Popek Alison Haynes Arkadiusz Przybysz Sharon A. Robinson As interest in improving urban air quality grows, phytoremediation—amelioration through plants—is an increasingly popular method of targeting particulate matter (PM), one of the most harmful pollutants....
Mon Oct 21, 2019 03:00
Biomedicines, Vol. 7, Pages 83: Increased Progesterone on the Day of Administration of hCG in Controlled Ovarian Hyperstimulation Affects the Expression of HOXA10 in Primates’ Endometrial Receptivity Biomedicines doi: 10.3390/biomedicines7040083 Authors: Nurhuda Sahar Ninik Mujihartini Dwi Ari Pudjianto Adhea Debby Pradhita Rosalina Thuffi Kusmardi Kusmardi The increase in progesterone (P4) levels on the day of human chorionic gonadotropin (hCG) administration have a negative...
Mon Oct 21, 2019 03:00
Biomolecules, Vol. 9, Pages 633: Disclosing the Impact of Carcinogenic SF3b Mutations on Pre-mRNA Recognition Via All-Atom Simulations Biomolecules doi: 10.3390/biom9100633 Authors: Borišek Saltalamacchia Gallì Palermo Molteni Malcovati Magistrato The spliceosome accurately promotes precursor messenger-RNA splicing by recognizing specific noncoding intronic tracts including the branch point sequence (BPS) and the 3’-splice-site (3’SS). Mutations...
Mon Oct 21, 2019 03:00
Biomolecules, Vol. 9, Pages 632: The Antifungal Effect of Garlic Essential Oil on Phytophthora nicotianae and the Inhibitory Component Involved Biomolecules doi: 10.3390/biom9100632 Authors: Yaochen Wang Keke Wei Xiaobin Han Donglin Zhao Yanfen Zheng Jianmin Chao Jianyu Gou Fanyu Kong Cheng-Sheng Zhang This study explored the chemical compositions of garlic essential oil, the inhibitory activity of garlic essential oil and diallyl disulfide (DADS) against Phytophthora...
Mon Oct 21, 2019 03:00
Biomolecules, Vol. 9, Pages 631: Synthesis of Novel Analogs of Thieno[2,3-d] Pyrimidin-4(3H)-ones as Selective Inhibitors of Cancer Cell Growth Biomolecules doi: 10.3390/biom9100631 Authors: Sheng Zhang Feize Liu Xueling Hou Jianguo Cao Xiling Dai Junjie Yu Guozheng Huang New 2,3-disubstituted thieno[2,3-d]pyrimidin-4(3H)-ones were synthesized via a one-pot reaction from 2H-thieno[2,3-d] [1,3]oxazine-2,4(1H)-diones, aromatic aldehydes, and benzylamine or 4-hydroxylbezylamine....
Mon Oct 21, 2019 03:00
Brain Sciences, Vol. 9, Pages 285: The Neuroprotective Effects of Melatonin: Possible Role in the Pathophysiology of Neuropsychiatric Disease Brain Sciences doi: 10.3390/brainsci9100285 Authors: Jung Goo Lee Young Sup Woo Sung Woo Park Dae-Hyun Seog Mi Kyoung Seo Won-Myong Bahk Melatonin is a hormone that is secreted by the pineal gland. To date, melatonin is known to regulate the sleep cycle by controlling the circadian rhythm. However, recent advances in neuroscience...
Mon Oct 21, 2019 03:00
Cancers, Vol. 11, Pages 1603: A Novel Predictor Tool of Biochemical Recurrence after Radical Prostatectomy Based on a Five-MicroRNA Tissue Signature Cancers doi: 10.3390/cancers11101603 Authors: Zhongwei Zhao Sabine Weickmann Monika Jung Michael Lein Ergin Kilic Carsten Stephan Andreas Erbersdobler Annika Fendler Klaus Jung Within five to ten years after radical prostatectomy (RP), approximately 15–34% of prostate cancer (PCa) patients experience biochemical...
Mon Oct 21, 2019 03:00
Cancers, Vol. 11, Pages 1607: Constitutive or Induced HIF-2 Addiction is Involved in Resistance to Anti-EGFR Treatment and Radiation Therapy in HNSCC Cancers doi: 10.3390/cancers11101607 Authors: Coliat Ramolu Jégu Gaiddon Jung Pencreach Background: management of head and neck squamous cell carcinomas (HNSCC) include anti-Epidermal Growth Factor Receptor (EGFR) antibodies and radiotherapy, but resistance emerges in most patients. RAS mutations lead to primary resistance...
Mon Oct 21, 2019 03:00
Cancers, Vol. 11, Pages 1606: A Toolbox for Functional Analysis and the Systematic Identification of Diagnostic and Prognostic Gene Expression Signatures Combining Meta-Analysis and Machine Learning Cancers doi: 10.3390/cancers11101606 Authors: Veronesi Kunz The identification of biomarker signatures is important for cancer diagnosis and prognosis. However, the detection of clinical reliable signatures is influenced by limited data availability, which may restrict statistical power....
Mon Oct 21, 2019 03:00
Cancers, Vol. 11, Pages 1608: Productive Cross-Talk with the Microenvironment: A Critical Step in Ovarian Cancer Metastasis Cancers doi: 10.3390/cancers11101608 Authors: Aziz Agarwal Dasari Mitra Most ovarian cancer patients present with disseminated disease at the time of their diagnosis, which is one of the main reasons for their poor prognosis. Metastasis is a multi-step process and a clear understanding of the mechanism of regulation of these steps remains elusive. Productive...
Mon Oct 21, 2019 03:00
Cancers, Vol. 11, Pages 1605: The Microenvironment of Pituitary Tumors—Biological and Therapeutic Implications Cancers doi: 10.3390/cancers11101605 Authors: Mirela Diana Ilie Alexandre Vasiljevic Gérald Raverot Philippe Bertolino The tumor microenvironment (TME) includes resident and infiltrative non-tumor cells, as well as blood and lymph vessels, extracellular matrix molecules, and numerous soluble factors, such as cytokines and chemokines. While the TME is now considered...
Mon Oct 21, 2019 03:00
Cancers, Vol. 11, Pages 1604: The Brain Penetrating and Dual TORC1/TORC2 Inhibitor, RES529, Elicits Anti-Glioma Activity and Enhances the Therapeutic Effects of Anti-Angiogenetic Compounds in Preclinical Murine Models Cancers doi: 10.3390/cancers11101604 Authors: Giovanni Luca Gravina Andrea Mancini Alessandro Colapietro Simona Delle Monache Roberta Sferra Simona Pompili Flora Vitale Stefano Martellucci Francesco Marampon Vincenzo Mattei Leda Biordi David Sherris...
Mon Oct 21, 2019 03:00
Cancers, Vol. 11, Pages 1602: Prognostic Implication of pAMPK Immunohistochemical Staining by Subcellular Location and Its Association with SMAD Protein Expression in Clear Cell Renal Cell Carcinoma Cancers doi: 10.3390/cancers11101602 Authors: Minsun Jung Jeong Hoon Lee Cheol Lee Jeong Hwan Park Yu Rang Park Kyung Chul Moon Although cytoplasmic AMP-activated protein kinase (AMPK) has been known as a tumor-suppressor protein, nuclear AMPK is suggested to support clear...
Mon Oct 21, 2019 03:00
Cancers, Vol. 11, Pages 1601: Exploiting ING2 Epigenetic Modulation as a Therapeutic Opportunity for Non-Small Cell Lung Cancer Cancers doi: 10.3390/cancers11101601 Authors: Alice Blondel Amine Benberghout Rémy Pedeux Charles Ricordel Non-small cell lung cancer (NSCLC) has been the leading cause of cancer-related death worldwide, over the last few decades. Survival remains extremely poor in the metastatic setting and, consequently, innovative therapeutic strategies are urgently...
Mon Oct 21, 2019 03:00
Cells, Vol. 8, Pages 1294: Tubulin: Structure, Functions and Roles in Disease Cells doi: 10.3390/cells8101294 Authors: Pavla Binarová Jack Tuszynski Highly conserved α- and β-tubulin heterodimers assemble into dynamic microtubules and perform multiple important cellular functions such as structural support, pathway for transport and force generation in cell division. Tubulin exists in different forms of isotypes expressed by specific genes with spatially- and temporally-regulated...
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Cells, Vol. 8, Pages 1293: What Do Microglia Really Do in Healthy Adult Brain? Cells doi: 10.3390/cells8101293 Authors: Marcus Augusto-Oliveira Gabriela P. Arrifano Amanda Lopes-Araújo Leticia Santos-Sacramento Priscila Y. Takeda Daniel C. Anthony João O. Malva Maria Elena Crespo-Lopez Microglia originate from yolk sac-primitive macrophages and auto-proliferate into adulthood without replacement by bone marrow-derived circulating cells. In inflammation, stroke, aging,...
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Cells, Vol. 8, Pages 1292: Turning the World Upside-Down in Cellulose for Improved Culturing and Imaging of Respiratory Challenges within a Human 3D Model Cells doi: 10.3390/cells8101292 Authors: V M C W D Polarized growth of human-derived respiratory epithelial cells on hydrogel-coated filters offers big advantages concerning detailed experiments with respect to drug screening or host pathogen interactions. Different microscopic approaches, such as confocal analyses...
Mon Oct 21, 2019 03:00
Cells, Vol. 8, Pages 1289: The Charcot–Marie Tooth Disease Mutation R94Q in MFN2 Decreases ATP Production but Increases Mitochondrial Respiration under Conditions of Mild Oxidative Stress Cells doi: 10.3390/cells8101289 Authors: Christina Wolf Rahel Zimmermann Osamah Thaher Diones Bueno Verena Wüllner Michael K.E. Schäfer Philipp Albrecht Axel Methner Charcot–Marie tooth disease is a hereditary polyneuropathy caused by mutations in Mitofusin-2 (MFN2), a...
Mon Oct 21, 2019 03:00
Cells, Vol. 8, Pages 1290: Helicobacter pylori Induces IL-33 Production and Recruits ST-2 to Lipid Rafts to Exacerbate Inflammation Cells doi: 10.3390/cells8101290 Authors: Kuo Chen Lo Feng Wu Huang Liao Chen Lai Helicobacter pylori colonizes human gastric epithelial cells and contributes to the development of several gastrointestinal disorders. Interleukin (IL)-33 is involved in various immune responses, with reported proinflammatory and anti-inflammatory...
Mon Oct 21, 2019 03:00
Cells, Vol. 8, Pages 1291: Current Paradigms of Tolerogenic Dendritic Cells and Clinical Implications for Systemic Lupus Erythematosus Cells doi: 10.3390/cells8101291 Authors: Ritprajak Kaewraemruaen Hirankarn Tolerogenic dendritic cells (tolDCs) are central players in the initiation and maintenance of immune tolerance and subsequent prevention of autoimmunity. Recent advances in treatment of autoimmune diseases including systemic lupus erythematosus (SLE) have focused on inducing...
Mon Oct 21, 2019 03:00
Cells, Vol. 8, Pages 1288: Subcutaneous and Visceral Adipose-Derived Mesenchymal Stem Cells: Commonality and Diversity Cells doi: 10.3390/cells8101288 Authors: Andreas Ritter Alexandra Friemel Susanne Roth Nina-Naomi Kreis Samira Catharina Hoock Babek Khan Safdar Kyra Fischer Charlotte Möllmann Christine Solbach Frank Louwen Juping Yuan Adipose-derived mesenchymal stem cells (ASCs) are considered to be a useful tool for regenerative medicine, owing to their...
Mon Oct 21, 2019 03:00
Cells, Vol. 8, Pages 1287: Estimating Dynamic Cellular Morphological Properties via the Combination of the RTCA System and a Hough-Transform-Based Algorithm Cells doi: 10.3390/cells8101287 Authors: Lejun Zhang Yang Ye Rana Dhar Jinsong Deng Huifang Tang The xCELLigence real-time cell analysis (RTCA) system has the potential to detect cellular proliferation, migration, cytotoxicity, adherence, and remodeling. Although the RTCA system is widely recognized as a noninvasive and...
Mon Oct 21, 2019 03:00
Cells, Vol. 8, Pages 1286: A Machine Learning-Based Prediction Platform for P-Glycoprotein Modulators and Its Validation by Molecular Docking Cells doi: 10.3390/cells8101286 Authors: Onat Kadioglu Thomas Efferth P-glycoprotein (P-gp) is an important determinant of multidrug resistance (MDR) because its overexpression is associated with increased efflux of various established chemotherapy drugs in many clinically resistant and refractory tumors. This leads to insufficient therapeutic...
Mon Oct 21, 2019 03:00
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