Cancers, Vol. 11, Pages 1497: Comprehensive Metabolomic Search for Biomarkers to Differentiate Early Stage Hepatocellular Carcinoma from Cirrhosis:
Cancers, Vol. 11, Pages 1497: Comprehensive Metabolomic Search for Biomarkers to Differentiate Early Stage Hepatocellular Carcinoma from Cirrhosis
Cancers doi: 10.3390/cancers11101497
Authors:
Kim
Cho
Yu
Jang
Yoon
Park
Cho
The established biomarker for hepatocellular carcinoma (HCC), serum α-fetoprotein (AFP), has suboptimal performance in early disease stages. This study aimed to develop a metabolite panel to differentiate early-stage HCC from cirrhosis. Cross-sectional metabolomic analyses of serum samples were performed for 53 and 47 patients with early HCC and cirrhosis, respectively, and 50 matched healthy controls. Results were validated in 82 and 80 patients with early HCC and cirrhosis, respectively. To retain a broad spectrum of metabolites, technically distinct analyses (global metabolomic profiling using gas chromatography time-of-flight mass spectrometry and targeted analyses using liquid chromatography with tandem mass spectrometry) were employed. Multivariate analyses classified distinct metabolites; logistic regression was employed to construct a prediction model for HCC diagnosis. Five metabolites (methionine, proline, ornithine, pimelylcarnitine, and octanoylcarnitine) were selected in a panel. The panel distinguished HCC from cirrhosis and normal controls, with an area under the receiver operating curve (AUC) of 0.82; this was significantly better than that of AFP (AUC: 0.75). During validation, the panel demonstrated significantly better predictability (AUC: 0.94) than did AFP (AUC: 0.78). Defects in ammonia recycling, the urea cycle, and amino acid metabolism, demonstrated on enrichment pathway analysis, may reliably distinguish HCC from cirrhosis. Compared with AFP alone, the metabolite panel substantially improved early-stage HCC detection.
Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00302841026182,00306932607174,alsfakia@gmail.com,
Πληροφορίες
Ετικέτες
Εγγραφή σε:
Σχόλια ανάρτησης (Atom)
Αρχειοθήκη ιστολογίου
-
►
2023
(276)
- ► Φεβρουαρίου (133)
- ► Ιανουαρίου (143)
-
►
2022
(1976)
- ► Δεκεμβρίου (116)
- ► Σεπτεμβρίου (158)
- ► Φεβρουαρίου (165)
- ► Ιανουαρίου (161)
-
►
2021
(3661)
- ► Δεκεμβρίου (161)
- ► Σεπτεμβρίου (274)
- ► Φεβρουαρίου (64)
- ► Ιανουαρίου (368)
-
►
2020
(4554)
- ► Δεκεμβρίου (400)
- ► Σεπτεμβρίου (381)
- ► Φεβρουαρίου (638)
- ► Ιανουαρίου (691)
-
▼
2019
(4999)
- ► Δεκεμβρίου (924)
-
▼
Οκτωβρίου
(1087)
- Medicine by Alexandros G. Sfakianakis,Anapafseos 5...
- Children, Vol. 6, Pages 119: Chest Compressi...
- Antibiotics, Vol. 8, Pages 203: Nursing St...
- Medicine by Alexandros G. Sfakianakis,Anapafseos 5...
- Cancer,
- Plants, Vol. 8, Pages 462: Effect of Oxygen ...
- Otology & Neurotology - Published Ahead-of-Pr...
- Hindawi Publishing Corporation,
- International Journal of Cancer,
- eCAM Evidence-Based Complementary and Alterna...
- Clinical Otolaryngology,
- A Study to Test Different Doses of BI 891065...
- Are BI-RADS 3 findings tracked effectively? ...
- The ROS-KRAS-Nrf2 axis in the control of the...
- Disseminated mucormycosis with cerebellum in...
- Definition of a Good Death, Attitudes Toward...
- Prognostic impact of the Controlling Nutriti...
- Peanut-allergy therapy 'protection not a cur...
- Applied Sciences, Vol. 9, Pages 4605: A Plan...
- Autophagy in Cancer Cell Death
- Remote Sensing, Vol. 11, Pages 2544: Suppres...
- IJMS, Vol. 20, Pages 5396: A Novel Claudinop...
- Agronomy, Vol. 9, Pages 694: Analysis of Fac...
- 3DPrint.com,
- Safety Profile of Sclerosing AgentsNo abstract a...
- Missed Study Visits and Subsequent HIV Incidence...
- What Are Our Opportunities in Preparing the Next...
- Comparison of drug-eluting balloon with repeat d...
- An unusual case of loperamide anaphylaxisPublica...
- Erreger, Resistenzmechanismen und etablierte The...
- Determination of Acrolein-Associated T 1 and T 2...
- Ovid and Titian 2012 The article Ovid and Titian...
- Endoscopic submucosal dissection of distal intes...
- The effect of transcutaneous electrical nerve sti...
- Assessment of post-operative healing following en...
- A comment on postmortem interrogation of cardiac...
- MR urethrography compared with operative finding...
- Understanding the Association Between Perceived ...
- Development of multiplex PCR to detect slow rust...
- Sicherheitsabstand von 2 cm ist bei Exzision von...
- Neonatal myocardial infarction: substantial impr...
- Diagnostic criteria should be considered when re...
- Predicting Psychiatric Rehospitalization in Adol...
- Robust protocol for feeder-free adaptation of cr...
- Molecular cloning and characterization of genes ...
- Therapeutic observation of Tui-pushing Wujing pl...
- Sitting time among adolescents across 26 Asia–Pa...
- Detection and measurements of apical lesions in ...
- Cortisol, oxytocin, and quality of life in major...
- Pharmaceutical applications of 3D printing techn...
- Sleep Med. 2019 Jun 8;63:142-150. doi: 10.1016/j...
- Med Educ. 2019 Oct 28. doi: 10.1111/medu.13998. ...
- Transl Androl Urol. 2019 Sep;8(Suppl 4):S436-S44...
- Biomed Chromatogr. 2019 Oct 28:e4727. doi: 10.10...
- The dental anomaly: how and why dental carie...
- Five decades of urologic pathology: the acce...
- [Diagnostic value of digital breast tomosynth...
- Tick-borne encephalitis virus detected in tic...
- Understanding and addressing social determina...
- The impact of targeted cathodal transcranial ...
- Anthropometric Analysis of the Human Skull f...
- Cancers, Vol. 11, Pages 1684: NEDD9 Inhibiti...
- Annexin A6 modulates TBC1D15/Rab7/StARD3 axi...
- Journal of Esthetic and Restorative Dentistry...
- Latest Results for Thyroid Research,
- NeuroImage,
- Trials -
- Latest Results for European Journal of Pediat...
- Journal of Oral and Maxillofacial Surgery,
- Milled versus moulded mock-ups based on the ...
- Phys.org: Cell & Microbiology News,
- Health sciences :
- American Journal of Epidemiology -
- Καλλιεργώντας ευγνωμοσύνη,
- American Journal of Otolaryngology,
- Formosan Journal of Surgery :
- Relaciones entre el factor-1α inducido por hipoxia...
- Medical News Today: What to know about press...
- Atmosphere, Vol. 10, Pages 660: Investigat...
- ScienceDirect Publication: Journal of Genetic...
- MedWorm Allergy & Immunology News,
- GEO series ,
- AUDIOLOGY,
- Latest Results for Conflict and Health,
- Modern Pathology -
- Latest Results for Der Chirurg,
- Latest Results for Pediatric Cardiology,
- Latest Results for Current Microbiology,
- BMJ Open recent issues,
- Plastic Surgery,
- American Society for Stereotactic and Functio...
- Latest Results for Maternal and Child Health ...
- ► Σεπτεμβρίου (845)
Δεν υπάρχουν σχόλια:
Δημοσίευση σχολίου