Date: Friday, 10 25, 2019; Speaker: Suzanne L. Topalian MD, Associate Director; Professor, Johns Hopkins University School of Medicine; Bldg 37; 2nd Floor Conference Rooms 2041& 2107 (Source: NIH Calendar of Events)MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.
Date: Friday, 10 25, 2019; Speaker: Nada Jabado, Professor, Department of Pediatrics, McGill University Health Centre (MUHC); Building: Building 10 (Clinical Center); Lipsett Amphitheater; Videocast Event (Source: NIH Calendar of Events)
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Related ArticlesLncRNA PTCSC3 inhibits the proliferation, invasion and migration of cervical cancer cells via sponging miR-574-5p. Clin Exp Pharmacol Physiol. 2019 Oct 06;: Authors: Tong R, Zhang J, Wang C, Li X, Yu T, Wang L Abstract Dysregulation of long non-coding RNA Papillary thyroid carcinoma susceptibility candidate 3 (lncRNA PTCSC3) has been found to correlate with various types of cancers. Quantitative RT-PCR showed a down-regulation of PTCSC3...
Related ArticlesAnti-tumor effects and associated molecular mechanisms of myricetin. Biomed Pharmacother. 2019 Oct 03;120:109506 Authors: Jiang M, Zhu M, Wang L, Yu S Abstract Myricetin (3, 5, 7, 3', 4', 5'-hexahydroxyflavone) is a natural flavonol compound found in a large variety of plants, including berries, oranges, grapes, herbs, teas, and wine. In the last decade, a convergence of evidence has demonstrated that myricetin has good biological activity...
Related ArticlesA potential role of cyclin-dependent kinase inhibitor 1 (p21/WAF1) in the pathogenesis of endometriosis: Directions for future research. Med Hypotheses. 2019 Sep 30;133:109414 Authors: Zarkadoulas N, Pergialiotis V, Dimitroulis D, Stefanidis K, Verikokos C, Perrea DN, Kontzoglou K Abstract Endometriosis is a common gynecological disorder that affects approximately 6-10% of the female population impairing the quality of life of patients....
Related ArticlesMicrowave synthesis of novel halogenated β-enaminonitriles linked 9-bromo-1H-benzo[f]chromene moieties: Induces cell cycle arrest and apoptosis in human cancer cells via dual inhibition of topoisomerase I and II. Bioorg Chem. 2019 Sep 20;93:103289 Authors: Fouda AM, Assiri MA, Mora A, Ali TE, Afifi TH, El-Agrody AM Abstract A novel series of halogenated β-enaminonitriles (4a-m), linked 9-bromo-1H-benzo[f]-hromene moieties, were synthesized...
Related ArticlesDesign, synthesis and biological evaluation of some new 1,3,4-thiadiazine-thiourea derivatives as potential antitumor agents against non-small cell lung cancer cells. Bioorg Chem. 2019 Sep 26;93:103323 Authors: Ragab FAF, Abdel-Aziz SA, Kamel M, Ouf AMA, Allam HA Abstract New 1,3,4-thiadiazine-thiourea derivatives have been synthesized. All the synthesized compounds were examined for in vitro cytotoxic activity against Non-Small Cell...
Related ArticlesThe antiproliferative effect of spectinabilins from Streptomyces spectabilis on hepatocellular carcinoma cells in vitro and in vivo. Bioorg Chem. 2019 Sep 24;93:103311 Authors: Gao X, Yao H, Mu Y, Guan P, Li G, Lin B, Jiang Y, Han L, Huang X, Jiang C Abstract Spectinabilin (1), spectinabilin derivative (2), and a new analogue, 2-demethyl-spectinabilin (3) were isolated from the fermentation broth of a soil-borne Streptomyces spectabilis...
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Acute encephalopathy is a common clinical presentation for hospital admissions. Autoimmune encephalitis is a rare cause of encephalopathy which has increasingly been recognized over the last decade. The detection of various neuronal antibodies has helped diagnose these syndromes, but they have limited availability, mostly in the developed countries. We present a case of a middle-aged female presenting with memory impairment, gait disturbances, and hyponatremia. A clinical diagnosis of autoimmune...
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Related ArticlesReal-time control of respiratory motion: Beyond radiation therapy. Phys Med. 2019 Oct 03;66:104-112 Authors: Cavedon C Abstract Motion management in radiation oncology is an important aspect of modern treatment planning and delivery. Special attention has been paid to control respiratory motion in recent years. However, other medical procedures related to both diagnosis and treatment are likely to benefit from the explicit control of...
Related ArticlesTrends in adherence to thromboprophylaxis guideline in patients undergoing radical cystectomy. Urology. 2019 Oct 03;: Authors: Tully KH, Krimphove MJ, Reese SW, Kibel AS, Noldus J, Krasnow RE, Trinh QD, Sonpavde GP, Chang SL, Mossanen M Abstract OBJECTIVE: To examine the use of in-hospital pharmacological thromboprophylaxis (PTP) in patients undergoing radical cystectomy (RC) between 2004-2014 and to assess the risk of VTE across the...
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Objectives The aim of this study was to describe our initial clinical experiences using a dedicated spiral breast computed tomography (B-CT) with a single photon-counting detector. Materials and Methods This retrospective study was approved by the institutional review board. Examinations of 300 consecutive women undergoing B-CT were evaluated on reason of assignment for B-CT instead of mammography, detection rate of breast cancer, and quality criteria of data acquisition. Further evaluated...
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Related ArticlesGlial pathology in a novel spontaneous mutant mouse of the Eif2b5 gene: a vanishing white matter disease model. J Neurochem. 2019 Oct 06;: Authors: Terumitsu-Tsujita M, Kitaura H, Miura I, Kiyama Y, Goto F, Muraki Y, Ominato S, Hara N, Simankova A, Bizen N, Kashiwagi K, Ito T, Toyoshima Y, Kakita A, Manabe T, Wakana S, Takebayashi H, Igarashi H Abstract Vanishing white matter disease (VWM) is an autosomal recessive neurological disorder...
Related ArticlesClinical features of vitamin D deficiency in children: A retrospective analysis. J Steroid Biochem Mol Biol. 2019 Oct 03;:105491 Authors: Zhang X, Liu Z, Xia L, Gao J, Xu F, Chen H, Du Y, Wang W Abstract Vitamin D is very important for children's health. Previous studies have shown that vitamin D deficiency leads to a series of diseases in adults. However, pediatricians are mostly aware of rickets caused by vitamin D deficiency in children...
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Pharmaceutics, Vol. 11, Pages 516: Evaluation of Different Techniques for Size Determination of Drug Nanocrystals: A Case Study of Celecoxib Nanocrystalline Solid Dispersion Pharmaceutics doi: 10.3390/pharmaceutics11100516 Authors: Kaur Parmar Bansal Celecoxib (CEL) Nanocrystalline Solid Dispersion (CEL_NCSD) was generated by spray drying CEL, mannitol (MAN) and sodium lauryl sulfate (SLS) from a solvent mixture of methanol, acetone and water. The purpose of the work was to...
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Postoperative biochemical recurrence occurs in up to 40% of prostate carcinoma patients treated with radical prostatectomy. Primary tumor grade and cribriform architecture are important parameters for clinical outcome; however, their relevance at positive surgical margins has not been completely elucidated yet. We reviewed 835 radical prostatectomy specimens and recorded pT-stage, surgical margin status, Grade Group, and cribriform architecture of the primary tumor and at positive surgical margins....
Sclerosing epithelioid fibrosarcoma (SEF) is an aggressive soft tissue sarcoma, characterized by a distinctive epithelioid phenotype in a densely sclerotic collagenous stroma, that shows frequent MUC4 immunoreactivity and recurrent gene fusions, often involving EWSR1 gene. A pathogenetic link with low-grade fibromyxoid sarcoma (LGFMS) has been suggested, due to cases with hybrid morphology as well as overlapping genetic signature. However, a small subset of SEF is negative for MUC4 and lacks the...
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