Effect of Vitamin C Infusion on Organ Failure and Biomarkers of Inflammation and Vascular Injury in Patients With Sepsis and Severe Acute Respiratory Failure: The CITRIS-ALI Randomized Clinical Trial

Alpha A. Fowler III, MD; Jonathon D. Truwit, MD; R. Duncan Hite, MD; et al

Editorial: Is High-Dose Vitamin C Beneficial for Patients With Sepsis?; Emily B. Brant, MD; Derek C. Angus, MD, MPH

JAMA

Effect of Postextubation High-Flow Nasal Oxygen With Noninvasive Ventilation vs High-Flow Nasal Oxygen Alone on Reintubation Among Patients at High Risk of Extubation Failure: A Randomized Clinical Trial

Arnaud W. Thille, MD, PhD; Grégoire Muller, MD; Arnaud Gacouin, MD; et al

Editorial: Added Benefit of Noninvasive Ventilation to High-Flow Nasal Oxygen to Prevent Reintubation in Higher-Risk Patients; Irene Telias, MD; Niall D. Ferguson, MD, MSc

JAMA Network Open

Association of Optimism With Cardiovascular Events and All-Cause Mortality: A Systematic Review and Meta-analysis

Alan Rozanski, MD; Chirag Bavishi, MD, MPH; Laura D. Kubzansky, PhD; et al

Invited Commentary: Optimism and Health; Jeff C. Huffman, MD

JAMA Oncology

Global, Regional, and National Cancer Incidence, Mortality, Years of Life Lost, Years Lived With Disability, and Disability-Adjusted Life-Years for 29 Cancer Groups, 1990 to 2017: A Systematic Analysis for the Global Burden of Disease Study

Global Burden of Disease Cancer Collaboration

JAMA Network Open

Alcohol Consumption and Risk of Dementia and Cognitive Decline Among Older Adults With or Without Mild Cognitive Impairment

Manja Koch, PhD; Annette L. Fitzpatrick, PhD; Stephen R. Rapp, PhD; et al

JAMA Oncology

The Effect of Abemaciclib Plus Fulvestrant on Overall Survival in Hormone Receptor–Positive, ERBB2-Negative Breast Cancer That Progressed on Endocrine Therapy—MONARCH 2: A Randomized Clinical Trial

George W. Sledge Jr, MD; Masakazu Toi, MD, PhD; Patrick Neven, MD, PhD; et al

JAMA Pediatrics

Association Between Screen Media Use and Academic Performance Among Children and Adolescents: A Systematic Review and Meta-analysis

Mireia Adelantado-Renau, MSc; Diego Moliner-Urdiales, PhD; Iván Cavero-Redondo, PhD; et al

Editorial: Disentangling the Association of Screen Time With Developmental Outcomes and Well-Being; Janis Whitlock, PhD, MPH; Philipp K. Masur, PhD

JAMA Pediatrics

Association of Relative Age in the School Year With Diagnosis of Intellectual Disability, Attention-Deficit/Hyperactivity Disorder, and Depression

Adrian Root, PhD; Jeremy P. Brown, MSc; Harriet J. Forbes, PhD; et al

JAMA Cardiology

Statin Use in Primary Prevention of Atherosclerotic Cardiovascular Disease According to 5 Major Guidelines for Sensitivity, Specificity, and Number Needed to Treat

Martin Bødtker Mortensen, MD, PhD; Børge Grønne Nordestgaard, MD, DMSc

JAMA Psychiatry

Association of Antidepressant Use With Adverse Health Outcomes: A Systematic Umbrella Review

Elena Dragioti, PhD; Marco Solmi, MD, PhD; Angela Favaro, MD, PhD; et al

JAMA Ophthalmology

Association of Opioids With Incisional Ocular Surgery

Anton M. Kolomeyer, MD, PhD; Yinxi Yu, MS; Brian L. VanderBeek, MD, MPH, MSCE

JAMA Surgery

Sex-Based Disparities in the Hourly Earnings of Surgeons in the Fee-for-Service System in Ontario, Canada

Fahima Dossa, MD; Andrea N. Simpson, MD, MSc; Rinku Sutradhar, PhD; et al

JAMA Otolaryngology - Head & Neck Surgery

A Next-Generation Single-Port Robotic Surgical System for Transoral Robotic Surgery: Results From Prospective Nonrandomized Clinical Trials

F. Christopher Holsinger, MD; J. Scott Magnuson, MD; Gregory S. Weinstein, MD; et al

JAMA Surgery

Guidelines for Perioperative Care in Cardiac Surgery: Enhanced Recovery After Surgery Society Recommendations

Daniel T. Engelman, MD; Walid Ben Ali, MD; Judson B. Williams, MD, MHS; et al

OPINION

JAMA

Is High-Dose Vitamin C Beneficial for Patients With Sepsis?

Emily B. Brant, MD; Derek C. Angus, MD, MPH

JAMA

Lefamulin—A New Antibiotic for Community-Acquired Pneumonia

Preeti N. Malani, MD, MSJ

JAMA Neurology

“It’s All in Your Head”—Medicine’s Silent Epidemic

Matthew J. Burke, MD, FRCPC

JAMA Dermatology

Natural Does Not Mean Safe—The Dirt on Clean Beauty Products

Courtney Blair Rubin, MD, MBE; Bruce Brod, MD

CLINICAL REVIEW & EDUCATION

JAMA

Prevention and Management of Venous Thromboembolism

Jonathan D. Paul, MD; Adam S. Cifu, MD

JAMA

Chronic Kidney Disease Diagnosis and Management: A Review

Teresa K. Chen, MD, MHS; Daphne H. Knicely, MD; Morgan E. Grams, MD, PhD

JAMA Internal Medicine

de Winter Electrocardiogram Pattern—An Unusual ST-Segment Elevation Myocardial Infarction Equivalent Pattern

Wei-Wei Xu, MD; Liang Lu, MD; Mei-Juan Jin, MD

JAMA Cardiology

Syncope After Percutaneous Coronary Intervention

Takahiro Tsushima, MD; Jayakumar Sahadevan, MD; Anselma Intini, MD

TRENDING AUDIO

JAMA Oncology Author Interview

Cost-effectiveness of Multigene Testing for All Patients With Breast Cancer

JAMA Dermatology Author Interview

Natural Does Not Mean Safe

JAMA Author Interview

The Risk and Cost of Limited Clinician and Patient Accountability in Health Care

JAMA Evidence: The Rational Clincial Examination

Does This Patient Have Acute Mountain Sickness?

JAMA Clinical Review

Update on Atrial Fibrillation: Review of the New AHA/ACC/HRS Treatment Guidelines