IJMS, Vol. 20, Pages 5218: The Antithrombotic Function of Sphingosine-1-Phosphate on Human Adipose-Stem-Cell-Recellularized Tissue Engineered Vascular Graft In Vitro International Journal of Molecular Sciences doi: 10.3390/ijms20205218 Authors: Chih-Hsun Lin Jen-Her Lu Kai Hsia Hsinyu Lee Chao-Ling Yao Hsu Ma Adipose stem cells (ASCs) show potential in the recellularization of tissue engineerined vascular grafts (TEVGs). However, whether sphingosine-1-phosphate (S1P) could...
Mon Oct 21, 2019 03:00
IJMS, Vol. 20, Pages 5214: Endothelial Dysfunction in Primary Aldosteronism International Journal of Molecular Sciences doi: 10.3390/ijms20205214 Authors: Zheng-Wei Chen Cheng-Hsuan Tsai Chien-Ting Pan Chia-Hung Chou Che-Wei Liao Chi-Sheng Hung Vin-Cent Wu Yen-Hung Lin TAIPAI Study Group Primary aldosteronism (PA) is characterized by excess production of aldosterone from the adrenal glands and is the most common and treatable cause of secondary hypertension....
Mon Oct 21, 2019 03:00
IJMS, Vol. 20, Pages 5215: Protective Effects of Flavone from Tamarix aphylla against CCl4-Induced Liver Injury in Mice Mediated by Suppression of Oxidative Stress, Apoptosis and Angiogenesis International Journal of Molecular Sciences doi: 10.3390/ijms20205215 Authors: Bishoy El-Aarag Asmaa Khairy Shaden A. M. Khalifa Hesham R. El-Seedi The current study aimed to investigate, for the first time, the beneficial effects of 3,5-dihydroxy-4′,7-dimethoxyflavone isolated...
Mon Oct 21, 2019 03:00
IJMS, Vol. 20, Pages 5213: Novel Peptidomic Approach for Identification of Low and High Molecular Weight Tauopathy Peptides Following Calpain Digestion, and Primary Culture Neurotoxic Challenges International Journal of Molecular Sciences doi: 10.3390/ijms20205213 Authors: Hamad Yadikar Connor Johnson Niko Pafundi Edwin Mouhawasse Lynn Nguyen Isabel Torres Milin Kurup Zhihui Yang Firas Kobeissy Richard Yost Kevin K. Wang Tauopathy is a class of a neurodegenerative...
Mon Oct 21, 2019 03:00
IJMS, Vol. 20, Pages 5211: Targeting NRF2 for the Treatment of Friedreich’s Ataxia: A Comparison among Drugs International Journal of Molecular Sciences doi: 10.3390/ijms20205211 Authors: Sara Petrillo Jessica D’Amico Piergiorgio La Rosa Enrico Silvio Bertini Fiorella Piemonte NRF2 (Nuclear factor Erythroid 2-related Factor 2) signaling is impaired in Friedreich’s Ataxia (FRDA), an autosomal recessive disease characterized by progressive nervous system damage and...
Mon Oct 21, 2019 03:00
IJMS, Vol. 20, Pages 5212: Trans-Kingdom Conjugation within Solid Media from Escherichia coli to Saccharomyces cerevisiae International Journal of Molecular Sciences doi: 10.3390/ijms20205212 Authors: Maximillian P. M. Soltysiak Rebecca S. Meaney Samir Hamadache Preetam Janakirama David R. Edgell Bogumil J. Karas Conjugation is a bacterial mechanism for DNA transfer from a donor cell to a wide range of recipients, including both prokaryotic and eukaryotic cells. In contrast...
Mon Oct 21, 2019 03:00
JCM, Vol. 8, Pages 1752: A TUG Value Longer Than 11 s Predicts Fall Risk at 6-Month in Individuals with COPD Journal of Clinical Medicine doi: 10.3390/jcm8101752 Authors: Vivien Reynaud Daniela Muti Bruno Pereira Annick Greil Denis Caillaud Ruddy Richard Emmanuel Coudeyre Frédéric Costes Risk of a fall is increased in individuals with chronic obstructive pulmonary disease (COPD), and is usually evaluated using the Berg Balance Scale (BBS), but this is difficult to...
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JCM, Vol. 8, Pages 1751: GSKIP-Mediated Anchoring Increases Phosphorylation of Tau by PKA but Not by GSK3beta via cAMP/PKA/GSKIP/GSK3/Tau Axis Signaling in Cerebrospinal Fluid and iPS Cells in Alzheimer Disease Journal of Clinical Medicine doi: 10.3390/jcm8101751 Authors: Ko Chiou Wong Wang Lai Chou Wang Loh Lieu Cheng Lin Lu Fann Huang Hong Based on the protein kinase A (PKA)/GSK3β interaction protein (GSKIP)/glycogen...
Mon Oct 21, 2019 03:00
JCM, Vol. 8, Pages 1749: Preoperative Clinical and Computed Tomography (CT)-Based Nomogram to Predict Oncologic Outcomes in Patients with Pancreatic Head Cancer Resected with Curative Intent: A Retrospective Study Journal of Clinical Medicine doi: 10.3390/jcm8101749 Authors: Shin Hye Hwang Ha Yan Kim Eun Ju Lee Ho Kyoung Hwang Mi-Suk Park Myeong-jin Kim Woo Jung Lee Yong Eun Chung Chang Moo Kang Background: Currently, proposed nomograms are mainly based on post-operative...
Mon Oct 21, 2019 03:00
JCM, Vol. 8, Pages 1750: Neonate Bloodstream Infections in Organization for Economic Cooperation and Development Countries: An Update on Epidemiology and Prevention Journal of Clinical Medicine doi: 10.3390/jcm8101750 Authors: Wójkowska-Mach Chmielarczyk Strus Lauterbach Heczko The term neonatal sepsis is used to describe a generalized bloodstream infection of bacterial, viral, or fungal origin which is associated with hemodynamic changes and other clinical symptoms...
Mon Oct 21, 2019 03:00
JCM, Vol. 8, Pages 1743: Probiotics in Adolescent Prediabetes: A Pilot RCT on Glycemic Control and Intestinal Bacteriome Journal of Clinical Medicine doi: 10.3390/jcm8101743 Authors: Charikleia Stefanaki Athanasios Michos George Mastorakos Aimilia Mantzou Georgios Landis Paraskevi Zosi Flora Bacopoulou Dysbiosis of intestinal ecology could be implicated in prediabetes. The aim of this pilot randomized controlled trial (RCT) was to collect preliminary data on the effects...
Mon Oct 21, 2019 03:00
JCM, Vol. 8, Pages 1747: Oral Anticoagulant Therapy—When Art Meets Science Journal of Clinical Medicine doi: 10.3390/jcm8101747 Authors: Patricia Lorena Cîmpan Romeo Ioan Chira Mihaela Mocan Florin Petru Anton Anca Daniela Farcaş Anticoagulant treatment is extremely important and frequently encountered in the therapy of various cardiovascular diseases. Vitamin K antagonists (VKA) are in use for the prevention and treatment of arterial and venous thromboembolism, despite the...
Mon Oct 21, 2019 03:00
JCM, Vol. 8, Pages 1748: Small Bowel—Key Player in Health and Disease Journal of Clinical Medicine doi: 10.3390/jcm8101748 Authors: Wojciech Marlicz Anastasios Koulaouzidis Over the last two decades, remarkable progress has been made in understanding the etiology and pathophysiology of diseases [...]
Mon Oct 21, 2019 03:00
JCM, Vol. 8, Pages 1746: The Endocrine Function of the Heart: Physiology and Involvements of Natriuretic Peptides and Cyclic Nucleotide Phosphodiesterases in Heart Failure Journal of Clinical Medicine doi: 10.3390/jcm8101746 Authors: Claire Lugnier Alain Meyer Anne Charloux Emmanuel Andrès Bernard Gény Samy Talha Besides pumping, the heart participates in hydro-sodium homeostasis and systemic blood pressure regulation through its endocrine function mainly represented by...
Mon Oct 21, 2019 03:00
JCM, Vol. 8, Pages 1745: Home-Based Exergaming on Preschoolers’ Energy Expenditure, Cardiovascular Fitness, Body Mass Index and Cognitive Flexibility: A Randomized Controlled Trial Journal of Clinical Medicine doi: 10.3390/jcm8101745 Authors: Zan Gao Jung Eun Lee Nan Zeng Zachary C. Pope Ying Zhang Xianxiong Li Purpose: The effects of exergaming-based physical activity (PA) interventions on preschoolers’ health outcomes and cognition remain largely unexplored....
Mon Oct 21, 2019 03:00
JCM, Vol. 8, Pages 1744: SOX2 Expression Is an Independent Predictor of Oral Cancer Progression Journal of Clinical Medicine doi: 10.3390/jcm8101744 Authors: Juan C. de Vicente Paula Donate-Pérez del Molino Juan P. Rodrigo Eva Allonca Francisco Hermida-Prado Rocío Granda-Díaz Tania Rodríguez Santamarta Juana M. García-Pedrero Potentially malignant oral lesions, mainly leukoplakia, are common. Malignant transformation varies widely, even in the absence of histological...
Mon Oct 21, 2019 03:00
J. Imaging, Vol. 5, Pages 82: Deep Learning of Fuzzy Weighted Multi-Resolution Depth Motion Maps with Spatial Feature Fusion for Action Recognition Journal of Imaging doi: 10.3390/jimaging5100082 Authors: Mahmoud Al-Faris John Chiverton Yanyan Yang David Ndzi Human action recognition (HAR) is an important yet challenging task. This paper presents a novel method. First, fuzzy weight functions are used in computations of depth motion maps (DMMs). Multiple length motion information...
Mon Oct 21, 2019 03:00
Medicina, Vol. 55, Pages 709: Left Atrial Function after Atrial Fibrillation Cryoablation Concomitant to Minimally Invasive Mitral Valve Repair: A Pilot Study on Long-Term Results and Clinical Implications Medicina doi: 10.3390/medicina55100709 Authors: Anselmino Rovera Marchetto Castagno Morello Frea Gaita Rinaldi De Ferrari Background and Objectives: Surgical atrial fibrillation (AF) ablation concomitant to minimally invasive mitral valve repair has...
Mon Oct 21, 2019 03:00
Medicina, Vol. 55, Pages 710: Assessing the Association of Elevated Zonulin Concentration in Stool with Increased Intestinal Permeability in Active Professional Athletes Medicina doi: 10.3390/medicina55100710 Authors: Hałasa Maciejewska Ryterska Baśkiewicz-Hałasa Safranow Stachowska Background and Objectives: The causative factors or conditions leading to increased intestinal permeability (IIP) have only been partly elucidated, suggesting excessive zonulin release...
Mon Oct 21, 2019 03:00
Medicina, Vol. 55, Pages 708: Maternal Blood Concentration of Tadalafil and Uterine Blood Flow in Pregnancy Medicina doi: 10.3390/medicina55100708 Authors: Tanaka Maki Magawa Nii Tanaka Ikemura Toriyabe Ikeda : Background and Objectives: Tadalafil for treatment of fetal growth restriction (FGR) or preeclampsia is given once a day orally. The drug kinetics of tadalafil were investigated to determine the ideal dosage to promote uterine blood flow. Materials...
Mon Oct 21, 2019 03:00
Medicina, Vol. 55, Pages 707: Predictive and Prognostic Factors in HCC Patients Treated with Sorafenib Medicina doi: 10.3390/medicina55100707 Authors: Oronzo Brunetti Antonio Gnoni Antonella Licchetta Vito Longo Angela Calabrese Antonella Argentiero Sabina Delcuratolo Antonio Giovanni Solimando Andrea Casadei-Gardini Nicola Silvestris Sorafenib is an oral kinase inhibitor that enhances survival in patients affected by advanced hepatocellular carcinoma (HCC)....
Mon Oct 21, 2019 03:00
Metabolites, Vol. 9, Pages 242: Inborn Errors of Metabolism in the Era of Untargeted Metabolomics and Lipidomics Metabolites doi: 10.3390/metabo9100242 Authors: Ismail Showalter Fiehn Inborn errors of metabolism (IEMs) are a group of inherited diseases with variable incidences. IEMs are caused by disrupting enzyme activities in specific metabolic pathways by genetic mutations, either directly or indirectly by cofactor deficiencies, causing altered levels of compounds associated...
Mon Oct 21, 2019 03:00
Metabolites, Vol. 9, Pages 241: Characterization of Lipid Profiles after Dietary Intake of Polyunsaturated Fatty Acids Using Integrated Untargeted and Targeted Lipidomics Metabolites doi: 10.3390/metabo9100241 Authors: Satoko Naoe Hiroshi Tsugawa Mikiko Takahashi Kazutaka Ikeda Makoto Arita Illuminating the comprehensive lipid profiles after dietary supplementation of polyunsaturated fatty acids (PUFAs) is crucial to revealing the tissue distribution of PUFAs in living organisms,...
Mon Oct 21, 2019 03:00
Metabolites, Vol. 9, Pages 240: Investigating the Protective Effect of Gross Saponins of Tribulus terrestris Fruit against Ischemic Stroke in Rat Using Metabolomics and Network Pharmacology Metabolites doi: 10.3390/metabo9100240 Authors: Yang Wang Wenjun Guo Yue Liu Jifeng Wang Meiling Fan Hongyu Zhao Shengxu Xie Yajuan Xu Stroke is one of the leading causes of death and long-term disability worldwide. Gross saponins of Tribulus terrestris fruit (GSTTF) has been...
Mon Oct 21, 2019 03:00
Molecules, Vol. 24, Pages 3794: Simultaneous Determination and Quantification of Triterpene Saponins from Camellia sinensis Seeds Using UPLC-PDA-QTOF-MS/MS Molecules doi: 10.3390/molecules24203794 Authors: Xuejin Wu Lingyan Jia Jiafan Wu Yawen Liu Hyunuk Kang Xiaobo Liu Pan Li Puming He Youying Tu Bo Li Saponins in the Camellia sinensis seeds have a broad spectrum of biological properties and application potentials. However, up to now, no chromatographic methods...
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Molecules, Vol. 24, Pages 3795: Bioactivities of Centaurium erythraea (Gentianaceae) Decoctions: Antioxidant Activity, Enzyme Inhibition and Docking Studies Molecules doi: 10.3390/molecules24203795 Authors: Laura Guedes Pedro B. P. S. Reis Miguel Machuqueiro Asma Ressaissi Rita Pacheco Maria Luísa Serralheiro Centaurium erythraea is recommended for the treatment of gastrointestinal disorders and to reduce hypercholesterolemia in ethno-medicinal practice. To perform a top-down...
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Molecules, Vol. 24, Pages 3793: Surface Display of Antigen Protein VP8* of Porcine Rotavirus on Bacillus Subtilis Spores Using CotB as a Fusion Partner Molecules doi: 10.3390/molecules24203793 Authors: Wanqiang Li Jie Feng Jiajun Li Jianzhen Li Zhenhua Wang Abdul Khalique Miao Yang Xueqin Ni Dong Zeng Dongmei Zhang Bo Jing Qihui Luo Kangcheng Pan Porcine rotavirus is a major cause of acute viral gastroenteritis in suckling piglets, and vaccination...
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Molecules, Vol. 24, Pages 3790: Levels of the Thiocyanate in the Saliva of Tobacco Smokers in Comparison to e-Cigarette Smokers and Nonsmokers Measured by HPLC on a Phosphatidylcholine Column Molecules doi: 10.3390/molecules24203790 Authors: Flieger Kawka Tatarczak-Michalewska The aim of the study was to estimate the thiocyanate levels in saliva of cigarette smokers in comparison to e-cigarette smokers and nonsmokers. To improve our understanding of the influence of smoking...
Mon Oct 21, 2019 03:00
Molecules, Vol. 24, Pages 3791: Effects of Olive and Pomegranate By-Products on Human Microbiota: A Study Using the SHIME® in Vitro Simulator Molecules doi: 10.3390/molecules24203791 Authors: Giuliani Marzorati Daghio Franzetti Innocenti Van de Wiele Mulinacci Two by-products containing phenols and polysaccharides, a “pâté” (OP) from the extra virgin olive oil milling process and a decoction of pomegranate mesocarp (PM),...
Mon Oct 21, 2019 03:00
Molecules, Vol. 24, Pages 3789: Atomic Force Microscope Guided SERS Spectra Observation for Au@Ag-4MBA@PVP Plasmonic Nanoparticles Molecules doi: 10.3390/molecules24203789 Authors: Yang Xu Wu Fang Zhong Wang Bu Yuan Recently polymer encapsulated surface-enhanced-Raman-scattering (SERS) probes with internal noble metal core–shell structure has found growing applications in biomedical applications. Here we studied the SERS spectra of Au@Ag–4MBA@PVP...
Mon Oct 21, 2019 03:00
Molecules, Vol. 24, Pages 3792: Study on Antibacterial and Quorum-Sensing Inhibition Activities of Cinnamomum camphora Leaf Essential Oil Molecules doi: 10.3390/molecules24203792 Authors: Wenting Wang Dongxiang Li Xiaoqin Huang Huixiang Yang Ziwen Qiu Liting Zou Qin Liang Yu Shi Yingxiang Wu Shaohua Wu Chao Yang Yongyu Li Many essential oils (EOs) regulate the quorum-sensing (QS) system of pathogens and inhibit the virulence expression. Interference with...
Mon Oct 21, 2019 03:00
Molecules, Vol. 24, Pages 3788: Erythroxylum in Focus: An Interdisciplinary Review of an Overlooked Genus Molecules doi: 10.3390/molecules24203788 Authors: Restrepo Saenz Jara-Muñoz Calixto-Botía Rodríguez-Suárez Zuleta Chavez Sanchez D’Auria The genus Erythroxylum contains species used by indigenous people of South America long before the domestication of plants. Two species, E. coca and E. novogranatense, have been utilized for thousands of years specifically...
Mon Oct 21, 2019 03:00
Molecules, Vol. 24, Pages 3787: Synthesis, Antiproliferative, and Antioxidant Evaluation of 2-Pentylquinazolin-4(3H)-one(thione) Derivatives with DFT Study Molecules doi: 10.3390/molecules24203787 Authors: Amira A. El-Sayed Mahmoud F. Ismail Abd El-Galil E. Amr Ahmed M. Naglah The current study was chiefly designed to examine the antiproliferative and antioxidant activities of some novel quinazolinone(thione) derivatives 6–14. The present work focused on two main points;...
Mon Oct 21, 2019 03:00
Molecules, Vol. 24, Pages 3786: A Glimepiride-Metformin Multidrug Crystal: Synthesis, Crystal Structure Analysis, and Physicochemical Properties Molecules doi: 10.3390/molecules24203786 Authors: Xufei Bian Lan Jiang Zongjie Gan Xiaoshu Guan Li Zhang Linhong Cai Xiangnan Hu A multidrug crystal based on drug combinations was synthesized by the solvent evaporation method. This multicomponent crystal consisted of antidiabetic drugs Glimepiride (Gli) and Metformin (Met),...
Mon Oct 21, 2019 03:00
Molecules, Vol. 24, Pages 3783: Succinylation Improves the Thermal Stability of Egg White Proteins Molecules doi: 10.3390/molecules24203783 Authors: Dabo He Ying Lv Qigen Tong Succinylation can improve the thermal stability of various proteins. In this study, succinylated egg white protein (SEWP) samples with different succinylation degrees were prepared by adding various succinic anhydride additives to egg white protein (EWP). The thermal stability of SEWP and the conformational...
Mon Oct 21, 2019 03:00
Molecules, Vol. 24, Pages 3784: PD-1-Targeted Discovery of Peptide Inhibitors by Virtual Screening, Molecular Dynamics Simulation, and Surface Plasmon Resonance Molecules doi: 10.3390/molecules24203784 Authors: Yuanqiang Wang Haiqiong Guo Zhiwei Feng Siyi Wang Yuxuan Wang Qingxiu He Guangping Li Weiwei Lin Xiang-Qun Xie Zhihua Lin The blockade of the programmed cell death protein 1/programmed cell death ligand 1 (PD-1/PD-L1) pathway plays a critical role in...
Mon Oct 21, 2019 03:00
Molecules, Vol. 24, Pages 3782: Synthesis of New Fused Heterocyclic 2-Quinolones and 3-Alkanonyl-4-Hydroxy-2-Quinolones Molecules doi: 10.3390/molecules24203782 Authors: Ashraf A. Aly Alaa A. Hassan Nasr K. Mohamed Lamiaa E. Abd El-Haleem Stefan Bräse Mika Polamo Martin Nieger Alan B. Brown Herein, we report the synthesis of 5,12-dihydropyrazino[2,3-c:5,6-c′]difuro[2,3-c:4,5-c′]-diquinoline-6,14(5H,12H)diones, 2-(4-hydroxy-2-oxo-1,2-dihydroquinolin-3-yl)-1,4-diphenyl-...
Mon Oct 21, 2019 03:00
Molecules, Vol. 24, Pages 3785: Sequential MCR via Staudinger/Aza-Wittig versus Cycloaddition Reaction to Access Diversely Functionalized 1-Amino-1H-Imidazole-2(3H)-Thiones Molecules doi: 10.3390/molecules24203785 Authors: Cecilia Ciccolini Giacomo Mari Gianfranco Favi Fabio Mantellini Lucia De Crescentini Stefania Santeusanio A multicomponent reaction (MCR) strategy, alternative to the known cycloaddition reaction, towards variously substituted 1-amino-1H-imidazole-2(3H)-thione...
Mon Oct 21, 2019 03:00
Molecules, Vol. 24, Pages 3781: G-Quadruplex-Forming Aptamers—Characteristics, Applications, and Perspectives Molecules doi: 10.3390/molecules24203781 Authors: Carolina Roxo Weronika Kotkowiak Anna Pasternak G-quadruplexes constitute a unique class of nucleic acid structures formed by G-rich oligonucleotides of DNA- or RNA-type. Depending on their chemical nature, loops length, and localization in the sequence or structure molecularity, G-quadruplexes are highly polymorphic structures...
Mon Oct 21, 2019 03:00
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