Tumor-Infiltrating CD1a + DCs and CD8 + /FoxP3 + Ratios Served as Predictors for Clinical Outcomes in Tongue Squamous Cell Carcinoma Patients

Abstract Tumor-infiltrating immune cells engage in an extensive crosstalk with tumors and act as two-edged swords by inhibiting or promoting cancer growth. Therefore, identifying the density and prognostic values of tumor-infiltrating immune cells will provide valuable tips for cancer treatments. In this study, we identified the density of tumor inflammatory infiltrates and the number of tumor-infiltrating immune cells, including CD3+, CD4+, CD8+, FoxP3+ T cells and CD1a+ dendritic...

Pathology & Oncology Research

03:00

Preoperative Diagnostic Categories of Noninvasive Follicular Thyroid Neoplasm with Papillary-Like Nuclear Features in Thyroid Core Needle Biopsy and Its Impact on Risk of Malignancy

Abstract This study was designed to evaluate the preoperative diagnostic categories of noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP) using thyroid core needle biopsy (CNB) and to analyze its impact on the risk of malignancy (ROM). A total of 2687 consecutive thyroid CNBs were reviewed retrospectively and classified into six diagnostic categories using a standardized reporting system similar to the Bethesda System for Reporting Thyroid Cytopathology....

Endocrine Pathology

03:00

Diagnostic concordance between whole slide imaging and conventional light microscopy in cytopathology: A systematic review

Many studies have examined the diagnostic concordance of whole slide imaging (WSI) and light microscopy (LM) for surgical pathology. In cytopathology, WSI use has been more limited, mainly because of technical issues. The aim of this study was to review the literature and determine the overall diagnostic concordance of WSI and LM in cytopathology. A systematic search of PubMed, Scopus, and the Cochrane Library was performed, with data extracted from the included articles. A quality assessment of...

Cancer Cytopathology

Thu Oct 10, 2019 16:26

Cytologic evaluation of p16 staining in head and neck squamous cell carcinoma in CytoLyt versus formalin‐fixed material

Background The management of high‐risk human papillomavirus (HR‐HPV)–related oropharyngeal head and neck squamous cell carcinomas (HNSCCs) are distinct from HNSCC linked to smoking and alcohol use. HR‐HPV–positive HNSCC frequently presents as a cervical lymph node metastasis. Because fine‐needle aspiration (FNA) is often the initial diagnostic procedure, evaluating HR‐HPV status in cytology specimens is important. The overexpression of p16 is a surrogate for HR‐HPV; however, the evaluation of p16...

Cancer Cytopathology

Thu Oct 10, 2019 16:23

Cytologic findings of proliferating trichilemmal tumor (PTT) of scalp

Diagnostic Cytopathology

Thu Oct 10, 2019 20:20