Abstract Iodinated contrast media (ICM) were introduced into clinical practice to improve both diagnostic imaging and therapeutic procedures. Current ICM formulations are based on tri‐iodobenzoic acid ring. Incidence of adverse reactions (AR) to ICM was 15% in 1975, but nowadays it has been reduced to 3% by using low‐osmolarity and non‐ionic ICM.
Mon Oct 21, 2019 12:50
Abstract Food allergy affects a small but significant number of children and adults. Food allergy is responsible for considerable morbidity and is the commonest cause of anaphylaxis in children. One of the aims of the European Union funded “Integrated Approaches to Food Allergen and Allergy Risk Management” (iFAAM) project was to improve our understanding of the best way to prevent the development of food allergy. Groups within the project worked on integrating the current prevention evidence base...
Sun Oct 20, 2019 20:29
Abstract Food allergy affects a small but important number of children and adults. Much of the morbidity associated with food allergy is driven by the fear of a severe reaction, and fatalities continue to occur. Foods are the commonest cause of anaphylaxis. One of the aims of the European Union funded Integrated Approaches to Food Allergen and Allergy Risk Management (iFAAM) project was to improve the identification and management of children and adults at risk of experiencing a severe reaction....
Sun Oct 20, 2019 20:23
Abstract Background Insomnia symptoms are common with asthma. The aim of the study was to analyze the associations between insomnia symptoms and asthma control, asthma severity, and asthma‐related comorbidity in a community‐based population. Methods Adults (n=23,875, ages 18‐45) from the community‐based LifeGene study answered a questionnaire on insomnia symptoms, airway symptoms, asthma diagnosis, asthma medication, and asthma‐related comorbidities (chronic rhinosinusitis, gastro‐esophageal...
Sun Oct 20, 2019 19:25
Background Significant advances have been made in transoral robotic surgery (TORS), yet its application in anterior skull‐base surgery has yet to be defined. This work explores the history of endoscopic sinus and anterior skull‐base surgery, and its advantages and disadvantages. The development of robotic surgery is then discussed as well as the advantages and disadvantages of TORS as it relates to the anterior skull base. The current applications for robotic surgery to the anterior skull base are...
Mon Oct 21, 2019 16:34
Key PointsThe mechanism of anemia in infection is unknown and differs according to infectious agent. M. avium infection causes reticulocytosis and enhanced liver erythrophagocytosis. IFN- is necessary for M. avium–induced anemia, but sensing by macrophages is not.
Mon Oct 21, 2019 23:00
Key PointsTopical CpG adjuvant with s.c. Ag vaccination promotes skin CD8 TRM. Topical CpG adjuvant activity depends on TLR9 expression by hematopoietic cells. Topical CpG adjuvant promotes global protection against dermal tumor challenge.
Mon Oct 21, 2019 23:00
Mon Oct 21, 2019 23:00
Key PointsDUOX2 mRNA expression is associated with poor prognosis in pancreatic cancer. IL-4 and IL-17A synergize to upregulate DUOX2 in pancreatic and colon cancer lines. DUOX2 upregulation increases the production of H2O2 and DNA damage.
Mon Oct 21, 2019 23:00
Mon Oct 21, 2019 23:00
Key PointsNKp44+ ILCs not only diminish SIV acquisition risk but also affect viremia control. NKp44+ and DN cells impact viremia control and disease course, respectively. Rectal SIV gp120-specific Ab-mediated ADCC is correlated with rectal CD16+NKp44+ ILCs.
Mon Oct 21, 2019 23:00
Platelets have long been known for their role in hemostasis. In this, platelet adhesion and activation leads to the formation of a firm thrombus and thus the sealing of a damaged blood vessel. More recently, inflammatory modes of function have been attributed to these non–nuclei-containing cellular fragments. Interaction with leukocytes, secretion of proinflammatory mediators, and migratory behavior are some of the recent discoveries. Nonetheless, platelets also have anti-inflammatory potential by...
Mon Oct 21, 2019 23:00
Key PointsInteraction of RV with TLR2 regulates RV-induced IFN expression via SIRT-1. SIRT-1 regulates RV-induced IFN expression via inhibition of JAK-STAT pathway. RV-induced excessive IFNs in COPD is associated with defective TLR2 signaling.
Mon Oct 21, 2019 23:00
Key PointsTCR- tetramer identified ligand expression by flow cytometry. TCR- ligands were induced on activated monocytes or T cells. Bioinformatics combined with mass spectrometry produced an overlapping list of 16 candidate ligands.
Mon Oct 21, 2019 23:00
Key PointsFlot1–/– CD8+ T cells have altered cell morphology and speeds in vivo. Flot1–/– CD8+ T cells show robust expansion and infiltration of peripheral tissues.
Mon Oct 21, 2019 23:00
Key PointsMice can control Mycobacterium avium infections independently of M activation by IFN-. TNF compensates for the lack of M activation by IFN-. Granulomas form without M activation by IFN-.
Mon Oct 21, 2019 23:00
Key PointsThe mRNA encoding for USP11 is preferentially translated in TREG cells. USP11 modulates TGF-β signaling in murine CD4+ T cells. The USP11/TGF-β axis favors TREG and TH17 cell development.
Mon Oct 21, 2019 23:00
Key PointsIntestinal ILCs protect against enteric L. monocytogenes infection. STAT4 signaling directs the protective ILC response to infection.
Mon Oct 21, 2019 23:00
Key PointsMice lacking Grk2 B cell expression develop a severe immune phenotype. Grk2 expression in B cells limits S1PR1 signaling but augments CXCR5 signaling. An S1PR1 antagonist partially normalizes the signaling defects and immune phenotypes.
Mon Oct 21, 2019 23:00
Key PointsA caspase-1 biosensor was generated to monitor spatiotemporal dynamics of inflammation. Biosensors allow the tracking of inflammatory events in living animals.
Mon Oct 21, 2019 23:00
Key PointsE. muris infection causes major changes in spleen morphology. The changes in lymphoid tissue organization were in part due to TNF-α. Neutralization of TNF-α resulted in an increase in GC-phenotype T-bet+ B cells.
Mon Oct 21, 2019 23:00
Key PointsHouse dust mites (HDM) may harbor a long dsRNA species (HDM-dsRNA). HDM-dsRNA induces an innate immune response that can attenuate type 2 inflammation.
Mon Oct 21, 2019 23:00
Key PointsBTLA–HVEM checkpoint axis regulates hepatic homeostasis and inflammation. Engagement of BTLA by HVEM triggers inhibitory signals for CD8+ T cell tolerization. A potential BTLA–HVEM–LIGHT modulatory network is involved in hepatitis.
Mon Oct 21, 2019 23:00
Key PointsThe structure of mite Der p 2 in complex with murine IgG mAb 7A1 was determined. Human IgE construct identified from phage-display library overlaps with mAb 7A1. Epitope mutagenesis analysis contributes to designing hypoallergens for therapy.
Mon Oct 21, 2019 23:00
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