• Latest Results for Journal of Cancer Research and Clinical Oncology
• Differential expression of p52 and RelB proteins in the metastatic and non-metastatic groups of uveal melanoma with patient outcome

  Abstract Purpose Non-canonical NFκB (NC-NFκB) pathway plays an influential role in metastasis, which promotes cancer proliferation and progression. The aim of the study was to examine the expression of NC-NFκB proteins and their correlation with clinicopathological factors associated with metastatic cases of uveal melanoma (UM) and with the patient outcome.

  Latest Results for Journal of Cancer Research and Clinical Oncology

  12h
• Postoperative biochemical recurrence of pathologically localized high-grade prostate cancer in adjuvant treatment-naïve patients

  Abstract Purpose To evaluate biochemical recurrence (BCR) risk in men with localized prostate cancer (PC) of pathological Gleason score (pGS) 8–10. Although such patients have low BCR-free survival (BCRFS) following radical prostatectomy (RP), they are not recommended for adjuvant radiation therapy (ART) as per current guidelines.

  Latest Results for Journal of Cancer Research and Clinical Oncology

  22h
• Latest Results for European Archives of Oto-Rhino-Laryngology
• Odontogenic tumours: a 25-year epidemiological study in the Marche region of Italy

  Abstract Purpose Epidemiological data of odontogenic tumours (OT) are conflicting, with significant differences among the countries. This study aims to evaluate incidence and prevalence of OTs in the Marche population in a period of 25 years, according to 4th Edition of WHO Classification. Methods In this

  Latest Results for European Archives of Oto-Rhino-Laryngology

  12h
• The use of structured reporting of head and neck ultrasound ensures time-efficiency and report quality during residency

  Abstract Purpose Free text reports (FTR) of head and neck ultrasound studies are currently deployed in most departments. Because of a lack of composition and language, these reports vary greatly in terms of quality and reliability. This may impair the learning process during residency. The purpose of the study was to analyze the longitudinal effects of using structured reports (SR) of

  Latest Results for European Archives of Oto-Rhino-Laryngology

  17h
• Latest Results for Clinical Oral Investigations
• Pain and quality of life after endodontic surgery with or without advanced platelet-rich fibrin membrane application: a randomized clinical trial

  Abstract Background Clinical evidence of the autologous platelet concentrates effects on the patient-reported outcome measures (PROMs) after endodontic surgery is still limited. Objectives To investigate the effect of the advanced platelet-rich fibrin (A-PRF+) membrane application upon patient postoperati

  Latest Results for Clinical Oral Investigations

  23h
• Latest Results for Clinical Drug Investigation
• Targeting Hormones for Improving Cognition in Major Mood Disorders and Schizophrenia: Thyroid Hormones and Prolactin

  Abstract Cognitive deficits are a core feature of serious mental illnesses such as major depression, bipolar disorder and schizophrenia and are a common cause of functional disability. However, the efficacy of pharmacological interventions for improving the cognitive deficits in these disorders is limited. As pro-cognitive pharmacological treatments are lacking, we aimed to review whether thyroid hormones or drugs that target p

  Latest Results for Clinical Drug Investigation

  13h
• Latest Results for European Journal of Nuclear Medicine and Molecular Imaging
• Head-to-head comparison of tau positron emission tomography tracers [ 18 F]flortaucipir and [ 18 F]RO948

  Abstract Purpose [18F]flortaucipir binds to paired helical filament tau and accurately identifies tau in Alzheimer’s disease (AD). However, “off-target” binding interferes with the quantification of [18F]flortaucipir in several brain regions. Recently, other tau PET tracers have been developed. Here, we compare [18F]flortaucipir with the novel tau tracer [18F]RO948 head-to-head in vivo

  Latest Results for European Journal of Nuclear Medicine and Molecular Imaging

  19h
• Latest Results for Nuclear Medicine and Molecular Imaging
• Amyloid PET Quantification Via End-to-End Training of a Deep Learning

  Abstract Purpose Although quantification of amyloid positron emission tomography (PET) is important for evaluating patients with cognitive impairment, its routine clinical use is hampered by complicated preprocessing steps and required MRI. Here, we suggested a one-step quantification based on deep learning using native-space amyloid PET images of different radiotracers acquired from m

  Latest Results for Nuclear Medicine and Molecular Imaging

  6h
• Odontology
• Surface roughness and wear behavior of occlusal splint materials made of contemporary and high-performance polymers

  Abstract With the development of a digital technology of computer-assisted manufacturing (CAD/CAM) and new age materials, the use of new types of occlusal splint is to consider. The aim of the present study was to evaluate the surface roughness (Ra) and wear behavior of different CAD/CAM materials against enamel antagonist through a simulated chewing test. A total of 75 specimens made from ethylene vinyl acetate (EVA), polymeth

  Odontology

  22h
• Journal of Clinical Periodontology
• Cleansing efficacy of waist‐shaped interdental brushes. A randomized‐controlled crossover study

  Abstract Objective To compare the cleansing efficacy of waist‐shaped versus cylindric interdental brushes in patients receiving supportive periodontal therapy. Materials and methods After sample size estimation, 20 periodontal maintenance patients diagnosed with periodontitis stage 3 were recruited. Brushing efficacy of waist‐shaped and cylindric interdental brushes was evaluated in a randomised‐controlled, examiner‐blinded, two‐period

  Journal of Clinical Periodontology

  10h
• Molecular Oral Microbiology
• Streptococcal peptides that signal Enterococcus faecalis cells carrying the pheromone‐responsive conjugative plasmid pAM373

  Abstract Pheromone‐mediated conjugative transfer of enterococcal plasmids can contribute to the dissemination of genes involved in antibiotic resistance, fitness, and virulence among co‐residents of mixed microbial communities. We have previously shown that intergeneric signaling by the Streptococcus gordonii strain Challis heptapeptide s.g.cAM373 (SVFILAA) induces an aggregation‐substance‐mediated mating response and facilitates plasmid transfe

  Molecular Oral Microbiology

  7h
• Bioethics.net » News
• Canada’s Decision To Make Public More Clinical Trial Data Puts Pressure On FDA

  Canada’s Decision To Make Public More Clinical Trial Data Puts Pressure On FDA Source: National Public RadioLast March, Canada’s department of health changed the way it handles the huge amount of data that companies submit when seeking approval for a new drug, biological treatment, or medical device — or a new use for an existing one. For the first time, Health Canada is making large chunks of this information publicly available after it approve

  Bioethics.net » News

  18h
• PeerJ
• ncRNA2MetS: a manually curated database for non-coding RNAs associated with metabolic syndrome

  Metabolic syndrome is a cluster of the most dangerous heart attack risk factors (diabetes and raised fasting plasma glucose, abdominal obesity, high cholesterol and high blood pressure), and has become a major global threat to human health. A number of studies have demonstrated that hundreds of non-coding RNAs, including miRNAs and lncRNAs, are involved in metabolic syndrome-related diseases such as obesity, type 2 diabetes mellitus, hypertension

  PeerJ

  36m
• Borrowing from Peter to pay Paul: managing threatened predators of endangered and declining prey species

  Conservation policy and practice can sometimes run counter to their mutual aims of ensuring species survival. In Kenya, where threatened predators such as lion deplete endangered prey such as Grevy’s zebra, conservation practitioners seek to ensure species success through exclusive strategies of protection, population increase and preservation. We found strong selection for the endangered Grevy’s zebra by both lion and hyena on two small fenced c

  PeerJ

  36m
• Preoperative inflammatory markers of NLR and PLR as indicators of poor prognosis in resectable HCC

  Background Many recent studies have demonstrated the predominant role chronic inflammation plays in cancer cell propagation, angiogenesis and immunosuppression. Cancer-related inflammation (CRI) has been shown to correlate with poor cancer prognosis. Our study aimed to evaluate the prognostic value of the neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) in patients with hepatocellular carcinoma (HCC) wh

  PeerJ

  22h
• Land use conversion from peat swamp forest to oil palm agriculture greatly modifies microclimate and soil conditions

  Oil palm (Elaeis guineensis) agriculture is rapidly expanding and requires large areas of land in the tropics to meet the global demand for palm oil products. Land cover conversion of peat swamp forest to oil palm (large- and small-scale oil palm production) is likely to have negative impacts on microhabitat conditions. This study assessed the impact of peat swamp forest conversion to oil palm plantation on microclimate conditions and soil charac

  PeerJ

  22h
• Population genetics and historical demographic inferences of the blue crab Callinectes sapidus in the US based on microsatellites

  The native range of the blue crab Callinectes sapidus spans Nova Scotia to northern Argentina. In the US, it constitutes a keystone species in estuarine habitats of the Atlantic coast and Gulf of Mexico (GOM), serving as both predator and prey to other species, and also has historically represented a multi-billion dollar fishery. Knowledge relevant to effective management and monitoring of this ecologically and economically important species, suc

  PeerJ

  22h
• Environmental filtering of body size and darker coloration in pollinator communities indicate thermal restrictions on bees, but not flies, at high elevations

  Background Bees and flies are the two most dominant pollinator taxa in mountain environments of the Southwest USA. Communities of both taxa change dramatically along elevation gradients. We examined whether bee and fly traits would also change along elevation gradients and if so, do they change in a predictable way related to a decrease in temperature as elevation increases. Methods

  PeerJ

  23h
• Supernumerary teeth observed in a live True’s beaked whale in the Bay of Biscay

  Mesoplodont beaked whales are one of the most enigmatic mammalian genera. We document a pod of four beaked whales in the Bay of Biscay breaching and tail slapping alongside a large passenger ferry. Photographs of the animals were independently reviewed by experts, and identified as True’s beaked whales (Mesoplodon mirus). This is the first conclusive live sighting of these animals in the north-east Atlantic, and adds information to previous sight

  PeerJ

  23h
• The planktonic stages of the salmon louse (Lepeophtheirus salmonis) are tolerant of end-of-century pCO2 concentrations

  The copepod Lepeophtheirus salmonis is an obligate ectoparasite of salmonids. Salmon lice are major pests in salmon aquaculture and due to its economic impact Lepeophtheirus salmonis is one of the most well studied species of marine parasite. However, there is limited understanding of how increased concentration of pCO2 associated with ocean acidification will impact host-parasite relationships. We investigated the effects of increased pCO2 on gr

  PeerJ

  23h
• The relationships between water storage and biomass components in two conifer species

  Background Water storage is a significant physiological index of vegetation growth. However, information on water storage at the individual tree level and its relationship to climatic conditions and productivity is scarce. Methods We performed a comparative analysis of water storage using field measurements acquired three age classes of Chinese fir (Cunninghamia lanceolata) and Korean larch (Larix olgensis). The distributions of water

  PeerJ

  23h
• Layered patterns in nature, medicine, and materials: quantifying anisotropic structures and cyclicity

  Various natural patterns—such as terrestrial sand dune ripples, lamellae in vertebrate bones, growth increments in fish scales and corals, aortas and lamellar corpuscles in humans and animals—comprise layers of different thicknesses and lengths. Microstructures in manmade materials—such as alloys, perlite steels, polymers, ceramics, and ripples induced by laser on the surface of graphen—also exhibit layered structures. These layered patterns form

  PeerJ

  23h
• A prognostic nomogram for overall survival in male breast cancer with histology of infiltrating duct carcinoma after surgery

  Objective The study was designed to construct and validate a nomogram for predicting overall survival (OS) of male breast cancer (MBC) patients with infiltrating duct carcinoma (IDC). Methods The cohort was selected from the Surveillance, Epidemiology, and End Results (SEER) database between January 1, 2004 and December 31, 2013. Univariate and multivariate Cox propo

  PeerJ

  23h
• Genome-wide identification and expression analysis of the WRKY genes in sugar beet (Beta vulgaris L.) under alkaline stress

  Background The WRKY transcription factor family plays crucial roles in many aspects of physiological processes and adaption to environment. Although the WRKY genes have been widely identified in various plant species, the structure and function of the WRKY family in sugar beet (Beta vulgaris L.) remains unknown. Methods In the present study, the WRKY genes were ident

  PeerJ

  23h
• Beetle larvae with unusually large terminal ends and a fossil that beats them all (Scraptiidae, Coleoptera)

  Larvae, and especially fossil larvae, are challenging to deal with from a purely taxonomic view. Often one cannot determine which species the larvae belong to. Yet, larvae can still contribute to various scientific questions. Especially morphological traits of a fossil larva can be highly informative for reconstructing character evolution. Also the occurrence of specific larval types and larval characters in time and the disappearance of such for

  PeerJ

  23h
• Bioinformatic and biochemical analysis of the key binding sites of the pheromone binding protein of Cyrtotrachelus buqueti Guerin-Meneville (Coleoptera: Curculionidea)

  The bamboo snout beetle Cyrtotrachelus buqueti is a widely distributed wood-boring pest found in China, and its larvae cause significant economic losses because this beetle targets a wide range of host plants. A potential pest management measure of this beetle involves regulating olfactory chemoreceptors. In the process of olfactory recognition, pheromone-binding proteins (PBPs) play an important role. Homology modeling and molecular docking were

  PeerJ

  23h
• Oomycete metabarcoding reveals the presence of Lagenidium spp. in phytotelmata

  The oomycete genus Lagenidium, which includes the mosquito biocontrol agent L. giganteum, is composed of animal pathogens, yet is phylogenetically closely related to the well characterized plant pathogens Phytophthora and Pythium spp. These phylogenetic affinities were further supported by the identification of canonical oomycete effectors in the L. giganteum transcriptome. In this study, culture-independent, metabarcoding analyses aimed at detec

  PeerJ

  23h