Paraoxonase 1: The Lectin-Like Oxidized LDL Receptor Type I and Oxidative Stress in the Blood of Men with Type II ObesityObjectives. Obesity has serious consequences such as the onset of metabolic syndrome, type 2 diabetes, atherosclerosis, or cardiovascular complications. The aim of this study was to evaluate the levels of paraoxonase 1 (PON1), lectin-like oxidized LDL receptor-1 (LOX-1), antioxidant enzymes (superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx)), and lipid peroxidation processes in the course of obesity. Methods. 28 men tooScienceDirect Publication: Medical Hypotheses
- Why is folate effective in preventing neural tube closure defects?Publication date: Available online 14 October 2019Source: Medical HypothesesAuthor(s): Kohji SatoAbstractNeural tube defects (NTDs) originate from a failure of the embryonic neural tube to close. The pathogenesis of NTDs is largely unknown. Fortunately, adequate maternal folate application is known to reduce the risk of human NTDs. However, why folate reduces NTDs is largely unknown.The main cause for NTDs is the disturbance of the cell growth in
- A plausible pathway of imprinted behaviors: skin-to-skin actions of the newborn immediately after birth follow the order of fetal development and intrauterine training of movementsPublication date: Available online 14 October 2019Source: Medical HypothesesAuthor(s): Ann-Marie Widström, Kajsa Brimdyr, Kristin Svensson, Karin Cadwell, Eva NissenAbstractWe hypothesize that the competence of a newborn in the first hours after birth is the direct result of behavior training that begins during the first 12 weeks of fetal life. Correlation of Widström’s 9 Instinctive Stages (behaviors of the full-term newborn during the first hou
Acta Cirurgica Brasileira
- Effect of miR-134 against myocardial hypoxia/reoxygenation injury by directly targeting NOS3 and regulating PI3K/Akt pathwayAbstract Purpose To reveal the function of miR-134 in myocardial ischemia. Methods Real-time PCR and western blotting were performed to measure the expression of miR-134, nitric oxide synthase 3 (NOS3) and apoptotic-associated proteins. Lactic dehydrogenase (LDH) assay, cell counting kit-8 (CCK-8), Hoechst 33342/PI double staining and flow cytometry assay were implemented in H9c2 cells, respectively. MiR-134 mimic/inhibitor was used to regulate
- Stereological analysis of elastic fibers of the corpus cavernosum of rats during the aging processAbstract Purpose To evaluate changes in the quantity of elastic fibers in the corpora cavernosa of rats during the natural aging process, and to assess the degree of this change by determining volumetric density (Vv) at different ages via stereological analysis. Methods Forty-eight rats, raised under similar conditions, were subjected to the natural aging process and divided into four groups (G1 to G4), according to age at the time of penecto
- The effect of different flushing methods in a short peripheral catheterAbstract Purpose To develop a rabbit model of a short peripheral catheter (SPC) and to observe the effects of different flushing methods on blood vessels. Methods Thirty rabbits were randomly divided into three groups (A, B, and C), with ten rabbits per group. In group A, we used pulsed flush; in group B, we used uniform flush; and no treatment was used in group C. Results We observed that a uniform flush reduced blockage, phlebitis, and ex
- Effect of sevoflurane pretreatment in relieving liver ischemia/reperfusion-induced pulmonary and hepatic injuryAbstract Purpose To investigate the effect of sevoflurane preconditioning on ischemia/reperfusion (I/R)-induced pulmonary/hepatic injury Methods Fifty-one Wistar rats were randomly grouped into sham, I/R, and sevoflurane groups. After reperfusion, the structural change of the lung was measured by Smith score, the wet and dry weights (W/D) were determined, malondialdehyde (MDA) myeloperoxidase (MPO) content was determined colorimetrically and
- The effect of fibrin glue in preventing staple-line leak after sleeve gastrectomy. An experimental study in ratsAbstract Purpose To evaluate the effect of fibrin glue on staple-line leak after sleeve gastrectomy. Methods Fourteen adult wistar rats 300 gr were randomized into two groups: Control group (n=7) and study group (n=7). All the rats underwent sleeve gastrectomy using lineer stapler. In the study group, fibrin glue was used to reinforce the staple-line. The rats were sacrificed 7 days after surgery. The stomach was resected, submerged in saline a
- Effects of cyclosporine on ischemia-reperfusion injuries in rat kidneys. An experimental modelAbstract Purpose To assess Cyclosporine A (CsA) therapy at an intraperitoneal dose of 15 mg.kg -1 in a rodent model of non-septic renal ischemia. Methods Twenty male Wistar rats were randomized to receive CsA therapy or none therapy before undergoing 30 minutes of renal ischemia followed by reperfusion. Additionally, 10 rats were randomized to undergo the same surgical procedure of the aforementioned animals with neither ischemia nor CsA therap
- Mitigating effect of tanshinone IIA on ventricular remodeling in rats with pressure overload-induced heart failureAbstract Purpose To investigate the effect of tanshinone IIA (TIIA) on ventricular remodeling in rats with pressure overload-induced heart failure. Methods Pressure overload-induced heart failure model (abdominal aortic coarctation) was established in 40 rats, which were divided into model and 5, 10 and 20 mg/kg TIIA groups. Ten rats receiving laparotomy excepting abdominal aortic coarctation were enrolled in sham-operated group. The 5, 10 and
!@ Rare Cancers
- Prognostic factors after treatment for iterative thymoma recurrences: A multicentric experience.Related ArticlesPrognostic factors after treatment for iterative thymoma recurrences: A multicentric experience. Lung Cancer. 2019 Sep 30;138:27-34 Authors: Chiappetta M, Zanfrini E, Giraldi L, Mastromarino MG, Petracca-Ciavarella L, Nachira D, Congedo MT, Aprile V, Ambrogi MC, Lucchi M, Filosso PL, Ruffini E, Guerrera F, Mulè A, Alì G, Molinaro L, Lococo F, Meacci E, Margaritora S Abstract OBJECTIVE
- A multifocal glioneuronal tumor with RGNT-like morphology occupying the supratentorial ventricular system and infiltrating the brain parenchyma.Related ArticlesA multifocal glioneuronal tumor with RGNT-like morphology occupying the supratentorial ventricular system and infiltrating the brain parenchyma. World Neurosurg. 2019 Oct 10;: Authors: Morassi M, Vivaldi O, Cobelli M, Liserre B, Zorzi F, Bnà C Abstract BACKGROUND: rosette forming glioneuronal tumors (RGNTs) with multifocal growth throughout the ventricular system are extremely rare, a
Mediators of Inflammation
- Possible Roles of IL-33 in the Innate-Adaptive Immune Crosstalk of Psoriasis PathogenesisBackground. IL-33 belongs to the IL-1 family, playing a role in several biologic processes as well as in the pathogenesis of different diseases, including skin pathologies. It acts as an alarmin, released by damaged cells. Binding to a ST2 receptor, it stimulates many immune cells such as ILC2 and Th2 cells. IL-33/ST2 axis seems to be involved in Th17 response. According to this, a review was performed to analyze if IL-33 even interplay in the on
Latest Results for Inflammation
- Inhibition of NADPH Oxidase-Derived Reactive Oxygen Species Decreases Expression of Inflammatory Cytokines in A549 CellsAbstract Various experimental models strongly support the hypothesis that airway inflammation can be caused by oxidative stress. Inflammatory airway diseases like asthma and COPD are characterized by higher levels of ROS and inflammatory cytokines. One of the sources of ROS is NADPH oxidase. Therefore, the aim of the study was to investigate influence of NADPH oxidase inhibition on the expression of IL-6, IL
- GFI-1 Protects Against Lipopolysaccharide-Induced Inflammatory Responses and Apoptosis by Inhibition of the NF-κB/TNF-α Pathway in H9c2 CellsAbstract Growth factor independence 1 (Gfi-1) has been widely studied for its anti-inflammatory and anti-apoptotic effects. However, whether Gfi-1 has similar effects on H9c2 cardiomyocytes has not yet been reported. In this study, we explored the effect of Gfi-1 on lipopolysaccharide (LPS)-induced inflammatory responses and apoptosis in H9c2 cells. We found that LPS induced the increased expression of TNF-α
- Pain and quality of life after endodontic surgery with or without advanced platelet-rich fibrin membrane application: a randomized clinical trialAbstract Background Clinical evidence of the autologous platelet concentrates effects on the patient-reported outcome measures (PROMs) after endodontic surgery is still limited. Objectives To investigate the effect of the advanced platelet-rich fibrin (A-PRF+) membrane application upon patient postoperati
- Lesion network mapping analysis identifies potential cause of post-operative depression in a case of cingulate low-grade glioma.Related ArticlesLesion network mapping analysis identifies potential cause of post-operative depression in a case of cingulate low-grade glioma. World Neurosurg. 2019 Oct 10;: Authors: Mansouri A, Boutet A, Elias G, Germann J, Yan H, Babu H, Lozano AM, Valiante T Abstract BACKGROUND: Depression following resection of diffuse low-grade gliomas (DLGG) has rarely been described. The location of the tumo
- Rare bony diastematomyelia associated with intraspinal teratoma.Related ArticlesRare bony diastematomyelia associated with intraspinal teratoma. World Neurosurg. 2019 Oct 10;: Authors: Ge CY, Hao DJ, M D, Shan LQ PMID: 31606509 [PubMed - as supplied by publisher]
- Gamma Knife Radiosurgery for Short Unilateral Neuralgiform Headache Attacks with Conjunctival injection and Tearing (SUNCT) Syndrome: Targeting the Trigeminal Nerve and the Sphenopalatine Ganglion. Case Report and Literature Review.Related ArticlesGamma Knife Radiosurgery for Short Unilateral Neuralgiform Headache Attacks with Conjunctival injection and Tearing (SUNCT) Syndrome: Targeting the Trigeminal Nerve and the Sphenopalatine Ganglion. Case Report and Literature Review. World Neurosurg. 2019 Oct 10;: Authors: Zaed I, Attuati L, Tommasino C, Arosio EM, Navarria P, Stravato A, Colombo G, Picozzi P Abstract BACKGROUND: Short
- Refined Functional Magnetic Resonance Imaging and Magnetoencephalography mapping reveals reorganization in language-relevant areas of lesioned brains.Related ArticlesRefined Functional Magnetic Resonance Imaging and Magnetoencephalography mapping reveals reorganization in language-relevant areas of lesioned brains. World Neurosurg. 2019 Oct 10;: Authors: Zimmermann M, Rössler K, Kaltenhäuser M, Grummich P, Yang B, Buchfelder M, Doerfler A, Kölble K, Stadlbauer A Abstract BACKGROUND: Neurosurgical decisions regarding interventions close to brain ar
- Ruptured persistent trigeminal artery-basilar artery junction aneurysm: a case report and review of literature.Related ArticlesRuptured persistent trigeminal artery-basilar artery junction aneurysm: a case report and review of literature. World Neurosurg. 2019 Oct 10;: Authors: Shah KA, Katz JM PMID: 31606505 [PubMed - as supplied by publisher]
- Establishment of a therapeutic ratio for Gamma Knife Radiosurgery of trigeminal neuralgia: The critical importance of biologically effective dose (BED) versus physical dose.Related ArticlesEstablishment of a therapeutic ratio for Gamma Knife Radiosurgery of trigeminal neuralgia: The critical importance of biologically effective dose (BED) versus physical dose. World Neurosurg. 2019 Oct 09;: Authors: Tuleasca C, Paddick I, Hopewell JW, Jones B, Millar WT, Hamdi H, Porcheron D, Levivier M, Régis J Abstract OBJECTIVES: How variations of treatment time affect the safety/eff
- YKL-40, SAA1, CRP and PCT are promising biomarkers for intracranial severity assessment of traumatic brain injury: Relationship with Glasgow Coma Scale and CT volumetry.Related ArticlesYKL-40, SAA1, CRP and PCT are promising biomarkers for intracranial severity assessment of traumatic brain injury: Relationship with Glasgow Coma Scale and CT volumetry. World Neurosurg. 2019 Oct 10;: Authors: Carabias CS, Gomez PA, Panero I, Eiriz C, Castaño-León AM, Egea J, Lagares A, i+12 Neurotraumatology Group collaborators, Paredes I, Fernández Alén JA, Moreno-Gómez LM, García-Pérez D, Chico-Fern
- Lower extremity paralysis after radiofrequency ablation of vertebral metastases.Related ArticlesLower extremity paralysis after radiofrequency ablation of vertebral metastases. World Neurosurg. 2019 Oct 10;: Authors: Huntoon K, Eltobgy M, Mohyeldin A, Elder JB Abstract BACKGROUND: Radiofrequency ablation (RFA) focally destroys abnormal or dysfunctional tissue using thermal energy generated from alternating current. The utilization of RFA has gained popularity as a minimally inva
- Big Data in Neurosurgery: Harder, Better, Faster, Stronger?Related ArticlesBig Data in Neurosurgery: Harder, Better, Faster, Stronger? World Neurosurg. 2019 Oct 10;: Authors: Kerezoudis P PMID: 31606501 [PubMed - as supplied by publisher]
- Reducing the reported mortality index within a neurocritical care unit through documentation and coding accuracy.Related ArticlesReducing the reported mortality index within a neurocritical care unit through documentation and coding accuracy. World Neurosurg. 2019 Oct 10;: Authors: Kessler BA, Catalino MP, Jordan JD Abstract BACKGROUND/OBJECTIVE: The mortality index, or the ratio of observed to expected mortality, is a reported quality metric that is assumed to directly reflect patient care. However, documentat
- An experimental clamping and cutting study of carotid and intracranial stents. Preparation for surgical rescue in stent troubles.Related ArticlesAn experimental clamping and cutting study of carotid and intracranial stents. Preparation for surgical rescue in stent troubles. World Neurosurg. 2019 Oct 10;: Authors: Arai S, Mizutani T, Sugiyama T, Sumi K, Matsumoto M, Okumura H, Shimizu K Abstract OBJECTIVE: To carry out surgery safely for vessels in which stents were placed, it is essential to have knowledge of what would happen
- Use of Cervical Disc Arthroplasty to Treat Non-Contiguous Cervical Disc Herniations: A Case Report.Related ArticlesUse of Cervical Disc Arthroplasty to Treat Non-Contiguous Cervical Disc Herniations: A Case Report. World Neurosurg. 2019 Oct 10;: Authors: Brusko GD, Luther E, Levi AD Abstract BACKGROUND: Cervical disc arthroplasty (CDA) is now a widely accepted alternative to anterior cervical interbody fusion, which is known to reduce normal cervical motion and increase the incidence of adjacent s
- Pseudohypoxic Brain Swelling: report of 2 cases and introduction of the Lentiform Rim Sign as Potential MRI Marker.Related ArticlesPseudohypoxic Brain Swelling: report of 2 cases and introduction of the Lentiform Rim Sign as Potential MRI Marker. World Neurosurg. 2019 Oct 10;: Authors: Sotoudeh H, Chapman PR, Sotoudeh E, Singhal A, Choudhary G, Shafaat O Abstract BACKGROUND: A rare but important complication related to otherwise uneventful brain and spine surgery is becoming more recognized and more frequently re
- Indirect Tumor Inhibitory Effects of MicroRNA-124 through Targeting EZH2 in The Multiple Myeloma Cell Line.Related ArticlesIndirect Tumor Inhibitory Effects of MicroRNA-124 through Targeting EZH2 in The Multiple Myeloma Cell Line. Cell J. 2020 Apr;22(1):23-29 Authors: Sabour Takanlu J, Aghaie Fard A, Mohammdi S, Hosseini Rad SMA, Abroun S, Nikbakht M Abstract Objective: Multiple myeloma (MM) is an incurable plasma cell malignancy. Several genetic and epigenetic changes affect numerous critical genes expre
- Methods for the expression, purification, and crystallization of histone deacetylase 6-inhibitor complexes.Related ArticlesMethods for the expression, purification, and crystallization of histone deacetylase 6-inhibitor complexes. Methods Enzymol. 2019;626:447-474 Authors: Osko JD, Christianson DW Abstract Histone deacetylase (HDAC) isozymes modulate numerous regulatory signals and pathways in biological systems, hence serving as targets for drug design. For example, HDAC6 is the cytosolic tubulin deacety
- Current and future aspects of several adjunctive treatment strategies in polycystic ovary syndrome.Related ArticlesCurrent and future aspects of several adjunctive treatment strategies in polycystic ovary syndrome. Reprod Biol. 2019 Oct 09;: Authors: Banaszewska B, Pawelczyk L, Spaczynski R Abstract Polycystic ovary syndrome (PCOS) is a common endocrinopathy in women of reproductive age. PCOS is characterized by hyperandrogenism, menstrual disorders, and polycystic ovarian morphology. PCOS patient
- Long-Term Response to Vasoactive Treatment in a Case of Kyphoscoliosis-Associated Pulmonary Hypertension.Related ArticlesLong-Term Response to Vasoactive Treatment in a Case of Kyphoscoliosis-Associated Pulmonary Hypertension. Am J Case Rep. 2019 Oct 13;20:1505-1508 Authors: Tellermann J, Sablinskis M, Machado PRR, Sablinskis K, Skride A Abstract BACKGROUND Kyphoscoliosis is an anatomical deformity of the spine often accompanied by an array of respiratory complications, pulmonary hypertension being amon
- Does dual task placement and duration affect split-belt treadmill adaptation?Publication date: Available online 13 October 2019Source: Gait & PostureAuthor(s): Dorelle C Hinton, David Conradsson, Laurent Bouyer, Caroline PaquetteAbstractBackgroundDual tasking during prolonged split-belt adaptation (10–15 min) has shown to slow the adaptation process and prolong aftereffects. Therefore, dual tasks during split-belt adaptation are being explored for their potential in gait symmetry rehabilitation. However, the ideal paradig
- Distinct, sex-dependent miRNA signatures in piglet hippocampus induced by a clinically relevant isoflurane exposure: a pilot studyAbstract Purpose To evaluate the effects of sex on miRNA expression in the hippocampus after isoflurane anesthesia in a neonatal piglet model. Methods Six male and 6 female piglets, aged 3–5 days, were anesthetized with 2% isoflurane in room air for 3 h. Full physiologic monitoring was observed. Untreated
- A review of the use of transnasal humidified rapid insufflation ventilatory exchange for patients undergoing surgery in the shared airway settingAbstract Transnasal humidified rapid insufflation ventilatory exchange (THRIVE) is a recent technique that delivers warm humidified high flow oxygen to patients, allowing for prolonged apneic oxygenation. A review of current literature was performed to determine the use of THRIVE in apneic patients undergoing surgery in a shared airway setting. An initial free hand search was done to identify keywords followed by a systematic s
- Temporal and Sequential Analysis of the Pharyngeal Phase of Swallowing in Poststroke PatientsAbstract The purpose of this study was to conduct a quantitative analysis of the temporal and sequential events of the pharyngeal phase of swallowing in 45 poststroke patients who presented or did not present with supraglottic penetration and/or laryngotracheal aspiration and to compare the groups with each other and to a group of 46 patients with normal swallowing. All individuals were assessed by videofluoroscopy and the temp
- The Effect of Lingual Resistance Training Interventions on Adult Swallow Function: A Systematic ReviewAbstract Lingual resistance training has been proposed as an intervention to improve decreased tongue pressure strength and endurance in patients with dysphagia. However, little is known about the impact of lingual resistance training on swallow physiology. This systematic review scrutinizes the available evidence regarding the effects of lingual resistance training on swallowing function in studies using Videofluoroscopic Swal
- Odontogenic tumours: a 25-year epidemiological study in the Marche region of ItalyAbstract Purpose Epidemiological data of odontogenic tumours (OT) are conflicting, with significant differences among the countries. This study aims to evaluate incidence and prevalence of OTs in the Marche population in a period of 25 years, according to 4th Edition of WHO Classification. Methods In this
- The use of structured reporting of head and neck ultrasound ensures time-efficiency and report quality during residencyAbstract Purpose Free text reports (FTR) of head and neck ultrasound studies are currently deployed in most departments. Because of a lack of composition and language, these reports vary greatly in terms of quality and reliability. This may impair the learning process during residency. The purpose of the study was to analyze the longitudinal effects of using structured reports (SR) of
Clinical Anatomy
- Motivation to Learn Neuroanatomy by Cadaveric Dissection is Correlated with Academic PerformanceBackground Implementing educational activities, such as a wet lab with cadaveric brain dissection, is known to have a direct impact on medical students' motivation. These activities demonstrate the clinical relevance of concepts taught in the classroom setting. The correlation between motivation and academic performance is not clear. Methods First year medical students participated in wet lab activities. The wet lab included cadaveric diss
- Three‐dimensional Morphological Variations of the Human Calcaneus Investigated Using Geometric MorphometricsIntroduction The shape of the calcaneus determines the mechanical interaction of the foot with the ground during the heel‐strike in human walking. Detailed knowledge of the pattern of sexual dimorphism of the human calcaneus could help to clarify the pathogenetic mechanism of foot and knee disorders, which are more prevalent in females. Therefore, the aim of this study was to characterize and visualize the three‐dimensional shape variations of t
The American Academy of Sleep Medicine
- Can We Predict Which Children With Autism Will Have Obstructive Sleep Apnea?Singer EV, Shelton AR, Malow BA. Can we predict which children with autism will have obstructive sleep apnea? J Clin Sleep Med. 2019;15(10):1389–1390.
- Cutting for Cures: Bariatric Surgery and Obstructive Sleep ApneaCastriotta RJ, Chung P. Cutting for cures: bariatric surgery and obstructive sleep apnea. J Clin Sleep Med. 2019;15(10):1391–1392.
- On Not Knowing What We Don’t Know to Knowing What We Don’t Know: Obstructive Sleep Apnea in the Transgender CommunityEarl DC, Brown LK. On not knowing what we don’t know to knowing what we don’t know: obstructive sleep apnea in the transgender community. J Clin Sleep Med. 2019;15(10):1393–1395.
- Temporal Association Between Respiratory Events and Reflux in Patients With Obstructive Sleep Apnea and Laryngopharyngeal RefluxStudy Objectives:The aim of the current study was to test the hypothesis that there is a temporal correlation between reflux episodes and respiratory events in patients with laryngopharyngeal reflux and obstructive sleep apnea.Methods:Adults with clinically diagnosed laryngopharyngeal reflux confirmed by two validated instruments (reflux symptom index ≥ 13 and reflux finding score ≥ 7) and obstructive sleep apnea (OSA) underwent full polysomnogra
- The Clinical Value of N-Terminal Pro B-Type Natriuretic Peptide in Evaluating Obstructive Sleep Apnea in Patients With Coronary Artery DiseaseStudy Objectives:Natriuretic peptides have been identified as biomarkers of increased myocardial wall stress in the context of obstructive sleep apnea (OSA) in the general population. However, the relationship between N-terminal pro B-type natriuretic peptide (NT-proBNP) and OSA remains unclear in patients with coronary artery disease (CAD). Hence, we aimed to investigate the clinical value of NT-proBNP in evaluating OSA in a large population of
- Automatic Sleep Staging in Patients With Obstructive Sleep Apnea Using Single-Channel Frontal EEGStudy Objectives:Reliable sleep staging is difficult to obtain from home sleep testing for diagnosis of obstructive sleep apnea (OSA), especially when it is self-applied. Hence, the current study aimed to develop a single frontal electroencephalography-based automatic sleep staging system (ASSS).Methods:The ASSS system was developed on a clinical dataset, with a high percentage of participants with OSA. The F4-M1 signal extracted from 62 particip
- Pregnancy and Contraception Experiences in Women With Narcolepsy: A Narcolepsy Network SurveyStudy Objectives:To explore knowledge and experiences of women with narcolepsy on pregnancy and contraception issues and their relationships with narcolepsy pharmacotherapy.Methods:An 18-item survey was administered through the Narcolepsy Network website for 8 weeks during the fall of 2012. The survey ascertained demographic information; prescription narcolepsy medication use and discontinuation during pregnancy; physician counseling regarding pr
- Current Practice Patterns in the Diagnosis and Management of Sleep-Disordered Breathing in InfantsStudy Objectives:Currently, there are no universally accepted guidelines for diagnosis and management of sleep-disordered breathing (SDB) in infants. The purpose of this study was to survey pediatric sleep medicine providers regarding their current practice patterns for diagnosis and management of SDB in infants.Methods:An anonymous, web-based survey with 71 questions was distributed via the PEDSLEEP and Ped-Lung listserv, which serve as a hub of
- Rates of Mental Health Symptoms and Associations With Self-Reported Sleep Quality and Sleep Hygiene in Adolescents Presenting for Insomnia TreatmentStudy Objectives:Despite high prevalence rates of both psychopathology and sleep problems during adolescence, as well as frequent co-occurrence, little is known about the mental health of adolescents presenting for insomnia evaluation and treatment. This study describes (1) rates of mental health symptoms and (2) associations of mental health symptoms with sleep behaviors and schedules in adolescents presenting to a behavioral sleep medicine clin
- Cumulative Childhood Lead Levels in Relation to Sleep During AdolescenceStudy Objectives:Lead exposure has been linked to adverse cognitive outcomes among children, and sleep disturbances could potentially mediate these relationships. As a first step, whether childhood lead levels are linked to sleep disturbances must be ascertained. Prior studies of lead and sleep are scarce and rely on parent-reported sleep data.Methods:The study population included 395 participants from the Early Life Exposure in Mexico to Environ
- Sleep-Disordered Breathing in Pediatric Patients With Rett SyndromeStudy Objectives:Although respiratory abnormalities occurring during wakefulness are well recognized in patients with Rett syndrome (RS), less has been reported regarding sleep-disordered breathing (SDB) in this population. This study aims to characterize the presenting complaints, types and severity of SDB, and treatment modalities of patients with RS and sleep concerns.Methods:Retrospective chart review of pediatric patients with RS referred to
- The Effect of Positive Airway Pressure Treatment of Obstructive and Central Sleep Apnea on the Recurrence of Atrial Fibrillation/Flutter PostinterventionStudy Objectives:A strong association between sleep-disordered breathing (SDB) and atrial fibrillation and/or atrial flutter (AF) has consistently been observed in epidemiologic and interventional studies. The effect of positive airway pressure (PAP) on AF recurrence is inconclusive. This study sought to evaluate the effectiveness of PAP therapy for SDB on AF recurrence.Methods:This was a single-center, retrospective study conducted at a tertiary
- Obstructive Sleep Apnea in Children With AutismStudy Objectives:To describe the demographic and clinical characteristics of children with autism spectrum disorder (ASD) referred for polysomnography (PSG) and to look for predictors of obstructive sleep apnea (OSA) and severe OSA in these children.Methods:This is a retrospective case series of children ages 2 to 18 years who underwent PSG between January 2009 and February 2015. Children were excluded if they had major comorbidities, prior tonsi
- Clinical- and Cost-Effectiveness of a Mandibular Advancement Device Versus Continuous Positive Airway Pressure in Moderate Obstructive Sleep ApneaStudy Objectives:Limited evidence exists on the cost-effectiveness of mandibular advancement device (MAD) compared to continuous positive airway pressure (CPAP) therapy in moderate obstructive sleep apnea (OSA). Therefore, this study compares the clinical and cost-effectiveness of MAD therapy with CPAP therapy in moderate OSA.Methods:In a multicentre randomized controlled trial, patients with an apnea-hypopnea index (AHI) of 15 to 30 events/h wer
- Sensitivity and Specificity of the Modified Epworth Sleepiness Scale in Children With CraniopharyngiomaStudy Objectives:Children with craniopharyngioma are at risk for excessive daytime sleepiness (EDS). Multiple Sleep Latency Testing (MSLT) is the gold standard for objective evaluation of EDS; however, it is time and resource intensive. We compared the reliability, sensitivity, and specificity of the modified Epworth Sleepiness Scale (M-ESS) and MSLT in monitoring EDS in children with craniopharyngioma.Methods:Seventy patients (ages 6 to 20 years
- Ten-Year Secular Trends in Sleep/Wake Patterns in Shanghai and Hong Kong School-Aged Children: A Tale of Two CitiesStudy Objectives:To compare the secular trends of sleep/wake patterns in school-aged children in Hong Kong and Shanghai, two major metropolitan cities in China with two different policies that school start time was delayed in Shanghai, but advanced in Hong Kong in 10 years’ time.Methods:Participants were from two waves of cross-sectional school-based surveys of children aged 6 to 11 years. In Shanghai, 4,339 and 13,795 children participated in th
- The Effect of the Modified Jaw-Thrust Maneuver on the Depth of Sedation During Drug-Induced Sleep EndoscopyStudy Objectives:The modified jaw-thrust maneuver (MJTM) during drug-induced sleep endoscopy (DISE) is known to predict the treatment effect of mandibular advancement devices. However, its effect on the depth of sedation and potential to provoke arousal by awakening patients during the maneuver has not been studied so far. This study investigated the effect of the MJTM on the depth of sedation during DISE.Methods:Forty patients on whom the MJTM w
- Evolution and Predictive Factors of Improvement of Obstructive Sleep Apnea in an Obese Population After Bariatric SurgeryStudy Objectives:Our objectives were to determine in an obese population (body mass index > 35 kg/m2) the number of patients, after gastric bypass (GBP), who no longer met French Ministry of Health criteria for utilizing positive airway pressure (PAP), and the predictive factors of obstructive sleep apnea (OSA) improvement.Methods:Between June 2012 and August 2014 we diagnosed OSA in 129 incident patients requiring PAP therapy before GBP. A posto
- Obstructive Sleep Apnea and Systemic Hypertension: Gut Dysbiosis as the Mediator?Introduction:Obstructive sleep apnea (OSA) and systemic hypertension (SH) are common and interrelated diseases. It is estimated that approximately 75% of treatment-resistant hypertension cases have an underlying OSA. Exploration of the gut microbiome is a new advance in medicine that has been linked to many comorbid illnesses, including SH and OSA. Here, we will review the literature in SH and gut dysbiosis, OSA and gut dysbiosis, and whether gut
- The Effects of Transgender Hormone Therapy on Sleep and Breathing: A Case SeriesThe effect of hormone therapy on sleep-disordered breathing in transgender patients has not been described. We present three cases of patients undergoing gender reassignment and treated with hormone replacement. The first case was a transgender woman (assigned male at birth) with a prolonged history of severe obstructive sleep apnea (OSA) that resolved following initiation of female sex hormones. The second and third cases both address transgende
- An Unusual Cause of CPAP IntoleranceContinuous positive airway pressure (CPAP) is a first-line treatment for obstructive sleep apnea (OSA). However, the adherence to CPAP can be difficult for patients due to several reasons. In this case report we describe a patient with severe OSA who initially was treated successfully with CPAP, but after a few months adherence problems developed because of macroglossia. This was caused by amyloidosis due to multiple myeloma. During treatment wit
- Case of an In-Laboratory Vagal Nerve Stimulator Titration for Vagal Nerve Stimulator-Induced Pediatric Obstructive Sleep ApneaWe present the case of a 12-year-old girl with medically refractory epilepsy and a vagal nerve stimulator (VNS), who experienced severe obstructive sleep apnea (OSA) with respiratory events closely matching her VNS settings. We demonstrated a real-time decrease in OSA through an in-laboratory VNS titration study, decreasing her VNS frequency from 20 Hz to 10 Hz. We were able to demonstrate a baseline level of OSA by turning off the VNS. We then e
- A Change of HeartPalen BN, He K, Redinger J, Parsons EC. A change of heart. J Clin Sleep Med. 2019;15(10):1543–1545.
- Persistent Hypoxemia in a Teen With Down SyndromeUpchurch A, Sharma S, Hadigal S, Wagner M, Berry R. Persistent hypoxemia in a teen with down syndrome. J Clin Sleep Med. 2019;15(10):1547–1549.
- When Sleeping With Eyes Closed Is OptionalDelRosso LM, Lehnert D, Chen ML.When sleeping with eyes closed is optional. J Clin Sleep Med. 2019;15(10):1551–1553.
- Effect of Varying Definitions of Hypopnea on the Calculation of the Apnea-Hypopnea Index May Depend Upon the Level of Sympathetic Activation: Results From a Patient With Posttraumatic Stress DisorderGupta MA. Effect of varying definitions of hypopnea on the calculation of the apnea-hypopnea index may depend upon the level of sympathetic activation: results from a patient with posttraumatic stress disorder. J Clin Sleep Med. 2019;15(10):1555.
Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00302841026182,00306932607174,alsfakia@gmail.com,
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Δευτέρα 14 Οκτωβρίου 2019
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Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00302841026182,00306932607174,alsfakia@gmail.com,
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00302841026182,
00306932607174,
alsfakia@gmail.com,
Anapafseos 5 Agios Nikolaos 72100 Crete Greece,
Medicine by Alexandros G. Sfakianakis,
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