• 
  New treatments for atopic dermatitis targeting beyond IL-4/IL-13 cytokines

  Disclosures: E. Guttman-Yassky received board membership from Sanofi Aventis, Regeneron, Stiefel/GlaxoSmithKline, MedImmune, Celgene, Anacor, Leo Pharma, AnaptysBio, Celsus, Dermira, Galderma, Novartis, Pfizer, Vitae, Glenmark, AbbVie, and Asana Biosciences and consultancy fees from Regeneron, Sanofi Aventis, MedImmune, Celgene, Stiefel/GlaxoSmithKline, Celsus, BMS, Amgen, Drais, AbbVie, Anacor, AnaptysBio, Dermira, Galderma, Leo Pharma, Novartis

  Annals of Allergy, Asthma & Immunology

  Sun Oct 13, 2019 17:00
• Increased cardiovascular and atherosclerosis markers in blood of older atopic dermatitis patients

  Atopic dermatitis (AD) is associated with increased systemic inflammation and cardiovascular risk. While previous studies showed increased inflammatory proteins in the blood of AD patients, detailed comparison among AD patients of different ages is unavailable.

  Annals of Allergy, Asthma & Immunology

  Sun Oct 13, 2019 17:00
• The Role of Filaggrin in Atopic Dermatitis and Allergic Disease

  Filaggrin is a major epidermal protein that has been shown to be a key player in the pathogenesis of AD and allergic disease. While filaggrin is a significant genetic risk factor for AD, it is also an important disease modifier in AD. Patients with filaggrin related AD and asthma have more frequent hospital admissions and long-term medication costs[1]. Atopic dermatitis patients with FLG mutations are more frequently affected by reduced health re

  Annals of Allergy, Asthma & Immunology

  Sun Oct 13, 2019 17:00
• Cancer
• Nationwide randomised trial evaluating elective neck dissection for early stage oral cancer (SEND study) with meta-analysis and concurrent real-world cohort

  British Journal of Cancer, Published online: 15 October 2019; doi:10.1038/s41416-019-0587-2Nationwide randomised trial evaluating elective neck dissection for early stage oral cancer (SEND study) with meta-analysis and concurrent real-world cohort

  Cancer

  Mon Oct 14, 2019 17:00
• Nationwide randomised trial evaluating elective neck dissection for early stage oral cancer (SEND study) with meta-analysis and concurrent real-world cohort

  Cancer

  Mon Oct 14, 2019 15:28
• The Journal of Physiology
• Mechanisms of improved exercise capacity following respiratory muscle training in athletes with cervical spinal cord injury

  The Journal of Physiology

  Mon Oct 14, 2019 02:03
• Inorganic nitrate supplementation and exercise. Is skeletal muscle involved in the heavy lifting?

  The Journal of Physiology

  Mon Oct 14, 2019 01:29
• Journal of Surgical Case Reports - current issue
• An unusual cause of bowel ischemia in an intensive care unit patient with herpes simplex virus encephalitis

  AbstractWe present a case of an unexpected cause of bowel ischemia in an intensive care unit patient with herpes simplex virus encephalitis who required an operation. A 79-year-old lady was being worked up and treated for encephalitis with antibiotics and an antiviral. On Day 13, she developed abdominal pain, and an ultrasound showed cholelithiasis but no cholecystitis; thus conservative treatment was advocated. By Day 18, pain localized to the r

  Journal of Surgical Case Reports - current issue

  Sun Oct 13, 2019 17:00
• Knotted nasogastric tube: a rare, overlooked yet preventable complication

  AbstractNasogastric tubes (NGTs) have long been used for various indications, most commonly to decompress the stomach of its contents in intestinal obstruction or after abdominal surgery, to provide enteral feeding or to allow enteral liquid medication administration. Recently greater importance has been given to the correct placement NGTs to avoid serious complications. We present a case of a spontaneously knotted NGT that was identified and saf

  Journal of Surgical Case Reports - current issue

  Sun Oct 13, 2019 17:00
• Iatrogenic injury to a vesicourachal diverticulum during laparoscopic appendectomy successfully managed conservatively

  AbstractA vesicourachal diverticulum is a rare congenital anomaly that arises from the incomplete closure of the urachus at the bladder end. We describe a 12-year-old boy who presented with severe persistent right iliac fossa pain associated with subjective fever, nausea, vomiting, and anorexia. A computed tomography (CT) scan of the abdomen and pelvis revealed findings consistent with appendicitis. The patient underwent a laparoscopic appendecto

  Journal of Surgical Case Reports - current issue

  Sun Oct 13, 2019 17:00
• Evolutionary Biology News -- ScienceDaily
• Investing in love and affection pays off for species that mate for life

  A new study by biologists explains how sexual cooperation and bonding evolves in bird species that form pair bonds.

  Evolutionary Biology News -- ScienceDaily

  Mon Oct 14, 2019 15:16
• Evolutionary history of oaks

  Oaks have a complex evolutionary history that has long eluded scientists. New research, however, provides the most detailed account to date of the evolution of oaks, recovering the 56-million-year history that has made the oaks one of the most diverse, abundant and important woody plant groups to the ecology and economy of the northern hemisphere.

  Evolutionary Biology News -- ScienceDaily

  Mon Oct 14, 2019 08:17
• Clinical Cancer Research Online First Articles
• Comprehensive Profiling of Poor-Risk Paired Primary and Recurrent Triple-Negative Breast Cancers Reveals Immune Phenotype Shifts

  Purpose: Emerging data suggest immune checkpoint inhibitors have reduced efficacy in heavily pretreated TNBCs, but underlying mechanisms are poorly understood. To better understand the phenotypic evolution of TNBCs, we studied the genomic and transcriptomic profiles of paired tumors from TNBC patients. Experimental Design: We collected paired primary and metastatic TNBC specimens from 43 patients and performed targeted exome sequencing and whole

  Clinical Cancer Research Online First Articles

  Mon Oct 14, 2019 08:23
• A new pathway emerges to interpret lung cancer genomic alterations

  The clinical utility of performing tumor genetic testing to assess for alterations beyond the known targetable oncogenes in lung adenocarcinoma is unclear. Analyzing cancer pathway alterations beyond single oncogenic driver mutations in addition to markers of tumor mutation burden and genomic instability may provide additional predictive and prognostic information.

  Clinical Cancer Research Online First Articles

  Mon Oct 14, 2019 08:23
• Clinical Otolaryngology
• Application of Augmented Reality to Surgical Practice: A Pilot Study using the ODG R‐7 Smartglasses

  Abstract This is the first documented application ODG R7 Smartglasses, an augmented reality device, to an Otolaryngology ‐ Head and Neck Surgery training laboratory setting. Staff surgeons and resident trainees were recruited to participate in a mixed‐methods pilot study evaluating the usefulness of the ODG R7 Smartglasses in the temporal bone cadaver drilling laboratory at our institution. In‐house software was developed specifically f

  Clinical Otolaryngology

  Mon Oct 14, 2019 10:34
• Annals of Internal Medicine Current Issue
• Evidence Relating Health Care Provider Burnout and Quality of Care A Systematic Review and Meta-analysis

  Background:Whether health care provider burnout contributes to lower quality of patient care is unclear.Purpose:To estimate the overall relationship between burnout and quality of care and to evaluate whether published studies provide exaggerated estimates of this relationship.Data Sources:MEDLINE, PsycINFO, Health and Psychosocial Instruments (EBSCO), Mental Measurements Yearbook (EBSCO), EMBASE (Elsevier), and Web of Science (Clarivate Analytic

  Annals of Internal Medicine Current Issue

  Mon Oct 14, 2019 14:48
• Annals Consult Guys - Preventing Coronary Disease in Rheumatoid Arthritis: Do Guidelines Apply?

  Annals of Internal Medicine Current Issue

  Mon Oct 14, 2019 14:48
• Review: Extended therapy with DOACs, but not VKAs, reduces mortality after VTE treated with initial anticoagulation

  Annals of Internal Medicine Current Issue

  Mon Oct 14, 2019 14:48
• Annals On Call - Making Sense of Breast Cancer Screening Guidelines

  Annals of Internal Medicine Current Issue

  Mon Oct 14, 2019 14:48
• Establishing the Prevalence and Prevalence at Birth of Hemophilia in Males A Meta-analytic Approach Using National Registries

  Background:The large observed variability in hemophilia prevalence prevents robust estimation of burden of disease.Objective:To estimate the prevalence and prevalence at birth of hemophilia and the associated life expectancy disadvantage.Design:Random-effects meta-analysis of registry data.Setting:Australia, Canada, France, Italy, New Zealand, and the United Kingdom.Participants:Male patients with hemophilia A or B.Measurements:Prevalence of hemo

  Annals of Internal Medicine Current Issue

  Mon Oct 14, 2019 14:48
• Annals for Hospitalist Inpatient Notes - Rethinking the Role of Functional Capacity in Preoperative Risk Stratification

  Annals of Internal Medicine Current Issue

  Mon Oct 14, 2019 14:48
• Guideline: USPSTF recommends preexposure prophylaxis with antiretroviral therapy for persons at high risk for HIV

  Annals of Internal Medicine Current Issue

  Mon Oct 14, 2019 14:48
• Annals for Hospitalists - 15 October 2019

  Annals of Internal Medicine Current Issue

  Mon Oct 14, 2019 14:48
• Antibiotics and the Yield of Blood Cultures: Sequence Matters

  Cheng and colleagues examined whether antibiotics can be administered before cultures are drawn without decreasing their yield in patients with sepsis. The editorialists discuss the findings and the need for diagnostic strategies that optimize both the timeliness and appropriateness of sepsis therapy.

  Annals of Internal Medicine Current Issue

  Mon Oct 14, 2019 14:48
• Annals Graphic Medicine - Progress Notes: Discharge

  Annals of Internal Medicine Current Issue

  Mon Oct 14, 2019 14:48
• Annals for Educators - 15 October 2019

  Annals of Internal Medicine Current Issue

  Mon Oct 14, 2019 14:48
• Overdose, Out Front

  Annals of Internal Medicine Current Issue

  Mon Oct 14, 2019 14:48
• Review: In nonsurgical settings, tranexamic acid reduces mortality and does not increase thrombotic events

  Annals of Internal Medicine Current Issue

  Mon Oct 14, 2019 14:48
• The Boy

  Annals of Internal Medicine Current Issue

  Mon Oct 14, 2019 14:48
• Deciphering the Relationship Between Health Care Provider Burnout and Quality of Care

  The editorialists discuss Tawfik and coworkers' findings and highlight future approaches that might provide a deeper understanding of the interplay between clinician burnout and quality of care.

  Annals of Internal Medicine Current Issue

  Mon Oct 14, 2019 14:48
• Fighter

  Annals of Internal Medicine Current Issue

  Mon Oct 14, 2019 14:48
• Fool Me Twice? The Reemergence of Rofecoxib and the Orphan Drug Act

  This commentary considers the implications of applying the Orphan Drug Act to products that may be at risk for off-label prescribing after approval.

  Annals of Internal Medicine Current Issue

  Mon Oct 14, 2019 14:48
• Cardiovascular Events and Mortality in White Coat Hypertension

  Annals of Internal Medicine Current Issue

  Mon Oct 14, 2019 14:48
• Personalized Prediction of Cardiovascular Benefits and Bleeding Harms From Aspirin for Primary Prevention A Benefit–Harm Analysis

  Background:Whether the benefits of aspirin for the primary prevention of cardiovascular disease (CVD) outweigh its bleeding harms in some patients is unclear.Objective:To identify persons without CVD for whom aspirin would probably result in a net benefit.Design:Individualized benefit–harm analysis based on sex-specific risk scores and estimates of the proportional effect of aspirin on CVD and major bleeding from a 2019 meta-analysis.Setting:New

  Annals of Internal Medicine Current Issue

  Mon Oct 14, 2019 14:48
• Cardiovascular Events and Mortality in White Coat Hypertension

  Annals of Internal Medicine Current Issue

  Mon Oct 14, 2019 14:48
• Firearm-Related Injury and Death in the United States: A Call to Action From the Nation's Leading Physician and Public Health Professional Organizations

  In this special article, leaders from 7 of the nation's largest physician and public health professional societies reiterate their commitment to finding solutions and call for policies to reduce firearm-related injuries and deaths.

  Annals of Internal Medicine Current Issue

  Mon Oct 14, 2019 14:48
• Estimating the Attributable Cost of Physician Burnout in the United States

  Annals of Internal Medicine Current Issue

  Mon Oct 14, 2019 14:48
• Dapagliflozin reduced cardiorenal outcomes but not MACE in T2 diabetes with or at risk for atherosclerotic CVD

  Annals of Internal Medicine Current Issue

  Mon Oct 14, 2019 14:48
• Estimating the Attributable Cost of Physician Burnout in the United States

  Annals of Internal Medicine Current Issue

  Mon Oct 14, 2019 14:48
• TXA plus compression and nasal packing did not differ for epistaxis, and both were better than compression alone

  Annals of Internal Medicine Current Issue

  Mon Oct 14, 2019 14:48
• Older Drugs With Limited Trial Evidence: Are They Worth the Expense?

  Annals of Internal Medicine Current Issue

  Mon Oct 14, 2019 14:48
• Review: In older adults with acute major depression, SNRIs, but not SSRIs, increase adverse events vs placebo

  Annals of Internal Medicine Current Issue

  Mon Oct 14, 2019 14:48
• Older Drugs With Limited Trial Evidence: Are They Worth the Expense?

  Annals of Internal Medicine Current Issue

  Mon Oct 14, 2019 14:48
• Annals Graphic Medicine - A Step Toward Health

  Annals of Internal Medicine Current Issue

  Mon Oct 14, 2019 14:48
• Older Drugs With Limited Trial Evidence: Are They Worth the Expense?

  Annals of Internal Medicine Current Issue

  Mon Oct 14, 2019 14:48
• Ensuring Sustainability of Needed Antibiotics: Aiming for the DART Board

  Current initiatives to incentivize development of antibiotics for resistant pathogens have yielded disappointing results because many recently approved antibiotics do not address clinical unmet needs or provide redundant coverage. In this article, the authors propose a different approach for guiding development of new antibiotics to combat resistant organisms.

  Annals of Internal Medicine Current Issue

  Mon Oct 14, 2019 14:48
• Fanconi Syndrome and Tenofovir Alafenamide

  Annals of Internal Medicine Current Issue

  Mon Oct 14, 2019 14:48
• Cases in Precision Medicine: Should You Participate in a Study Involving Genomic Sequencing of Your Patients?

  Internists and other physicians may be asked to participate in research studies that include genomic screening of their patients. Because genomic studies can identify many variants with potential clinical or personal implications, physicians should carefully consider the effect of participation on their patients, as well as the time and effort needed for the physicians to interpret the results and decide how best to use the information. Among the

  Annals of Internal Medicine Current Issue

  Mon Oct 14, 2019 14:48
• Fanconi Syndrome and Tenofovir Alafenamide

  Annals of Internal Medicine Current Issue

  Mon Oct 14, 2019 14:48
• Individualize Treatment With Aspirin for Primary Prevention

  The editorialist discusses Selak and colleagues' model and its application to clinical practice in light of other conflicting evidence.

  Annals of Internal Medicine Current Issue

  Mon Oct 14, 2019 14:48
• In patients with suspected AMI and LBBB, algorithms based on ECG and troponin data were tested to rule MI in or out

  Annals of Internal Medicine Current Issue

  Mon Oct 14, 2019 14:48
• Blood Culture Results Before and After Antimicrobial Administration in Patients With Severe Manifestations of Sepsis A Diagnostic Study

  Background:Administering antimicrobial agents before obtaining blood cultures could potentially decrease time to treatment and improve outcomes, but it is unclear how this strategy affects diagnostic sensitivity.Objective:To determine the sensitivity of blood cultures obtained shortly after initiation of antimicrobial therapy in patients with severe manifestations of sepsis.Design:Patient-level, single-group, diagnostic study. (ClinicalTrials.gov

  Annals of Internal Medicine Current Issue

  Mon Oct 14, 2019 14:48
• In suspected MI without ST elevation, a risk tool including hs-cTnI or hs-cTnT predicted diagnosis and 30-d outcomes

  Annals of Internal Medicine Current Issue

  Mon Oct 14, 2019 14:48
• Global Hemophilia Care: Data for Action

  Iorio and coworkers make the case that measuring the global burden of hemophilia is important in developing strategies to address gaps in access to care for this condition. The editorialist discusses the findings.

  Annals of Internal Medicine Current Issue

  Mon Oct 14, 2019 14:48
• Pantoprazole did not reduce risk for a composite of upper gastrointestinal events in stable arterial disease

  Annals of Internal Medicine Current Issue

  Mon Oct 14, 2019 14:48
• Coagulopathy After Synthetic Cannabinoid Use: A Case Report

  Annals of Internal Medicine Current Issue

  Mon Oct 14, 2019 14:48
• Pooled RCTs: In acute ischemic stroke with salvageable brain tissue, alteplase at 4.5 to 9 hours improved function

  Annals of Internal Medicine Current Issue

  Mon Oct 14, 2019 14:48
• Prevalence of Aspirin Use for Primary Prevention of Cardiovascular Disease in the United States: Results From the 2017 National Health Interview Survey

  Annals of Internal Medicine Current Issue

  Mon Oct 14, 2019 14:48